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317 条记录 (耗时 0.128 秒)

    Antibodies against interleukin 17 receptor-like protein
    41.
    发明授权
    Antibodies against interleukin 17 receptor-like protein 失效
    抗白细胞介素17受体样蛋白的抗体

    公开(公告)号：US07638603B2

    公开(公告)日：2009-12-29

    申请号：US11567524

    申请日：2006-12-06

    申请人： Yanggu Shi ,  Steven M. Ruben

    发明人： Yanggu Shi ,  Steven M. Ruben

    IPC分类号： C07K16/00 ,  C12P21/08

    CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K14/54 ,  C07K16/2866 ,  C07K2319/30 ,  C12N2799/026 ,  G01N2333/715

    摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

    摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

    Antibody to an IL-17 receptor like protein
    42.
    发明授权
    Antibody to an IL-17 receptor like protein 失效
    IL-17受体样蛋白的抗体

    公开(公告)号：US06849719B2

    公开(公告)日：2005-02-01

    申请号：US09796844

    申请日：2001-03-02

    申请人： Yanggu Shi ,  Steven M. Ruben

    发明人： Yanggu Shi ,  Steven M. Ruben

    IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K16/28 ,  C07K16/00

    CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K14/54 ,  C07K16/2866 ,  C07K2319/30 ,  C12N2799/026 ,  G01N2333/715

    摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

    摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

    Lysyl-oxidase HOHEC84 polynucleotides
    43.
    发明授权
    Lysyl-oxidase HOHEC84 polynucleotides 失效
    赖氨酰氧化酶HOHEC84多核苷酸

    公开(公告)号：US06743613B2

    公开(公告)日：2004-06-01

    申请号：US10067422

    申请日：2002-02-07

    申请人： Jian Ni ,  Steven M. Ruben ,  Yanggu Shi

    发明人： Jian Ni ,  Steven M. Ruben ,  Yanggu Shi

    IPC分类号： C12N906

    CPC分类号： C07K14/51 ,  A61K38/00

    摘要： The present invention relates to novel human BMP polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human BMP polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human BMP polypeptides.

    摘要翻译： 本发明涉及新的人BMP多肽和含有编码这些多肽的基因的编码区的分离的核酸。 还提供了用于产生人BMP多肽的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人BMP多肽相关的疾病的诊断和治疗方法。

    Antibodies to HNFIP24 polypeptides
    45.
    发明授权
    Antibodies to HNFIP24 polypeptides 失效
    HNFIP24多肽的抗体

    公开(公告)号：US08106165B2

    公开(公告)日：2012-01-31

    申请号：US11745580

    申请日：2007-05-08

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

    IPC分类号： C07K16/26 ,  C07K16/00 ,  C12N5/12

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N2800/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

    Human G-Protein Chemokine Receptor (CCR5) HDGNR10
    46.
    发明申请
    Human G-Protein Chemokine Receptor (CCR5) HDGNR10 审中-公开
    人类G蛋白趋化因子受体（CCR5）HDGNR10

    公开(公告)号：US20110081360A1

    公开(公告)日：2011-04-07

    申请号：US12943722

    申请日：2010-11-10

    申请人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  A61P37/04 ,  A61P9/00 ,  A61P17/06 ,  A61P17/00 ,  A61P11/00

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/24 ,  C07K16/2866 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.

    摘要翻译： 本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

    HEMCM42 nucleic acids
    47.
    发明授权
    HEMCM42 nucleic acids 有权
    HEMCM42核酸

    公开(公告)号：US07906634B2

    公开(公告)日：2011-03-15

    申请号：US12324825

    申请日：2008-11-26

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Gregory A. Endress

    IPC分类号： C07H21/04

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K16/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

    Antibodies to HWHGU54 polypeptides
    48.
    发明授权
    Antibodies to HWHGU54 polypeptides 有权
    HWHGU54多肽的抗体

    公开(公告)号：US07838636B1

    公开(公告)日：2010-11-23

    申请号：US11760578

    申请日：2007-06-08

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

    IPC分类号： C07K16/40 ,  C12P21/08 ,  C12P21/06 ,  C12N15/09

    CPC分类号： C07K14/47

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

    Antibodies that specifically bind to neurokinin B
    50.
    发明授权
    Antibodies that specifically bind to neurokinin B 失效
    特异性结合神经激肽B的抗体

    公开(公告)号：US07514079B2

    公开(公告)日：2009-04-07

    申请号：US10981692

    申请日：2004-11-05

    申请人： Craig A. Rosen ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C07K16/26

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S424/80 ,  Y10S424/804 ,  Y10S424/806 ,  Y10S424/809 ,  Y10S435/975

    摘要： The present invention relates to antibodies and related molecules that specifically bind to neurokinin B. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including pre-eclampsia, hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain. The invention also relates to nucleic acid molecules encoding anti-neurokinin B antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially pre-eclampsia, as well as hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to neurokinin B.

    摘要翻译： 本发明涉及与神经激肽B特异性结合的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及免疫系统疾病和病症，包括先兆子痫，高血压，炎症，哮喘， 胃肠道疾病，焦虑症，抑郁症，成瘾症或疼痛。 本发明还涉及编码抗神经激肽B抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是先兆子痫以及高血压，炎症，哮喘，胃肠道疾病，焦虑，抑郁，成瘾或疼痛的方法和组合物，其包括 向动物，优选人施用有效量的一种或多种特异性结合神经激肽B的抗体或其片段或变体或相关分子。