公开(公告)号：US06690005B2

公开(公告)日：2004-02-10

申请号：US09910197

申请日：2001-07-20

申请人： Anthony Jenkins ,  William J. McGann

发明人： Anthony Jenkins ,  William J. McGann

IPC分类号： H01J4940

CPC分类号： H01J49/12 ,  G01N27/622

摘要： An ion trap mobility spectrometer is provided with a reaction chamber and a drift chamber. Ions are produced in the reaction chamber by high voltage electronic pulses. More particularly, the ions are formed periodically and are allowed to thermalize in a field-free environment of the reaction chamber. The ions then react with molecular species in the gas phase in the reaction chamber. After a short period, the ions are pulsed into the drift section and are collected on a collector electrode disposed at the end of the drift chamber remote from the reaction chamber. The reaction period may be varied to sample the ion population at different intervals. This enables the ion-molecule reactions to be monitored as the ion population approaches equilibrium. The monitoring results can be used to determine differences between reacting species because the molecular ion population varies at different time points approaching equilibrium. This in turn provides improved identification of target materials.

摘要翻译： 离子阱迁移谱仪设有反应室和漂移室。 离子在高压电子脉冲在反应室中产生。 更具体地，周期性地形成离子，并且允许在无反应室的无场环境中热离子化。 离子然后与反应室中的气相中的分子物质反应。 短时间后，将离子脉冲进入漂移部分，并收集在设置在远离反应室的漂移室末端的集电极上。 可以改变反应时间以以不同的间隔对离子群进行取样。 这使得离子分子反应可以随着离子群体接近平衡而被监测。 监测结果可用于确定反应物质之间的差异，因为分子离子群体在接近平衡的不同时间点变化。 这反过来又提供了目标材料的改进识别。

公开(公告)号：US06680475B2

公开(公告)日：2004-01-20

申请号：US09989882

申请日：2001-11-21

申请人： Andrew N. Krutchinsky ,  Alexandre V. Loboda ,  Victor L. Spicer ,  Werner Ens ,  Kenneth G. Standing

发明人： Andrew N. Krutchinsky ,  Alexandre V. Loboda ,  Victor L. Spicer ,  Werner Ens ,  Kenneth G. Standing

IPC分类号： H01J4940

CPC分类号： H01J49/063 ,  H01J49/04 ,  H01J49/164 ,  H01J49/401

摘要： A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and includes a damping gas, to damp spatial and energy spreads of ions generated by a pulsed ion source. The multipole rod set has the effect of guiding the ions along an ion path, so that they can be directed into the inlet of a mass spectrometer. The invention has particular application to MALDI (matrix-assisted laser desorption/ionization) ion sources, which produce a small supersonic jet of matrix molecules and ions, which is substantially non-directional, and can have ions travelling in all available directions from the source and having a wide range of energy spreads. The ion transmission device can have a number of effects, including: substantially spreading out the generated ions along an ion axis to generate a quasi-continuous beam; reducing the energy spread of ions emitted from the source; and at least partially suppressing unwanted fragmentation of analyte ions. Consequently, a number of pulses of ions can be delivered to the time-of-flight or other spectrometer, for each cycle of the ion generation.

公开(公告)号：US06674068B1

公开(公告)日：2004-01-06

申请号：US09561193

申请日：2000-04-27

申请人： Yoshihiro Kammei

发明人： Yoshihiro Kammei

IPC分类号： H01J4940

CPC分类号： H01J49/025 ,  H01J49/40

摘要： There is disclosed a time-of-flight (TOF) mass spectrometer using microchannel plates (MCPs), that are prevented from saturating even if strong ion pulses hit the microchannel plates. Usually, the saturation would result in a dead time, removing parts of the produced mass spectrum and shortening the lifetimes of the microchannel plates. An intermediate ion detector is mounted at the spatial focusing point of a reflectron TOF-MS spectrometer portion to measure the current values of ion pulses arriving from an external ion source, as well as the elapsed times since start of travel of the ion pulses. Information obtained by the measurement is fed back to the final ion detector. Thus, the gain of the final ion detector is controlled before the ion pulses reach the final ion detector. This prevents saturation of the final ion detector. The invention can also be applied to a TOF mass spectrometer using pulsed ionization and to an electrostatic sector field TOF mass spectrometer.

