公开(公告)号：US09216237B2

公开(公告)日：2015-12-22

申请号：US14246696

申请日：2014-04-07

申请人： Personics Holdings, LLC.

发明人： John P. Keady

IPC分类号： H04R25/00 ,  A61L31/04 ,  H04R17/00 ,  A61F11/08 ,  A61L31/14 ,  H04R1/10

CPC分类号： A61L31/04 ,  A61F11/08 ,  A61L31/14 ,  A61L2400/00 ,  H04R1/10 ,  H04R17/00 ,  H04R25/00 ,  H04R25/652 ,  H04R2460/15 ,  H04R2499/11 ,  Y10T428/249953

摘要： A device includes a core, a membrane, at least one first electrode coupled to the core, at least one second electrode coupled to the core or the membrane and a collapsible electroactive polymer element. The collapsible polymer element is configured to extend from or extend around at least a portion of the core where the element is in an expanded configuration without application of a voltage and in a collapsed configuration with the application of the voltage or in a collapsed configuration without application of a voltage and in an expanded configuration with the application of the voltage. The voltage is applied via the at least one first electrode and the at least one second electrode. Other embodiments are disclosed.

摘要翻译： 一种器件包括芯，膜，耦合到芯的至少一个第一电极，耦合到芯或膜的至少一个第二电极和可折叠的电活性聚合物元件。 可折叠聚合物元件构造成从芯部的至少一部分延伸或延伸，其中元件处于扩展构型中，而不施加电压，并且在施加电压或处于折叠构造的情况下处于折叠构型，而不应用 的电压并且在扩展的配置中施加电压。 经由至少一个第一电极和至少一个第二电极施加电压。 公开了其他实施例。

公开(公告)号：US09101695B2

公开(公告)日：2015-08-11

申请号：US14496742

申请日：2014-09-25

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L31/06 ,  A61K9/00 ,  A61F2/02 ,  A61L31/14 ,  A61L27/26 ,  A61L27/58 ,  A61L31/16

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。

公开(公告)号：US20140228793A1

公开(公告)日：2014-08-14

申请号：US14348530

申请日：2012-09-26

申请人： UNICHARM CORPORATION

发明人： Akira Hashino ,  Yuki Noda ,  Tatsuya Tamura

IPC分类号： A61L15/42 ,  A61F13/537 ,  A61F13/511 ,  A61L15/20

CPC分类号： A61L15/42 ,  A61F13/47 ,  A61F13/511 ,  A61F13/51113 ,  A61F13/53747 ,  A61L15/20 ,  A61L2300/20 ,  A61L2300/216 ,  A61L2300/22 ,  A61L2400/00

摘要： An object of the disclosure is to provide an absorbent article without a sticky feel on the top sheet and with a smooth top sheet, even after highly viscous menstrual blood has been absorbed. An absorbent article comprising a liquid-permeable top sheet, an absorbent body, a liquid-impermeable back sheet, and a second sheet between the liquid-permeable top sheet and the absorbent body, wherein the top sheet and the second sheet comprise a blood modifying agent with an IOB of 0.00-0.60, a melting point of no higher than 45° C., and a water solubility of 0.00-0.05 g in 100 g of water at 25° C.

摘要翻译： 本发明的目的是提供一种吸收制品，即使在吸收了高度粘性的月经血液之后，在顶片上也具有光滑的顶片，而没有粘性感。 一种吸收性物品，其特征在于，所述吸收性物品包括透液性顶片，吸收体，不透液性底片，以及在所述透液性顶片与所述吸收体之间的第二片，其中所述顶片和所述第二片包含血液修复 试剂的IOB为0.00-0.60，熔点不高于45℃，水溶性为0.00-0.05g，在100g水中在25℃。

公开(公告)号：US20140161861A1

公开(公告)日：2014-06-12

申请号：US14177888

申请日：2014-02-11

申请人： Massachusetts Institute of Technology ,  Children's Medical Center Corporation

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L27/58 ,  A61L27/26

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。

公开(公告)号：US08647701B2

公开(公告)日：2014-02-11

申请号：US13170084

申请日：2011-06-27

申请人： Vivek Pawar ,  Shilesh C. Jani ,  Carolyn Weaver

发明人： Vivek Pawar ,  Shilesh C. Jani ,  Carolyn Weaver

IPC分类号： C23C22/00 ,  C23C8/10 ,  A61F2/28 ,  B05D3/02 ,  B05D3/12

CPC分类号： A61L27/10 ,  A61F2/28 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2/32 ,  A61F2/38 ,  A61F2/44 ,  A61F2002/30016 ,  A61F2002/30922 ,  A61F2002/30929 ,  A61F2210/0076 ,  A61F2250/0019 ,  A61F2250/0041 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00089 ,  A61F2310/00101 ,  A61F2310/00485 ,  A61F2310/00592 ,  A61F2310/00598 ,  A61F2310/00856 ,  A61L27/045 ,  A61L27/047 ,  A61L27/06 ,  A61L27/30 ,  A61L27/50 ,  A61L2400/00 ,  Y10T428/12611

摘要： Methods of making surface hardened medical implants comprising providing a biocompatible alloy with a surface comprising an oxide or nitride layer, diffusing at least a portion of the respective oxygen or nitrogen from the oxide or nitride layer the substrate for a period of time to form a diffusion hardened zone of desired thickness. The period of time is based at least on (1) the diffusivity of a diffusing specie in the oxide or nitride layer, (2) a desired hardness profile of at least a portion of said implant defined by a function selected from the group consisting of: an error function, an exponential function, a near uniform distribution function, and any sequential combination thereof, or (3) a desired thickness of said oxide or nitride layer to be retained.

