公开(公告)号：US2624764A

公开(公告)日：1953-01-06

申请号：US13530449

申请日：1949-12-27

Applicant: MONSANTO CHEMICALS

Inventor： EMERSON WILLIAM S ,  LONGLEY JR RAYMOND I

IPC: C07C45/60 ,  C07C49/185 ,  C07C49/258 ,  C07C49/355

CPC classification number: C07C45/60 ,  C07C49/185 ,  C07C49/258 ,  C07C49/355

公开(公告)号：US20230321228A1

公开(公告)日：2023-10-12

申请号：US18014881

申请日：2021-07-07

Applicant: Amyris, Inc.

Inventor： Christopher John PADDON ,  Karl Joseph FISHER

IPC: A61K39/39 ,  C07C43/15 ,  C07C43/215 ,  C07C49/258

CPC classification number: A61K39/39 ,  C07C43/15 ,  C07C43/215 ,  C07C49/258 ,  A61K2039/55511

Abstract: The disclosure provides compounds useful as adjuvants in vaccines, as well as methods of synthesizing such compounds and methods of using such compounds in the formulation of a vaccine. The disclosure also features methods of administering such vaccines to a subject (e.g., a mammalian subject, such as a human) in order to treat or prevent one or more diseases, such as a disease caused by a viral or bacterial infection.

公开(公告)号：US09737504B2

公开(公告)日：2017-08-22

申请号：US15181458

申请日：2016-06-14

Applicant: NAI INC.

Inventor： Kiyoshi Kita ,  Ken Daniel Inaoka ,  Hiroyuki Saimoto ,  Masaichi Yamamoto

IPC: A61K31/341 ,  A61K31/216 ,  A61K31/11 ,  A61K31/336 ,  C07D309/12 ,  C07C69/738 ,  C07C47/56 ,  C07C47/565 ,  C07C47/575 ,  C07C49/258 ,  C07D303/14 ,  C07D307/20 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48 ,  C07C69/63 ,  A61K31/121 ,  A61K31/222 ,  A61K31/351 ,  A61K31/357 ,  C07C49/248 ,  C07C49/255 ,  C07D303/32 ,  A61K47/02 ,  A61K47/12 ,  A61K47/34 ,  A61K9/16

CPC classification number: A61K31/341 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4866 ,  A61K31/11 ,  A61K31/121 ,  A61K31/216 ,  A61K31/222 ,  A61K31/336 ,  A61K31/351 ,  A61K31/357 ,  A61K47/02 ,  A61K47/12 ,  A61K47/34 ,  C07C47/56 ,  C07C47/565 ,  C07C47/575 ,  C07C49/248 ,  C07C49/255 ,  C07C49/258 ,  C07C69/63 ,  C07C69/738 ,  C07D303/14 ,  C07D303/32 ,  C07D307/20 ,  C07D309/12

Abstract: The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents —CHO, and R4 represents —CH2—CH═C(CH3)—R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.

公开(公告)号：US20150166498A1

公开(公告)日：2015-06-18

申请号：US14404252

申请日：2013-05-28

Applicant: NAI INC.

Inventor： Kiyoshi Kita ,  Ken Daniel Inaoka ,  Hiroyuki Saimoto ,  Masaichi Yamamoto

IPC: C07D307/20 ,  C07C49/255 ,  C07D303/32 ,  C07C49/248 ,  C07C49/258 ,  C07C69/738 ,  C07C47/56

CPC classification number: A61K31/341 ,  A61K9/0019 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4866 ,  A61K31/11 ,  A61K31/121 ,  A61K31/216 ,  A61K31/222 ,  A61K31/336 ,  A61K31/351 ,  A61K31/357 ,  A61K47/02 ,  A61K47/12 ,  A61K47/34 ,  C07C47/56 ,  C07C47/565 ,  C07C47/575 ,  C07C49/248 ,  C07C49/255 ,  C07C49/258 ,  C07C69/63 ,  C07C69/738 ,  C07D303/14 ,  C07D303/32 ,  C07D307/20 ,  C07D309/12

Abstract: The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents —CHO, and R4 represents —CH2—CH═C(CH3)—R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.

