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公开(公告)号：US5368859A
公开(公告)日：1994-11-29
申请号：US84777
申请日：1993-06-29
IPC分类号： A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61L24/00 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/08 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K6/0038 , A61K6/0041 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C67/06 , A61L2300/404 , A61L2300/406 , A61L2300/412 , A61L2300/414 , A61L2300/604 , Y10S514/90
摘要： Methods are described for assisting the restoration of periodontal tissue in a periodontal pocket and for retarding migration of epithelial cells along the root surface of a tooth. The methods involve placement of an in-situ forming biodegradable barrier adjacent the surface of a tooth. The barrier is microporous and includes pores of defined size. The barrier can include a biologically active agent.
摘要翻译： 描述了用于协助牙周袋中牙周组织恢复并延缓上皮细胞沿牙根表面的迁移的方法。 该方法涉及在牙齿表面附近放置原位形成的可生物降解的屏障。 屏障是微孔的，并且包括具有规定尺寸的孔。 屏障可以包括生物活性剂。
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公开(公告)号：US5324520A
公开(公告)日：1994-06-28
申请号：US46396
申请日：1993-04-13
CPC分类号： A61B5/411 , A61B5/02411 , A61B5/0422 , A61B5/0448 , A61B5/4362 , A61B5/4547 , Y10S436/829 , Y10S514/953 , Y10S514/963
摘要： A polymeric controlled delivery system is provided for use in treating periodontal disease. The delivery system in a variety of forms is placed directly in the infected gingival tissue where the chemotherapeutic agent is slowly released into the tissue and into the infected periodontal pocket by means of the gingival crevicular fluid originating in the gingival tissue.
摘要翻译： 提供用于治疗牙周病的聚合物控制递送系统。 各种形式的递送系统直接放置在感染的牙龈组织中，其中化学治疗剂通过源自牙龈组织的牙龈沟液缓慢释放到组织中并进入感染的牙周袋中。
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公开(公告)号：US5324519A
公开(公告)日：1994-06-28
申请号：US783512
申请日：1991-10-28
IPC分类号： A61K6/083 , A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61K39/00 , A61K45/00 , A61K47/02 , A61K47/26 , A61K47/30 , A61K47/34 , A61L24/00 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/08 , B29C41/12 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K47/34 , A61K6/0044 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C41/12 , B29C67/06 , A61L2300/406 , A61L2300/412 , A61L2300/602 , A61L2300/604
摘要： The invention is directed to a composition composed of a thermoplastic or thermosetting polymer which is capable of forming a biodegradable and/or bioerodible microporous, solid or gelatinous polymer matrix. The matrix is useful as an implant in animals for enhancing regeneration of cells and tissue, such as bone and nerve cells, or for delivery of biologically-active substances to tissue or organs. The composition is administered to an implant site as a liquid. The invention also includes a method of preventing and treating disorders and diseases, such as bone or nerve growth disorders, or of altering body functions such as birth control, using the compositions and implants of the invention.
摘要翻译： 本发明涉及由热塑性或热固性聚合物组成的组合物，其能够形成可生物降解和/或生物腐蚀性微孔，固体或凝胶状聚合物基质。 该基质可用作动物中的植入物，用于增强细胞和组织的再生，例如骨和神经细胞，或将生物活性物质递送至组织或器官。 将组合物作为液体施用于植入部位。 本发明还包括使用本发明的组合物和植入物来预防和治疗诸如骨骼或神经生长障碍的疾病和疾病或改变身体功能例如避孕的方法。
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公开(公告)号：US5175000A
公开(公告)日：1992-12-29
申请号：US696093
申请日：1991-05-06
IPC分类号： A61K6/00 , A61K6/08 , A61K8/49 , A61K9/00 , A61K9/06 , A61K9/12 , A61K31/435 , A61K31/47 , A61K36/00 , A61K36/66 , A61K47/48 , A61Q5/02 , A61Q11/00 , A61Q19/00
CPC分类号： A61K47/48176 , A61K31/435 , A61K31/47 , A61K6/0058 , A61K6/08 , A61K6/083 , A61K6/087 , A61K8/49 , A61K9/0063 , A61Q11/00 , A61Q17/005 , A61Q5/02 , Y10S514/886 , Y10S514/887 , Y10S514/902 , Y10S514/937 , Y10S514/944 , Y10S514/951 , Y10S514/969
摘要： A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.
