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公开(公告)号：US20150080429A1
公开(公告)日：2015-03-19
申请号：US14540216
申请日：2014-11-13
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： C07D215/20
CPC分类号： C07D215/20 , A61K31/47 , A61K31/4706 , A61K31/4709 , C07D215/00 , C07D215/42 , C07D215/46 , C07D215/54 , C07D215/60 , C07D401/04 , C07D401/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10
摘要： The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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公开(公告)号：US08822691B2
公开(公告)日：2014-09-02
申请号：US13386598
申请日：2010-07-10
申请人： Jun Mihara , Koichi Araki , Takuma Mori , Tetsuya Murata , Yasushi Yoneta , Eiichi Shimojo , Teruyuki Ichihara , Masashi Ataka , Katsuhiko Shibuya , Ulrich Görgens
发明人： Jun Mihara , Koichi Araki , Takuma Mori , Tetsuya Murata , Yasushi Yoneta , Eiichi Shimojo , Teruyuki Ichihara , Masashi Ataka , Katsuhiko Shibuya , Ulrich Görgens
IPC分类号： A01N37/34 , A01N43/42 , C07D215/48 , C07D215/60 , C07D277/68
CPC分类号： C07D215/48 , A01N37/34 , A01N43/42 , A01N43/78 , A01N43/82 , C07C211/52 , C07C217/84 , C07C233/66 , C07C237/48 , C07C255/57 , C07C2601/14 , C07D215/60 , C07D277/68
摘要： To provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Carboxamides represented by the following Formula (I) and use thereof as pesticides and an animal parasite control agent: wherein each substituent is as defined in the specification.
摘要翻译： 提供作为农药具有优良杀虫活性的新型甲酰胺。 由下式（I）表示的羧酰胺及其作为农药的用途和动物寄生虫控制剂：其中每个取代基如说明书中所定义。
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公开(公告)号：US08772200B2
公开(公告)日：2014-07-08
申请号：US13519209
申请日：2010-12-28
申请人： Kotaro Shibayama , Jun Inagaki , Yuto Saiki , Akira Mitani , Raito Kuwahara , Motoaki Sato , Satoshi Nishimura , Mami Kuboki
发明人： Kotaro Shibayama , Jun Inagaki , Yuto Saiki , Akira Mitani , Raito Kuwahara , Motoaki Sato , Satoshi Nishimura , Mami Kuboki
IPC分类号： C07D215/60 , A01N43/42 , A01N43/40 , C07D215/20 , C07D215/18
CPC分类号： A01N43/42 , A01N43/40 , A01N43/56 , A01N43/90 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/60 , C07D221/04 , C07D401/12 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Provided is an agricultural fungicide that contains at least one selected from the group consisting of a novel nitrogen-containing heterocyclic compound represented by Formula (I), a salt thereof, or an N-oxide compound thereof. In Formula (I), R represents a group represented by CR1R2R3 or a cyano group. R1 to R3 each independently represents a hydrogen atom, an unsubstituted or substituted C1-8 alkyl group, an unsubstituted or substituted hydroxyl group, or the like. R4 or R5 represents a halogeno group or the like. Y or Z represents a carbon atom or the like, and A or D represents a benzene ring or the like. X represents an oxygen atom or a nitrogen atom or the like.
摘要翻译： 本发明提供含有选自由式（I）表示的新型含氮杂环化合物，其盐或其N-氧化物化合物中的至少一种的农业杀真菌剂。 在式（I）中，R表示由CR 1 R 2 R 3表示的基团或氰基。 R 1〜R 3各自独立地表示氢原子，未取代或取代的C 1-8烷基，未取代或取代的羟基等。 R4或R5表示卤代基等。 Y或Z表示碳原子等，A或D表示苯环等。 X表示氧原子或氮原子等。
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公开(公告)号：US20140094465A1
公开(公告)日：2014-04-03
申请号：US14123220
申请日：2012-06-05
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： C07D417/10 , C07D401/10 , C07D413/10 , C07D409/04 , C07D215/46 , C07D215/60 , C07D239/74 , C07D401/04 , C07D241/42 , C07D403/10 , C07D403/04 , C07D253/10 , C07D217/02 , C07C59/115 , C07D213/55 , C07D241/12 , C07D239/26 , C07D295/155 , C07D237/24 , C07D311/22 , C07D215/20
