公开(公告)号：US20110036913A1

公开(公告)日：2011-02-17

申请号：US12858353

申请日：2010-08-17

Applicant: Matthias Merz ,  Youri Victorovitch Ponomarev

Inventor： Matthias Merz ,  Youri Victorovitch Ponomarev

IPC: G06K19/073 ,  G01N27/28 ,  H05K3/30

CPC classification number: G01N27/4167 ,  G01N27/333 ,  G01N27/414 ,  Y10T29/4913

Abstract: An electrochemical sensor device including a sensor chip having an integrated electrochemical sensor element; and a substrate having a first surface on which the sensor chip is mounted, the substrate comprising a reference electrode structure for the integrated electrochemical sensor element, the reference electrode structure connected to the sensor chip via an electrical connection on the first surface of the substrate.

Abstract translation: 一种电化学传感器装置，包括具有集成的电化学传感器元件的传感器芯片; 以及基板，其具有安装有传感器芯片的第一表面，所述基板包括用于所述一体化电化学传感器元件的参考电极结构，所述参考电极结构通过所述基板的第一表面上的电连接连接到所述传感器芯片。

公开(公告)号：US20100076536A1

公开(公告)日：2010-03-25

申请号：US12442133

申请日：2007-09-18

Applicant: Matthias Merz ,  Youri V. Ponomarev ,  Remco H.W. Pijnenburg

Inventor： Matthias Merz ,  Youri V. Ponomarev ,  Remco H.W. Pijnenburg

IPC: A61N1/05 ,  A61B17/00

CPC classification number: A61N1/0529 ,  A61B5/04001 ,  A61L31/148 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/0539 ,  A61N1/0558 ,  A61N1/36082

Abstract: The invention provides an implantable multi-electrode device (300) and related methods and apparatuses. In one embodiment, the invention includes an implantable device (300) comprising: an assembly block (320); and a plurality of leads (340 . . . 348) radiating from the assembly block (320), each of the plurality of leads (340 . . . 348) containing at least one electrode (342A), such that the electrodes are distributed within a three-dimensional space, wherein the assembly block (320) includes a barb (350) for anchoring the assembly block (320) within implanted tissue.

Abstract translation: 本发明提供一种可植入式多电极装置（300）及其相关方法和装置。 在一个实施例中，本发明包括可植入装置（300），包括：组装块（320）; 以及从所述组装块（320）辐射的多个引线（340 ... 348），所述多个引线（340 ... 348）中的每一个包含至少一个电极（342A），使得所述电极分布在 三维空间，其中组装块（320）包括用于将组装块（320）固定在植入的组织内的倒钩（350）。

公开(公告)号：US20100045440A1

公开(公告)日：2010-02-25

申请号：US12447678

申请日：2007-10-31

Applicant: Remco Henricus Wilhelmus Pijnenburg ,  Youri Victorovitch Ponomarev ,  Matthias Merz ,  Ronald Dekker

Inventor： Remco Henricus Wilhelmus Pijnenburg ,  Youri Victorovitch Ponomarev ,  Matthias Merz ,  Ronald Dekker

IPC: H04Q5/22

CPC classification number: G06K19/0723 ,  G06K7/0008

Abstract: The invention relates to a remotely readable electronic device (10), particularly an implantable device, with an O associated reader (20). The device comprises a resonance circuit (12) that can selectively be set into one of at least three different resonance states, wherein this state can wirelessly be sensed by the remote reader. In a particular embodiment, the resonance circuit (12) comprises two capacitors (C1, C2) that can selectively be connected or disconnected to the resonance circuit (12). The reader (20) preferably scans a given frequency range to detect spectral absorption patterns that correspond to certain resonance states of the resonance circuit (12).

Abstract translation: 本发明涉及一种具有O相关阅读器（20）的远程可读电子设备（10），特别是可植入设备。 该装置包括可选择性地设置为至少三种不同共振状态中的一种的谐振电路（12），其中该状态可以由远程读取器无线地感测。 在一个具体实施例中，谐振电路（12）包括两个电容器（C1，C2），可以选择性地连接或断开到谐振电路（12）。 读取器（20）优选地扫描给定的频率范围以检测对应于谐振电路（12）的某些谐振状态的光谱吸收模式。

公开(公告)号：US09034637B2

公开(公告)日：2015-05-19

申请号：US12595090

申请日：2008-04-05

Applicant: Matthias Merz ,  Youri V. Ponomarev ,  Gilberto Curatola

Inventor： Matthias Merz ,  Youri V. Ponomarev ,  Gilberto Curatola

IPC: C12M1/34 ,  C12M1/00 ,  C12M3/00 ,  G01R31/26 ,  H01L21/66 ,  G01N33/487 ,  C12Q1/68 ,  G01N27/414

CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N27/414 ,  C12Q2565/631

Abstract: A detector device comprises a substrate (50), a source region (S) and a drain region (D), and a channel region (65) between the source and drain regions. A nanopore (54) passes through the channel region, and connects fluid chambers (56,58) on opposite sides of the substrate. A voltage bias is provided between the fluid chambers, the source and drain regions and a charge flow between the source and drain regions is sensed. The device uses a nanopore for the confinement of a sample under test (for example nucleotides) close to a sensor. The size of the sensor can be made similar to the spacing of adjacent nucleotides in a DNA strand. In this way, the disadvantages of PCR based techniques for DNA sequencing are avoided, and single nucleotide resolution can be attained.

