公开(公告)号：US20180193425A1

公开(公告)日：2018-07-12

申请号：US15867829

申请日：2018-01-11

申请人： ARES TRADING S.A.

发明人： ALENA ZALUTSKAYA ,  JOHN GOURLEY ,  NICOLAS CHOMONT ,  JEAN-PIERRE ROUTY ,  STEVEN DEEKS

IPC分类号： A61K38/27 ,  A61P31/18 ,  A61K31/52 ,  A61K31/708 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/675 ,  A61K31/496 ,  A61K31/536 ,  A61K31/505 ,  A61K31/551 ,  A61K31/341

CPC分类号： A61K38/27 ,  A61K31/341 ,  A61K31/496 ,  A61K31/505 ,  A61K31/52 ,  A61K31/536 ,  A61K31/551 ,  A61K31/675 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/708 ,  A61P31/18

摘要： The subject invention pertains to methods of treating HIV-1 infected subject comprising the administration of growth hormone to a subject infected by HIV-1. The subject may be undergoing co-administration of anti-retroviral therapies (ARTs), may be untreated with anti-retroviral drugs (ARDs) or may be in a period of time where no ART is being administered. Growth hormone may be administered at a fixed dosage for a set period of time or may be administered at a first dosage for a first period of time that may then be increased or decreased to a second dosage for a second period of time.

公开(公告)号：US20180085370A1

公开(公告)日：2018-03-29

申请号：US15659526

申请日：2017-07-25

申请人： Gilead Sciences, Inc.

发明人： Manoj C. Desai ,  Randall L. Halcomb ,  Paul Hrvatin ,  Hon Chung Hui ,  Ryan McFadden ,  Paul A. Roethle ,  Hong Yang

IPC分类号： A61K31/519 ,  A61K38/21 ,  C07D475/06 ,  A61K38/16 ,  A61K31/708 ,  A61K31/7072 ,  A61K31/7056 ,  A61K31/683 ,  A61K31/573 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/551 ,  A61K31/527 ,  C07D403/12 ,  C07D475/10 ,  C07D487/04 ,  C07D475/12 ,  C07D475/08

CPC分类号： A61K31/519 ,  A61K31/527 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/573 ,  A61K31/683 ,  A61K31/7056 ,  A61K31/7072 ,  A61K31/708 ,  A61K38/16 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  C07D403/12 ,  C07D475/06 ,  C07D475/08 ,  C07D475/10 ,  C07D475/12 ,  C07D487/04 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/391 ,  Y02A50/393 ,  Y02A50/395

摘要： Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

公开(公告)号：US20180085359A1

公开(公告)日：2018-03-29

申请号：US15710436

申请日：2017-09-20

申请人： CHILDREN'S MEDICAL CENTER CORPORATION ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： Larry I. Benowitz ,  Stephen J. Lippard ,  Paul Rosenberg ,  Yiqing Li ,  Zhen Huang

IPC分类号： A61K31/444 ,  A61K31/198 ,  A61K31/708 ,  A61K31/716 ,  A61K45/06

CPC分类号： A61K31/444 ,  A61K31/198 ,  A61K31/708 ,  A61K31/716 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, Also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. Examples of such chelating agents are provided.

公开(公告)号：US09913856B2

公开(公告)日：2018-03-13

申请号：US15174386

申请日：2016-06-06

申请人： Astex Pharmaceuticals, Inc.

发明人： Rajashree Joshi-Hangal ,  Chunlin Tang ,  Sanjeev Redkar ,  Harish Ravivarapu

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/7084 ,  A61K31/706 ,  A61K31/7056 ,  A61K31/7064 ,  A61K31/7052 ,  A61K9/00 ,  A61K47/10 ,  A61K47/20 ,  A61K9/19 ,  A61K31/708

CPC分类号： A61K31/7084 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/708 ,  A61K47/10 ,  A61K47/20

摘要： The invention provides derivatives of decitabine with superior chemical stability and shelf life, with similar physiological activity. The derivatives are provided in a non-aqueous formulation, which further stabilizes the derivatives. Methods of treating one or more myelodysplastic syndromes, leukemia, or solid tumours using the formulations are described.