摘要翻译： 公开了游离胺苯并菲啶生物碱和药学上可接受的载体的药物组合物。 该组合物是抗菌和抗真菌剂。
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公开(公告)号：US08974808B2
公开(公告)日：2015-03-10
申请号：US12643546
申请日：2009-12-21
申请人： Arthur J. Tipton , Kevin W. Burton
发明人： Arthur J. Tipton , Kevin W. Burton
CPC分类号： A61K9/0024 , A61M5/14276 , A61M2205/04 , A61N1/36036 , A61N1/362 , A61N1/38
摘要： Described herein are implantable composites, kits comprising the composites, implant devices comprising the composites, and methods of making and using same, including point of use methods.
摘要翻译： 本文描述的是可植入复合材料，包括复合材料的试剂盒，包含复合材料的植入装置，以及制造和使用它们的方法，包括使用方法。
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公开(公告)号：US20100160891A1
公开(公告)日：2010-06-24
申请号：US12643546
申请日：2009-12-21
申请人： Arthur J. Tipton , Kevin W. Burton
发明人： Arthur J. Tipton , Kevin W. Burton
IPC分类号： A61M37/00
CPC分类号： A61K9/0024 , A61M5/14276 , A61M2205/04 , A61N1/36036 , A61N1/362 , A61N1/38
摘要： Described herein are implantable composites, kits comprising the composites, implant devices comprising the composites, and methods of making and using same, including point of use methods.
摘要翻译： 本文描述的是可植入复合材料，包括复合材料的试剂盒，包含复合材料的植入装置，以及制造和使用它们的方法，包括使用方法。
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公开(公告)号：US20100016267A1
公开(公告)日：2010-01-21
申请号：US10592886
申请日：2005-03-15
申请人： Felix Theeuwes , Arthur J. Tipton
发明人： Felix Theeuwes , Arthur J. Tipton
CPC分类号： A61K9/0043
摘要： Pharmaceutical compositions for delivering a drug to a sinus in a subject are provided. The compositions are formed by the combination of a carrier material and a drug and are specially adapted for delivery to a sinus. The compositions have no fixed shape, and the carrier material serves to increase the viscosity or specific volume of the composition after introduction of the composition into the sinus. Also provided are methods for delivering a drug to a subject. The methods entail administering a pharmaceutical composition according to the present invention directly to a sinus. The drug is then released from the composition to the sinus. The pharmaceutical compositions can be administered to a sinus in liquid form, for example, as a suspension or solution using standard techniques. Also provided is the use of a carrier material in the manufacture of a drug delivery composition. The drug delivery composition is for delivering a drug to a sinus in a subject. The composition comprises the carrier material combined with the drug to be delivered, and has no fixed shape. After the composition is introduced into a sinus, the carrier material serves to increase the viscosity or specific volume of the composition.