Abstract translation: 检测器装置包括衬底（50），源极区（S）和漏极区（D）以及在源极和漏极区之间的沟道区（65）。 纳米孔（54）穿过沟道区域，并且连接在衬底的相对侧上的流体室（56,58）。 在流体室，源极和漏极区之间提供电压偏置，并且感测源区和漏区之间的电荷流。 该装置使用纳米孔来限制待测样品（例如核苷酸）靠近传感器。 可以使传感器的尺寸与DNA链中相邻核苷酸的间隔相似。 以这种方式，避免了基于PCR的DNA测序技术的缺点，可以实现单核苷酸分辨率。

公开(公告)号：US08957687B2

公开(公告)日：2015-02-17

申请号：US13457072

申请日：2012-04-26

Applicant: Axel Nackaerts ,  Matthias Merz ,  Youri Victorovitch Ponomarev

Inventor： Axel Nackaerts ,  Matthias Merz ,  Youri Victorovitch Ponomarev

IPC: G01R27/28 ,  G01N27/414

CPC classification number: G01N27/414 ,  G01N27/4148

Abstract: The invention relates to an electrochemical sensor integrated on a substrate, the electrochemical sensor including: a field effect transistor integrated on the substrate and having a source, gate and drain connections, said gate of the field effect transistor including: a sensing gate conductively coupled to a sensing electrode; and a bias gate, wherein the sensing gate is capacitively coupled to the bias gate and the bias gate is capacitively coupled to the substrate.

Abstract translation: 本发明涉及集成在基板上的电化学传感器，该电化学传感器包括：集成在基板上并具有源极，栅极和漏极连接的场效应晶体管，场效应晶体管的所述栅极包括：感测栅极，导电耦合到 感测电极; 以及偏置栅极，其中所述感测栅极电容耦合到所述偏置栅极，并且所述偏置栅极电容耦合到所述衬底。

公开(公告)号：US08866239B2

公开(公告)日：2014-10-21

申请号：US13289063

申请日：2011-11-04

Applicant: Marcus Van Dal ,  Aurelie Humbert ,  Matthias Merz ,  Youri Victorovitch Ponomarev

Inventor： Marcus Van Dal ,  Aurelie Humbert ,  Matthias Merz ,  Youri Victorovitch Ponomarev

IPC: H01L27/14 ,  H01L29/66 ,  H01L23/34

CPC classification number: B81B7/0012 ,  B81B2201/0214 ,  B81B2207/015 ,  B81C2201/016

Abstract: A method of manufacturing an integrated circuit having a substrate comprising a plurality of components and a metallization stack over the components, the metallization stack comprising a first sensing element and a second sensing element adjacent to the first sensing element.

Abstract translation: 一种制造集成电路的方法，所述集成电路具有包括多个部件的基板和在所述部件上的金属化叠层，所述金属化堆叠包括第一感测元件和与所述第一感测元件相邻的第二感测元件。

公开(公告)号：US08742470B2

公开(公告)日：2014-06-03

申请号：US13600385

申请日：2012-08-31

Applicant: Matthias Merz ,  Coenraad Cornelis Tak ,  Romano Hoofman

Inventor： Matthias Merz ,  Coenraad Cornelis Tak ,  Romano Hoofman

IPC: G01N27/403

CPC classification number: G01N27/302 ,  G01N27/4148 ,  G01N27/4167 ,  G01N33/02 ,  G01N33/04 ,  G01N33/12 ,  H01L2224/48091 ,  H01L2924/1815 ,  Y10T29/49002 ,  H01L2924/00014

Abstract: Disclosed is a pH sensor comprising a carrier (10) comprising a plurality of conductive tracks and an exposed conductive area (40) defining a reference electrode connected to one of said conductive tracks; a sensing device (30) mounted on the carrier and connected at least one other of said conductive tracks; an encapsulation (20) covering the carrier, said encapsulation comprising a first cavity (22) exposing a surface (32) of the sensing device and a second cavity (24) exposing the exposed conductive area, said second cavity comprising a reference electrode material (42) and an ion reservoir material (44) sharing at least one ion type with said reference electrode material, the reference electrode material being sandwiched between the exposed conductive area and the ion reservoir material. A method of manufacturing such a pH sensor is also disclosed.

