公开(公告)号：US20030187379A1

公开(公告)日：2003-10-02

申请号：US10115313

申请日：2002-04-02

发明人： JIAN-DONG SUN

IPC分类号： A61M037/00 ,  C02F001/44

CPC分类号： A61M1/367 ,  A61M1/16 ,  A61M39/281

摘要： The HEDD consists of a compressible bodynulltop half (11) with a guide groove (12) and a cutting blade (13), a compressible bodynullbottom half (18) with a guide pillar (17), and a pair of special clamps (14) which are located to the left side and the right side of the guide pillar between the two halves of the compressible body (11 and 18). Under external compression, the two halves of the compressible body (11 and 18) are squeezed together to compress the special clamps (14) along the direction of the guide pillar (17). After the special clamps (14) completely block the hemodialysis blood-tubes (16) and are locked up due to elasticity, the cutting-blade (13) moves further to cut the hemodialysis blood tubes (16). When the external compression is released, the special clamps (14) and the blood tubes (16) are released from the device. The patient is then completely disengaged from the dialysis machine.

摘要翻译： HEDD包括具有引导槽（12）和切割刀片（13）的可压缩体上半部（11），具有引导柱（17）的可压缩体下半部（18）和一对特殊的 位于导柱的左侧和右侧的可压缩体（11和18）的两半之间的夹具（14）。 在外部压缩下，可压缩体（11和18）的两半被挤压在一起以沿着导柱（17）的方向压缩特殊夹具（14）。 在特殊夹具（14）完全阻挡血液透析血管（16）并由于弹性而被锁定之后，切割刀片（13）进一步移动以切割血液透析血管（16）。 当释放外部压缩时，特殊夹具（14）和血管（16）从装置释放。 然后患者完全脱离透析机。

公开(公告)号：US20030148017A1

公开(公告)日：2003-08-07

申请号：US10013323

申请日：2001-12-07

发明人： Olli Tuominen ,  Eric W. Stroup ,  Chih-Hu Ho ,  Justin W. Cook

IPC分类号： B05D003/00 ,  C02F001/44 ,  A61M037/00

CPC分类号： B01D67/0088 ,  A61M1/3672 ,  A61M1/3673 ,  B01D63/021 ,  B01D67/0093 ,  C08G2650/58 ,  C08J7/047 ,  C08J2471/00 ,  C08L81/06 ,  C09D171/02

摘要： A coating material and a method for coating a hydrophobic membrane with a copolymer that contains at least one hydrophilic segment and at least one hydrophilic segment, such as a PEOnullPPOnullPEO triblock copolymer, so that the surface of the membrane becomes hydrophilic. The hydrophilic coating helps repel biological molecules, thereby reducing the risk that these molecules will adsorb or deposit on the membrane surface. When the copolymers are modified with an active group, ligands can be immobilized on the copolymer through the active group so that specific molecules that will bind with the ligands can be targeted for immobilization on the copolymer coating, thereby improving the efficiency of the removal of specific targets.

摘要翻译： 一种涂料和用包含至少一个亲水链段和至少一个亲水链段如PEO-PPO-PEO三嵌段共聚物的共聚物涂覆疏水膜的方法，使得该膜的表面变得亲水。 亲水涂层有助于排斥生物分子，从而降低这些分子吸附或沉积在膜表面上的风险。 当共聚物用活性基团修饰时，配体可以通过活性基团固定在共聚物上，使得能够将与配体结合的特定分子靶向固定在共聚物涂层上，从而提高去除特异性 目标。

公开(公告)号：US20030130606A1

公开(公告)日：2003-07-10

申请号：US10040659

申请日：2002-01-07

发明人： Joseph E. Tuck

IPC分类号： A61M037/00 ,  C02F001/44

CPC分类号： A61M1/3462

摘要： An infusible replacement fluid does not require separate regulatory clearance and does not need to be prepared by a pharmacist. The fluid is made from constituent fluids that are cleared for infusion. Further, the fluids are available in standard volumes of such size that that the proper proportions may be provided by a convenient number and size of packages. In a preferred embodiment, the replacement fluid is provided to the patient by nullhangingnull five bags of fluid, one of half-normal saline (e.g., 1 liter bag), three of ringers solution (e.g., 3 liter bags), and one sodium lactate for injection (e.g., 1 liter bag). The resulting concentrations of solutes closely approximates an ideal solution. The above constituents may be purchased and stored in a convenient location and used as required without the need for a pharmacist to prepare the fluids.

