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95 条记录 (耗时 0.053 秒)

    Method and apparatus for performing assays
    41.
    发明授权
    Method and apparatus for performing assays 有权
    用于进行测定的方法和装置

    公开(公告)号：US09229001B2

    公开(公告)日：2016-01-05

    申请号：US13511593

    申请日：2010-11-23

    申请人： Martin A. Putnam ,  Alan D. Kersey

    发明人： Martin A. Putnam ,  Alan D. Kersey

    IPC分类号： G01N33/543 ,  B01L3/00 ,  G01N35/10

    CPC分类号： G01N33/54366 ,  B01L3/502715 ,  B01L3/502784 ,  B01L3/527 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2400/0633 ,  G01N35/1097

    摘要： An apparatus is provided for performing an chemical, biochemical, or biological assay on a sample comprising: a microfluidic assay cartridge (1) that contains at least one sample inlet well (2) configured to receive a sample; and a microfluidic sub-unit (3) associated with the microfluidic assay cartridge (1) and comprising microfluidic channels (8), micro-valves (4, 4a, 9) and at least one separate and fluidicly-isolated isolation channel (5), and at least one hollow element (14); the at least one hollow element (14) being functionalized with a capture moiety or molecules (15) so as to form at least one reaction vessel (19); the microfluidic channels (8) and micro-valves (4, 4a, 9) configured to respond to signaling containing information about performing the assay and to controllably receive the sample and at least one reagent in the at least one reaction vessel (19), and to provide from the at least one reaction vessel (19) light containing information about the assay performed on the sample inside the at least one reaction vessel (19) as a result of said at least one reagent.

    摘要翻译： 提供了一种用于对样品进行化学，生化或生物测定的装置，包括：微流体测定盒（1），其包含至少一个被配置为接收样品的样品入口孔（2） 和与微流体测定盒（1）相关联并且包括微流体通道（8），微阀（4,4a，9）和至少一个单独和流体隔离的隔离通道（5）的微流体子单元（3） ，和至少一个中空元件（14）; 所述至少一个中空元件（14）被捕获部分或分子（15）功能化，以形成至少一个反应容器（19）; 微流体通道（8）和微阀（4,4a，9）被配置为对包含关于进行测定的信息的信号进行响应并且可控制地接收样品和至少一个反应容器（19）中的至少一个试剂， 并且从所述至少一个反应容器（19）提供含有关于由所述至少一种试剂的结果对所述至少一个反应容器（19）内的样品进行的测定的信息的光。

    Optical system and method for reading encoded microbeads
    44.
    发明授权
    Optical system and method for reading encoded microbeads 有权
    用于读取编码微珠的光学系统和方法

    公开(公告)号：US08565475B2

    公开(公告)日：2013-10-22

    申请号：US13243422

    申请日：2011-09-23

    申请人： John A. Moon ,  Martin A. Putnam

    发明人： John A. Moon ,  Martin A. Putnam

    IPC分类号： G06K9/00 ,  G06K5/00

    CPC分类号： G06K7/10821 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00704 ,  B82Y20/00 ,  G01N15/1468 ,  G02B1/005 ,  G06E3/005 ,  G06K7/10722

    摘要： An optical system for reading encoded microbeads. The microbeads provide output light signals onto a Fourier plane when illuminated by an incident light. The system includes an input light source that is configured to illuminate the microbeads thereby providing the output light signals. The output light signals are configured to be projected onto the Fourier plane in a readable manner. The system also includes a reading device that is positioned to detect the output light signals from the Fourier plane. The system also includes a processor that is configured to perform Fourier plane analysis of the optical light signals to determine corresponding codes of the microbeads.

