-
41.发明申请METHOD AND APPARATUS FOR DETERMINING RED BLOOD CELL INDICES OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 有权用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的红血细胞指数的方法和装置公开(公告)号：US20110059481A1
公开(公告)日：2011-03-10
申请号：US12946503
申请日：2010-11-15
申请人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
发明人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided.
摘要翻译： 用于确定红细胞指数的方法，包括体积和各个红细胞的血红蛋白含量和浓度，以及包括样品中存在的红细胞总数的红细胞群统计，以及平均值 提供了基本上未稀释的血液样品中的每个上述指标。
-
公开(公告)号：US07903241B2
公开(公告)日：2011-03-08
申请号：US12408357
申请日：2009-03-20
申请人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
发明人： Stephen C. Wardlaw , Robert A. Levine , Darryn W. Unfricht , Niten V. Lalpuria , Jeremy R. Hill
IPC分类号： G01N33/48
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided.
-
公开(公告)号：US06762017B2
公开(公告)日：2004-07-13
申请号：US10053946
申请日：2002-01-24
IPC分类号： G01N3100
CPC分类号： G01N33/96 , Y10T436/10 , Y10T436/106664
摘要： A non-animal based mixture of components serves as a control for complete blood count (CBC) analysis instruments and paraphernalia. The centrifugible non-animal based mixture simulates blood, and contains blood cell-simulating and other blood constituent-simulating components which are present in the mixture in controlled and known amounts. The mixture can be gravimetrically separated into its blood constituent-simulating components so as to serve as a control that simulates a centrifuged blood sample, and is thus used to check the accuracy of CBC blood analysis instruments, such as those marketed by Becton Dickinson and Company, under the trademark “QBC”.
摘要翻译： 基于非动物的组分混合物用作完全血细胞计数（CBC）分析仪器和用具的对照。 离心非基于动物的混合物模拟血液，并含有以受控和已知量存在于混合物中的血细胞模拟和其他血液成分模拟组分。 混合物可以重力分离成其血液成分模拟组分，以作为模拟离心血液样品的对照，因此用于检查CBC血液分析仪器的准确性，如Becton Dickinson和Company ，商标为“QBC”。
-
44.发明授权Determination of an individual's inflammation index from whole blood fibrinogen and hematocrit or hemoglobin measurements 失效从全血纤维蛋白原和血细胞比容或血红蛋白测定中测定个体的炎症指数
公开(公告)号：US5506145A
公开(公告)日：1996-04-09
申请号：US348345
申请日：1994-12-02
CPC分类号： C12Q1/56 , G01N33/721 , G01N33/86 , G01N2333/75 , G01N2333/805
摘要： Useful information about a subject's level of systemic inflammation is obtained by quantitatively measuring the amount of fibrinogen and the hematocrit and or hemoglobin in the subject's whole blood. The fibrinogen measurement, when combined with an hematocrit or hemoglobin measurement, provides a systemic Inflammation Index value for the donor. The method is not affected by blood variables which are not related to the presence of inflammation, which blood variables are known to invalidate an erythrocyte sedimentation rate, which is the most frequently used blood test for detecting systemic inflammation in humans.
摘要翻译： 通过定量测量受检者全血中纤维蛋白原的量和血细胞比容和/或血红蛋白的量，获得关于受试者全身炎症水平的有用信息。 当与血细胞比容或血红蛋白测量结合时，纤维蛋白原测量为供体提供系统性炎症指数值。 该方法不受与炎症存在无关的血液变量的影响，已知血液变量使红细胞沉降率无效，这是用于检测人体全身炎症的最常用的血液检查。
-
公开(公告)号：US5496704A
公开(公告)日：1996-03-05
申请号：US312513
申请日：1994-09-26
IPC分类号： G01N33/569 , G01N33/574
CPC分类号： G01N33/569 , G01N33/56966 , G01N33/574 , Y10S436/80 , Y10S436/805 , Y10S436/81 , Y10S436/813 , Y10S436/824
摘要： A biological sample such as feces, sputum, cervical tissue, pleural fluids, exudates, cytologic specimens, or the like, is tested for the presence or absence of: ova; parasites; microorganisms; inflammatory, neoplastic tissue cells; or other target materials which are indicative of infestation, disease or infection. The sample is mixed with a buffer fluid and placed in a transparent tube which contains a volume-constricting cylindrical insert for gravimetric separation of components of the sample. The mixture is centrifuged, and the annular space between the insert and tube bore is examined under magnification for the presence of the target materials.
