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41.发明申请PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF PANCREATIC CANCER 有权用于治疗和/或预防胰腺癌的药物组合物公开(公告)号：US20140308283A1
公开(公告)日：2014-10-16
申请号：US14236818
申请日：2012-08-03
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/303 , A61K39/0011 , A61K39/39558 , A61K2039/505 , A61K2039/5258 , C07K14/4738 , C07K16/28 , C07K16/30 , C07K2317/10 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/732
摘要： This invention relates to a pharmaceutical composition for treatment and/or prevention of pancreatic cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 to 12 or more consecutive amino acid residues.
摘要翻译： 本发明涉及一种用于治疗和/或预防胰腺癌的药物组合物，其包含与CAPRIN-1蛋白或其片段具有免疫反应性的抗体或其片段作为活性成分，其包含7至12个或更多个连续氨基 酸残留。
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公开(公告)号：US08835811B2
公开(公告)日：2014-09-16
申请号：US13408223
申请日：2012-02-29
申请人： Koji Yoshii , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji Yoshii , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
CPC分类号： H01L21/67115 , F27B17/0025 , F27D19/00 , F27D21/0014 , H01L21/67109 , H01L21/67248
摘要： A control unit can select a large-number control zone model in which the number of control zones, which are independently controlled, is large, and a small-number control zone model in which the number of control zones, which are independently controlled, is small. When a temperature is increased or decreased, the control unit can select the small-number control zone model so as to control, based on signals from temperature sensors of the respective control zones C1 . . . C5 whose number is small, heaters located on the respective control zones C1 . . . C5. When a temperature is stabilized, the control unit can select the large-number control zone model so as to control, based on signals from the temperature sensors of the respective control zones C1 . . . C10 whose number is large, the heaters located on the respective control zones C1 . . . C10.
摘要翻译： 控制单元可以选择其中独立控制的控制区域的数量大的大量控制区域模型，以及独立控制的控制区域的数量为少数的控制区域模型 小。 当温度升高或降低时，控制单元可以根据来自相应控制区C1的温度传感器的信号，选择小数控制区模型，以便控制。 。 。 数量少的加热器位于相应控制区C1上。 。 。 C5。 当温度稳定时，控制单元可以根据来自相应控制区C1的温度传感器的信号来选择大数量的控制区域模型。 。 。 C10，其数量大，位于各个控制区C1上的加热器。 。 。 C10。
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公开(公告)号：US20140186359A1
公开(公告)日：2014-07-03
申请号：US14236793
申请日：2012-08-03
IPC分类号： C07K16/18 , A61K45/06 , A61K39/395
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.
摘要翻译： 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。 更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段 和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。
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公开(公告)号：US20130071398A1
公开(公告)日：2013-03-21
申请号：US13577028
申请日：2011-02-04
IPC分类号： A61K39/395 , C07K16/18 , C07K16/30
CPC分类号： A61K39/39533 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K16/3015 , C07K16/3053 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/732 , C07K2317/734
摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody or a fragment thereof as an active ingredient having immunological reactivity with a partial polypeptide of CAPRIN-1, which is represented by any of even-numbered sequences of SEQ ID NOS: 2 to 30, wherein the polypeptide has the amino acid sequence represented by SEQ ID NO: 37 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence represented by SEQ ID NO: 37.
摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体地说，本发明提供了一种用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为与CAPRIN-1的部分多肽具有免疫反应性的活性成分， SEQ ID NO：2至30的编号序列，其中所述多肽具有由SEQ ID NO：37表示的氨基酸序列或与SEQ ID NO：37所示氨基酸序列具有80％或更多序列同一性的氨基酸序列 。
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公开(公告)号：US20120321641A1
公开(公告)日：2012-12-20
申请号：US13576955
申请日：2011-02-04
申请人： Fumiyoshi Okano , Takanori Saito
发明人： Fumiyoshi Okano , Takanori Saito
IPC分类号： A61K39/395 , A61P35/00 , C07K16/22
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/3015 , C07K16/3053 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/732 , C07K2317/734
摘要： According to the present invention, a cancer antigen protein to be specifically expressed on the surfaces of cancer cells is identified and thus the use of an antibody targeting the cancer antigen protein as an agent for treating and/or preventing a cancer is provided. Specifically, the present invention provides a pharmaceutical composition for treating and/or preventing a cancer, which comprises an antibody comprising a heavy chain variable region that comprises SEQ ID NOS: 39, 40, and 41 and a light chain variable region that comprises SEQ ID NOS: 43, 44, and 45 or a fragment thereof as an active ingredient and having immunological reactivity with a CAPRIN-1 protein.
