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公开(公告)号：US5395615A
公开(公告)日：1995-03-07
申请号：US954337
申请日：1992-09-30
IPC分类号： A61K6/00 , A61K6/08 , A61K8/49 , A61K9/00 , A61K9/06 , A61K9/12 , A61K31/435 , A61K31/47 , A61K36/00 , A61K36/66 , A61K47/48 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61K9/14 , A61K7/16 , A61K35/78
CPC分类号： A61K47/48176 , A61K31/435 , A61K31/47 , A61K6/0058 , A61K6/08 , A61K6/083 , A61K6/087 , A61K8/49 , A61K9/0063 , A61Q11/00 , A61Q17/005 , A61Q5/02 , Y10S514/886 , Y10S514/887 , Y10S514/902 , Y10S514/937 , Y10S514/944 , Y10S514/951 , Y10S514/969
摘要： A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.
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公开(公告)号：US5175000A
公开(公告)日：1992-12-29
申请号：US696093
申请日：1991-05-06
IPC分类号： A61K6/00 , A61K6/08 , A61K8/49 , A61K9/00 , A61K9/06 , A61K9/12 , A61K31/435 , A61K31/47 , A61K36/00 , A61K36/66 , A61K47/48 , A61Q5/02 , A61Q11/00 , A61Q19/00
CPC分类号： A61K47/48176 , A61K31/435 , A61K31/47 , A61K6/0058 , A61K6/08 , A61K6/083 , A61K6/087 , A61K8/49 , A61K9/0063 , A61Q11/00 , A61Q17/005 , A61Q5/02 , Y10S514/886 , Y10S514/887 , Y10S514/902 , Y10S514/937 , Y10S514/944 , Y10S514/951 , Y10S514/969
摘要： A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.
摘要翻译： 公开了游离胺苯并菲啶生物碱和药学上可接受的载体的药物组合物。 该组合物是抗菌和抗真菌剂。
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公开(公告)号：US5324520A
公开(公告)日：1994-06-28
申请号：US46396
申请日：1993-04-13
CPC分类号： A61B5/411 , A61B5/02411 , A61B5/0422 , A61B5/0448 , A61B5/4362 , A61B5/4547 , Y10S436/829 , Y10S514/953 , Y10S514/963
摘要： A polymeric controlled delivery system is provided for use in treating periodontal disease. The delivery system in a variety of forms is placed directly in the infected gingival tissue where the chemotherapeutic agent is slowly released into the tissue and into the infected periodontal pocket by means of the gingival crevicular fluid originating in the gingival tissue.
摘要翻译： 提供用于治疗牙周病的聚合物控制递送系统。 各种形式的递送系统直接放置在感染的牙龈组织中，其中化学治疗剂通过源自牙龈组织的牙龈沟液缓慢释放到组织中并进入感染的牙周袋中。
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公开(公告)号：US5759563A
公开(公告)日：1998-06-02
申请号：US486262
申请日：1995-06-07
申请人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
发明人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
IPC分类号： A61K9/00 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/70 , A61K47/48 , A61K49/00 , A61L15/44 , A61K9/127 , A61F13/00
CPC分类号： A61K9/0024 , A61K31/4439 , A61K31/485 , A61K31/704 , A61K38/09 , A61K38/27 , A61K47/34 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48784 , A61K47/48853 , A61K49/0017 , A61K49/0036 , A61K49/0054 , A61K49/0063 , A61K49/0091 , A61K9/10 , A61K9/146 , A61K9/5026 , A61K9/5047 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , A61L31/16 , A61K47/42 , A61L2300/604 , A61L2300/62 , A61L2400/06 , Y10S514/90 , Y10S525/937 , Y10S977/774 , Y10S977/783 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/918
摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.
摘要翻译： 提供改进的生物相容性液体递送组合物，其可用于形成活性剂的缓释递送系统。 组合物包括与受控释放组分组合的生物相容性聚合物或预聚物的液体制剂。 受控释放组分包括活性剂。 这些组合物可以以液体形式引入受试者的身体，其然后在现场固化或固化以形成控释植入物或膜敷料。 液体递送组合物也可以非原位地用于产生控释植入物。 还提供了形成受控释放植入物并使用液体制剂治疗受试者的方法。
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公开(公告)号：US5792469A
公开(公告)日：1998-08-11
申请号：US482851
申请日：1995-06-07
CPC分类号： A61L15/44 , A61K9/7015 , A61L24/0042 , A61L26/00 , A61L26/0066 , A61L26/0076 , A61L26/0085 , A61L26/009 , A61L2300/252 , A61L2300/604
摘要： The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing-on a human or animal tissue. The film dressing is formed from a liquid composition of at least one biodegradable/bioerodible thermoplastic polymer in a pharmaceutically acceptable solvent. The spray apparatus includes a vessel containing the liquid composition with a dispensing means. The film is formed by dispensing, preferably by spraying, the liquid composition onto a tissue site and contacting the liquid composition with an aqueous based fluid to coagulate or solidify the film onto the human or animal tissue. The biodegradable film can be used to protect and to promote healing of injured tissue and/or to deliver biologically active agents.