摘要翻译： 对生物样品如粪便，痰液，宫颈组织，胸膜液，渗出物，细胞学标本等进行测试，以证明是否存在：ova; 寄生虫 微生物 炎性，肿瘤组织细胞; 或指示感染，疾病或感染的其他目标材料。 将样品与缓冲液混合并置于含有体积收缩的圆柱形插入物的透明管中，用于重量分离样品组分。 将混合物离心，并且在放大下检查插入件和管孔之间的环形空间以存在目标材料。
-
公开(公告)号：US5480778A
公开(公告)日：1996-01-02
申请号：US6766
申请日：1993-01-21
IPC分类号： G01N33/50 , G01N33/53 , G01N33/569
CPC分类号： G01N33/5091 , G01N33/56972 , Y10S435/975 , Y10T436/25375
摘要： A patient's blood sample is incubated with an antigen and tested for lymphocyte response, ie. an activation of lymphocytes and/or a conversion of lymphocytes to lymphoblasts, which indicates prior exposure of the patient to the antigen. A positive response indicates the presence of prior exposure to prior diseases or clinical conditions such as parasitic diseases, tuberculosis, salmonellosis, gonorrhea, fungal infections, rickettsial infections, Lyme disease or allergens. Whole blood from the patient is incubated with the antigen of the disease or condition for which the patient is being tested. After a suitable time, a fluorescent dye or colorant is added which has an affinity for a discriminant characteristic of the activated lymphocytes or lymphoblasts, such as: intracellular calcium; surface activation antigens such as transferrin receptor; HLA-Dr; Leu-23; and the like. The incubated blood is then drawn into a transparent tube containing a float which concentrates the buffy coat constituent layers upon centrifugation of the blood sample. The concentrated lymphocyte layer is then examined for fluorescence or coloration which is indicative of the presence of the activated lymphocytes or lymphoblasts, and their concentration. The fluorescence or coloration can be qualified and/or quantified by a reader instrument.
摘要翻译： 将患者的血液样品与抗原孵育并测试淋巴细胞反应，即。 淋巴细胞的激活和/或淋巴细胞转化成淋巴母细胞，其指示患者事先暴露于抗原。 阳性反应表明先前接触先前疾病或临床病症如寄生虫病，结核病，沙门氏菌病，淋病，真菌感染，立克次体感染，莱姆病或过敏原。 将来自患者的全血与患者正在测试的疾病或病症的抗原一起温育。 在合适的时间之后，添加荧光染料或着色剂，其对于活化的淋巴细胞或淋巴母细胞的鉴别特征具有亲和性，例如：细胞内钙; 表面活化抗原如转铁蛋白受体; HLA-Dr; Leu-23; 等等。 然后将孵育的血液吸入含有浮子的透明管中，该浮子在血液样品离心时浓缩血沉棕黄层组成层。 然后检查浓缩的淋巴细胞层的荧光或着色，其指示活化的淋巴细胞或淋巴母细胞的存在及其浓度。 荧光或着色可由阅读器仪器进行鉴定和/或定量。
-
47.发明授权
公开(公告)号：US5460969A
公开(公告)日：1995-10-24
申请号：US31544
申请日：1993-03-15
CPC分类号： C12Q1/28 , G01N33/725 , A61B10/0038 , Y10T436/25125
摘要： The presence of fecal occult blood in a stool sample is detected by mixing a liquid stool sample with an acidic liquid, such as a phosphate/citrate buffer, to precipitate hematin from the solution. The precipitated hematin is separated and the presence or absence of hemoglobin is determined by exposing the solution to a peroxidase diagnostic assay. A positive response indicates the presence of blood originating in the lower gastrointestinal tract, a leading indicator of lower GI cancer.
