公开(公告)号：US20060257896A1

公开(公告)日：2006-11-16

申请号：US11362260

申请日：2006-02-24

申请人： Sarah Pollock ,  Anat Cohen-Dayag ,  Osnat Sella-Tavor ,  Shirley Sameah-Greenwald ,  Shira Walach ,  Lily Bazak

发明人： Sarah Pollock ,  Anat Cohen-Dayag ,  Osnat Sella-Tavor ,  Shirley Sameah-Greenwald ,  Shira Walach ,  Lily Bazak

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Y304/21109 ,  C12N9/6424 ,  C12Q1/6886 ,  C12Q2600/106

摘要： Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry.

摘要翻译： 新型剪接变体作为诊断标记，优选膜结合。 根据本发明的新型变体可任选地通过免疫组织化学方法用于本文所述的可标记可检测疾病的诊断。

公开(公告)号：US20090275021A1

公开(公告)日：2009-11-05

申请号：US12095110

申请日：2006-11-27

申请人： Osnat Sella-Tavor ,  Sarah Pollock ,  Lily Bazak ,  Elena Tsypkin ,  Shira Wallach ,  Eve Montia ,  Shirley Sameah-Greenwald

发明人： Osnat Sella-Tavor ,  Sarah Pollock ,  Lily Bazak ,  Elena Tsypkin ,  Shira Wallach ,  Eve Montia ,  Shirley Sameah-Greenwald

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C07H21/04 ,  C12N5/06 ,  C12P21/02 ,  G01N33/53

CPC分类号： C12Q1/6876 ,  C07K14/47 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158

摘要： Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.

摘要翻译： 新型剪接变体，氨基酸序列及其核苷酸序列及其使用方法。

公开(公告)号：US20140206956A1

公开(公告)日：2014-07-24

申请号：US14237019

申请日：2012-08-01

申请人： Elisha Rabinovitz ,  Zvika Gilad ,  Osnat Sella-Tavor ,  Amit Pascal

发明人： Elisha Rabinovitz ,  Zvika Gilad ,  Osnat Sella-Tavor ,  Amit Pascal

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/1473 ,  G01N33/53 ,  A61B5/07

CPC分类号： A61B5/14503 ,  A61B1/041 ,  A61B5/0084 ,  A61B5/061 ,  A61B5/07 ,  A61B5/1032 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/6861 ,  A61B2562/0295 ,  A61B2562/162 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/5302 ,  G01N33/54386 ,  G01N33/558

摘要： In vivo devices, systems and methods for in vivo immunoassay include inserting into a patient's body lumen an in vivo diagnostic device comprising a housing. The housing of the device comprises a chamber, and a chromatography strip for immunoassay of a body lumen substance. The housing may further comprise a casing for the chromatography strip. The casing may comprise a first opening to allow entrance of in vivo liquids into the casing and a second opening into the chamber. The housing may further comprise a sensor to sense a property of the chromatography strip. Following insertion of the device into the patient's body, a sample is collected and the immunoassay is performed in vivo in areas of pathological lesions for a predetermined period of time. An in vivo image may be acquired or other data such as colorimetric or intensity data may be obtained from the chromatography strip.

摘要翻译： 用于体内免疫测定的体内装置，系统和方法包括将包括外壳的体内诊断装置插入患者体腔。 该装置的外壳包括室和用于体内物质的免疫测定的色谱条。 壳体还可以包括用于色谱条的壳体。 壳体可以包括允许体内液体进入壳体的第一开口和进入腔室的第二开口。 壳体还可以包括感测色谱条的性质的传感器。 在将装置插入患者体内后，收集样品，并在病理损伤区域内进行预定时间段的免疫测定。 可以获取体内图像，或者可以从色谱条获得其他数据，例如比色或强度数据。

公开(公告)号：US20100184021A1

公开(公告)日：2010-07-22

申请号：US12161158

申请日：2007-01-16

申请人： Osnat Sella-Tavor ,  Sarah Pollack ,  Lily Bazak ,  Elena Tsypkin ,  Dan Sztybel ,  Shirley Sameah-Greenwald

发明人： Osnat Sella-Tavor ,  Sarah Pollack ,  Lily Bazak ,  Elena Tsypkin ,  Dan Sztybel ,  Shirley Sameah-Greenwald

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/00 ,  C07K16/00 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02

CPC分类号： G01N33/57423

摘要： The present invention relates to diagnostic markers comprising novel splice variants of known proteins and polynucleotides encoding same, useful in the qualitative and/or quantitative detection of various diseases and/or pathological conditions in a subject, and to the use of known proteins and polynucleotides encoding same for diagnosis. Particularly, the invention relates to the diagnosis of a disease in a sample of body fluid or secretion obtained from the subject, and to the diagnosis of cancer.