摘要翻译： 本发明涉及具有或不具有另外的治疗剂的可生物降解的膜敷料，用于喷雾递送的装置和用于在人或动物组织上形成膜的方法。 薄膜敷料由药学上可接受的溶剂中的至少一种可生物降解/生物侵蚀的热塑性聚合物的液体组合物形成。 喷雾装置包括容纳具有分配装置的液体组合物的容器。 通过优选通过将液体组合物分配到组织部位上并将液体组合物与基于水的液体接触使凝胶或固化到人体或动物组织上而形成薄膜。 可生物降解膜可用于保护和促进损伤组织的愈合和/或递送生物活性剂。
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公开(公告)号：US5945115A
公开(公告)日：1999-08-31
申请号：US908263
申请日：1997-08-08
申请人： Richard L. Dunn , Arthur J. Tipton
发明人： Richard L. Dunn , Arthur J. Tipton
CPC分类号： A61K9/0024 , A61K47/14 , A61K47/34 , A61K9/0019
摘要： The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a thermoplastic polymer, rate modifying agent, bioactive material and organic solvent. The liquid composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of biologically active substances to tissues or organs.
摘要翻译： 本发明涉及用于控制释放生物活性物质和用于其形成的液体组合物的改进系统。 液体组合物由热塑性聚合物，速率改性剂，生物活性材料和有机溶剂组成。 液体组合物能够形成可生物降解和/或生物腐蚀性微孔固体聚合物基质。 该基质可用作患者（人和动物）中用于将生物活性物质递送至组织或器官的植入物。
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公开(公告)号：US5744153A
公开(公告)日：1998-04-28
申请号：US871492
申请日：1997-06-09
申请人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
发明人： Gerald L. Yewey , Nancy L. Krinick , Richard L. Dunn , Michael L. Radomsky , Gerbrand Brouwer , Arthur J. Tipton
IPC分类号： A61K9/00 , A61K9/08 , A61K9/20 , A61K9/22 , A61K9/70 , A61K47/48 , A61K49/00 , A61L15/44 , A61F2/00 , A61K9/127 , A61K9/52
CPC分类号： A61K9/0024 , A61K31/4439 , A61K31/485 , A61K31/704 , A61K38/09 , A61K38/27 , A61K47/34 , A61K47/48176 , A61K47/48192 , A61K47/482 , A61K47/48784 , A61K47/48853 , A61K49/0017 , A61K49/0036 , A61K49/0054 , A61K49/0063 , A61K49/0091 , A61K9/10 , A61K9/146 , A61K9/5026 , A61K9/5047 , A61L26/0019 , A61L26/0066 , A61L26/0085 , A61L27/18 , A61L27/56 , A61L31/06 , A61L31/146 , A61L31/16 , A61K47/42 , A61L2300/604 , A61L2300/62 , A61L2400/06 , Y10S514/90 , Y10S525/937 , Y10S977/774 , Y10S977/783 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/918
摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.
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公开(公告)号：US5599552A
公开(公告)日：1997-02-04
申请号：US249630
申请日：1994-05-26
IPC分类号： A61K6/083 , A61K6/00 , A61K9/00 , A61K9/16 , A61K31/74 , A61K33/42 , A61K39/00 , A61K45/00 , A61K47/02 , A61K47/26 , A61K47/30 , A61K47/34 , A61L24/00 , A61L27/00 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , B29C41/08 , B29C41/12 , B29C67/06 , A61F2/00
CPC分类号： A61K9/0024 , A61K31/74 , A61K33/42 , A61K47/34 , A61K6/0044 , A61K9/0063 , A61K9/1647 , A61L27/16 , A61L27/18 , A61L27/50 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/14 , A61L31/148 , B29C41/08 , B29C41/12 , B29C67/06 , A61L2300/406 , A61L2300/412 , A61L2300/602 , A61L2300/604
摘要： The invention is directed to a composition composed of a thermoplastic or thermosetting polymer which is capable of forming a biodegradable and/or bioerodible microporous, solid or gelatinous polymer matrix. The matrix is useful as an implant in animals for enhancing regeneration of cells and tissue, such as bone and nerve cells, or for delivery of biologically-active substances to tissue or organs. The composition is administered to an implant site as a liquid. The invention also includes a method of preventing and treating disorders and diseases, such as bone or nerve growth disorders, or of altering body functions such as birth control, using the compositions and implants of the invention.
