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公开(公告)号：US20210046019A1
公开(公告)日：2021-02-18
申请号：US16966212
申请日：2019-01-31
Inventor： Siegfried HEKIMI , Ying WANG
IPC: A61K31/122 , A61K47/42 , A61K9/107 , A61K31/337
Abstract: The present disclosure concerns methods and formulations for delivery of hydrophobic agents (such as ubiquinone or poorly soluble drugs) for therapeutic and bioanalytical use. It further concerns use of lipopeptides (e.g. caspofungin) or surfactants to solubilize hydrophobic agents and thus increase their bioavailability. Also described are therapeutic methods for the treatment of conditions that benefit from such hydrophobic agents. The present disclosure further relates to methods of identifying drug candidates for treatment of ubiquinone deficiency.
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42.发明授权公开(公告)号：US10766851B1
公开(公告)日：2020-09-08
申请号：US16547748
申请日：2019-08-22
Applicant: LANZHOU UNIVERSITY , THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY
Inventor： Huiying Zeng , Chao-Jun Li , Dawei Cao
IPC: C07C209/18 , B01J23/44
Abstract: It is provided a method of converting a diaryl ether source such as lignin and/or polyphenylene oxide (PPO) containing 4-O-5 linkages and an inorganic chemical such as ammonia into an organic compound, comprising reacting said diaryl ether source with the inorganic chemical in presence of a catalyst, preferably palladium, transforming the 4-O-5 linkages of said diaryl ether source into the organic compound. It is provided a palladium-catalyzed synthesis of aniline derivatives from 4-O-5 linkage lignin model compounds and cheap industrial inorganic chemical ammonia via dual C(Ar)—O bond cleavage.
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公开(公告)号：US10690255B2
公开(公告)日：2020-06-23
申请号：US15785592
申请日：2017-10-17
Inventor： David Juncker , Hosseinali Safavieh
Abstract: A major challenge for the general use of “lab-on-a-chip” (LOAC) systems and point-of-care (POC) devices has been the generally complex and need for sophisticated peripheral equipment, such that it is more difficult than anticipated to implement low cost, robust and portable LOAC/POC solutions. It would be beneficial for chemical, medical, healthcare, and environmental applications to provide designs for inexpensive LOAC/POC solutions compatible with miniaturization and mass production, and are potentially portable, using compact possibly hand-held instruments, using reusable or disposable detectors. Embodiments of the invention address improved circuit elements for self-powered self-regulating microfluidic circuits including programmable retention valves, programmable trigger valves, enhanced capillary pumps, and flow resonators. Additionally embodiments of the invention allow for the flow direction within a microfluidic circuit to be reversed as well as for retention of reagents prior to sale or deployment of the microfluidic circuit for eased user use.
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公开(公告)号：US10420757B2
公开(公告)日：2019-09-24
申请号：US15304598
申请日：2015-04-17
Applicant: Deutsches Krebsforschungszentrum Stiftung des Öffentlichenrechts , The Royal Institution for the Advancement of Learning/McGill University
Inventor： Pouria Jandaghi , Jörg Hoheisel , Yasser Riazalhosseini
IPC: A61K45/06 , A61K31/454 , A61K31/7068
Abstract: The current disclosure relates to methods for treating pancreatic cancer or chronic pancreatitis in a subject comprising administering an antagonist of a dopamine receptor to the subject wherein the dopamine receptor is, in some specific cases dopamine receptor D2 (DRD2). The antagonist in some specific cases is an RNAi construct, an antibody, or a small molecule and in more specific cases pimozide or L-741,626. The disclosure also relates to diagnostic methods comprising the detection of the expression of DRD2 in pancreatic tissue and kits for doing the same.
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公开(公告)号：US10394978B2
公开(公告)日：2019-08-27
申请号：US14526651
申请日：2014-10-29
Inventor： Dennis Giannacopoulos , Yousef El Kurdi , Warren Gross
Abstract: Herein provided are methods and systems for generating finite element modelling results. Finite element method (FEM) data relating to establish a FEM problem to be solved for a portion of a physical system being analyzed is received. A FEM mesh comprising at least FEM mesh node locations relating to the portion of the physical system is generated. FEM mesh values for each FEM mesh node location are automatically generated with a microprocessor. A factor graph model comprising a plurality of random variable nodes and a plurality of factor nodes is automatically generated with a microprocessor based upon the FEM mesh node locations. A set of belief propagation update rules are automatically executed upon the factor graph model using Gaussian function parametrization and the FEM mesh values. The belief propagation update rules are iteratively executed until a predetermined condition has been met.