    摘要翻译： 用于读取编码微珠的光学系统。 当由入射光照射时，微珠将输出光信号提供到傅立叶平面上。 该系统包括被配置为照亮微珠从而提供输出光信号的输入光源。 输出光信号被配置为以可读方式投影到傅立叶平面上。 该系统还包括读取装置，其被定位成检测来自傅里叶平面的输出光信号。 该系统还包括处理器，其被配置为对光信号进行傅立叶平面分析以确定微珠的相应代码。

    Optical reader system for substrates having an optically readable code
    45.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US08333325B2

    公开(公告)日：2012-12-18

    申请号：US13014298

    申请日：2011-01-26

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system including a source light assembly that has a code-reading beam and a fluorescence-excitation beam that are configured to illuminate encoded substrates. The substrates have optically readable codes that provide output signals when the code-reading beam is incident thereon. The output signals are indicative of the codes. The reader system also includes a fluorescence detector that is configured to detect fluorescent signals from the substrates and code pickup optics that are configured to project the output signals from the optically readable codes onto a Fourier plane. The reader system also includes a code detector that is positioned to detect the output signals in the Fourier plane.

    摘要翻译： 一种光学读取器系统，包括具有代码读取光束的源光组件和被配置为照亮编码的基板的荧光激发光束。 衬底具有光学可读代码，当代码读取光束入射时，其提供输出信号。 输出信号表示代码。 读取器系统还包括荧光检测器，其被配置为检测来自基板的荧光信号和被配置为将来自光学可读代码的输出信号投影到傅立叶平面上的代码拾取光学器件。 读取器系统还包括代码检测器，其被定位成检测傅立叶平面中的输出信号。

    LARGE DIAMETER OPTICAL WAVEGUIDE, GRATING AND LASER
    46.
    发明申请
    LARGE DIAMETER OPTICAL WAVEGUIDE, GRATING AND LASER 有权
    大直径光波导，光栅和激光

    公开(公告)号：US20120082175A1

    公开(公告)日：2012-04-05

    申请号：US13316069

    申请日：2011-12-09

    申请人： Martin A. Putnam ,  Robert N. Brucato ,  Paul E. Sanders ,  Timothy J. Bailey ,  James M. Sullivan ,  Alan D. Kersey

    发明人： Martin A. Putnam ,  Robert N. Brucato ,  Paul E. Sanders ,  Timothy J. Bailey ,  James M. Sullivan ,  Alan D. Kersey

    IPC分类号： H01S3/30 ,  G02B6/036 ,  H01S3/08 ,  G02B6/02

    CPC分类号： G02B6/022 ,  G02B6/02 ,  G02B6/02042 ,  H01S3/06708 ,  H01S3/06729 ,  H01S3/06754

    摘要： A large diameter optical waveguide, grating, and laser includes a waveguide having at least one core surrounded by a cladding, the core propagating light in substantially a few transverse spatial modes; and having an outer waveguide dimension of said waveguide being greater than about 0.3 mm. At least one Bragg grating may be impressed in the waveguide. The waveguide may be axially compressed which causes the length of the waveguide to decrease without buckling. The waveguide may be used for any application where a waveguide needs to be compression tuned. Also, the waveguide exhibits lower mode coupling from the core to the cladding and allows for higher optical power to be used when writing gratings without damaging the waveguide. The waveguide may resemble a short “block” or a longer “cane” type, depending on the application and dimensions used.

    摘要翻译： 大直径光波导，光栅和激光器包括具有由包层围绕的至少一个核的波导，所述核以基本上几个横向空间模式传播光; 并且具有所述波导的外波导尺寸大于约0.3mm。 至少一个布拉格光栅可以印在波导中。 波导可以被轴向压缩，这导致波导的长度减小而没有弯曲。 波导可以用于波导需要被压缩调谐的任何应用。 此外，波导表现出从芯到包层的较低模式耦合，并且允许在写入光栅时使用更高的光功率而不损坏波导。 根据使用的应用和尺寸，波导可能类似于短的“块”或更长的“手杖”类型。

    Optical reader system for substrates having an optically readable code
    48.
    发明授权
    Optical reader system for substrates having an optically readable code 有权
    具有光学可读代码的基板的光学读取器系统

    公开(公告)号：US07900836B2

    公开(公告)日：2011-03-08

    申请号：US12174490

    申请日：2008-07-16

    申请人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    发明人： John A. Moon ,  David R. Fournier ,  Martin A. Putnam ,  Alan D. Kersey ,  Tuo Li