摘要翻译： 提供用于将药物递送至受试者的窦的药物组合物。 组合物通过载体材料和药物的组合形成，并且特别适于递送至窦。 组合物没有固定的形状，并且载体材料用于在将组合物引入窦内后增加组合物的粘度或比体积。 还提供了将药物递送到受试者的方法。 所述方法需要将根据本发明的药物组合物直接给予鼻窦。 然后将药物从组合物释放到窦。 药物组合物可以以液体形式施用于窦，例如使用标准技术作为悬浮液或溶液施用。 还提供了载体材料在制备药物递送组合物中的用途。 药物递送组合物用于将药物递送至受试者的窦。 该组合物包含与待输送药物结合的载体材料，并且不具有固定形状。 在将组合物引入窦中之后，载体材料用于增加组合物的粘度或比体积。
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公开(公告)号：US5780044A
公开(公告)日：1998-07-14
申请号：US761015
申请日：1996-12-05
申请人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
发明人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
IPC分类号： A61K9/00 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/70 , A61K47/48 , A61K49/00 , A61L15/44 , A61F2/00 , A61K9/127 , A61K9/52
CPC分类号： A61K9/0024 , A61K31/4439 , A61K31/485 , A61K31/704 , A61K38/09 , A61K38/27 , A61K47/34 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48784 , A61K47/48853 , A61K49/0017 , A61K49/0036 , A61K49/0054 , A61K49/0063 , A61K49/0091 , A61K9/10 , A61K9/146 , A61K9/5026 , A61K9/5047 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , A61L31/16 , A61K47/42 , A61L2300/604 , A61L2300/62 , A61L2400/06 , Y10S514/90 , Y10S525/937 , Y10S977/774 , Y10S977/783 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/918
摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.
摘要翻译： 提供改进的生物相容性液体递送组合物，其可用于形成活性剂的缓释递送系统。 组合物包括与受控释放组分组合的生物相容性聚合物或预聚物的液体制剂。 受控释放组分包括活性剂。 这些组合物可以以液体形式引入受试者的身体，其然后在现场固化或固化以形成控释植入物或膜敷料。 液体递送组合物也可以非原位地用于产生控释植入物。 还提供了形成受控释放植入物并使用液体制剂治疗受试者的方法。
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公开(公告)号：US5747058A
公开(公告)日：1998-05-05
申请号：US474337
申请日：1995-06-07
申请人： Arthur J. Tipton , Richard J. Holl
发明人： Arthur J. Tipton , Richard J. Holl
IPC分类号： A61K8/60 , A61K9/00 , A61K9/10 , A61K38/18 , A61K47/26 , A61L15/44 , A61L24/00 , A61L26/00 , A61L27/54 , A61L31/16 , A61Q11/00 , A61F2/02 , A61F6/06 , A61F9/02 , A61L9/04
CPC分类号： A61L31/16 , A61K47/26 , A61K8/60 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61L15/44 , A61L24/0015 , A61L26/0066 , A61L27/54 , A61Q11/00 , A61Q5/006 , A61L2300/602
摘要： A composition for the controlled release of substances is provided that includes: (i) a non-polymeric, non-water soluble liquid carrier material (HVLCM) of viscosity of at least 5,000 cP at 37.degree. C. that does not crystallize neat under ambient or physiological conditions; and (ii) a substance to be delivered.
摘要翻译： 提供了用于控制释放物质的组合物，其包括：（i）在37℃下粘度为至少5,000cP的非聚合的非水溶性液体载体材料（HVLCM），其在环境下不结晶 或生理条件; 和（ii）待送达的物质。
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公开(公告)号：US5702716A
公开(公告)日：1997-12-30
申请号：US70498
申请日：1993-06-02
申请人： Richard L. Dunn , Arthur J. Tipton
发明人： Richard L. Dunn , Arthur J. Tipton
IPC分类号： A61K9/00 , A61K9/22 , A61K47/34 , A61L15/44 , A61L24/00 , A61L24/04 , A61L24/06 , A61L26/00 , A61K9/20
CPC分类号： A61K9/0024 , A61K47/34 , A61L15/44 , A61L24/0015 , A61L24/0026 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L26/0019 , A61L26/0076 , A61L26/009 , A61L2300/602
摘要： The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a thermoplastic polymer, rate modifying agent, bioactive material and organic solvent. The liquid composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of biologically active substances to tissues or organs.
摘要翻译： 本发明涉及用于控制释放生物活性物质和用于其形成的液体组合物的改进系统。 液体组合物由热塑性聚合物，速率改性剂，生物活性材料和有机溶剂组成。 液体组合物能够形成可生物降解和/或生物腐蚀性微孔固体聚合物基质。 该基质可用作患者（人和动物）中用于将生物活性物质递送至组织或器官的植入物。
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