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公开(公告)号：US09801677B2
公开(公告)日：2017-10-31
申请号：US13057939
申请日：2009-08-07
CPC分类号： A61B18/0218 , A61B2017/00747 , A61B2018/00005 , A61B2018/00458 , A61B2018/0047 , A61B2018/00577 , A61B2018/00714 , A61B2018/00815 , A61B2018/00821 , A61B2018/0237 , A61B2018/0293 , A61B2018/143 , A61F7/00 , A61F7/0085 , A61F7/10 , A61F2007/0052 , A61F2007/0056 , A61F2007/0063 , A61F2007/0075 , A61F2007/0086 , A61F2007/0087 , A61F2007/0089 , A61F2007/0095 , A61F2007/0096 , A61F2007/0292
摘要： Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or 0.5 mm, and a distance between these frozen regions can be greater than about 3 times the width of the regions. An exemplary apparatus can be provided that includes a plurality of spatially-separated thermally conductive arrangements that can be affixed or otherwise coupled to a base. For example, the conductive arrangements can be regions of conductive material provided in or proximal to a thermal insulator, or thermally conductive protrusions affixed to the base. The conductive arrangements can be cooled and then contacted with the skin surface to produce the small regions of hypopigmentation.
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公开(公告)号：US08961450B2
公开(公告)日：2015-02-24
申请号：US12787655
申请日：2010-05-26
CPC分类号： A61K33/24 , A61B18/04 , A61K8/19 , A61K9/0014 , A61K9/16 , A61K41/0052 , A61K41/0057 , A61K2800/81 , A61M1/0084 , A61M1/08 , A61M35/003 , A61M37/0092 , A61M2205/3653 , A61M2205/368 , A61M2210/04 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61Q19/00 , A61Q19/10
摘要： The present invention is directed to a method and apparatus for delivering substances, e.g., therapeutic substances, into openings on or near a skin surface, such as hair follicles, pores and/or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and/or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the therapeutic substance.
摘要翻译： 本发明涉及用于将诸如治疗物质的物质输送到诸如毛囊，孔和/或皮脂腺的皮肤表面上或附近的开口中的方法和装置。 这可以通过使用装置通过一个或多个喷嘴或狭缝将物质引导到压力下的开口中来实现。 存在于毛囊中的皮脂的一部分任选地被加热和/或去除，例如， 在引入治疗物质之前，使用位于装置下表面上的低压导管。
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公开(公告)号：US20120041430A1
公开(公告)日：2012-02-16
申请号：US12936173
申请日：2009-04-01
IPC分类号： A61B17/322 , A61B18/20
CPC分类号： A61B17/32053 , A61B10/0233 , A61B17/32093 , A61B17/322 , A61B2017/00752 , A61B2017/00969 , A61B2017/306 , A61B2017/3225
摘要： Exemplary embodiments of apparatus and method for harvesting small portions of tissue (“micrografts”) to form grafts can be provided. For example, a hollow tube can be inserted into tissue at a donor site, where a distal end of the hollow tube can have two or more points or extensions to facilitate separation of the micrografts from the surrounding tissue. The exemplary apparatus can be provided that includes a plurality of such tubes for simultaneous harvesting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, or less than about 0.3 mm, which can promote healing of the donor site and/or viability of the harvested tissue. The micrografts can be approximately cylindrical or strip-shaped, and can be placed in a biocompatible matrix to form a graft or directly into tissue at the recipient site. Such exemplary micrografts can be obtained from skin or other types of tissue, e.g., various internal organs.
摘要翻译： 可以提供用于收集小部分组织（“微移植物”）以形成移植物的装置和方法的示例性实施方案。 例如，中空管可以在供体部位的组织中插入，其中中空管的远端可以具有两个或更多个点或延伸部，以促进微移植物与周围组织的分离。 可以提供示例性装置，其包括多个这样的管，用于同时收集多个微移植物。 收获的微移植物可以具有小尺寸，例如小于约1mm，或小于约0.3mm，这可以促进供体部位的愈合和/或收获的组织的活力。 微移植物可以是大致圆柱形或带状，并且可以放置在生物相容性基质中以在受体部位形成移植物或直接进入组织。 这样的示例性微移植物可以从皮肤或其他类型的组织例如各种内部器官获得。
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公开(公告)号：US20110313411A1
公开(公告)日：2011-12-22
申请号：US13057939
申请日：2009-08-07
IPC分类号： A61B18/02
CPC分类号： A61B18/0218 , A61B2017/00747 , A61B2018/00005 , A61B2018/00458 , A61B2018/0047 , A61B2018/00577 , A61B2018/00714 , A61B2018/00815 , A61B2018/00821 , A61B2018/0237 , A61B2018/0293 , A61B2018/143 , A61F7/00 , A61F7/0085 , A61F7/10 , A61F2007/0052 , A61F2007/0056 , A61F2007/0063 , A61F2007/0075 , A61F2007/0086 , A61F2007/0087 , A61F2007/0089 , A61F2007/0095 , A61F2007/0096 , A61F2007/0292
摘要： Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or 0.5 mm, and a distance between these frozen regions can be greater than about 3 times the width of the regions. An exemplary apparatus can be provided that includes a plurality of spatially-separated thermally conductive arrangements that can be affixed or otherwise coupled to a base. For example, the conductive arrangements can be regions of conductive material provided in or proximal to a thermal insulator, or thermally conductive protrusions affixed to the base. The conductive arrangements can be cooled and then contacted with the skin surface to produce the small regions of hypopigmentation.