公开(公告)号：US20170209447A1

公开(公告)日：2017-07-27

申请号：US15329269

申请日：2014-12-19

申请人： Nitor Therapeutics

发明人： Shanta Bantia

IPC分类号： A61K31/519 ,  A61K35/17 ,  A61K31/708

CPC分类号： A61K31/519 ,  A61K31/522 ,  A61K31/708 ,  A61K35/17 ,  A61K39/00 ,  A61K45/06 ,  A61K2300/00

摘要： Compositions and methods including at least one PNP inhibitor or at least one PNP inhibitor in combination with guanosine identified as endogenous adjuvant useful to enhance Graft versus Malignancy effects in patients, with relapse of malignancy after hematopoietic stem cell transplantation, to reverse or prevent relapse or progression of malignancy. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits.

公开(公告)号：US20170088577A1

公开(公告)日：2017-03-30

申请号：US15379415

申请日：2016-12-14

申请人： Idenix Pharmaceuticals LLC ,  Universita degli Studi di Cagliari ,  Centre National De La Recherche Scientifique ,  Universite de Montpellier

发明人： Richard STORER ,  Gilles GOSSELIN ,  Jean-Pierre SOMMADOSSI ,  Paolo LACOLLA

IPC分类号： C07H19/16 ,  A61K38/21 ,  A61K9/20 ,  A61K9/48 ,  C07H19/056 ,  A61K31/7068 ,  A61K31/7076 ,  A61K31/7072 ,  A61K31/7056 ,  A61K31/708 ,  A61K45/06 ,  C07H19/06

CPC分类号： C07H19/16 ,  A61K9/20 ,  A61K9/48 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  A61K47/60 ,  C07H19/00 ,  C07H19/04 ,  C07H19/048 ,  C07H19/056 ,  C07H19/06 ,  C07H19/22 ,  A61K2300/00

摘要： 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

公开(公告)号：US09603863B2

公开(公告)日：2017-03-28

申请号：US14746138

申请日：2015-06-22

申请人： ALIOS BIOPHARMA, INC.

发明人： Lawrence M. Blatt ,  Leonid Beigelman ,  Natalia Dyatkina ,  Julian Alexander Symons ,  David Bernard Smith

IPC分类号： A61K31/70 ,  A01N43/04 ,  A61K31/708 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076

CPC分类号： A61K31/7068 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708

摘要： Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

公开(公告)号：US09596876B2

公开(公告)日：2017-03-21

申请号：US14973166

申请日：2015-12-17

申请人： N.V. Nutricia

发明人： Günther Boehm ,  Bernd Stahl ,  Jan Knol

IPC分类号： A23L1/30 ,  A61K31/7016 ,  A23C9/123 ,  A23C9/20 ,  A61K31/202 ,  A61K31/702 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/732 ,  A61K31/734 ,  A61K35/745 ,  A61K35/747 ,  A61K35/74 ,  A61K47/36 ,  A61K31/7064

CPC分类号： A23L33/21 ,  A23C9/1234 ,  A23C9/203 ,  A23C9/206 ,  A23L29/065 ,  A23L33/10 ,  A23L33/12 ,  A23L33/135 ,  A23L33/17 ,  A23L33/40 ,  A23V2002/00 ,  A23Y2220/85 ,  A23Y2300/19 ,  A23Y2300/21 ,  A23Y2300/25 ,  A23Y2300/29 ,  A23Y2300/31 ,  A23Y2300/41 ,  A23Y2300/45 ,  A23Y2300/49 ,  A23Y2300/55 ,  A23Y2300/59 ,  A23Y2300/65 ,  A61K31/202 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/732 ,  A61K31/734 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K47/36 ,  Y02A50/473 ,  Y02A50/475 ,  A23V2200/32 ,  A23V2200/3204 ,  A23V2200/3202 ,  A23V2200/30 ,  A23V2200/324 ,  A23V2250/28 ,  A61K2300/00

