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    IMMOBILIZED LEWIS ACID CATALYSTS COATED WITH IONIC LIQUIDS AND USE THEREOF
    42.
    发明申请
    IMMOBILIZED LEWIS ACID CATALYSTS COATED WITH IONIC LIQUIDS AND USE THEREOF 有权
    用离子液体涂覆的固化的LEWIS酸催化剂及其用途

    公开(公告)号：US20090318729A1

    公开(公告)日：2009-12-24

    申请号：US12282444

    申请日：2007-03-12

    Applicant: Shu Kobayashi ,  Yuichiro Mori ,  Gu Yanlong

    Inventor： Shu Kobayashi ,  Yuichiro Mori ,  Gu Yanlong

    IPC: B01J31/12 ,  C07C327/04 ,  C07C215/20 ,  C07C33/30

    CPC classification number: C07C29/40 ,  B01J31/0252 ,  B01J31/0254 ,  B01J31/0284 ,  B01J31/0288 ,  B01J31/0292 ,  B01J31/1633 ,  B01J31/2256 ,  B01J2231/32 ,  B01J2231/342 ,  B01J2231/346 ,  B01J2531/35 ,  B01J2531/36 ,  B01J2531/38 ,  B01J2531/54 ,  B01J2531/96 ,  C07C221/00 ,  C07C327/22 ,  Y02P20/588 ,  C07C225/18 ,  C07C33/30

    Abstract: The invention provides a novel immobilized Lewis acid catalyst which exhibits high catalytic activity in an aqueous solution and which permits recovery and reuse or long-term continuous use. The invention relates to an immobilized Lewis acid catalyst comprising a solid substance and a Lewis acid supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are coated with an ionic liquid, more specifically, an immobilized Lewis acid catalyst comprising a solid substance such as silica gel or an organic polymer and a Lewis acid stable even in water which is supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are completely or partially coated with a hydrophobic ionic liquid; a process for the production of the catalyst; use thereof; and a process for the preparation of compounds with the catalyst.

    Abstract translation: 本发明提供了一种在水溶液中显示出高催化活性并且允许回收和再利用或长期连续使用的新型固定化路易斯酸催化剂。 本发明涉及一种固定化的路易斯酸催化剂，其包含通过化学键合负载在固体物质的表面上的固体物质和路易斯酸，其中固体物质的表面和路易斯酸的外围被离子液体包覆， 更具体地，包含固体物质例如硅胶或有机聚合物的固定化路易斯酸催化剂和即使在水中稳定的路易斯酸，其通过化学键合负载在固体物质的表面上，其中固体物质的表面和 路易斯酸的外围部分被完全或部分地涂覆有疏水性离子液体; 催化剂的生产方法; 使用; 以及用催化剂制备化合物的方法。

    Method for Manufacturing an Optically Active Hydroxymethylated Compound and a Catalyst Therefore
    44.
    发明申请
    Method for Manufacturing an Optically Active Hydroxymethylated Compound and a Catalyst Therefore 有权
    因此制造光学活性羟甲基化合物和催化剂的方法

    公开(公告)号：US20080139835A1

    公开(公告)日：2008-06-12

    申请号：US11795525

    申请日：2006-01-27

    Applicant: Shu Kobayashi ,  Kei Manabe

    Inventor： Shu Kobayashi ,  Kei Manabe

    IPC: C07F7/02 ,  B01J23/16

    CPC classification number: B01J31/2213 ,  B01J31/1815 ,  B01J2231/321 ,  B01J2531/0252 ,  B01J2531/54 ,  C07B53/00 ,  C07B2200/07 ,  C07C45/511 ,  C07C49/497 ,  C07C49/747 ,  C07C49/82 ,  C07C49/84

    Abstract: A silicon enolate represented by the following formula (Formula 1) (in the formula, R5 to R7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromatic or aromatic-aliphatic hydrocarbon groups or heterocyclic groups, R5 and R7 are different, R6 is not a hydrogen atom, each R8 may be identical or different and represents a methyl group, ethyl group or isopropyl group) and formaldehyde are allowed to react in an aqueous solution or a mixed solvent of water and an organic solvent in the presence of a catalyst obtained by mixing a ligand comprising a chiral bipyridine compound or its antipode and Bi(OTf)3.

    Abstract translation: 由下式（式1）（式中，R 5至R 7表示）的硅烯醇酯代表氢原子，脂族烃基，单环或多环脂环族烃基 ，单环或多环芳族或芳族 - 脂族烃基或杂环基，R 5和R 7不同，R 6不是氢 原子，每个R 8可以相同或不同，表示甲基，乙基或异丙基），并使甲醛在水和有机溶剂的混合溶剂中反应， 通过混合包含手性联吡啶化合物或其对映体和Bi（OTf）3 N 3的配体获得的催化剂的存在。

    Process for asymmetric intramolecular [3+2] cyclo-addition of hydrazones
    45.
    发明授权
    Process for asymmetric intramolecular [3+2] cyclo-addition of hydrazones 有权
    腙的不对称分子内[3 + 2]环加成方法