摘要翻译： 本公开的示例性实施方案提供了通过冷却或冷冻皮肤的小分离表面区域来实现（例如，减轻）皮肤外观的方法和装置，以产生局部色素沉着的区域。 区域的宽度可以例如小于约1mm或0.5mm，并且这些冻结区域之间的距离可以大于区域宽度的约3倍。 可以提供一种示例性装置，其包括可以固定或以其他方式耦合到基座的多个空间分离的导热装置。 例如，导电布置可以是设置在绝热体中或靠近热绝缘体的导电材料区域，或者固定到基底的导热突起。 导电布置可以被冷却，然后与皮肤表面接触以产生色素减少的小区域。
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45.发明申请公开(公告)号：US20080137080A1
公开(公告)日：2008-06-12
申请号：US11835982
申请日：2007-08-08
IPC分类号： G01J3/00
CPC分类号： G01N21/47 , G01N15/0205 , G01N15/1475 , G01N21/49 , G01N21/554 , G01N33/54346 , G01N33/58 , G01N33/6803 , G01N2015/1472 , G01N2021/4764 , G01N2021/6421 , G01N2021/6441
摘要： The present invention is directed to deconvolution and normalization of assay data. The present invention includes a control and analysis system, used in conjunction with a signal generation and detection apparatus, for capturing, processing and analyzing images of samples having resonance light scattering (RLS) particle labels. The control and analysis system processes instructions and algorithms for performing multiplexed assays of two or more colors, for example, to allow separation and analysis of detected light that contains information from two or more different types or sizes of RLS particles. The multiplexing analysis software is preferably incorporated within the system of the present invention, and the multiplexing analysis is preferably performed in real-time during a scanning or assay procedure. The invention provides for a computer readable medium containing instructions for carrying out the same.
摘要翻译： 本发明涉及分析数据的去卷积和归一化。 本发明包括与信号发生和检测装置结合使用的用于捕获，处理和分析具有共振光散射（RLS）粒子标签的样品的图像的控制和分析系统。 控制和分析系统处理用于执行两种或更多种颜色的多路复用测定的指令和算法，例如允许分离和分析包含来自两种或更多种不同类型或尺寸的RLS颗粒的信息的检测到的光。 复用分析软件优选地并入本发明的系统内，并且优选地在扫描或测定程序期间实时地进行复用分析。 本发明提供一种包含用于执行该指令的计算机可读介质。
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46.发明申请公开(公告)号：US20080116179A1
公开(公告)日：2008-05-22
申请号：US11945481
申请日：2007-11-27
申请人： David J. Cook , Richard W. Couch , Aaron D. Brandt , Richard R. Anderson , Brian J. Currier , Jon W. Lindsay , Zheng Duan , Casey Jones , Edward M. Shipulski
发明人： David J. Cook , Richard W. Couch , Aaron D. Brandt , Richard R. Anderson , Brian J. Currier , Jon W. Lindsay , Zheng Duan , Casey Jones , Edward M. Shipulski
CPC分类号： H05H1/28 , H05H1/34 , H05H2001/3436 , H05H2001/3478
摘要： A coolant tube and electrode are adapted to mate with each other to align the tube relative to the electrode during operation of the torch. Improved alignment ensures an adequate flow of coolant along an interior surface of the electrode. In one aspect, an elongated body of the coolant tube has a surface adapted to mate with the electrode. In another aspect, an elongated body of the electrode has a surface adapted to mate with the coolant tube. The surfaces of the tube and electrode may, for example, be flanges, tapered surfaces, contours, or steps.
摘要翻译： 冷却剂管和电极适于在割炬操作期间彼此配合以使管相对于电极对准。 改进的对准确保沿着电极内表面的冷却剂足够的流动。 在一个方面，冷却剂管的细长体具有适于与电极配合的表面。 在另一方面，电极的细长体具有适于与冷却剂管配合的表面。 管和电极的表面可以例如是凸缘，锥形表面，轮廓或台阶。
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公开(公告)号：US6143939A
公开(公告)日：2000-11-07
申请号：US259419
申请日：1999-02-26
CPC分类号： C07C17/25 , C07C1/26 , C07C17/23 , Y10S977/775 , Y10S977/84 , Y10S977/896
摘要： A method for preparing olefins and halogenated olefins is provided comprising contacting halogenated compounds with diamonds for a sufficient time and at a sufficient temperature to convert the halogenated compounds to olefins and halogenated olefins via elimination reactions.
摘要翻译： 提供了一种制备烯烃和卤代烯烃的方法，包括使卤代化合物与金刚石接触足够的时间和足够的温度，以通过消除反应将卤代化合物转化成烯烃和卤代烯烃。
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