公开(公告)号：US11998513B2

公开(公告)日：2024-06-04

申请号：US16976382

申请日：2019-02-28

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Joshua C. Doverspike ,  James Phan ,  Jianfeng Wu ,  Chuanwu Xi ,  Yu Qin ,  Mark E. Meyerhoff ,  Yang Zhou

IPC分类号： A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/06 ,  A61K47/06 ,  B01J23/72 ,  B01J31/02 ,  A61K9/00 ,  A61K9/06

CPC分类号： A61K31/04 ,  A61K31/198 ,  A61K33/30 ,  A61K38/063 ,  A61K47/06 ,  B01J23/72 ,  B01J31/0272 ,  A61K9/0014 ,  A61K9/06

摘要： A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.

公开(公告)号：US20240173347A1

公开(公告)日：2024-05-30

申请号：US18522970

申请日：2023-11-29

申请人： ACCURI, LLC

发明人： Boying DUN ,  Jin-Xiong SHE

IPC分类号： A61K31/7084 ,  A61K31/198 ,  A61K31/455 ,  A61K31/7004 ,  A61K31/7012 ,  A61K31/706 ,  A61P43/00

CPC分类号： A61K31/7084 ,  A61K31/198 ,  A61K31/455 ,  A61K31/7004 ,  A61K31/7012 ,  A61K31/706 ,  A61P43/00

摘要： Provided herein are compositions and methods of use thereof for efficiently raising NAD levels in a subject in need thereof, and improving the body's functions associated with low NAD levels. The composition comprises NAD precursors and additional components that elevate NAD levels and improve mitochondrial and cellular functions. The additional components include NAD+, NADH, D-ribose and creatine monohydrate, nicotinamide and/or nicotinic acid (NA) and may be added to the formulation to further enhance the composition's efficacy.

公开(公告)号：US20240173295A1

公开(公告)日：2024-05-30

申请号：US18552064

申请日：2022-03-25

申请人： Brain Luxury Inc.

发明人： Axel Bouchon ,  Herman Schützinger

IPC分类号： A61K31/405 ,  A61K9/00 ,  A61K9/107 ,  A61K31/198 ,  A61K31/355 ,  A61K31/593 ,  A61K47/12 ,  A61K47/22 ,  A61K47/46 ,  A61P25/24

CPC分类号： A61K31/405 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/107 ,  A61K31/198 ,  A61K31/355 ,  A61K31/593 ,  A61K47/12 ,  A61K47/22 ,  A61K47/46 ,  A61P25/24

摘要： The disclosure is in part directed to shelf-stable, emulsion-forming liquid compositions, liquid beverage compositions, and fatty acid vesicle-forming liquid compositions for increased neurosystem uptake of amino acids present in the compositions when consumed by a subject.

公开(公告)号：US20240173284A1

公开(公告)日：2024-05-30

申请号：US18435678

申请日：2024-02-07

申请人： Cancer Prevention Pharmaceuticals, Inc.

发明人： Patrick SHANNON ,  Roberto Carlos BRAVO GONZÁLEZ ,  Jean DUCASSOU

IPC分类号： A61K31/198 ,  A61K9/20 ,  A61K9/28 ,  A61K31/192

CPC分类号： A61K31/198 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/2813 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/192

摘要： Provided herein are fixed-dose combination formulations of a pharmaceutically effective amount of eflorithine together with a pharmaceutically effective amount of sulindac. Also provided are methods of use and of methods of manufacture of these formulations.

公开(公告)号：US11986507B1

公开(公告)日：2024-05-21

申请号：US18242099

申请日：2023-09-05

申请人： Matthias W Rath

发明人： Aleksandra Niedzwiecki ,  Matthias W Rath ,  Vadim O Ivanov

IPC分类号： A61K33/30 ,  A61K31/198 ,  A61K31/404 ,  A61K31/455 ,  A61K31/566 ,  A61K31/593 ,  A61K31/685 ,  A61K36/48 ,  A61K36/482 ,  A61K36/537 ,  A61P5/26 ,  A61P29/00