摘要翻译： 根据本发明，鉴定在癌细胞表面特异性表达的癌抗原蛋白，因此提供了靶向癌抗原蛋白的抗体作为治疗和/或预防癌症的药剂的用途。 具体而言，本发明提供了用于治疗和/或预防癌症的药物组合物，其包含含有包含SEQ ID NO：39,40和41的重链可变区的抗体和包含SEQ ID NO：39,40和41的轻链可变区， NOS：43,44和45或其片段作为活性成分，并与CAPRIN-1蛋白具有免疫反应性。
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公开(公告)号：US20120064472A1
公开(公告)日：2012-03-15
申请号：US13226120
申请日：2011-09-06
申请人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
CPC分类号： F27B17/0025 , H01L21/67109 , H01L21/67248
摘要： A heat treatment apparatus and control method enabling the apparatus to settle down an internal temperature of a treating vessel to a target temperature accurately and quickly. The heat treatment apparatus includes a furnace body with a heater on an inner circumferential surface thereof, the treating vessel disposed inside the furnace body, a cooling medium supply blower and cooling medium release blower each connected to the furnace body, and a temperature sensor provided inside the treating vessel. A signal from the temperature sensor is sent to a heater output computing unit and blower output computing unit included in a controller. The heater output computing unit determines a heater output level based on a heater output numerical model and the signal from the temperature sensor. The blower output computing unit determines a blower output level based on a blower output numerical model and the signal from the temperature sensor.
摘要翻译： 一种热处理装置和控制方法，能够使装置能够准确且快速地将处理容器的内部温度稳定到目标温度。 该热处理装置具有在内周面具有加热器的炉体，设置在炉体内部的处理容器，与炉体连接的冷却介质供给鼓风机和冷却介质排出用鼓风机，以及设置在炉体内部的温度传感器 处理容器。 来自温度传感器的信号被发送到包括在控制器中的加热器输出计算单元和鼓风机输出计算单元。 加热器输出计算单元基于加热器输出数值模型和来自温度传感器的信号确定加热器输出电平。 鼓风机输出计算单元基于鼓风机输出数值模型和来自温度传感器的信号确定鼓风机输出水平。
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公开(公告)号：US20110130343A1
公开(公告)日：2011-06-02
申请号：US13002629
申请日：2009-07-10
申请人： Fumiyoshi Okano , Masaki Shimizu , Takanori Saito
发明人： Fumiyoshi Okano , Masaki Shimizu , Takanori Saito
IPC分类号： A61K38/08 , A61K31/7084 , C12N5/00 , G01N33/574 , C07K7/06 , C07K7/08 , C07K14/00 , A61P35/00
CPC分类号： C07K14/47 , A61K31/711 , A61K38/00 , A61K39/0011 , A61K2039/55566 , G01N33/57415 , G01N33/57426
摘要： An immunity-inducing agent comprising as an effective ingredient(s) at least one polypeptide selected from the following polypeptides, the polypeptide(s) having an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo can be used for therapy and/or prophylaxis of cancer: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in the odd number IDs of SEQ ID NOs:3 to 95 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof. Further, since the above polypeptide(s) react(s) with antibodies existing specifically in serum of a cancer patient, it is possible to detect cancer in a living body by measuring the antibodies in a sample.