摘要翻译： 通过将液体粪便样品与酸性液体如磷酸盐/柠檬酸盐缓冲液混合来检测粪便样品中粪便潜血的存在，以从溶液中沉淀血红蛋白。 分离沉淀的血红蛋白，通过将溶液暴露于过氧化物酶诊断测定法来测定是否存在血红蛋白。 阳性反应表明存在源自下胃肠道的血液，这是GI下降的主要指标。
-
公开(公告)号：US5403714A
公开(公告)日：1995-04-04
申请号：US5086
申请日：1993-01-15
IPC分类号： G01N33/569 , G01N33/574 , G01N33/536 , G01N33/558
CPC分类号： G01N33/569 , G01N33/56966 , G01N33/574 , Y10S436/80 , Y10S436/805 , Y10S436/81 , Y10S436/813 , Y10S436/824
摘要： A biologic sample such as feces, sputum, cervical tissue, pleural fluids, exudates, cytologic specimens, or the like, is tested for the presence or absence of: ova; parasites; microorganisms; inflammatory, neoplastic tissue cells; or other target materials which are indicative of infestation, disease or infection. The sample is mixed with a buffer fluid and placed in a transparent tube which contains a volume-constricting cylindrical insert for gravimetric separation of components of the sample. The mixture is centrifuged, and the annular space between the insert and tube bore is examined under magnification for the presence of the target materials.
摘要翻译： 对生物样品如粪便，痰液，宫颈组织，胸膜液，渗出液，细胞学标本等进行测试，以确定是否存在：ova; 寄生虫 微生物 炎性，肿瘤组织细胞; 或指示感染，疾病或感染的其他目标材料。 将样品与缓冲液混合并置于含有体积收缩的圆柱形插入物的透明管中，用于重量分离样品组分。 将混合物离心，并且在放大下检查插入件和管孔之间的环形空间以存在目标材料。
-
公开(公告)号：US5132087A
公开(公告)日：1992-07-21
申请号：US421639
申请日：1989-10-16
CPC分类号： B01L3/5021 , G01N15/05 , G01N33/491
摘要： Blood constituents are separated by centrifugation in a transparent tube which contains a float for physically elongating certain of the constituents. The centrifuged sample in the tube is positioned on a layer measuring device with which red cell and buffy coat constituent band heights can be measured in ambient light. The buffy coat constituent measurements are made under optical magnification. The measuring device has a mathematically derived red cell layer nomogram printed thereon, and a separate scale for measuring buffy coat constituent bands. Conversion tables are provided for converting the measured buffy coat constituent band lengths into constituent cell counts. The measuring device includes tube-engaging portions for properly positioning the tube during the measurements, and the red cell scale automatically compensates for the presence of the float and densification of red cells needed for proper banding.
-
公开(公告)号：US4952054A
公开(公告)日：1990-08-28
申请号：US303120
申请日：1989-01-30
IPC分类号： G01N15/05
CPC分类号： G01N15/05
摘要： The method of correcting readings of cell counts in a centrifuged blood sample contained in a transparent tube which also contains a transparent cylindrical float. Light absorption measurements are made at different locations in the tube. A beam of light is directed through the tube and the float and a light absorption reading is taken. A light beam is also directed through the sample above the float and another absorption reading is taken. The ratio of the two readings is determined and compared to a target ratio that is precalculated from an ideal tube and float. Any deviations from the target ratio are proportional to correction factors which are applied to the cell readings taken. A colorant is added to the sample to impart the light absorption capability thereto.
摘要翻译： 在包含透明圆柱形浮子的透明管中的离心血样中校正细胞计数读数的方法。 光吸收测量在管中的不同位置进行。 光束被引导通过管和浮子并获得光吸收读数。 光束也被引导通过浮子上方的样品，并且进行另一吸收读数。 确定两个读数的比例，并与从理想管和浮子预先计算的目标比率进行比较。 与目标比率的任何偏差都与校正因子成比例，这些校正因子应用于所采集的细胞读数。 向样品中加入着色剂以赋予其光吸收能力。
-
-
-
-
-
-
-
-
-
搜索结果
209 条记录 (耗时 0.028 秒)