摘要： The present invention relates to methods for feeding and to compositions to be administered to infants delivered via caesarian section and in particular to the use of a) at least two different microorganisms; or b) at least one microorganism and at least one indigestible oligosaccharide; or c)at least two different Bifidobacteria species, subspecies or strains for the manufacture of a composition for enteral administration to an infant delivered via caesarean section. Thereby it is possible to stimulate the healthy development of the intestinal flora of said infants.

公开(公告)号：US09549942B2

公开(公告)日：2017-01-24

申请号：US14330583

申请日：2014-07-14

申请人： RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

发明人： Dong Gyu Jo ,  Jong Sung Park ,  Youngkwang Youn ,  Yuri Choi ,  Ui Jeong Yun

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/7076 ,  A61K31/155 ,  A61K31/045 ,  A61K31/165 ,  A61K31/4184 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/708 ,  A61K31/7064

CPC分类号： A61K31/7076 ,  A23L33/10 ,  A61K31/045 ,  A61K31/155 ,  A61K31/165 ,  A61K31/4184 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/708

摘要： The present disclosure relates to a pharmaceutical composition, a health functional food composition, and a method for preventing or treating a brain disease or diabetes. The pharmaceutical composition, health functional food composition, and method includes at least one active ingredient that is chlorhexidine, thioguanosine, mebendazole, fenbendazole, colchicine, farnesol, trimethobenzamide hydrochloride, disulfuram, azathioprine, mebeverine hydrochloride, zaprinast, tosufloxacin hydrochloride, efavirenz, thiostrepton, probenecid, entacapone, harmine hydrochloride, flunisolide, thimerosal, hexestrol, sulfaquinoxaline sodium salt, monensin sodium salt, raloxifene hydrochloride, 2-chloropyrazine, or topotecan.

摘要翻译： 本公开涉及药物组合物，健康功能性食品组合物，以及预防或治疗脑病或糖尿病的方法。 药物组合物，健康功能食品组合物和方法包括至少一种活性成分，其为氯己定，硫鸟苷，甲苯达唑，芬苯达唑，秋水仙素，法尼醇，盐酸三苯甲酰胺，二磺酰胺，硫唑嘌呤，盐酸美贝维素，卡普拉斯特，盐酸妥福辛，依法韦仑，硫代三环素， 丙磺舒，恩他卡朋，盐酸海洛芬，氟尼缩松，硫柳汞，己烯雌酚，磺喹喹啉钠盐，莫能菌素钠盐，雷洛昔芬盐酸盐，2-氯吡嗪或托泊替康。

公开(公告)号：US09445596B2

公开(公告)日：2016-09-20

申请号：US14237774

申请日：2012-08-08

申请人： Frank C. Schroeder ,  Stephan H. von Reuss ,  Andrea Choe ,  Paul W. Sternberg

发明人： Frank C. Schroeder ,  Stephan H. von Reuss ,  Andrea Choe ,  Paul W. Sternberg

IPC分类号： C07H15/04 ,  C07H15/10 ,  C07H15/18 ,  A01N63/02 ,  A01N47/36 ,  A01N37/46 ,  A61K31/7076 ,  A61K31/708 ,  A01N43/90 ,  C07H19/16 ,  A01N43/16 ,  A01N43/38

CPC分类号： A01N43/90 ,  A01N37/46 ,  A01N43/16 ,  A01N43/38 ,  A01N47/36 ,  A01N63/02 ,  A61K31/7076 ,  A61K31/708 ,  C07H15/04 ,  C07H15/10 ,  C07H15/18 ,  C07H19/16

摘要： The present invention relates to compounds involved in nematode signaling.

摘要翻译： 本发明涉及涉及线虫信号传导的化合物。