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    Methods and Kits for Treating Lacerations and Puncture Wounds Using Inverse Therosensitive Polymers
    41.
    发明申请
    Methods and Kits for Treating Lacerations and Puncture Wounds Using Inverse Therosensitive Polymers 审中-公开
    使用反向敏感聚合物治疗撕裂和穿刺伤口的方法和试剂盒

    公开(公告)号：US20120029558A1

    公开(公告)日：2012-02-02

    申请号：US13272025

    申请日：2011-10-12

    申请人： William E. Cohn ,  Jean-Marie Vogel

    发明人： William E. Cohn ,  Jean-Marie Vogel

    IPC分类号： A61B17/08

    CPC分类号： A61L26/0019 ,  A61K31/74 ,  A61K31/765 ,  A61K31/785 ,  A61K45/06 ,  A61L26/0066 ,  A61L26/0095 ,  A61L2400/04 ,  A61L2400/06 ,  A61L2430/36 ,  A61M25/10 ,  A61M29/02

    摘要： In certain embodiments, the present invention relates to methods and kits for treating wounds, comprising the step of introducing into said wound a composition comprising at least one optionally purified inverse thermosensitive polymer, wherein said at least one optionally purified inverse thermosensitive polymer forms a gel in said wound, thereby temporarily occluding said wound. In certain embodiments, the present invention relates to the aforementioned method wherein a wound to a blood vessel or a segment of the GI tract is occluded, thereby preventing exsanguination and/or septicemia. In other embodiments, the inventive methods and kits described herein may be used to ameliorate (e.g., fill) temporarily a defect in a biological lumen, thereby strengthening said defect, preventing rupture of, or maintaining, improving or optimizing fluid flow through said lumen.

    摘要翻译： 在某些实施方案中，本发明涉及用于治疗伤口的方法和试剂盒，其包括将包含至少一种任选纯化的反相热敏聚合物的组合物引入所述伤口的步骤，其中所述至少一种任选纯化的反相热敏聚合物在 所述伤口，从而暂时封闭所述伤口。 在某些实施方案中，本发明涉及上述方法，其中伤口到血管或胃肠道的一部分被阻塞，从而防止放血和/或败血症。 在其它实施方案中，本文所述的本发明的方法和试剂盒可用于临时改善（例如，填充）生物腔内的缺陷，从而加强所述缺陷，防止破裂或保持，改善或优化通过所述内腔的流体流动。

    Method and apparatus for stabilization and positioning during surgery
    42.
    发明授权
    Method and apparatus for stabilization and positioning during surgery 有权
    手术期间稳定和定位的方法和装置

    公开(公告)号：US07717844B2

    公开(公告)日：2010-05-18

    申请号：US11770254

    申请日：2007-06-28

    申请人： William E. Cohn

    发明人： William E. Cohn

    IPC分类号： A61F2/00

    CPC分类号： A61B17/32 ,  A61B17/32053 ,  A61B17/34 ,  A61B90/50 ,  A61B2017/00243 ,  A61B2017/00278 ,  A61B2017/0243 ,  A61B2017/1135 ,  A61B2017/306 ,  A61B2017/3425 ,  A61B2017/3484 ,  A61B2017/3488 ,  A61M1/10 ,  A61M1/1008 ,  A61M1/12 ,  A61M1/122 ,  A61M1/3653 ,  A61M1/3659

    摘要： Novel surgical devices for off-pump surgery are described herein. The disclosed apparatus employs a novel suction element that releasably couples to a surgical connector. In an embodiment, a surgical device comprises a suction element adapted to be releasably coupled to a surgical connector. The suction element has an opening for stabilizing said surgical connector against the surface of an organ by suction. The surgical device further comprises a flexible arm connected to the suction element. The flexible arm is capable of being fixed in a stationary position to hold the surgical connector and the organ in place. The novel suction element in combination with a flexible arm not only positions and stabilizes an organ during surgery, but also positions and stabilizes the surgical connector on the organ during a surgical procedure such as an LVAD implantation.