CPC分类号： A61K36/537 ,  A61K31/198 ,  A61K31/404 ,  A61K31/455 ,  A61K31/566 ,  A61K31/593 ,  A61K31/685 ,  A61K33/30 ,  A61K36/48 ,  A61K36/482 ,  A61P5/26 ,  A61P29/00

摘要： A micronutrient composition shown as Mix 1 comprises Rosemary extract at 1 mg-6,000 mg, Fenugreek extract 1 mg-50,000 mg and Fenugreek seed powder at 2 mg-8,000 mg, Cassia nomane seed extract powder 1 mg to 1,000 mg and dry extract 1 mg-300 mg, 3′3-di indolylmethylene 1 mg-800 mg, Zinc 0.1 mg-1,000 mg, Phosphatidylserine 1 mg-1,500 mg, Vitamin D 20 IU-10,000 IU, Vitamin C 10 mg-50,000 mg, Niacin 1 mg-3,000 mg, Theanine 0.1 mg-10,000 mg, Aspartic acid 10 mg-10,000 mg, Arginine 10 mg-50,000 mg and Dehydroepiandrosterone (DHEA) 1 mg-500 mg and Mix A comprising of all the ingredients of Mix 1 but does not contain DHEA and both are used improve men's health.

公开(公告)号：US20240156860A1

公开(公告)日：2024-05-16

申请号：US18282627

申请日：2022-03-17

申请人： UNIVERSITY OF CINCINNATI

发明人： DANIEL HASSETT ,  LATHA SATISH

IPC分类号： A61K33/00 ,  A61K9/00 ,  A61K9/06 ,  A61K31/198 ,  A61K47/10 ,  A61P17/02 ,  A61P31/04

CPC分类号： A61K33/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/198 ,  A61K47/10 ,  A61P17/02 ,  A61P31/04

摘要： A method for treating a subject having a cutaneous thermal injury is disclosed. The method comprises administering a therapeutically effective amount of a bactericidal compound topically to the injury. Use of a therapeutically effective amount of a bactericidal compound topically for treating a subject having a cutaneous thermal injury is also disclosed. The bactericidal compound comprises a therapeutically effective amount of NaNO2 (A-NO2—) and di-sodium EDTA (Na2-EDTA).

公开(公告)号：US20240148896A1

公开(公告)日：2024-05-09

申请号：US18356901

申请日：2023-07-21

申请人： Viking Scientific, Inc.

发明人： Paul Fisher ,  Paulina Davis

IPC分类号： A61K47/69 ,  A61K9/00 ,  A61K9/06 ,  A61K9/14 ,  A61K9/70 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/245 ,  A61K31/522 ,  A61K31/555 ,  A61K31/606 ,  A61K31/675 ,  A61K31/704 ,  A61K45/06 ,  A61K47/08 ,  A61K47/34 ,  A61K47/55 ,  A61K47/59 ,  A61K47/60

CPC分类号： A61K47/6903 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/14 ,  A61K9/7007 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/245 ,  A61K31/522 ,  A61K31/555 ,  A61K31/606 ,  A61K31/675 ,  A61K31/704 ,  A61K45/06 ,  A61K47/08 ,  A61K47/34 ,  A61K47/55 ,  A61K47/59 ,  A61K47/60

摘要： Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug delivery. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.

公开(公告)号：US20240148748A1

公开(公告)日：2024-05-09

申请号：US18511413

申请日：2023-11-16

申请人： Nutrition21, LLC

发明人： James R. Komorowski

IPC分类号： A61K31/555 ,  A23L33/125 ,  A23L33/16 ,  A23L33/165 ,  A23L33/17 ,  A61K9/08 ,  A61K9/14 ,  A61K31/198 ,  A61K31/718 ,  A61K31/732 ,  A61K33/24 ,  A61K36/899 ,  A61K38/01 ,  A61K45/06

CPC分类号： A61K31/555 ,  A23L33/125 ,  A23L33/16 ,  A23L33/165 ,  A23L33/17 ,  A61K9/08 ,  A61K9/14 ,  A61K31/198 ,  A61K31/718 ,  A61K31/732 ,  A61K33/24 ,  A61K36/899 ,  A61K38/018 ,  A61K45/06 ,  A23V2002/00

摘要： Administration of certain chromium complexes in combination with a starch provide unexpected benefits regarding increasing amino acid absorption, protein synthesis, exercise tolerance, lean muscle mass, skeletal muscle hypertrophy, muscle power, muscle endurance, muscle strength, FSR, and decreasing delayed onset muscle soreness, muscle protein breakdown, and fat mass.