摘要翻译： 不可替代的液体不需要单独的监管许可，不需要由药剂师准备。 流体由清除输液的成分流体制成。 此外，流体可以以这样的尺寸的标准体积获得，使得可以通过方便的数量和尺寸的包装提供适当的比例。 在优选实施例中，通过“悬挂”五袋流体，半正常生理盐水（例如，1升袋）之一，三个溶液（例如3升袋）和一个 注射用乳酸钠（例如，1升袋）。 所得到的溶质浓度近似于理想的溶液。 上述组分可以购买并存储在方便的位置并且根据需要使用，而不需要药剂师来制备流体。

公开(公告)号：US20030127390A1

公开(公告)日：2003-07-10

申请号：US10316895

申请日：2002-12-12

申请人： OccuLogix Corporation

发明人： Richard C. Davis JR.

IPC分类号： A61K039/395 ,  C02F001/44 ,  G06F017/60

CPC分类号： A61M1/3472 ,  A61M1/3413 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2205/84 ,  G06F19/3481 ,  G06Q50/22 ,  G06Q50/24 ,  G16H10/20

摘要： Therapeutic apheresis treatments and diagnostic monitoring methods are described, specifically relating to the depletion and/or removal of a broad bandwidth of certain rheologically active elements from the blood of a patient followed by return of the blood so treated to the patient, and to methods or procedures of apheresis treatment, especially biophysiologic blood filtering treatments and computer medicated delivery methods configured to provide such apheresis treatments to patients with certain chronic, age-related, degenerative, atherogenic, thrombotic or inflammatory diseases; especially those associated with RAM accumulation-deposition causing disturbances of blood rheology or microcirculatory impairment.

公开(公告)号：US20030028044A1

公开(公告)日：2003-02-06

申请号：US09891908

申请日：2001-06-26

发明人： J. Scott Buchanan ,  Lawrence J. Altman ,  John W. Diehl

IPC分类号： C07C069/96 ,  C02F001/44

CPC分类号： B01D61/362 ,  B01D61/246 ,  B01D71/24 ,  C07B63/00 ,  C07C29/76 ,  C07C68/08 ,  Y02P20/582 ,  C07C69/96 ,  C07C31/202

摘要： A method for separating at least one lower polarity fluid from a mixture of fluids having varying polarity, comprising contacting at least one low polarity or non-polar polymeric membrane with the mixture of fluids under conditions such that the at least one lower polarity fluid selectively permeates through the membrane, wherein the membrane is one which has a ratio of heteroatoms chemically bonded to the carbon atoms in the membrane to the number of carbon atoms of less than about 0.2, preferably less than about 0.05.

公开(公告)号：US20020175123A1

公开(公告)日：2002-11-28

申请号：US10055652

申请日：2002-01-23

发明人： Wolfgang Anderheggen ,  Toni Herbertz ,  Ulrich Reinehr ,  Tilo Sehm

IPC分类号： C02F001/44

CPC分类号： B01F7/00208 ,  B01F7/00283 ,  B01F7/1665 ,  B29B17/02 ,  B29B2017/0203 ,  B29B2017/0231 ,  B29B2017/0289 ,  B29B2017/0293 ,  B29K2067/00 ,  B29K2075/00 ,  B29K2105/065 ,  B29K2313/00 ,  B29L2031/731 ,  D01F13/04 ,  Y02P70/629 ,  Y02W30/622

摘要： A process and an apparatus are described for separating at least 50% by weight of oleaginous preparation media from elastane fibers which contain preparations, with respect to 100% by weight of the initial content of preparation media in the elastane starting material, wherein a mixture of elastane fibers of different titres is used as chopped fiber, wherein fibers with a titre of 11 to 10,000 dtex or more are used as a starting material, which chopped elastane fibers are mixed with water in a mixing vessel in a bath ratio of water to chopped elastane fibers of at least 5/1, wherein mixing is effected using mixing devices (3) with a speed of rotation of at least 1500 rpm, treatment is carried out at room temperature or at an elevated temperature, particularly up to 90null C., a treatment duration of 10 to 60 minutes is maintained, and the aqueous bat which contains preparation media is subsequently separated from the fiber material.