    摘要翻译： 本文描述了用于非泵手术的新型外科装置。 所公开的装置采用可释放地联接到手术连接器的新颖的抽吸元件。 在一个实施例中，手术装置包括适于可释放地联接到手术连接器的抽吸元件。 抽吸元件具有用于通过抽吸使所述手术连接器抵靠器官表面稳定的开口。 手术装置还包括连接到抽吸元件的柔性臂。 柔性臂能够固定在固定位置以将手术连接器和器官保持在适当位置。 新颖的吸引元件与柔性臂组合不仅在外科手术期间定位和稳定器官，而且还在诸如LVAD植入的外科手术过程中将器官的外科连接器定位并稳定。

    Biological fluid warmer
    44.
    发明授权
    Biological fluid warmer 失效
    生物体温暖

    公开(公告)号：US5101804A

    公开(公告)日：1992-04-07

    申请号：US579003

    申请日：1990-09-04

    申请人： William E. Cohn

    发明人： William E. Cohn

    IPC分类号： A61M5/44 ,  F24V30/00

    CPC分类号： F24J1/00 ,  A61M5/44 ,  A61M2205/364

    摘要： The present invention relates to a device and method for warming biological fluids. The portable self-contained device which warms physiological fluids including blood is comprised of a reaction container which is capable of storing at least one chemical which when mixed with a second chemical will produce an exothermic chemical reaction, a mixing means for mixing the two chemicals to produce the exothermic chemical reaction, a heat exchanger to absorb heat from the exothermic reaction and transfer it to the physiological fluid or blood, a temperature regulating means to regulate the maximum temperature of the device and an insulating container for enclosing the reaction means, heat exchanger and temperature regulating means. The method of rapidly heating the stored cold physiological fluids including blood to about 39.degree. during infusion comprise the step of activating the physiological fluid warming device by mixing the chemicals to produce the exothermic chemical reaction and passing the physiological fluid or blood through the heat exchanger.

    摘要翻译： 本发明涉及一种用于升温生物流体的装置和方法。 包括血液在内的生理液体加热的便携式独立装置由能够储存至少一种化学物质的反应容器组成，当与第二种化学物质混合时会产生放热化学反应，将两种化学物质混合的混合装置 产生放热化学反应，热交换器吸收放热反应的热量并将其转移到生理液体或血液中，调节装置的最高温度的温度调节装置和用于封闭反应装置的绝热容器，热交换器 和温度调节装置。 在输液期间将包含血液的存储的冷生理液体迅速加热至约39℃的方法包括通过混合化学品以产生放热化学反应并使生理流体或血液通过热交换器而激活生理液体加温装置的步骤。

    INTRAATRIAL VENTRICULAR ASSIST DEVICE
    45.
    发明申请
    INTRAATRIAL VENTRICULAR ASSIST DEVICE 审中-公开
    内部静脉辅助装置

    公开(公告)号：US20160166747A1

    公开(公告)日：2016-06-16

    申请号：US15052158

    申请日：2016-02-24

    申请人： Oscar H. Frazier ,  William E. Cohn

    发明人： Oscar H. Frazier ,  William E. Cohn

    IPC分类号： A61M1/12

    CPC分类号： A61M1/122 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1034 ,  A61M1/1086 ,  A61M1/125 ,  A61M1/127

    摘要： A medical devices and methods related thereto are disclosed. In an embodiment, the medical device including a pump configured to be inserted within an atrium of a heart, said pump comprising an inlet and an outlet. In addition, the pump includes a flexible outflow conduit coupled to the outlet. The outflow conduit includes a radially inner surface defining a throughbore, and a radially outer surface. Further, the pump comprises a driveline configured to conduct control and power signals between the pump and an external device. The driveline extends through the outflow conduit between the radially inner surface and the radially outer surface.

    摘要翻译： 公开了与此相关的医疗装置和方法。 在一个实施例中，医疗装置包括构造成插入心脏心房内的泵，所述泵包括入口和出口。 此外，泵包括联接到出口的柔性流出管道。 流出管道包括限定穿透孔的径向内表面和径向外表面。 此外，泵包括构造成在泵和外部装置之间进行控制和动力信号的传动系。 传动系在径向内表面和径向外表面之间延伸穿过流出管道。

    Cardiac support device delivery tool with independently movable arms
    47.
    发明授权
    Cardiac support device delivery tool with independently movable arms 有权
    心脏支持装置输送工具，具有独立的可移动臂

