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    Method and apparatus for determining the cell activation of a target cell by an activator
    43.
    发明授权
    Method and apparatus for determining the cell activation of a target cell by an activator 有权
    用于通过活化剂确定靶细胞的细胞活化的方法和装置

    公开(公告)号：US09018018B2

    公开(公告)日：2015-04-28

    申请号：US12486674

    申请日：2009-06-17

    申请人： Matthias Amrein ,  Yan Shi

    发明人： Matthias Amrein ,  Yan Shi

    IPC分类号： G01N33/00 ,  G01Q60/42 ,  B82Y35/00 ,  G01N33/50 ,  G01Q20/00

    CPC分类号： G01Q60/42 ,  B82Y35/00 ,  G01N33/5008 ,  G01Q20/00

    摘要： The invention relates to a method and a device for determining the cell activation of a target cell by an activator, said method having the following steps: provision of a probe measuring device with a probe sample arrangement having a measuring probe and a sample holder; loading of the probe sample arrangement with a target cell and with an activator assigned to the target cell, the measuring probe being loaded with the activator, and the sample holder being loaded with the target cell, or vice versa; relative mutual displacement of the measuring probe and the sample holder until contact is made between the target cell and the activator by means of a displacement apparatus of the probe measuring device; recording of measurement values, indicating binding between the target cell and the activator, for the measuring probe with the probe measuring device during the relative displacement of the measuring probe and the sample holder; and determination of a dimension for the cell activation of the target cell from the measurement values recorded.

    摘要翻译： 本发明涉及一种用于通过活化剂确定靶细胞的细胞活化的方法和装置，所述方法具有以下步骤：提供具有测量探针和样品架的探针样品装置的探针测量装置; 将探针样品装置与目标细胞装载并分配给目标细胞的激活剂，测量探针装载有活化剂，并且样品保持器装载目标细胞，反之亦然; 通过探头测量装置的位移装置接触测量探针和样品架之间的相对相互位移，直到目标单元与激活器接触; 在测量探头和样品架的相对位移期间，使用探针测量装置记录测量值，指示目标单元和激活器之间的结合; 以及从记录的测量值确定靶细胞的细胞活化的维度。

    FUNCTIONAL-IMAGING-BASED ABLATION MONITORING
    44.
    发明申请
    FUNCTIONAL-IMAGING-BASED ABLATION MONITORING 有权
    基于功能成像的ABIATION监测

    公开(公告)号：US20140088418A1

    公开(公告)日：2014-03-27

    申请号：US14007029

    申请日：2012-03-27

    申请人： Emil Radulescu ,  Sheng-Wen Huang ,  Ramon Erkamp ,  Ladislav Jankovic ,  Yan Shi ,  Khalid Shahzad

    发明人： Emil Radulescu ,  Sheng-Wen Huang ,  Ramon Erkamp ,  Ladislav Jankovic ,  Yan Shi ,  Khalid Shahzad

    IPC分类号： A61B5/00 ,  A61B18/18 ,  A61B18/14 ,  A61K49/00

    CPC分类号： A61B5/4836 ,  A61B5/0044 ,  A61B5/0059 ,  A61B5/0084 ,  A61B5/0095 ,  A61B5/6852 ,  A61B5/742 ,  A61B18/1492 ,  A61B18/18 ,  A61B2018/00577 ,  A61B2090/378 ,  A61B2576/00 ,  A61K49/0002

    摘要： Functional imaging for localization in biological tissue entails measuring a response in the tissue (240) to electromagnetic radiation. A catheter (200) for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone (232) from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption (244) of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S310, S320) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data. In either case, the members of the dataset pair are combined (110, 122) by subtraction or division to effect the piece-wise cancellation/enhancement for display (218) of the resulting signal in real time.