摘要翻译： 公开了使用微通道板（MCP）的飞行时间（TOF）质谱仪，即使强离子脉冲撞击微通道板，也能防止饱和。 通常，饱和度将导致死区时间，去除产生的质谱的部分并缩短微通道板的寿命。 中间离子检测器安装在反射器TOF-MS光谱仪部分的空间聚焦点处，以测量从外部离子源到达的离子脉冲的电流值以及从离子脉冲开始行驶起经过的时间。 通过测量得到的信息反馈给最终的离子检测器。 因此，在离子脉冲到达最终离子检测器之前控制最终离子检测器的增益。 这可以防止最终离子检测器的饱和。 本发明也可应用于使用脉冲电离的TOF质谱仪和静电扇区场TOF质谱仪。

公开(公告)号：US06653627B2

公开(公告)日：2003-11-25

申请号：US10220602

申请日：2002-09-03

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

IPC分类号： H01J4940

CPC分类号： H01J49/004 ,  G01N27/624

摘要： Generally, the present invention provides a device for heating the sample stream inlet of an ion mobility spectrometry (IMS) sensor. The heating device increases the temperature of the sample stream inlet surface to reduce the amount of time between adsorption and desorption taking place on the surface. This greatly improves the ability of the IMS sensor to follow rapidly changing analyte concentration levels. An alternate preferred embodiment of the present invention provides a flow smoothing device for decreasing the turbulence present in the fluid flow entering the IMS sensor's carrier stream inlet. This flow smoothing insert permits increasing the fluid flow rate entering the IMS sensor's carrier stream inlet to levels which maximize the IMS sensor's measurement sensitivity without causing mixing of the sample and carrier fluid stream flows.

摘要翻译： 通常，本发明提供了用于加热离子迁移谱（IMS）传感器的样品流入口的装置。 加热装置增加了样品流入口表面的温度，以减少在表面上发生的吸附和解吸时间。 这大大提高了IMS传感器跟随快速变化的分析物浓度水平的能力。 本发明的替代优选实施例提供一种用于减少流入IMS传感器的载体流入口的流体流中存在的湍流的流动平滑装置。 这种流动平滑插入件允许将进入IMS传感器的载体流入口的流体流速增加到使得传感器的测量灵敏度最大化的水平，而不引起样品和载体流体流流的混合。

公开(公告)号：US06630663B2

公开(公告)日：2003-10-07

申请号：US09176561

申请日：1998-10-21

申请人： J. Brian Murphy ,  Clifford A. Megerle ,  Carl W. Townsend

发明人： J. Brian Murphy ,  Clifford A. Megerle ,  Carl W. Townsend

IPC分类号： H01J4940

CPC分类号： G01N27/622

摘要： An ion mobility spectrometer includes a housing with a flow channel, an air pump to force air through the flow channel, a heater at an inlet end of the flow channel, and an ionization source that ionizes the air after it is heated. The heated, ionized air passes through an electric field produced by a field source and a plurality of sensor elements located within in the wall of the flow channel in the measurement region of the electric field. The sensor elements include a plurality of sensor electrodes in one wall of the flow channel. Ion currents to the sensor electrodes are measured by an integrated high-sensitivity readout circuit array, permitting the sensor electrodes to be quite small. The sensor electrodes may be arranged in one-dimensional or two-dimensional arrays.

摘要翻译： 离子迁移谱仪包括具有流动通道的壳体，用于迫使空气通过流动通道的空气泵，在流动通道的入口端处的加热器，以及在加热之后使空气电离的离子源。 加热的电离空气通过场电源和位于电场测量区域内的流动通道壁内的多个传感器元件产生的电场。 传感器元件包括在流动通道的一个壁中的多个传感器电极。 通过集成的高灵敏度读出电路阵列测量传感器电极的离子电流，允许传感器电极相当小。 传感器电极可以被布置成一维或二维阵列。

公开(公告)号：USRE38138E1

公开(公告)日：2003-06-10

申请号：US09686194

申请日：2000-10-06

申请人： David H. Holkeboer ,  Robert E. Ellefson

发明人： David H. Holkeboer ,  Robert E. Ellefson

IPC分类号： H01J4940

CPC分类号： H01J49/0027 ,  G01L21/30 ,  H01J41/10 ,  H01J49/02 ,  H01J49/42

摘要： A method for linearizing the sensitivity of a quadrupole mass spectrometric system to allow the sensor to more accurately report partial pressures of a gas in high pressure areas in which the reported data is effected by a number of loss mechanisms. According to the invention, correction factors can be applied empirically or software in a quadrupole mass analyzer system can be equipped with correcting software to expand the useful range of the mass spectrometer.