    公开(公告)号：US07351831B2

    公开(公告)日：2008-04-01

    申请号：US10507309

    申请日：2003-03-11

    Applicant: Shu Kobayashi ,  Yasuhiro Yamashita ,  Haruro Ishitani

    Inventor： Shu Kobayashi ,  Yasuhiro Yamashita ,  Haruro Ishitani

    IPC: C07D471/04

    CPC classification number: C07D231/56

    Abstract: An intramolecular [3+2] cycloaddition reaction of a hydrazone is carried out under a mild condition with a high stereoselectivity and yield by reacting a hydrazone derivative in the presence of an asymmetric catalyst system obtained by mixing a zirconium alkoxide represented by the following formula (I): Zr(OR)4   (I) (wherein R is a hydrocarbon group which may have a substituent) with a binaphthol derivative represented by the following formula (II): (wherein Y1 and Y2 are each identical or different and denote a hydrogen atom or a halogen atom, and at least one of Y1 and Y2 denotes a halogen atom).

    Abstract translation: 腙的分子内[3 + 2]环加成反应在具有高立体选择性的温和条件下进行，并且通过使腙衍生物在由下式表示的锆烷氧化物 I）：<？in-line-formula description =“In-line Formulas”end =“lead”？> Zr（OR）4（I）<？in-line-formula description =“ （其中R是可以具有取代基的烃基）与下式（II）表示的联萘酚衍生物：（其中Y 1和X 2） Y 2各自相同或不同，表示氢原子或卤素原子，Y 1和Y 2中的至少一个表示一个 卤素原子）。

    Process for the allylation of n-acylhydrazones
    49.
    发明申请
    Process for the allylation of n-acylhydrazones 失效
    N-酰基腙的烯丙基化方法

    公开(公告)号：US20070142672A1

    公开(公告)日：2007-06-21

    申请号：US10591094

    申请日：2005-02-24

    Applicant: Shu Kobayashi ,  Masaharu Sugiura

    Inventor： Shu Kobayashi ,  Masaharu Sugiura

    IPC: C07C243/10

    CPC classification number: C07C241/02 ,  C07B53/00 ,  C07C2601/14 ,  C07C243/38

    Abstract: [PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained. [MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectively allylated N-acylhydrazines represented by the general formula [3]: [wherein R0 is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or —COOR1 (wherein R1 is a hydrocarbon group); R2 is acyl; R3 and R4 are each hydrogen, or one of R3 and R4 is hydrogen and the other is a hydrocarbon group; and R5 and R6 are each independently hydrogen or a hydrocarbon group], characterized by reacting an N-acylhydrazone represented by the general formula [1]: [wherein R0 and R2 are as defined above] with an allylating agent such as allyltrichlorosilane or crotyltrichlorosilane in the presence of a chiral phosphine oxide.

    Abstract translation: [问题]提供N-酰腙的烯丙基化的新方法，通过该方法可以有效地获得对映选择性烯丙化的N-酰肼。 用于解决问题的方法制备由通式[3]表示的对映选择性烯丙化N-酰肼的方法：其中R 0为任选取代的烃基，任选取代的杂环基， 或-COOR 1（其中R 1为烃基）; R 2是酰基; R 3和R 4各自为氢，R 3和R 4中的一个为氢，另一个为氢 是一个烃基; 和R 5和R 6各自独立地为氢或烃基]，其特征在于使由通式[1]表示的N-酰腙：[其中R' 在含有手性氧化膦的存在下，与烯丙基化试剂如烯丙基三氯硅烷或巴豆基三氯硅烷进行反应来制备。

    Method for Friedel-Crafts acylation of anilides
    50.
    发明授权
    Method for Friedel-Crafts acylation of anilides 失效
    酰苯衍生物酰化方法

    公开(公告)号：US07214827B2

    公开(公告)日：2007-05-08

    申请号：US11194554

    申请日：2005-08-02

    Applicant: Shu Kobayashi

    Inventor： Shu Kobayashi

    IPC: C07C215/00

    CPC classification number: C07C269/06 ,  C07C231/12 ,  C07C303/40 ,  C07C311/08 ,  C07C233/33 ,  C07C271/28

    Abstract: An anilide is reacted with an acylating agent by using as a catalyst a tri(perfluoroalkane sulfonate) compound of any of the elements belonging to groups 3 to 5 and groups 13 to 15 in periods 4 to 6 of the periodic table, thereby bonding an acyl group to the benzene ring. Thus, ketoaniline derivatives, which are useful as physiologically active compounds or intermediates in synthesizing the same, are synthesized in high reaction yield by catalytic acylation.

    Abstract translation: 通过在周期表第4-6周期中使用属于3至5族和13至15族的任何元素的三（全氟烷基磺酸酯）化合物作为催化剂使酰苯胺与酰化剂反应，从而将酰基 组成苯环。 因此，作为生理活性化合物或其合成中间体的酮苯胺衍生物通过催化酰化以高反应收率合成。

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