CPC分类号： C07D417/10 , A61K31/08 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/275 , A61K31/341 , A61K31/352 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/4192 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4418 , A61K31/47 , A61K31/4709 , A61K31/4965 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/53 , A61K31/5375 , C07C59/115 , C07D213/55 , C07D215/20 , C07D215/46 , C07D215/60 , C07D217/02 , C07D237/24 , C07D239/26 , C07D239/74 , C07D241/12 , C07D241/42 , C07D253/10 , C07D295/155 , C07D311/22 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D409/04 , C07D413/10
摘要： The present invention is directed to compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
摘要翻译： 本发明涉及可用作S-亚硝基谷胱甘肽还原酶（GSNOR）抑制剂的化合物，包含这些化合物的药物组合物及其制备和使用方法。
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公开(公告)号：US08598354B2
公开(公告)日：2013-12-03
申请号：US13153350
申请日：2011-06-03
申请人： Michael K. Riscoe , Jane X. Kelly , Rolf W. Winter , David J. Hinrichs , Martin J. Smilkstein , Aaron Nilsen , Jeremy Burrows , Dennis Kyle , Roman Manetsch , Richard M. Cross , Andrii Monastyrskyi , David L. Flanigan
发明人： Michael K. Riscoe , Jane X. Kelly , Rolf W. Winter , David J. Hinrichs , Martin J. Smilkstein , Aaron Nilsen , Jeremy Burrows , Dennis Kyle , Roman Manetsch , Richard M. Cross , Andrii Monastyrskyi , David L. Flanigan
CPC分类号： C07D215/233 , C07D215/42 , C07D215/60 , C07D239/90 , C07D279/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D413/04 , C07D491/052
摘要： Compounds of formula I: or formula II: or a pharmaceutically acceptable salt of formula I or formula II, wherein: R1 is H, hydroxyl, alkoxy, acyl, alkyl, cycloalkyl, aryl, or heteroaryl; R2 is methyl or haloalkyl; R4 is hydroxyl, carbonyloxy, or carbonyldioxy; and R3 is aliphatic, aryl, aralkyl, or alkylaryl; and R5, R6, R7 and R8 are each individually H, halogen, alkoxy, alkyl, haloalkyl, aryl, nitro, cyano, amino, amido, acyl, carboxyl, substituted carboxyl, or —SO2R10, wherein R10 is H, alkyl, amino or haloalkyl; provided that in formula I, R5 and R7 are not both H or R6 is not H or methoxy; and in formula II that if R4 is carbonyldioxy then R7 is not methoxy.
摘要翻译： 式I化合物或式II化合物或式I或式II的药学上可接受的盐，其中：R 1是H，羟基，烷氧基，酰基，烷基，环烷基，芳基或杂芳基; R2是甲基或卤代烷基; R4是羟基，羰基氧基或羰基二氧基; 并且R 3是脂族，芳基，芳烷基或烷基芳基; 和R 5，R 6，R 7和R 8各自独立地为H，卤素，烷氧基，烷基，卤代烷基，芳基，硝基，氰基，氨基，酰胺基，酰基，羧基，取代的羧基或-SO 2 R 10，其中R 10为H，烷基，氨基 或卤代烷基; 条件是在式Ⅰ中，R5和R7不同时为H或R6不为H或甲氧基; 在式II中，如果R 4是羰基二氧基，那么R 7不是甲氧基。
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公开(公告)号：US08592592B2
公开(公告)日：2013-11-26
申请号：US13076632
申请日：2011-03-31
申请人： Catherine Tachdjian , Xiao Qing Tang , Donald S. Karanewsky , Guy Servant , Xiaodong Li , Feng Zhang , Qing Chen , Hong Zhang , Timothy Davis , Vincent Darmohusodo , Melissa Wong , Victor Selchau
发明人： Catherine Tachdjian , Xiao Qing Tang , Donald S. Karanewsky , Guy Servant , Xiaodong Li , Feng Zhang , Qing Chen , Hong Zhang , Timothy Davis , Vincent Darmohusodo , Melissa Wong , Victor Selchau
IPC分类号： C07D215/42
CPC分类号： C07D495/04 , A23L2/56 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/54 , C07D215/60 , C07D401/12 , C07D405/12 , C07D471/04 , C07D491/048
摘要： The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.
