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1245 条记录 (耗时 0.044 秒)

    Neuroprotective agents for treatment of neurodegenerative diseases
    42.
    发明授权
    Neuroprotective agents for treatment of neurodegenerative diseases 有权

    公开(公告)号：US10125127B2

    公开(公告)日：2018-11-13

    申请号：US14648413

    申请日：2013-11-27

    申请人： WAYNE STATE UNIVERSITY

    发明人： Aloke K. Dutta

    IPC分类号： C07D277/82 ,  C07D417/12 ,  C07D417/14 ,  A61K31/496 ,  A61K31/428 ,  A61K31/517

    摘要： A compound having formula I is useful for treating a neurodegenerative disease: R1 is an C1-12 organyl group; is a C1-12 heterocyclic ring system containing 5 to 12 ring atoms and up to three heteroatoms individually selected from the group consisting of N, O, S, and Se; R2 are C1-12 organyl groups; R7, R8 are each independently, hydrogen (H), hydroxyl, oxo (i.e., carbonyl), C1-8 alkyl, C1-8 alkoxyl, C2-8 alkenyl, C2-10 alkynyl, C5-7 cycloalkyl, C5-7 cycloalkenyl, halo, C1-4 aldehyde, or —NR4q where R4 is H, C1-8 alkyl, C2-8 alkenyl, C4-8 cycloalkyl, C4-8 cycloalkenyl, or C6-10 aryl; o is 0, 1, 2, 3, or 4; A is a C6-12 aryl group, C5-12 heteroaryl group, or an optionally substituted 3-hydroxypyridin-4(1H)-one; p is an integer from 1 to 6; and Zm is absent or a divalent linking moiety; and m is an integer representing the number of time Z is repeated.

    MIXTURE OF POLYMERIZABLE COMPOUND AND METHOD OF PRODUCING THE SAME
    46.
    发明申请
    MIXTURE OF POLYMERIZABLE COMPOUND AND METHOD OF PRODUCING THE SAME 审中-公开

    公开(公告)号：US20180099921A1

    公开(公告)日：2018-04-12

    申请号：US15560646

    申请日：2016-03-30

    申请人： ZEON CORPORATION

    发明人： Kei SAKAMOTO ,  Kumi OKUYAMA ,  Kanako SANUKI

    IPC分类号： C07C67/58 ,  C07C67/14 ,  C07C69/75 ,  C07D277/82

    摘要： Disclosed is a mixture containing compound (I) and polymerizable compound (II) wherein compound (I) accounts for 50 mol % or more of the entire mixture and 1,4-cyclohexanedicarboxylic acid accounts for less than 5 mol % of the entire mixture; a method of producing the mixture which includes reacting in a water-immiscible organic solvent 1,4-cyclohexanedicarboxylic acid dichloride with compound (IV) in the presence of a base, and washing the obtained reaction solution with a weakly acidic buffer solution; etc. The disclosure provides mixtures useful for low-cost production of polymerizable compounds which have low melting points suitable for practical use, show superior solubility to general-purpose solvents, can be produced at low costs, and allow for provision of optical films capable of uniform polarized light conversion over a wide wavelength range, and methods of producing the mixtures. where A represents hydrogen, methyl group or chlorine, and n represents an integer of 1 to 20.

    AGENT FOR REDUCING VISCERAL FAT WEIGHT
    47.
    发明申请
    AGENT FOR REDUCING VISCERAL FAT WEIGHT 审中-公开

    公开(公告)号：US20180078530A1

    公开(公告)日：2018-03-22

    申请号：US15787049

    申请日：2017-10-18

    申请人： Kowa Co., Ltd.

    发明人： Toshiaki TAKIZAWA ,  Kentaro MURAKAMI

    IPC分类号： A61K31/423 ,  C07D277/82 ,  C07D231/56 ,  C07D263/58

    CPC分类号： A61K31/423 ,  C07D231/56 ,  C07D263/58 ,  C07D277/82

    摘要： An FGF21 production promoting agent containing, as an active ingredient, a compound represented by the following formula (1): wherein each of R1 and R2, which may be identical to or different from each other, represents, for example, a hydrogen atom; each of R3a, R3b, R4a, and R4b, which may be identical to or different from one another, represents, for example, a hydrogen atom or a halogen atom, or R3a and R3b or R4a and R4b may bond together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents, for example, a hydrogen atom or a C1-4 alkyl group); Y represents, for example, an oxygen atom, an S(O)l group (l is a number of from 0 to 2), or a carbonyl group; Z represents CH or N; n is a number of from 1 to 6; and m is a number from 2 to 6, a salt of the compound, or a solvate of the compound or the salt.