    IPC分类号： G06K7/10

    CPC分类号： G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

    摘要： An optical reader system that includes a plurality of substrates. The substrates have an optically readable code disposed therein and a source light assembly that is configured to illuminate the substrates with a code-reading beam and another beam for detecting another optically readable property of the substrate. The code-reading beam and the other beam form beam spots on the substrates that have different shapes. The system also includes a reader that is configured to receive output signals from the code-reading beam and the other beam when the substrates are illuminated. The output signals from the code-reading beam are indicative of the code.

    摘要翻译： 一种包括多个基板的光学读取器系统。 基板具有设置在其中的光学可读代码，以及源光组件，其被配置为用代码读取光束照射基板，另一个光束用于检测基板的另一光学可读性。 代码读取光束和另一个光束在具有不同形状的基板上形成光束点。 该系统还包括读取器，其被配置为当基板被照亮时从代码读取光束和另一个光束接收输出信号。 代码读取波束的输出信号表示代码。

    Methods of identifying an analyte and nucleic acid analysis
    49.
    发明授权
    Methods of identifying an analyte and nucleic acid analysis 有权
    识别分析物和核酸分析的方法

    公开(公告)号：US07843567B2

    公开(公告)日：2010-11-30

    申请号：US12644255

    申请日：2009-12-22

    申请人： John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    发明人： John A. Moon ,  Alan D. Kersey ,  Martin A. Putnam ,  Tuo Li

    IPC分类号： G01N21/25

    CPC分类号： G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

    摘要： A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding microparticle. The microparticles have the chemical probes attached thereto. Each of the chemical probes is associated with a corresponding one of the codes. The method also includes selectively binding target analytes to the chemical probes on the microparticles to produce labeled microparticles and distributing the labeled microparticles to random locations of a substrate. The method also includes determining the codes for the labeled microparticles in the random array and code positions of the codes in the random array. The method further includes detecting the label on the labeled microparticles in the random array and label positions of the labels in the random array. The method also includes using the code positions and the label positions to analyze the target analyte.

    摘要翻译： 识别分析物的方法。 该方法包括提供多个微粒。 微粒具有沿相应微粒的主体延伸的光学检测码。 微粒具有附着于其上的化学探针。 每个化学探针与相应的一个代码相关联。 该方法还包括将目标分析物选择性地结合到微粒上的化学探针以产生标记的微粒并将标记的微粒分布到基底的随机位置。 该方法还包括确定随机阵列中的标记微粒的代码和随机阵列中代码的代码位置。 该方法还包括随机阵列中标记的微粒上的标记和随机阵列中的标记的标记位置的检测。 该方法还包括使用代码位置和标签位置来分析目标分析物。

    Optical identification element having a non-waveguide substrate
    50.
    发明授权
    Optical identification element having a non-waveguide substrate 有权
    具有非波导基板的光学识别元件

    公开(公告)号：US07791802B2

    公开(公告)日：2010-09-07

    申请号：US12144209

    申请日：2008-06-23

    申请人： Martin A. Putnam ,  John A. Moon

    发明人： Martin A. Putnam ,  John A. Moon

    IPC分类号： G02B5/18

    CPC分类号： G02B6/021 ,  G06K19/06018 ,  G06K19/06046

    摘要： An optical identification element including a non-waveguide optical substrate. The optical substrate has a volume and includes an inner region surrounded by an outer region. The inner region has an index of refraction that prevents the optical substrate from forming an optical waveguide. The optical substrate includes a diffraction grating within the volume, and the grating provides an output signal indicative of a code when illuminated by an incident light.

    摘要翻译： 一种包括非波导光学基片的光学识别元件。 光学基板具有体积并且包括被外部区域包围的内部区域。 内部区域具有防止光学基板形成光波导的折射率。 光学基板包括体积内的衍射光栅，并且当由入射光照射时，光栅提供指示代码的输出信号。