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公开(公告)号：US06632836B1
公开(公告)日：2003-10-14
申请号：US09422143
申请日：1999-10-21
申请人： Robert K. Baker , Jianming Bao , Jennifer Chee , Maria L. Garcia , Gregory J. Kaczorowski , Frank Kayser , Andrew Kotliar , Chou Juitsai Liu , Shouwu Miao , William H. Parsons , Kathleen M. Rupprecht , William A. Schmalhofer , Christopher F. Claiborne , David A. Claremon , Nigel Liverton , Wayne J. Thompson
发明人： Robert K. Baker , Jianming Bao , Jennifer Chee , Maria L. Garcia , Gregory J. Kaczorowski , Frank Kayser , Andrew Kotliar , Chou Juitsai Liu , Shouwu Miao , William H. Parsons , Kathleen M. Rupprecht , William A. Schmalhofer , Christopher F. Claiborne , David A. Claremon , Nigel Liverton , Wayne J. Thompson
IPC分类号： A61K3116
CPC分类号： C07D207/08 , C07B2200/07 , C07C235/60 , C07C237/22 , C07C255/46 , C07C271/12 , C07C271/34 , C07C271/38 , C07C271/56 , C07C275/26 , C07C309/66 , C07C309/67 , C07C309/73 , C07C311/05 , C07C311/07 , C07C311/20 , C07C333/06 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D209/14 , C07D213/643 , C07D233/64 , C07D263/28 , C07D307/14 , C07D307/79
摘要： The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及可用作治疗自身免疫性疾病，心律失常等的钾通道抑制剂的一类式I的碳环化合物。
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42.发明授权公开(公告)号：US06489354B1
公开(公告)日：2002-12-03
申请号：US09516771
申请日：2000-03-01
IPC分类号： A61K3140
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.
摘要翻译： 本发明涉及可用作趋化因子受体活性调节剂的式I的吡咯烷化合物（其中R1，R2，R3，R4c，R4d和R4f如本文所定义）。 特别地，这些化合物可用作趋化因子受体CCR-3和/或CCR-5的调节剂。
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公开(公告)号：US5998408A
公开(公告)日：1999-12-07
申请号：US946801
申请日：1997-10-08
申请人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
发明人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
IPC分类号： A61K31/34 , A61K31/365 , A61K31/445 , A61K31/47 , A61K31/52 , A61K38/13 , A61K45/06 , A61K31/35 , A61K31/54 , A61K31/535 , C07D313/02 , C07D307/77 , C07D409/02 , C07D493/22
CPC分类号： A61K31/52 , A61K31/34 , A61K31/365 , A61K31/445 , A61K31/47 , A61K38/13 , A61K45/06
摘要： The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
摘要翻译： 式I的化合物可用作免疫抑制剂。
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公开(公告)号：US5952371A
公开(公告)日：1999-09-14
申请号：US943869
申请日：1997-10-08
申请人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
发明人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
IPC分类号： A61K31/335 , A61K31/365 , A61K31/445 , A61K31/47 , A61K31/52 , A61K38/13 , A61K45/06 , C07D493/04 , A61K31/34 , C07D307/77
CPC分类号： C07D493/04 , A61K31/335 , A61K31/365 , A61K31/445 , A61K31/47 , A61K31/52 , A61K38/13 , A61K45/06
摘要： The compounds of Formula I ##STR1## are useful as iumnunosuppressive agents.
摘要翻译： 式I的化合物可用作抑泡剂。
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公开(公告)号：US5874594A
公开(公告)日：1999-02-23
申请号：US947307
申请日：1997-10-08
申请人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
发明人： Robert K. Baker , Frank Kayser , Jianming Bao , Andrew Kotliar , William H. Parsons , Kathleen M. Rupprecht
IPC分类号： C07D493/04 , C07D333/02 , A61K31/335 , A61K31/35 , A61K31/38
CPC分类号： C07D493/04
摘要： ##STR1## are useful as immunosuppressive agents.
摘要翻译：
我作为免疫抑制剂是有用的。 -
公开(公告)号：US5679705A
公开(公告)日：1997-10-21
申请号：US734247
申请日：1996-10-16
IPC分类号： A61K31/365 , C07D493/04 , A61K31/335 , C07D313/08
CPC分类号： C07D493/04 , A61K31/365
摘要： The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
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![6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor](/abs-image/US/2019/06/25/US10329289B2/abs.jpg.150x150.jpg)
47.发明授权公开(公告)号：US10329289B2
公开(公告)日：2019-06-25
申请号：US15386009
申请日：2016-12-21
申请人： Jianming Bao , Xiaolei Gao , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Debra L. Ondeyka , Andrew W. Stamford , Fengqi Zhang
发明人： Jianming Bao , Xiaolei Gao , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Debra L. Ondeyka , Andrew W. Stamford , Fengqi Zhang
IPC分类号： C07D471/04 , C07F9/22 , C07D519/00 , C07D491/048 , C07D471/08 , C07D491/052 , A61K31/437 , A61P25/00
摘要： The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
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公开(公告)号：US08563746B2
公开(公告)日：2013-10-22
申请号：US13125329
申请日：2009-10-19
申请人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
发明人： Qun Dang , De Michael Chung , Tony S. Gibson , Hongjian Jiang , Daniel K. Cashion , Jianming Bao , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , Dariusz Wodka
IPC分类号： A61K31/4184 , A61K31/5377 , A61K31/497 , C07D235/26 , C07D235/28 , C07D401/10 , C07D401/06 , C07D409/04 , C07D403/10 , C07D413/10 , C07D413/14 , C07D417/04
CPC分类号： C07D235/28 , C07D235/26 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/06 , C07D417/04
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖症，高胆固醇血症和高血压。
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公开(公告)号：US20130131042A1
公开(公告)日：2013-05-23
申请号：US13810946
申请日：2011-08-12
申请人： Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
发明人： Joseph L. Duffy , Jianming Bao , Debra L. Ondeyka , Sriram Tyagarajan , Patrick Shao , Feng Ye , Revathi Katipally , Aaron Zwicker , Edward C. Sherer , Michael A. Plotkin , Remond Moningka , Zahid Hussain , Harold B. Wood , Feroze Ujjainwalla , F. Anthony Romero , Paul E. Finke , Yi Zang , Weiguo Liu
IPC分类号： C07D498/10 , C07D519/00
CPC分类号： C07D498/10 , C07D519/00
摘要： Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
摘要翻译： 结构式（I）的取代的螺环胺是生长抑素亚型受体5（SSTR5）的选择性拮抗剂，可用于治疗，控制或预防对SSTR5的拮抗作用反应的病症，例如2型糖尿病，胰岛素抵抗，脂质障碍 ，肥胖症，动脉粥样硬化，代谢综合征，抑郁症和焦虑症。
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公开(公告)号：US08410284B2
公开(公告)日：2013-04-02
申请号：US13124898
申请日：2009-10-12
申请人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
发明人： Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
IPC分类号： A61K31/675 , C07F9/00 , C07F9/6506
CPC分类号： C07F9/65068 , C07F9/65583 , C07F9/657181
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
摘要翻译： 结构式（I）的新型化合物是AMP-蛋白激酶的活化剂，可用于治疗，预防和抑制AMPK活化蛋白激酶介导的疾病。 本发明的化合物可用于治疗2型糖尿病，高血糖症，代谢综合征，肥胖，高胆固醇血症和高血压。
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