Abstract translation: 本发明提供了适用于各种疾病的新型二氢原酸脱氢酶抑制剂。 当用作活性成分时，由式（I）表示的化合物（其中X表示卤素原子，R1表示氢原子，R2表示含有1至7个碳原子的烷基，R3表示-CHO，R4表示 -CH 2 -CH = C（CH 3）-R 0（其中R 0表示可以在末端碳上和/或非末端碳上具有取代基的含有1至12个碳原子的烷基等），光学 异构体或其药学上可接受的盐对二氢原酸脱氢酶具有高的抑制作用，可用作免疫抑制剂，风湿病治疗剂，抗癌剂，移植排斥反应治疗剂，抗病毒剂， H。 幽门螺杆菌药，糖尿病治疗剂等。

公开(公告)号：US5648550A

公开(公告)日：1997-07-15

申请号：US567818

申请日：1995-12-06

Applicant: Andreas Brungger ,  Hansjorg Grundler ,  Werner Simon

Inventor： Andreas Brungger ,  Hansjorg Grundler ,  Werner Simon

IPC: A23K1/16 ,  A23L1/275 ,  C07C45/59 ,  C07C45/68 ,  C07C49/24 ,  C07C49/258 ,  C07C49/743 ,  C07C403/16 ,  C07C45/45

CPC classification number: C07C403/16 ,  A23K20/179 ,  A23L5/44 ,  C07C45/59 ,  C07C49/24 ,  C07B2200/09 ,  C07C2101/16

Abstract: A novel process for the manufacture of .beta.-keto alcohols from aldehydes comprising reacting a conjugated polyene aldehyde under basic conditions with a cyclocarbonate or derivative thereof. Certain carotenoid products of this process are novel compounds and are also an object of the present invention. The products, which for the most part belong to the carotenoid field, find corresponding use, for example, as colorants or pigments for foodstuffs, egg yolk, integuments and/or subcutaneous fat of poultry and flesh and/or integuments of fish and crustaceans.

Abstract translation: 一种用于从醛制造β-酮醇的新方法，包括在碱性条件下使共轭多烯醛与环碳酸酯或其衍生物反应。 该方法的某些类胡萝卜素产物是新化合物，也是本发明的目的。 大部分属于类胡萝卜素领域的产品可以找到相应的用途，例如作为用于食品，蛋黄，皮肤和/或家禽肉皮和/或皮肤和/或皮肤和皮肤外壳的皮肤脂肪的着色剂或颜料。

公开(公告)号：US5292771A

公开(公告)日：1994-03-08

申请号：US958487

申请日：1992-10-08

Applicant: Reijo J. Backstrom ,  Erkki J. Honkanen ,  Jarmo J. Pystynen ,  Anne M. Luiro ,  Paivi A. Aho ,  Inge-Britt Y. Linden ,  Erkki A. O. Nissinen ,  Pentti Pohto

Inventor： Reijo J. Backstrom ,  Erkki J. Honkanen ,  Jarmo J. Pystynen ,  Anne M. Luiro ,  Paivi A. Aho ,  Inge-Britt Y. Linden ,  Erkki A. O. Nissinen ,  Pentti Pohto

IPC: A61K31/00 ,  A61K31/06 ,  A61K31/12 ,  A61K31/165 ,  A61K31/275 ,  A61K31/345 ,  C07C49/217 ,  C07C49/235 ,  C07C49/248 ,  C07C49/255 ,  C07C49/258 ,  C07C49/567 ,  C07C49/577 ,  C07C65/36 ,  C07C65/40 ,  C07C205/45 ,  C07C233/31 ,  C07C235/84 ,  C07C255/56 ,  C07C317/24 ,  A61K31/38 ,  A61K31/44 ,  A61K31/47

CPC classification number: C07C205/45 ,  A61K31/00 ,  A61K31/06 ,  A61K31/12 ,  A61K31/165 ,  A61K31/275 ,  A61K31/345 ,  C07C233/31 ,  C07C235/84 ,  C07C255/56 ,  C07C317/24 ,  C07C49/217 ,  C07C49/235 ,  C07C49/248 ,  C07C49/255 ,  C07C49/258 ,  C07C49/567 ,  C07C49/577 ,  C07C65/36 ,  C07C65/40 ,  C07C2101/02

Abstract: Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.

Abstract translation: 式（Ⅰ）化合物其中n为0或1，R 1和R 2独立地为甲基，乙基或环丙基，R为任选取代的苯基或杂芳基或其盐或酯可用于治疗炎症性肠病。

公开(公告)号：US4806280A

公开(公告)日：1989-02-21

申请号：US81634

申请日：1987-08-03

Applicant: Gerard Mignani ,  Didier Morel

Inventor： Gerard Mignani ,  Didier Morel

IPC: C07C45/63 ,  C07C45/00 ,  C07C45/65 ,  C07C45/67 ,  C07C47/24 ,  C07C49/203 ,  C07C49/227 ,  C07C49/258 ,  C07C67/00 ,  C07C67/307 ,  C07C69/587 ,  C07C69/73 ,  C07C69/738 ,  C07C201/00 ,  C07C201/12 ,  C07C205/09 ,  C07C231/00 ,  C07C231/12 ,  C07C233/09 ,  C07C253/00 ,  C07C253/30 ,  C07C255/10 ,  C07C255/17 ,  C07C269/06 ,  C07C271/18 ,  C07C313/00 ,  C07C315/04 ,  C07C317/04 ,  C07C317/24 ,  C07C317/44 ,  C07C69/60 ,  C11C3/00

CPC classification number: C07C49/227 ,  C07C45/65 ,  C07C45/673 ,  C07C45/676 ,  C07C49/203

Abstract: Compounds of formula ##STR1## in which n denotes an integer from 1 to 10 and X and Y, which are identical or different, each denote an electron-attracting group, are made by reacting a halogenating agent with a compound of formula ##STR2## in which R, X and Y are as hereinbefore defined, anionized by a base.