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公开(公告)号：US20120289702A1
公开(公告)日：2012-11-15
申请号：US13519209
申请日：2010-12-28
申请人： Kotaro Shibayama , Jun Inagaki , Yuto Saiki , Akira Mitani , Raito Kuwahara , Motoaki Sato , Satoshi Nishimura , Mami Kuboki
发明人： Kotaro Shibayama , Jun Inagaki , Yuto Saiki , Akira Mitani , Raito Kuwahara , Motoaki Sato , Satoshi Nishimura , Mami Kuboki
IPC分类号： C07D215/20 , C07D215/18 , C07D215/14 , C07D215/60 , C07F7/18 , C07D409/12 , C07D495/04 , C07D221/04 , C07D471/04 , C07D491/052 , C07D491/048 , C07D221/22 , C07D215/38 , C07D401/12
CPC分类号： A01N43/42 , A01N43/40 , A01N43/56 , A01N43/90 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/60 , C07D221/04 , C07D401/12 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Provided is an agricultural fungicide that contains at least one selected from the group consisting of a novel nitrogen-containing heterocyclic compound represented by Formula (I), a salt thereof, or an N-oxide compound thereof. In Formula (I), R represents a group represented by CR1R2R3 or a cyano group. R1 to R3 each independently represents a hydrogen atom, an unsubstituted or substituted C1-8 alkyl group, an unsubstituted or substituted hydroxyl group, or the like. R4 or R5 represents a halogeno group or the like. Y or Z represents a carbon atom or the like, and A or D represents a benzene ring or the like. X represents an oxygen atom or a nitrogen atom or the like.
摘要翻译： 本发明提供一种农药杀菌剂，其含有选自由式（I）表示的新型含氮杂环化合物，其盐或其N-氧化物化合物中的至少一种。 在式（I）中，R表示由CR 1 R 2 R 3表示的基团或氰基。 R 1〜R 3各自独立地表示氢原子，未取代或取代的C 1-8烷基，未取代或取代的羟基等。 R4或R5表示卤代基等。 Y或Z表示碳原子等，A或D表示苯环等。 X表示氧原子或氮原子等。
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公开(公告)号：US20120252808A1
公开(公告)日：2012-10-04
申请号：US13515724
申请日：2010-12-13
IPC分类号： A61K31/4709 , C07D405/12 , A61K31/506 , A61K31/47 , C07D413/04 , A61K31/5377 , C07D401/04 , A61K31/497 , A61K31/501 , C07D471/04 , A61K31/437 , A61P25/28 , A61P25/18 , A61P29/00 , A61P25/00 , C07D215/14
CPC分类号： C07D215/60 , C07D215/48 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04
摘要： The present invention is directed to quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
摘要翻译： 本发明涉及作为M1受体阳性变构调节剂的式（I）的喹啉酰胺化合物，其可用于治疗涉及M1受体的疾病，例如阿尔茨海默氏病，精神分裂症，疼痛或睡眠障碍。 本发明还涉及包含该化合物的药物组合物，以及该化合物和组合物在治疗由M1受体介导的疾病中的用途。
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公开(公告)号：US20110245353A1
公开(公告)日：2011-10-06
申请号：US13076632
申请日：2011-03-31
申请人： Catherine TACHDJIAN , Xiao Qing TANG , Donald S. KARANEWSKY , Guy SERVANT , Xiaodong LI , Feng ZHANG , Qing CHEN , Hong ZHANG , Timothy DAVIS , Vincent DARMOHUSODO , Melissa WONG , Victor SELCHAU
发明人： Catherine TACHDJIAN , Xiao Qing TANG , Donald S. KARANEWSKY , Guy SERVANT , Xiaodong LI , Feng ZHANG , Qing CHEN , Hong ZHANG , Timothy DAVIS , Vincent DARMOHUSODO , Melissa WONG , Victor SELCHAU
IPC分类号： A61K47/22 , C07D215/54 , C07D471/04 , C07D495/04 , C07D401/12 , C07D405/12 , C07D491/048 , A23L1/226 , A23L1/30 , A23L1/302 , A23L1/304 , A23L1/305
CPC分类号： C07D495/04 , A23L2/56 , A23L27/2054 , A23L27/88 , A23V2002/00 , A61K47/22 , C07D215/54 , C07D215/60 , C07D401/12 , C07D405/12 , C07D471/04 , C07D491/048
摘要： The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.
摘要翻译： 本发明包括具有结构式（I）的化合物或其药学上可接受的盐，溶剂化物和/或酯。 这些化合物可用作甜味调味剂。 本发明还包括包含本发明化合物的组合物和增强可摄入组合物的甜味的方法。 此外，本发明提供了制备化合物的方法。
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公开(公告)号：US07612084B2
公开(公告)日：2009-11-03
申请号：US11725335
申请日：2007-03-19
申请人： Kim James , Lyn Howard Jones , David Anthony Price
发明人： Kim James , Lyn Howard Jones , David Anthony Price
IPC分类号： A61K31/44
CPC分类号： C07C311/08 , C07C215/54 , C07C217/48 , C07C217/62 , C07C223/02 , C07C233/43 , C07C255/13 , C07C271/16 , C07C271/66 , C07D215/26 , C07D215/60 , C07F7/1804
摘要： The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译： 本发明涉及式（1）化合物以及制备用于制备含这些衍生物的组合物和用途的中间体的方法。 根据本发明的化合物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。
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