摘要翻译： 用于线性化四极质谱系统的灵敏度的方法，以允许传感器更准确地报告高压区域中的气体的分压，其中通过多种损失机制实现所报告的数据。 根据本发明，校正因子可以经验地应用，或者在四极质谱仪系统中的软件可以配备校正软件来扩大质谱仪的有用范围。

公开(公告)号：US06369383B1

公开(公告)日：2002-04-09

申请号：US09639145

申请日：2000-08-16

申请人： Timothy J. Cornish ,  Harry K. Charles ,  Paul D. Wienhold

发明人： Timothy J. Cornish ,  Harry K. Charles ,  Paul D. Wienhold

IPC分类号： H01J4940

CPC分类号： H01J49/405 ,  G21K1/06 ,  H05K1/118 ,  H05K3/0014 ,  H05K2201/09018 ,  H05K2203/1327

摘要： A novel technique utilizing the precision of printed circuit board design and the physical versatility of thin, flexible substrates is disclosed to produce a new type of ion reflector. A precisely defined series of thin conductive strips (traces) are etched onto a flat, flexible circuit board substrate. Preferably, the thin conductive strips are further apart at one end of the substrate and get increasingly closer towards the other end of the substrate. The flexible substrate is then rolled into a tube to form the reflector body, with the conductive strips forming the rings of the ion reflector. The spacing between the traces, and hence the ring spacing, can be readily varied by adjusting the conductor pattern on the substrate sheet during the etching process. By adjusting the spacing between the rings, the characteristics of the field created by the reflectron can be easily customized to the needs of the user.

摘要翻译： 公开了一种利用印刷电路板设计的精确性和薄的柔性基板的物理通用性的新技术，以产生新型的离子反射器。 将精确定义的一系列薄导电条（迹线）蚀刻到平坦，柔性的电路板基板上。 优选地，薄导电条在衬底的一端处进一步分开，并且越来越靠近衬底的另一端。 然后将柔性基材卷成管以形成反射体，导电条形成离子反射体的环。 通过在蚀刻工艺期间调节衬底片上的导体图案，可以容易地改变迹线之间的间隔以及因此的环间隔。 通过调整环之间的间距，可以根据用户的需要轻松定制由反射镜产生的场的特性。

公开(公告)号：US06316768B1

公开(公告)日：2001-11-13

申请号：US08818376

申请日：1997-03-14

申请人： Alan L. Rockwood ,  Larry J. Davis ,  Jeffrey L. Jones ,  Edgar D. Lee

发明人： Alan L. Rockwood ,  Larry J. Davis ,  Jeffrey L. Jones ,  Edgar D. Lee

IPC分类号： H01J4940

CPC分类号： H01J49/40 ,  H05K1/0218 ,  H05K1/14 ,  H05K2201/047

摘要： The present invention is embodied in a method and apparatus for utilizing inherently insulative material, such as the glass and epoxy resins used in construction of printed circuit boards, for construction of components in a time of flight mass spectrometer. By using printed circuit board materials, the present invention can take advantage of fabrication techniques for providing circuit traces on surfaces, from one side to another as a via, or embedded within the printed circuit material so as to be covered except where necessary to be exposed to make contact with other electrical devices. Embedded circuit traces also enable capacitive coupling to AC energy while maintaining electrical and physical isolation. Consequently, the present invention enables both invasive and non-invasive access to pressure and vacuum chambers.

摘要翻译： 本发明在用于构建印刷电路板中的玻璃和环氧树脂等固有绝缘材料的飞行时间质谱仪中构成部件的方法和装置中体现。 通过使用印刷电路板材料，本发明可以利用制造技术，用于在表面上提供电路迹线，从一侧到另一侧作为通孔，或嵌入在印刷电路材料内，以便被覆盖，除非需要暴露 与其他电气设备接触。 嵌入式电路迹线还可以实现电容耦合到交流能量，同时保持电气和物理隔离。 因此，本发明能够使侵入式和非侵入性地进入压力和真空室。

公开(公告)号：US06239428B1

公开(公告)日：2001-05-29

申请号：US09517041

申请日：2000-03-02

申请人： Roderick R. Kunz

发明人： Roderick R. Kunz

IPC分类号： H01J4940

CPC分类号： G01N27/622

摘要： Ion mobility spectrometer systems and methods of using such systems are disclosed. The systems and methods can combine two different ionization techniques (e.g., proton affinity ionization and electron transfer ionization) to provide enhanced detection sensitivity and/or detection selectivity of certain target compounds.

摘要翻译： 公开了离子迁移谱仪系统和使用这种系统的方法。 系统和方法可以组合两种不同的电离技术（例如，质子亲和电离和电子转移电离）以提供某些目标化合物的增强的检测灵敏度和/或检测选择性。

公开(公告)号：US06831273B2

公开(公告)日：2004-12-14

申请号：US10628753

申请日：2003-07-28

申请人： Anthony Jenkins ,  William J. McGann

发明人： Anthony Jenkins ,  William J. McGann

IPC分类号： H01J4940

CPC分类号： G01N27/622

摘要： An apparatus is provided for detecting whether substances of interest are present in a sample of air. The apparatus includes a detector, such as an ion trap mobility spectrometer. The detector is operated at a high drift voltage and then is switched to a low drift voltage. Spectra are collected at the high and low field strengths and are compared with standard spectra at those strengths to determine whether materials of interest are present.