Abstract translation: 其中n表示1至10的整数并且相同或不同的X和Y各自表示吸电子基团的式（Ia）或（IMA）化合物或其中n表示电子吸引基团， 卤化剂与式（IIa）化合物或式（IIb）化合物反应，其中R，X和Y如上所定义，被碱阴离子化。

公开(公告)号：US4207419A

公开(公告)日：1980-06-10

申请号：US759314

申请日：1977-01-13

Applicant: Wenling Kao

Inventor： Wenling Kao

IPC: C07C29/40 ,  C07C33/48 ,  C07C45/00 ,  C07C45/52 ,  C07C45/63 ,  C07C49/258 ,  C07C405/00 ,  C07F7/18 ,  C07C177/00

CPC classification number: C07F7/1852 ,  C07C29/40 ,  C07C33/483 ,  C07C405/00 ,  C07C45/00 ,  C07C45/52 ,  C07C45/63 ,  C07C49/258 ,  C07B2200/09

Abstract: Derivatives of 11-deoxy-PGE.sub.2 are prepared. These new compounds not heretofore found in nature possess various pharmacological activities, one of which is bronchodilation.

Abstract translation: 制备11-deoxy-PGE2的衍生物。 迄今尚未发现的这些新化合物具有各种药理活性，其中之一是支气管扩张。

公开(公告)号：US4092350A

公开(公告)日：1978-05-30

申请号：US677092

申请日：1976-04-14

Applicant: Koji Miura ,  Kenjun Takeshima ,  Takuya Kodama ,  Masashi Imamura ,  Kyoko Hongo ,  Noboru Takagawa ,  Yukitaka Hamatani ,  Yasuyuki Suzuki

Inventor： Koji Miura ,  Kenjun Takeshima ,  Takuya Kodama ,  Masashi Imamura ,  Kyoko Hongo ,  Noboru Takagawa ,  Yukitaka Hamatani ,  Yasuyuki Suzuki

IPC: A61K31/19 ,  A61P25/04 ,  A61P29/00 ,  C07C45/46 ,  C07C45/58 ,  C07C45/59 ,  C07C47/228 ,  C07C47/27 ,  C07C49/258 ,  C07C49/86 ,  C07C51/00 ,  C07C51/16 ,  C07C59/42 ,  C07C59/48 ,  C07C59/84 ,  C07C67/00 ,  C07D303/48 ,  C07C65/02

CPC classification number: C07C45/58 ,  C07C45/46 ,  C07C45/59 ,  C07C51/16 ,  C07C59/48 ,  C07C59/84 ,  C07D303/48 ,  Y10S514/87 ,  Y10S514/96

Abstract: A novel 2-[4-(3-oxo- or hydroxy-alkyl)phenyl]alkanoic acid and a non-toxic salt thereof. These compounds are useful for treating symptoms of inflammation and pain in mammals including man. This disclosure relates to such compounds, a process for producing the same, a pharmaceutical composition containing such a compound, and a method for treating symptoms of inflammation and pain.

Abstract translation: 一种新的2- [4-（3-氧代 - 或羟基 - 烷基）苯基]链烷酸及其无毒盐。 这些化合物可用于治疗包括人在内的哺乳动物的炎症和疼痛的症状。 本公开涉及这样的化合物，其制备方法，含有这种化合物的药物组合物，以及治疗炎症和疼痛症状的方法。

公开(公告)号：US3840559A

公开(公告)日：1974-10-08

申请号：US22826672

申请日：1972-02-22

Applicant: BASF AG

Inventor： HOFFMANN W

IPC: C07C45/59 ,  C07C49/258 ,  C11B9/00 ,  C07D13/04 ,  C07D15/04

CPC classification number: C07C45/59 ,  C07C45/515 ,  C07C45/60 ,  C07C49/258 ,  C11B9/0015 ,  C11B9/0061

Abstract: 1. A COMPOUND OF THE FORMULA (I):

R-O-CH(-O-R2)-C(-CH3)=CH-CH2-CH2-CO-CH3

WHERE R1 AND R2 TOGETHER ARE A 1,2- OR 1,3-ALKYLENE GROUP OF TWO TO EIGHT CARBON ATOMS.