摘要翻译： 一种免疫诱导剂，其包含选自以下多肽的至少一种多肽，具有免疫诱导活性/活性的多肽或作为有效成分的重组载体（s）的有效成分 ），其可以用于治疗和/或预防癌症：（a）基本上包含编码多肽并且能够在体内表达多肽的多核苷酸的多核苷酸 在SEQUENCE LISTING中SEQ ID NO：3至95的奇数ID中显示的任何一个氨基酸序列中不少于7个连续氨基酸; （b）与多肽（a）具有不小于90％的序列同一性并且基本上由不少于7个氨基酸组成的多肽; 和（c）包含多肽（a）或（b）作为其部分序列的多肽。 此外，由于上述多肽与癌症患者的血清中特异性存在的抗体反应，因此可以通过测量样品中的抗体来检测活体中的癌症。
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公开(公告)号：US20110129478A1
公开(公告)日：2011-06-02
申请号：US13002636
申请日：2009-07-10
申请人： Fumiyoshi Okano , Takanori Saito , Takayoshi Ido , Masaki Shimizu
发明人： Fumiyoshi Okano , Takanori Saito , Takayoshi Ido , Masaki Shimizu
IPC分类号： A61K39/395 , C07K16/18 , C07K2/00 , C12N15/13 , A61P35/00
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/3015 , C07K16/3061 , C07K2317/732 , C07K2317/734
摘要： An antibody or a fragment thereof having immunoreactivity to a polypeptide comprising not less than 7 continuous amino acids in the CD179b protein, which was identified as a cancer antigen protein specifically expressed on the surfaces of cancer cells, can be used as a pharmaceutical composition for therapy and/or prophylaxis of cancer.
摘要翻译： 可以将被鉴定为在癌细胞表面特异表达的癌抗原蛋白质的CD179b蛋白质中包含不少于7个连续氨基酸的多肽具有免疫反应性的抗体或其片段作为治疗用药物组合物 和/或预防癌症。
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公开(公告)号：US20070095288A1
公开(公告)日：2007-05-03
申请号：US10551033
申请日：2004-03-29
CPC分类号： H01L21/67109
摘要： The present invention is a thermal processing method including: a step of conducting a predetermined thermal process in a low temperature zone to a plurality of objects to be processed held in a tier-like manner by a heating unit, in a processing container that is made of metal and has the heating unit therein, and a step of introducing a cooling gas into respective areas in the processing container divided in a height direction of the objects to be processed.
摘要翻译： 本发明是一种热处理方法，其特征在于，包括以下步骤：在制造的处理容器中，通过加热单元，在低温区域对多个被处理物进行预定的热处理， 的金属，并且在其中具有加热单元，以及将冷却气体引入处理容器中的被处理物体的高度方向上划分的各个区域的步骤。
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公开(公告)号：US07141765B2
公开(公告)日：2006-11-28
申请号：US10473248
申请日：2002-03-20
申请人： Toshiyuki Makiya , Takanori Saito , Karuki Eickmann , Sanjeev Kaushal , Anthony Dip , David L. O'meara
发明人： Toshiyuki Makiya , Takanori Saito , Karuki Eickmann , Sanjeev Kaushal , Anthony Dip , David L. O'meara
摘要： A antireflective film 50 is formed on a thermocouple 42 arranged in a processing vessel 1 of a heat treatment apparatus in order to improve the transient response characteristics of the thermocouple 42. In a typical embodiment, the thermocouple 42 is made by connecting a platinum wire 43A and a platinum-rhodium alloy wire 43B, and the antireflective film 50 is composed by stacking a silicon nitride layer 50C, silicon layer 50B and a silicon nitride layer 50A in that order.
摘要翻译： 为了改善热电偶42的瞬态响应特性，在设置在热处理装置的处理容器1中的热电偶42上形成防反射膜50。 在一个典型的实施例中，热电偶42是通过连接铂线43A和铂 - 铑合金线43B制成的，并且抗反射膜50由叠氮化硅层50C，硅层50B和硅 氮化物层50A。
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