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Patent Agency Ranking
公开(公告)号：US20190185844A1
公开(公告)日：2019-06-20
申请号：US16327605
申请日：2017-09-22
Applicant: Board of Trustees of Southern lllinois University , The Royal Institution for the Advancement of Learning/McGill University
Inventor： Keith GAGNON , Masad DAMHA , Elise MALEK-ADAMIAN , Maryam HABIBIAN , Daniel O'REILLY , Zachery KARTJE
IPC: C12N15/10 , C12N9/22 , C12N15/11 , C12N15/113 , C12N15/90
CPC classification number: C12N15/102 , A61K48/00 , C12N9/22 , C12N15/11 , C12N15/113 , C12N15/90 , C12N15/907 , C12N2310/20 , C12N2310/315 , C12N2310/318 , C12N2310/319 , C12N2310/3231 , C12N2310/344 , C12N2310/346 , C12N2800/80 , C12N2310/322 , C12N2310/3533 , C12N2310/321 , C12N2310/3521 , C12N2310/3531
Abstract: The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.
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公开(公告)号：US10301357B2
公开(公告)日：2019-05-28
申请号：US14897782
申请日：2014-05-21
Inventor： Vassilios Papadopoulos , Yasaman Aghazadeh , Jinjiang Fan
IPC: C07K7/08 , A61K31/713 , C07K14/705 , C07K14/47 , C12P33/00 , C12N15/113 , G01N33/50 , G01N33/74 , C07K7/06 , A61K38/00
Abstract: The present disclosure provides agents capable of promoting endogenous steroid production (such as endogenous testosterone production) without altering the endogenous luteinizing hormone. The present disclosure also provides associated therapeutic methods as well as screening assays for identifying further therapeutic agents for the prevention, treatment and/or alleviations of symptoms associated with hypogonadism.
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公开(公告)号：US10290767B2
公开(公告)日：2019-05-14
申请号：US15177608
申请日：2016-06-09
Inventor： Zetian Mi , Songrui Zhao , Renjie Wang
IPC: H01L33/06 , H01L33/08 , H01L33/32 , H01L33/00 , H01S5/10 , H01S5/323 , H01L33/18 , H01S5/02 , H01S5/40
Abstract: GaN-based nanowire heterostructures have been intensively studied for applications in light emitting diodes (LEDs), lasers, solar cells and solar fuel devices. Surface charge properties play a dominant role on the device performance and have been addressed within the prior art by use of a relatively thick large bandgap AlGaN shell covering the surfaces of axial InGaN nanowire LED heterostructures has been explored and shown substantial promise in reducing surface recombination leading to improved carrier injection efficiency and output power. However, these lead to increased complexity in device design, growth and fabrication processes thereby reducing yield/performance and increasing costs for devices. Accordingly, there are taught self-organizing InGaN/AlGaN core-shell quaternary nanowire heterostructures wherein the In-rich core and Al-rich shell spontaneously form during the growth process.
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49.发明授权公开(公告)号：US10112871B2
公开(公告)日：2018-10-30
申请号：US15124856
申请日：2015-03-23
Inventor： Yixin Shao , Mehrdad Mahoutian , Zaid Ghouleh
Abstract: A building product is made from granular material and a binder that includes steel slag. A process for making the building product includes combining the granular material and the binder and then curing the combined granular material and binder with carbon dioxide. A building material includes a mixture of steel slag and a silica-rich material. The steel slag and silica-rich material is treated by heating. The silica-rich material may be waste glass and/or fly ash. A process for making the building material includes mixing the steel slag and silica-rich material and further heating the mixture.
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公开(公告)号：US09764060B2
公开(公告)日：2017-09-19
申请号：US14420585
申请日：2013-08-09
Inventor： Showan Nazhat , Benedetto Marelli , Chiara Ghezzi , Neysan Nejat Oliver Kamranpour
CPC classification number: A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/34 , B01J13/0069 , C08J3/075 , C08J2389/00
Abstract: There is provided a method for preparing a dense hydrogel comprising providing an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.
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