    公开(公告)号：US08870744B2

    公开(公告)日：2014-10-28

    申请号：US12764508

    申请日：2010-04-21

    申请人： Aaron J. Hjelle ,  Paul Andrew Pignato ,  Robert G. Walsh ,  William E. Cohn ,  Ann Margaret Thomas

    发明人： Aaron J. Hjelle ,  Paul Andrew Pignato ,  Robert G. Walsh ,  William E. Cohn ,  Ann Margaret Thomas

    IPC分类号： A61F2/00 ,  A61F2/24 ,  A61B17/221 ,  A61B17/22 ,  A61B17/00

    CPC分类号： A61F2/2481 ,  A61B2017/00243 ,  A61B2017/22035 ,  A61B2017/2215 ,  A61F2002/2484

    摘要： A device for delivery of a cardiac support device for treating cardiac disease of a heart includes a multistage deployment mechanism and an actuating mechanism for controlling the positions of the deployment mechanism. The deployment mechanism is operable to change between a retracted state and an extended state, and includes a plurality of independent stages, including, in one embodiment, a first stage including a guide structure for location adjacent a portion of the patient's heart when in the extended state. A second stage is movably coupled to the first stage, and is guided by the guide structure between the retracted and extended states. The second stage further releasably engages and supports the cardiac support device and positions the cardiac support device at the desired implantation location, guided by the guide structure of the stage. In some embodiments, the deployment mechanism may include additional stages. The actuating mechanism drives the deployment mechanism between the retracted and extended states, and independently controls the positions of the multiple stages of the deployment mechanism.

    摘要翻译： 用于递送用于治疗心脏心脏病的心脏支持装置的装置包括多级部署机构和用于控制部署机构的位置的致动机构。 展开机构可操作以在缩回状态和延伸状态之间改变，并且包括多个独立的台阶，在一个实施例中，包括用于在延伸的患者的心脏的一部分附近定位的引导结构的第一阶段 州。 第二级可移动地联接到第一级，并且由引导结构在缩回状态和伸出状态之间引导。 第二阶段进一步可释放地接合和支撑心脏支持装置，并且将心脏支持装置定位在期望的植入位置，并由舞台的引导结构引导。 在一些实施例中，展开机构可以包括附加阶段。 致动机构在缩回状态和伸展状态之间驱动展开机构，并且独立地控制展开机构的多个阶段的位置。

    Atraumatic occlusion balloons and skirts, and methods of use thereof
    48.
    发明授权
    Atraumatic occlusion balloons and skirts, and methods of use thereof 有权
    无创伤闭塞气球和裙子及其使用方法

    公开(公告)号：US08491623B2

    公开(公告)日：2013-07-23

    申请号：US11851848

    申请日：2007-09-07

    申请人： Jean-Marie Vogel ,  William E. Cohn

    发明人： Jean-Marie Vogel ,  William E. Cohn

    IPC分类号： A61M29/00

    CPC分类号： A61B17/12195 ,  A61B17/08 ,  A61B17/12031 ,  A61B17/1204 ,  A61B17/12045 ,  A61B17/12109 ,  A61B17/12131 ,  A61B17/12136 ,  A61B17/12186 ,  A61B2017/1205 ,  A61M29/02 ,  A61M2025/1052

    摘要： One aspect of the present invention relates to catheters that can be placed in or around bodily conduits to occlude or widen a biological lumen without imparting significant trauma to the lumen. In certain embodiments, the invention particularly relates to the use of a polymer composition which can be made to gel upon insertion into said balloon or skirt. In certain embodiments, the inflating viscous polymer composition is a liquid at room temperature and a gel at mammalian physiological temperature. In certain embodiments, the inflating viscous polymer composition comprises an optionally purified inverse thermosensitive polymer.

    摘要翻译： 本发明的一个方面涉及可以放置在身体管道中或周围的导管，以封闭或加宽生物腔，而不会对内腔产生显着的创伤。 在某些实施方案中，本发明特别涉及聚合物组合物的用途，所述聚合物组合物可以在插入所述气囊或裙部时使其凝胶化。 在某些实施方案中，充气粘性聚合物组合物在室温下为液体，在哺乳动物生理温度下为凝胶。 在某些实施方案中，充气粘性聚合物组合物包含任选纯化的反相热敏聚合物。