    摘要翻译： 用于在生物组织中定位的功能成像需要测量组织（240）中的电磁辐射的响应。 用于实时监测心脏消融的导管（200）用于区分出血区域（232）与夹心的坏死和健康组织，或区分外源光声造影剂与边界的天然组织。 选择一对波长用于相应地出血区域或存在造影剂的辐射的差异吸收（244）以及其他地方相对相似的吸收。 可以使用近红外激光器或LED光源来连续采集要比较的两个数据集（S310，S320），每个代表一个时间波形。 或者，采集是用于微波诱导的热声数据的一对波段。 在任一情况下，数据集对的成员通过减法或除法组合（110,122）以实现分段取消/增强以实时显示（218）所得到的信号。

    REMOTE MOUSE AND KEYBOARD USING BLUETOOTH
    48.
    发明申请
    REMOTE MOUSE AND KEYBOARD USING BLUETOOTH 审中-公开
    远程鼠标和键盘使用蓝牙

    公开(公告)号：US20080120448A1

    公开(公告)日：2008-05-22

    申请号：US11562398

    申请日：2006-11-21

    申请人： Yan Shi ,  Kong-Kat Wong ,  Difei Tang ,  Wei Hun Liew ,  Sun Hsuen Shaw

    发明人： Yan Shi ,  Kong-Kat Wong ,  Difei Tang ,  Wei Hun Liew ,  Sun Hsuen Shaw

    IPC分类号： G06F13/12

    CPC分类号： G06F3/0231 ,  G06F3/03543

    摘要： A remote pointing device and keyboard system and method for remotely mimicking the pointing device and keyboard of a personal computing device (such as a laptop or desktop computer) using a handheld computing device (such as Pocket PC or smartphone). Remote control is achieved using Bluetooth wireless technology. A user inputs commands on a touch panel of the handheld device to remotely control the pointing device on the personal computing device. Similarly, the user input data on a keypad of the handheld device to remotely enter keystrokes to the personal computing device, thereby bypassing the keyboard. This allows the user to remotely access the pointing device and keyboard of the personal computing device through the touch panel and keypad of the handheld device.

    摘要翻译： 用于使用手持计算设备（例如Pocket PC或智能手机）远程模拟个人计算设备（例如膝上型或台式计算机）的指点设备和键盘的远程指点设备和键盘系统和方法。 使用蓝牙无线技术实现遥控。 用户在手持设备的触摸面板上输入命令以远程控制个人计算设备上的指点设备。 类似地，用户在手持设备的键盘上输入数据以远程输入到个人计算设备的击键，从而绕过键盘。 这允许用户通过手持设备的触摸面板和小键盘远程访问个人计算设备的指点设备和键盘。

    HMG-CoA reductase inhibitors
    49.
    发明申请
    HMG-CoA reductase inhibitors 有权
    HMG-CoA还原酶抑制剂

    公开(公告)号：US20070249583A1

    公开(公告)日：2007-10-25

    申请号：US11789335

    申请日：2007-04-24

    申请人： Philip D. Stein ,  Steven P. Seitz ,  David J. Carini ,  Yan Shi ,  Jeffrey A. Robl ,  Jay A. Markwalder ,  Chunhong He

    发明人： Philip D. Stein ,  Steven P. Seitz ,  David J. Carini ,  Yan Shi ,  Jeffrey A. Robl ,  Jay A. Markwalder ,  Chunhong He

    IPC分类号： A61K31/553 ,  A61K31/55 ,  A61K31/473

    CPC分类号： C07D221/16 ,  C07D471/04

    摘要： Compounds are provided of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia and dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis wherein A is chosen from B is chosen from wherein the variables R1 to R7, m, n, are as defined herein.A method for treating the above diseases employing the above compounds is also provided.

    摘要翻译： 提供以下结构的化合物是HMG CoA还原酶抑制剂，因此有效抑制胆固醇生物合成，调节血清脂质，例如降低LDL胆固醇和/或增加HDL胆固醇，以及治疗高脂血症和血脂异常，高胆固醇血症，高甘油三酯血症和动脉粥样硬化 其中A选自B，其中变量R 1至R 7，m，n，如本文所定义。 还提供了使用上述化合物治疗上述疾病的方法。