摘要翻译： 描述了一种方法和装置，用于将至少50重量％的含油制剂介质与含有制剂的弹性纤维分离，相对于弹性纤维起始原料中100重量％的初始含量的制备介质， 使用不同滴度的弹性纤维作为短切纤维，其中使用滴定度为11〜10,000dtex以上的纤维作为起始原料，将切断的弹性纤维与水混合在混合容器中，以水浴比切割 弹性纤维为至少5/1，其中使用混合装置（3）以至少1500rpm的旋转速度进行混合，在室温或升高的温度，特别是高达90℃下进行处理。 ，维持10至60分钟的处理持续时间，随后将含有制备介质的水蝙蝠与纤维材料分离。

公开(公告)号：US20020091350A1

公开(公告)日：2002-07-11

申请号：US09992526

申请日：2001-11-13

发明人： Amir Belson

IPC分类号： A61M037/00 ,  C02F001/44

CPC分类号： B01D61/243 ,  A61M1/16 ,  A61M1/26 ,  A61M1/363 ,  A61M1/3672 ,  A61M2205/3375 ,  A61M2205/7554 ,  A61M2205/7563 ,  B01D61/30 ,  B01D63/02 ,  B01D63/16 ,  B01D2313/36

摘要： An improved apparatus for hemodialysis treatment includes an ultrasonic module with an ultrasonic transducer coupled to a membrane or hollow fiber dialyzer. An ultrasonic waveform generator is switchable between various modes, including a narrowband sine wave, a variable or sweeping frequency sine wave and a broadband square or sawtooth waveform. A low power setting is used to increase the diffusion rate across the semipermeable membranes of the dialyzer and a high power setting is used intermittently to break up thrombus that may form within the dialyzer. A chamber downstream of the dialyzer has an ultrasonic or optical emboli detector for detecting thrombi or emboli exiting the dialyzer and a focused ultrasonic transducer to break up any emboli in the chamber. A screen or filter at the exit of the chamber prevents thrombi and emboli larger than a certain size from entering the patient's circulatory system.

摘要翻译： 用于血液透析治疗的改进装置包括具有耦合到膜或中空纤维透析器的超声波换能器的超声波模块。 超声波波形发生器可在各种​​模式之间切换，包括窄带正弦波，可变或扫频频率正弦波和宽带平方或锯齿波形。 使用低功率设置来增加透析器半透膜上的扩散速率，并且间歇地使用高功率设置来分解可能在透析器内形成的血栓。 在透析器下游的腔室具有超声或光学栓塞检测器，用于检测离开透析器的血栓或栓塞以及聚焦的超声换能器以分解腔室中的任何栓塞。 在室的出口处的屏幕或过滤器防止大于一定尺寸的血栓和栓塞进入患者的循环系统。

公开(公告)号：US20020049401A1

公开(公告)日：2002-04-25

申请号：US09920999

申请日：2001-08-02

发明人： Nicola Ghelli ,  Edgardo Costa Maianti ,  Ivo Panzani

IPC分类号： A61M037/00 ,  C02F001/44 ,  B01D011/00 ,  B01D061/00

CPC分类号： B01D61/58 ,  A61M1/1625 ,  A61M1/1627 ,  A61M1/1629 ,  A61M1/1698 ,  A61M1/3627 ,  B01D63/02 ,  B01D2313/90 ,  Y10S128/03 ,  Y10S261/28

摘要： A device for oxygenating blood in an extracorporeal circuit includes a first structure suitable to delimit a portion of space-containing capillaries made of microporous membrane. The capillaries convey oxygen and are wet externally by blood flowing through a portion of space between an intake connector, which is connected to a venous line of the extracorporeal circuit, and a delivery connector. The device includes a second structure monolithically connected and contiguous to the first structure. The second structure is suitable to contain blood filtration means that divide the portion of space delimited thereby into a blood distribution chamber, provided with an air vent and connected to the delivery connector of the first structure, and a blood collection chamber provided with a delivery connector connected to the arterial line of the extracorporeal circuit.