Abstract translation: 公开了一种pH传感器，其包括包括多个导电轨道的载体（10）和限定连接到所述导电轨道之一的参考电极的暴露导电区域（40） 感测装置（30），其安装在所述载体上并且连接至少另一个所述导电轨道; 覆盖所述载体的封装（20），所述封装包括暴露所述感测装置的表面（32）的第一空腔（22）和暴露所述暴露的导电区域的第二空腔（24），所述第二空腔包括参考电极材料 42）和与所述参考电极材料共享至少一种离子型离子储存器材料（44），所述参考电极材料夹在所述暴露的导电区域和所述离子储存器材料之间。 还公开了制造这种pH传感器的方法。

公开(公告)号：US08707781B2

公开(公告)日：2014-04-29

申请号：US13063325

申请日：2009-09-10

Applicant: Aurelie Humbert ,  Matthias Merz

Inventor： Aurelie Humbert ,  Matthias Merz

IPC: G01N27/22

CPC classification number: G01N27/223

Abstract: A sensor senses a magnitude of a physical parameter of the sensor's environment. The sensor has first and second electrodes, and a material layer between them. The material has an electrical property, e.g., capacitance or resistance, whose value depends on the magnitude of the physical parameter. The first electrode is formed in a first layer, and the second electrode is formed in a second layer, different from the first layer. The first layer has a trench and an elevation next to the trench. The trench has a bottom wall and a side wall. The material is positioned on the bottom wall and on the side wall and on top of the elevation. The trench accommodates at least a part of the second electrode. The second electrode leaves exposed the material formed on top of the elevation.

Abstract translation: 传感器感测传感器环境的物理参数的大小。 传感器具有第一和第二电极以及它们之间的材料层。 该材料具有电性能，例如电容或电阻，其值取决于物理参数的大小。 第一电极形成在第一层中，并且第二电极形成在与第一层不同的第二层中。 第一层在沟槽旁边具有沟槽和高度。 沟槽具有底壁和侧壁。 材料位于底壁和侧壁上以及高度的顶部。 沟槽容纳至少一部分第二电极。 第二个电极离开了形成在高程顶部的材料。

公开(公告)号：US08683861B2

公开(公告)日：2014-04-01

申请号：US12670715

申请日：2008-07-30

Applicant: Aurelie Humbert ,  Youri Victorovitch Ponomarev ,  Matthias Merz ,  Romano Hoofman

Inventor： Aurelie Humbert ,  Youri Victorovitch Ponomarev ,  Matthias Merz ,  Romano Hoofman

IPC: G01N19/00

CPC classification number: G01N17/04

Abstract: A sensor senses a characteristic of an environment, e.g., humidity. The sensor has a substrate with strips of material that is sensitive to corrosion as a result of the characteristic. The strips are configured to respond differently to the characteristic. By means of repeatedly measuring the resistances of the strips, the environment can be monitored in terms of accumulated exposure to the characteristic. The strips are manufactured in a semiconductor technology so as to generate accurate sensors that behave predictably.

Abstract translation: 传感器感测环境的特性，例如湿度。 传感器具有由于特性而对腐蚀敏感的材料条带的基板。 条带被配置为对特性做出不同的响应。 通过重复测量条的电阻，可以根据特征的累积暴露来监测环境。 这些条以半导体技术制造，以便产生可预测地行为的精确传感器。

公开(公告)号：US20120286803A1

公开(公告)日：2012-11-15

申请号：US13457072

申请日：2012-04-26

Applicant: Axel Nackaerts ,  Matthias Merz ,  Youri Victorovitch Ponomarev

Inventor： Axel Nackaerts ,  Matthias Merz ,  Youri Victorovitch Ponomarev

IPC: G01R27/28 ,  H01L29/78

CPC classification number: G01N27/414 ,  G01N27/4148

Abstract: The invention relates to an electrochemical sensor integrated on a substrate, the electrochemical sensor comprising: a field effect transistor integrated on the substrate and having a source, gate and drain connections, said gate of the field effect transistor comprising: a sensing gate conductively coupled to a sensing electrode; and a bias gate, wherein the sensing gate is capacitively coupled to the bias gate and the bias gate is capacitively coupled to the substrate.

Abstract translation: 本发明涉及集成在衬底上的电化学传感器，该电化学传感器包括：集成在衬底上并具有源极，栅极和漏极连接的场效应晶体管，场效应晶体管的所述栅极包括：传感栅极，其传导耦合到 感测电极; 以及偏置栅极，其中所述感测栅极电容耦合到所述偏置栅极，并且所述偏置栅极电容耦合到所述衬底。