公开(公告)号：US11975086B2

公开(公告)日：2024-05-07

申请号：US17809661

申请日：2022-06-29

申请人： KAO CORPORATION

发明人： Toshiaki Ozawa ,  Takaya Sakai ,  Mariko Miyoshi ,  Daisuke Furukawa ,  Aya Shirai

IPC分类号： A61K8/41 ,  A61K8/36 ,  A61K8/37 ,  A61K8/39 ,  A61K8/44 ,  A61K8/46 ,  A61K8/49 ,  A61K31/075 ,  A61K31/08 ,  A61K31/133 ,  A61K31/198 ,  A61K31/225 ,  A61K31/23 ,  A61K31/231 ,  A61K31/25 ,  A61K31/351 ,  A61K31/5375 ,  A61K45/06 ,  A61P17/00 ,  A61P17/10 ,  A61Q19/00 ,  A61Q19/10

CPC分类号： A61K8/41 ,  A61K8/361 ,  A61K8/37 ,  A61K8/375 ,  A61K8/39 ,  A61K8/44 ,  A61K8/463 ,  A61K8/466 ,  A61K8/49 ,  A61K8/498 ,  A61K31/075 ,  A61K31/08 ,  A61K31/133 ,  A61K31/198 ,  A61K31/225 ,  A61K31/23 ,  A61K31/231 ,  A61K31/25 ,  A61K31/351 ,  A61K31/5375 ,  A61K45/06 ,  A61P17/00 ,  A61P17/10 ,  A61Q19/00 ,  A61Q19/10 ,  A61K2800/596

摘要： A method for removing keratotic plugs capable of sufficiently exhibiting an excellent keratotic plug-removing effect without a burden, such as pam and of irritation, on the skin. The method comprises applying a composition comprising (X) one or more selected from (X1) 2-amino-2-hydroxymethyl-1,3-propanediol, (X2) 2-amino-2-methyl-1-propanol, and (X3) 2-amino-2-methyl-1,3-propanediol and a nonionic surfactant to the skin.

公开(公告)号：US11974982B2

公开(公告)日：2024-05-07

申请号：US17217524

申请日：2021-03-30

申请人： The Board of Trustees of the University of Illinois

发明人： Hyunjoon Kong ,  Byoungsoo Kim ,  Jonghwi Lee ,  Youngjun Kim ,  Ryan Cree Miller

IPC分类号： A61K31/375 ,  A61K31/198 ,  A61K31/353 ,  A61K47/18 ,  A61K47/24 ,  A61K47/59 ,  A61K47/61

CPC分类号： A61K31/375 ,  A61K31/198 ,  A61K31/353 ,  A61K47/18 ,  A61K47/24 ,  A61K47/59 ,  A61K47/61

摘要： Compositions comprising an active oxygen-responsive antioxidant crystal, methods of making them, and methods for controlling the dissolution rate and/or altering the crystallization behavior of an antioxidant are disclosed. The crystals comprise an antioxidant and a disulfide- or diselenide-crosslinked polymer that is adsorbed onto a surface of the antioxidant. Upon exposure to an active-oxygen stimulus, the polymer de-crosslinks to release the antioxidant from the composition in an amount effective to counteract the stimulus. While prior approaches to altering dissolution rates have relied on passive zero- or first-order kinetics that are independent of ROS levels, the inventive compositions actively respond by releasing antioxidant in an amount proportional to the concentration of active-oxygen species present. The crystallization methods are simple and scalable. The antioxidant balances ROS concentration and allows formulators of nutritional supplements, drug therapies, and other applications to more effectively use antioxidants while avoiding undesirable levels of antioxidative stress.