摘要翻译： 本发明涉及由热塑性或热固性聚合物组成的组合物，其能够形成可生物降解和/或生物腐蚀性微孔，固体或凝胶状聚合物基质。 该基质可用作动物中的植入物，用于增强细胞和组织的再生，例如骨和神经细胞，或将生物活性物质递送至组织或器官。 将组合物作为液体施用于植入部位。 本发明还包括使用本发明的组合物和植入物来预防和治疗诸如骨骼或神经生长障碍的疾病和疾病或改变身体功能例如避孕的方法。
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公开(公告)号：US5725491A
公开(公告)日：1998-03-10
申请号：US336017
申请日：1994-11-08
IPC分类号： A61F2/02 , A61F2/30 , A61K9/00 , A61K9/70 , A61K47/34 , A61L15/44 , A61L15/62 , A61L24/00 , A61L24/04 , A61L24/06 , A61L26/00 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/58 , A61F13/00 , A61F15/00 , A61K31/74 , A61M35/00
CPC分类号： A61K9/7015 , A61K47/34 , A61K9/0024 , A61L15/44 , A61L15/62 , A61L24/0015 , A61L24/0026 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L26/00 , A61L26/0019 , A61L26/0066 , A61L26/0076 , A61L26/0085 , A61L26/009 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/58 , A61F2002/30062 , A61F2002/30583 , A61F2210/0004 , A61F2210/0085 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/604 , Y10S602/904
摘要： The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing on a human or animal tissue. The film dressing is formed from a liquid composition of at least one biodegradable/bioerodible thermoplastic polymer such as polylactides, polyglycolides, polycaprolactones or copolymers thereof in a pharmaceutically acceptable solvent such as N-methylpyrrolidone, alcohols or alkyl esters. The spray apparatus includes a vessel containing the liquid composition with a dispensing means. The film is formed by dispensing, preferably by spraying, the liquid composition onto a tissue site and contacting the liquid composition with an aqueous based fluid such as water, saline solution or body fluid to coagulate or solidify the film onto the human or animal tissue. The biodegradable film can be used to protect and to promote healing of injured tissue and/or to deliver biologically active agents such as growth.
摘要翻译： 本发明涉及具有或不具有其它治疗剂的生物降解性膜敷料，用于喷雾递送的装置和在人或动物组织上形成膜敷料的方法。 薄膜敷料由药学上可接受的溶剂如N-甲基吡咯烷酮，醇或烷基酯中的至少一种生物可降解/生物侵蚀性热塑性聚合物如聚丙交酯，聚乙交酯，聚己内酯或其共聚物的液体组合物形成。 喷雾装置包括容纳具有分配装置的液体组合物的容器。 通过优选通过将液体组合物分配到组织部位上并使液体组合物与基于水的液体，例如水，盐水溶液或体液接触使凝胶或固化在人体或动物组织上而形成薄膜。 可生物降解的膜可用于保护和促进损伤组织的愈合和/或递送生物活性剂如生长。
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公开(公告)号：US5632727A
公开(公告)日：1997-05-27
申请号：US487547
申请日：1995-06-07
IPC分类号： A61F2/02 , A61F2/30 , A61K9/00 , A61K9/70 , A61K47/34 , A61L15/44 , A61L15/62 , A61L24/00 , A61L24/04 , A61L24/06 , A61L26/00 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/58 , A61F13/00
CPC分类号： A61K9/0024 , A61K47/34 , A61K9/7015 , A61L15/44 , A61L15/62 , A61L24/0015 , A61L24/0026 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L26/00 , A61L26/0019 , A61L26/0066 , A61L26/0076 , A61L26/0085 , A61L26/009 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/34 , A61L27/54 , A61L27/58 , A61F2002/30062 , A61F2002/30583 , A61F2210/0004 , A61F2210/0085 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/414 , A61L2300/604 , Y10S602/90 , Y10S602/904
摘要： The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing on a human or animal tissue. The film dressing is formed from a liquid composition of at least one biodegradable/bioerodible thermoplastic polymer in a pharmaceutically acceptable solvent. The spray apparatus includes a vessel containing the liquid composition with a dispensing means. The film is formed by dispensing, preferably by spraying, the liquid composition onto a tissue site and contacting the liquid composition with an aqueous based fluid to coagulate or solidify the film onto the human or animal tissue. The biodegradable film can be used to protect and to promote healing of injured tissue and/or to deliver biologically active agents.
摘要翻译： 本发明涉及具有或不具有其它治疗剂的生物降解性膜敷料，用于喷雾递送的装置和在人或动物组织上形成膜敷料的方法。 薄膜敷料由药学上可接受的溶剂中的至少一种可生物降解/生物侵蚀的热塑性聚合物的液体组合物形成。 喷雾装置包括容纳具有分配装置的液体组合物的容器。 通过优选通过将液体组合物分配到组织部位上并将液体组合物与基于水的液体接触使凝胶或固化到人体或动物组织上而形成薄膜。 可生物降解膜可用于保护和促进损伤组织的愈合和/或递送生物活性剂。
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