摘要翻译： 用于在体外循环中对血液进行氧合的装置包括适于限定由微多孔膜制成的包含空间的毛细管的一部分的第一结构。 毛细血管传送氧气，并且通过连接到体外回路的静脉线的进气连接器和输送连接器之间的血液流过一部分空间而被外部湿润。 该装置包括与第一结构单片连接并邻接的第二结构。 第二结构适于包含血液过滤装置，其将由此分隔的空间的部分划分成具有通气口并连接到第一结构的输送连接器的血液分配室，以及设置有输送连接器 连接到体外循环的动脉线。

公开(公告)号：US20020041825A1

公开(公告)日：2002-04-11

申请号：US09940389

申请日：2001-08-27

发明人： Peter Scheunert ,  Martin Lauer ,  Manfred Weis ,  Josef Beden ,  Martin Herklotz ,  Joachim Manke ,  Uwe Hahmann

IPC分类号： A61M001/14 ,  A61M037/00 ,  C02F001/44 ,  B01D061/00

CPC分类号： A61M1/3621 ,  A61M1/16 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M2205/128

摘要： A blood treatment device, in particular a dialysis machine, which permits both single-needle and dual-needle operation. The device has a blood treatment unit, in particular a dialyzer that has an inlet connected to a feed line and an outlet connected to a return line. The feed line has two parallel line branches with a positive displacement pump being connected into the first and second line branches. To produce a fluid connection between the outlet of the dialyzer and one of the two pumps, a connection line is provided. For dual-needle operation, the feed and return lines are connected to an arterial and a venous needle. For single-needle operation, the feed and return lines are brought together and connected to a common needle. The connection line permits single-needle operation without great changes to the structure of the blood treatment device.

摘要翻译： 一种血液处理装置，特别是透析机，其允许单针和双针操作。 该装置具有血液处理单元，特别是透析器，其具有连接到馈送线的入口和连接到返回线的出口。 进料管线具有两个平行的管线分支，其中正排量泵连接到第一和第二管线分支中。 为了在透析器的出口和两个泵中的一个之间产生流体连接，提供连接线。 对于双针操作，进给和返回线连接到动脉和静脉针。 对于单针操作，将进给和返回线连接在一起并连接到公共针。 连接线允许单针操作，而对血液处理装置的结构没有大的变化。

公开(公告)号：US20020009385A1

公开(公告)日：2002-01-24

申请号：US09337109

申请日：1999-06-21

发明人： NIKOLAI M. KRIVITSKI ,  VICTOR V. KISLUKHIN

IPC分类号： A61M001/14 ,  A61M037/00 ,  B01D035/00 ,  C02F001/44

CPC分类号： A61M1/16 ,  A61M1/1605 ,  A61M1/3609 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3669 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2205/702 ,  A61M2205/707

摘要： A method and apparatus for monitoring and measuring the filter blood volume by dilution techniques in real time, wherein the filter may be in use or off line during the measurements. The system includes a method and apparatus for measuring or monitoring the volume of a blood side of a filter by employing one of a bolus in the blood side upstream of the filter; a change of the filtration rate in the filter; and a bolus on the dialysate side, wherein the filter blood volume is calculated from the obtained data.

摘要翻译： 一种用于通过实时稀释技术来监测和测量过滤血液体积的方法和装置，其中在测量期间可以使用或离线过滤器。 该系统包括用于通过使用在过滤器上游的血液侧中的推注中的一种来测量或监测过滤器的血液侧的体积的方法和装置; 过滤器中过滤速率的变化; 并且在透析液侧进行推注，其中根据获得的数据计算出过滤血液体积。