摘要翻译： 本发明涉及包括已知蛋白质的新型剪接变体和编码其的多核苷酸的诊断标记物，其可用于定性和/或定量检测受试者的各种疾病和/或病理状况，以及编码已知蛋白质和多核苷酸的用途 相同的诊断。 特别地，本发明涉及从受试者获得的体液或分泌物的样品中的疾病的诊断以及癌症的诊断。

公开(公告)号：US08515507B2

公开(公告)日：2013-08-20

申请号：US12485665

申请日：2009-06-16

申请人： Elisha Rabinovitz ,  Osnat Sella-Tavor ,  Amit Pascal ,  Noam Emanuel

发明人： Elisha Rabinovitz ,  Osnat Sella-Tavor ,  Amit Pascal ,  Noam Emanuel

IPC分类号： A61B5/1455

CPC分类号： A61B5/0071 ,  A61B1/041 ,  A61B1/043 ,  A61B5/0084

摘要： Devices, systems and methods for detecting in vivo pathology are provided. An in vivo sensing device comprises a reacting layer with at least one type of binding agent attached thereon, a sensor configured for sensing an optical change occurring on the reacting substrate, and at least one illumination source. In-vivo fluids are in constant contact with the reacting substrate so that in vivo marker indicating pathology may bind to the binding agent attached onto the reacting layer and may be viewed by the sensor.

摘要翻译： 提供用于检测体内病理学的装置，系统和方法。 体内感测装置包括具有附着在其上的至少一种类型的粘合剂的反应层，被配置为感测在反应基底上发生的光学变化的传感器和至少一个照明源。 体内流体与反应底物恒定接触，使体内标记指示病理学可以结合附着在反应层上的结合剂并且可以由传感器观察。

公开(公告)号：US08911368B2

公开(公告)日：2014-12-16

申请号：US13146482

申请日：2010-01-31

申请人： Elisha Rabinovitz ,  Amit Pascal ,  Ori Braun ,  Zvika Gilad ,  Osnat Sella-Tavor ,  Yaniv Birnboim

发明人： Elisha Rabinovitz ,  Amit Pascal ,  Ori Braun ,  Zvika Gilad ,  Osnat Sella-Tavor ,  Yaniv Birnboim

IPC分类号： A61B5/05 ,  A61B5/07 ,  A61B5/00 ,  A61B5/02 ,  A61B5/145 ,  A61B5/1459

CPC分类号： A61B5/073 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02042 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1459 ,  A61B5/4283 ,  A61B5/6861 ,  A61B2560/0406 ,  A61B2562/0238

摘要： A device, system and method for detecting bile and blood are provided. The device may comprise a housing having a gap through which in-vivo fluids may flow, illumination sources on one side of the gap, a light detector which is facing the illumination sources and is positioned on the opposite side of the gap for detecting light which passes through the in-vivo fluids, and a transmitter to transmit the detected signals generated according to the detected light. The system may further comprise a receiver to receive the detected signals transmitted by the transmitter, and a processor. The method may comprise comparing the detected signals with a predetermined threshold calculated from the transmission spectra of bile and of blood and determining the presence and/or concentration of bile and blood in-vivo.

摘要翻译： 提供了一种用于检测胆汁和血液的装置，系统和方法。 该装置可以包括具有间隙的壳体，体内流体可流过该间隙，间隙的一侧上的照明源，面向照明源的光检测器，并位于间隙的相对侧上，用于检测光， 穿过体内流体，以及发射器，用于传输根据检测到的光产生的检测信号。 系统还可以包括接收器，用于接收由发射器发射的检测信号和处理器。 该方法可以包括将检测到的信号与从胆汁和血液的透射光谱计算出的预定阈值进行比较，并确定胆汁和血液在体内的存在和/或浓度。

公开(公告)号：US20110306855A1

公开(公告)日：2011-12-15

申请号：US13146482

申请日：2010-01-31

申请人： Elisha Rabinovitz ,  Amit Pascal ,  Ori Braun ,  Zvika Gilad ,  Osnat Sella-Tavor ,  Yaniv Birnboim

发明人： Elisha Rabinovitz ,  Amit Pascal ,  Ori Braun ,  Zvika Gilad ,  Osnat Sella-Tavor ,  Yaniv Birnboim

IPC分类号： A61B5/1459 ,  A61B6/00

CPC分类号： A61B5/073 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02042 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/1459 ,  A61B5/4283 ,  A61B5/6861 ,  A61B2560/0406 ,  A61B2562/0238

摘要： A device, system and method for detecting bile and blood are provided. The device may comprise a housing having a gap through which in-vivo fluids may flow, illumination sources on one side of the gap, a light detector which is facing the illumination sources and is positioned on the opposite side of the gap for detecting light which passes through the in-vivo fluids, and a transmitter to transmit the detected signals generated according to the detected light. The system may further comprise a receiver to receive the detected signals transmitted by the transmitter, and a processor. The method may comprise comparing the detected signals with a predetermined threshold calculated from the transmission spectra of bile and of blood and determining the presence and/or concentration of bile and blood in-vivo.

摘要翻译： 提供了一种用于检测胆汁和血液的装置，系统和方法。 该装置可以包括具有间隙的壳体，体内流体可流过该间隙，间隙的一侧上的照明源，面向照明源的光检测器，并位于间隙的相对侧上，用于检测光， 穿过体内流体，以及发射器，用于传输根据检测到的光产生的检测信号。 系统还可以包括接收器，用于接收由发射器发射的检测信号和处理器。 该方法可以包括将检测到的信号与从胆汁和血液的透射光谱计算出的预定阈值进行比较，并确定胆汁和血液在体内的存在和/或浓度。