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    Implantable Electroacupuncture System and Method for Treating Parkinson's Disease and Essential Tremor Through Application of Stimului At or Near An Acupoint on the Chorea Line
    41.
    发明申请
    Implantable Electroacupuncture System and Method for Treating Parkinson's Disease and Essential Tremor Through Application of Stimului At or Near An Acupoint on the Chorea Line 有权
    植入式电针系统及治疗帕金森氏病和基础震颤的方法，通过施用Stimului在Chorea线上或附近的穴位

    公开(公告)号：US20150148864A1

    公开(公告)日：2015-05-28

    申请号：US14609108

    申请日：2015-01-29

    Applicant: Valencia Technologies Corporation

    Inventor： David K. L. Peterson ,  Stacy Greiner Chambliss

    IPC: A61N1/36 ,  A61N1/05 ,  A61N1/375

    CPC classification number: A61N1/36067 ,  A61N1/0504 ,  A61N1/0529 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782

    Abstract: An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied to at least one of the acupoints on the chorea line. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device and a conduit extending therefrom. At least one electrode is located on the outside of the housing. At least one electrode is located at an opening formed through the conduit. The housing contains a primary power source and pulse generation circuitry. A sensor wirelessly senses externally-generated operating commands, such as ON, OFF and AMPLITUDE. The pulse generation circuitry generates stimulation pulses. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen.

    Abstract translation: 可植入电针装置（IEAD）通过施加施加到舞蹈线上至少一个穴位的刺激脉冲来治疗帕金森病或基本震颤。 IEAD包括密封的可植入电针（EA）装置和从其延伸的导管。 至少一个电极位于外壳的外侧。 至少一个电极位于通过导管形成的开口处。 外壳包含主电源和脉冲发生电路。 传感器无线地感测外部产生的操作命令，例如ON，OFF和AMPLITUDE。 脉冲产生电路产生刺激脉冲。 刺激脉冲根据指定的刺激方案通过电极施加到指定的穴位或神经。

    Electrode Configuration for an Implantable Electroacupuncture Device
    42.
    发明申请
    Electrode Configuration for an Implantable Electroacupuncture Device 有权
    可植入电针装置的电极配置

    公开(公告)号：US20140214144A1

    公开(公告)日：2014-07-31

    申请号：US13776155

    申请日：2013-02-25

    Applicant: Valencia Technologies Corporation

    Inventor： David K. L. Peterson ,  Chuladatta H. Thenuwara

    IPC: A61H39/00

    CPC classification number: A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/04 ,  A61N1/0504 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782

    Abstract: An implantable electroacupuncture device (IEAD) treats a disease or medical condition of a patient through application of stimulation pulses applied at a specified acupoint or other target tissue location at a very low duty cycle. In a preferred implementation, the IEAD is an implantable, coin-sized, self-contained, leadless device having at least two electrodes attached to an outside surface of its housing, with at least one electrode on the top or bottom surface of the housing functioning as a cathode, and at least one electrode on the perimeter edge of the housing functioning as an anode. The electrodes may be segmented to include an array of smaller cathodic or anodic electrodes, each of which may be selectively turned ON or OFF so as to provide a convenient mechanism for adjusting the density of the stimulus current flowing through the cathodic electrode surface area.

    Abstract translation: 可植入电针装置（IEAD）通过在非常低的占空比下施加在特定穴位或其他目标组织位置施加的刺激脉冲来治疗患者的疾病或医疗状况。 在优选的实施方案中，IEAD是可植入的，硬币尺寸的独立的无引线装置，其具有附接到其壳体的外表面的至少两个电极，其中壳体的顶部或底部表面上的至少一个电极起作用 作为阴极，并且在壳体的周边边缘上的至少一个电极用作阳极。 电极可以被分段以包括更小的阴极或阳极电极的阵列，每个电极可被选择性地导通或关闭，以便提供用于调节流过阴极电极表面区域的刺激电流的密度的方便的机构。

    Implantable Electroacupuncture System and Method for Treating Depression and Similar Mental Conditions
    43.
    发明申请
    Implantable Electroacupuncture System and Method for Treating Depression and Similar Mental Conditions 有权
    植入式电针系统及治疗抑郁症及类似心理病症的方法

    公开(公告)号：US20140214118A1

    公开(公告)日：2014-07-31

    申请号：US13630522

    申请日：2012-09-28

    Applicant: VALENCIA TECHNOLOGIES CORPORATION

    Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

    IPC: A61H39/00

    CPC classification number: A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36096 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49117

    Abstract: An implantable electroacupuncture device (IEAD) treats mental illness through application of stimulation pulses applied at a specified tissue location, including at least one of acupoints GV20 and EXHN3, or their underlying nerves. In one embodiment, the IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

    Abstract translation: 可植入电针装置（IEAD）通过施加在指定组织位置施加的刺激脉冲来治疗精神疾病，包括至少一个穴位GV20和EXHN3或其潜在的神经。 在一个实施例中，IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

    Methods and systems for predicting patient responsiveness to subcutaneous neuromodulation therapy as a treatment for hypertension
    44.
    发明授权
    Methods and systems for predicting patient responsiveness to subcutaneous neuromodulation therapy as a treatment for hypertension 有权

    公开(公告)号：US10820864B2

    公开(公告)日：2020-11-03

    申请号：US15057106

    申请日：2016-02-29

    Applicant: Valencia Technologies Corporation

    Inventor： David K. L. Peterson

    IPC: A61B5/00 ,  A61B5/021 ,  A61N1/36 ,  A61N1/05 ,  G16H50/30 ,  G16H20/40 ,  G16H20/10

    Abstract: An exemplary method includes determining a variability of a plurality of measurements of a cardiovascular parameter of a patient suffering from hypertension, the plurality of measurements recorded one at a time over a predetermined time period. The method further includes comparing the determined variability with a predetermined reference value. If the comparing indicates that the determined variability is less than the predetermined reference value, the method includes designating the patient to be within a first class of patients representative of patients that are likely to be responsive to subcutaneous neuromodulation therapy as a treatment for hypertension. If the comparing indicates that the determined variability is greater than the predetermined reference value, the method includes designating the patient to be within a second class of patients representative of patients that are likely to be unresponsive to subcutaneous neuromodulation therapy as a treatment for hypertension. Corresponding systems and methods are also described.

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