摘要翻译： 制造表面硬化的医疗植入物的方法包括提供与包含氧化物或氮化物层的表面的生物相容性合金，将来自氧化物或氮化物层的相应氧或氮的至少一部分从衬底延伸一段时间以形成扩散 所需厚度的硬化区。 所述时间段至少基于（1）扩散物质在氧化物或氮化物层中的扩散率，（2）所述植入物的至少一部分的期望硬度分布由选自以下的功能定义： ：误差函数，指数函数，近均匀分布函数及其任何顺序组合，或（3）要保留的所述氧化物或氮化物层的期望厚度。

公开(公告)号：US08377463B2

公开(公告)日：2013-02-19

申请号：US11789538

申请日：2007-04-25

申请人： Robert Langer ,  Rajiv Saigal ,  Yang Teng

发明人： Robert Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61F2/00

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物填充绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。

公开(公告)号：US08172958B2

公开(公告)日：2012-05-08

申请号：US12127413

申请日：2008-05-27

申请人： Vivek Pawar ,  Shilesh C. Jani ,  Carolyn Weaver

发明人： Vivek Pawar ,  Shilesh C. Jani ,  Carolyn Weaver

IPC分类号： C23C8/00 ,  C21D9/00 ,  C22F1/18 ,  A61F2/00

CPC分类号： A61L27/10 ,  A61F2/28 ,  A61F2/30767 ,  A61F2/3094 ,  A61F2/32 ,  A61F2/38 ,  A61F2/44 ,  A61F2002/30016 ,  A61F2002/30922 ,  A61F2002/30929 ,  A61F2210/0076 ,  A61F2250/0019 ,  A61F2250/0041 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00089 ,  A61F2310/00101 ,  A61F2310/00485 ,  A61F2310/00592 ,  A61F2310/00598 ,  A61F2310/00856 ,  A61L27/045 ,  A61L27/047 ,  A61L27/06 ,  A61L27/30 ,  A61L27/50 ,  A61L2400/00 ,  Y10T428/12611

摘要： The present disclosure provides methods of making an improved composition and medical implant made therefrom. The methods generally comprise forming a ceramic layer, diffusion hardening, and optionally, forming another ceramic layer. The present disclosure provides methods of making an improved composition having a thick diffusion hardened zone and orthopedic implants comprising the improved composition.

摘要翻译： 本公开提供了由其制备改进的组合物和医疗植入物的方法。 所述方法通常包括形成陶瓷层，扩散硬化，以及任选地形成另一陶瓷层。 本公开提供了制备具有厚扩散硬化区和包含改进组合物的矫形植入物的改进组合物的方法。

公开(公告)号：US20110172507A1

公开(公告)日：2011-07-14

申请号：US13032398

申请日：2011-02-22

申请人： Jurgen Lademann ,  Laura M. Frazier ,  Woraphon Kataphinan

发明人： Jurgen Lademann ,  Laura M. Frazier ,  Woraphon Kataphinan

IPC分类号： A61L15/22 ,  A61F7/02 ,  A61B5/00

CPC分类号： A61F13/538 ,  A61F13/0203 ,  A61F13/58 ,  A61F2013/00187 ,  A61F2013/00234 ,  A61F2013/00425 ,  A61F2013/00536 ,  A61F2013/00753 ,  A61F2013/15081 ,  A61F2013/530481 ,  A61L15/44 ,  A61L15/56 ,  A61L15/58 ,  A61L15/60 ,  A61L2400/00 ,  A61L2400/12 ,  D04H1/407 ,  D04H1/4382

摘要： Among others, the present invention provides an absorbent textile composite material which comprises a flexible carrier layer and an active layer connected with the carrier layer, wherein the active layer comprises a nanofiber nonwoven optionally filled with a superabsorbent.

摘要翻译： 其中，本发明提供一种吸收性纺织复合材料，其包括柔性载体层和与载体层连接的活性层，其中活性层包含任选填充有超吸收剂的纳米纤维非织造布。

公开(公告)号：US20180169302A1

公开(公告)日：2018-06-21

申请号：US15896948

申请日：2018-02-14

申请人： Children`s Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L27/50 ,  A61L27/26 ,  A61L31/14 ,  A61K9/00 ,  A61L27/54 ,  A61L27/38 ,  A61L31/00 ,  A61F2/44 ,  A61L27/56 ,  A61L27/18 ,  A61L31/06 ,  A61L27/58 ,  A61L31/16 ,  A61F2/02 ,  A61L31/04 ,  C08L67/04

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

公开(公告)号：US09861794B2

公开(公告)日：2018-01-09

申请号：US15288157

申请日：2016-10-07

申请人： COOK MEDICAL TECHNOLGOES LLC

发明人： Bo Ringvad Andersen ,  Kim Holm Andersen

IPC分类号： A61L29/02 ,  A61M25/10 ,  A61L29/06 ,  A61L29/18

CPC分类号： A61M25/10 ,  A61L29/02 ,  A61L29/06 ,  A61L29/18 ,  A61L2400/00 ,  A61M2025/1059 ,  A61M2025/1072 ,  A61M2025/1075 ,  A61M2025/1079

摘要： A medical balloon includes at least one internal wall dividing the balloon into a plurality of separate chambers which may be separately inflatable and deflatable. The at least one internal wall is impregnated with heat conductive particles. The heat conductive particles enable heat produced during the balloon blowing process to pass through the polymer material of the balloon and specifically into the internal wall or walls, enabling these to soften and stretch during the process. This improves the integrity of the balloon and also balloon flexibility. The radiopaque particles embedded in the internal wall or walls of the balloon can also, in preferred embodiments, be of radiopaque material, providing the balloon with imaging visibility during deployment thereof in a patient.