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    Systems and methods for biomimetic fluid processing
    42.
    发明授权
    Systems and methods for biomimetic fluid processing 有权

    公开(公告)号：US11566214B2

    公开(公告)日：2023-01-31

    申请号：US16792484

    申请日：2020-02-17

    Applicant: BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  President and Fellows of Harvard College ,  Vilnius University

    Inventor： Jonathan N. Thon ,  Joseph E. Italiano ,  Linas Mazutis ,  David A. Weitz

    IPC: C12M3/06 ,  C12M1/42 ,  B01L3/00 ,  C12M3/00 ,  C12N5/078

    Abstract: Systems and methods generating physiologic models that can produce functional biological substances are provided. In some aspects, a system includes a substrate and a first and second channel formed therein. The channels extend longitudinally and are substantially parallel to each other. A series of apertures extend between the first channel and second channel to create a fluid communication path passing through columns separating the channels that extends further along the longitudinal dimension than other dimensions. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate, wherein the first channel flow rate and the second channel flow rate create a differential configured to generate physiological shear rates within a predetermined range in the channels.

    Acoustic waves in microfluidics
    43.
    发明授权
    Acoustic waves in microfluidics 有权

    公开(公告)号：US11229911B2

    公开(公告)日：2022-01-25

    申请号：US16238467

    申请日：2019-01-02

    Applicant: President and Fellows of Harvard College ,  Universität Augsburg

    Inventor： David A. Weitz ,  Thomas Franke ,  Achim Wixforth ,  Lothar Schmid ,  Jeremy Agresti ,  Adam R. Abate

    IPC: B01L3/00 ,  C12M1/00 ,  C12M3/06 ,  F17D3/01 ,  G01N15/10

    Abstract: Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated from the microfluidic substrate except at or proximate the location where the droplets are sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting.

    FLUID INJECTION
    45.
    发明申请
    FLUID INJECTION 有权

    公开(公告)号：US20210197146A1

    公开(公告)日：2021-07-01

    申请号：US17145684

    申请日：2021-01-11

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

    IPC: B01F5/04 ,  F16K99/00 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00

    Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

    Fluid injection
    47.
    发明授权
    Fluid injection 有权

    公开(公告)号：US10919008B2

    公开(公告)日：2021-02-16

    申请号：US15659307

    申请日：2017-07-25

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

    IPC: B01F5/04 ,  F16K99/00 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N27/447 ,  G01N35/10

    Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

    System and Method for a Biomimetic Fluid Processing
    50.
    发明申请
    System and Method for a Biomimetic Fluid Processing 审中-公开

    公开(公告)号：US20200316597A1

    公开(公告)日：2020-10-08

    申请号：US16904523

    申请日：2020-06-17

    Applicant: The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College ,  Vilnius University

    Inventor： Joseph Italiano ,  Linas Mazutis ,  Jonathan Thon ,  David A. Weitz

    IPC: B01L3/00 ,  C12M3/06 ,  C12M1/12 ,  C12M1/34 ,  G01N33/86 ,  C12M1/00

    Abstract: A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.

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