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    Compound heparin anticoagulant coating liquid, a microsphere for coating and its preparation methods and applications
    42.
    发明授权
    Compound heparin anticoagulant coating liquid, a microsphere for coating and its preparation methods and applications 有权

    公开(公告)号：US11083824B2

    公开(公告)日：2021-08-10

    申请号：US16691688

    申请日：2019-11-22

    申请人： WUHAN YOUNGSEN BIOTECH CO., LTD

    发明人： Tuo Yan ,  Chenxi Ouyang ,  Yawen Liu ,  Sishi Liu ,  Yuan Liu

    IPC分类号： A61L33/00 ,  A61L33/04 ,  A61L33/12

    摘要： The present invention discloses a compound heparin anticoagulant coating liquid, a microsphere for coating and its preparation methods and applications. In the present invention, the combination of curcumin and heparin can enhance the anticoagulation functions of heparin coating, and further enhance the stability using the properties of PLA-PEG-PLA drug-loaded sustained-release microspheres, achieving the functions of anti-tissue proliferation and anti-inflammatory reactions that cannot be achieved by coatings alone such as heparin or protein, which is very important for implanted devices such as artificial blood vessels, vascular stents and vascular patches to reduce thrombosis in the human body, lower postoperative complications and improve product lifespan.

    Antithrombotic metallic material
    43.
    发明授权
    Antithrombotic metallic material 有权

    公开(公告)号：US10709822B2

    公开(公告)日：2020-07-14

    申请号：US15562324

    申请日：2016-03-31

    申请人： Toray Industries, Inc.

    发明人： Koji Kadowaki ,  Masaki Fujita ,  Yuka Sakaguchi ,  Kazuhiro Tanahashi

    IPC分类号： A61L33/00 ,  A61L33/06 ,  A61L33/04 ,  A61L31/10

    摘要： An antithrombogenic metallic material includes a metallic material whose surface is coated with a coating material, the coating material containing: a phosphonic acid derivative or a catechol derivative; a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride; and an anionic compound containing a sulfur atom and having anticoagulant activity; the polymer being covalently bound to the phosphonic acid derivative or the catechol derivative, the phosphonic acid derivative or the catechol derivative being bound to the metallic material through a phosphonic acid group or a catechol group thereof, wherein the abundance ratio of nitrogen atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on the surface is 4.0 to 13.0 atomic percent.

    COMPOUND HEPARIN ANTICOAGULANT COATING LIQUID, A MICROSPHERE FOR COATING AND ITS PREPARATION METHODS AND APPLICATIONS
    44.
    发明申请
    COMPOUND HEPARIN ANTICOAGULANT COATING LIQUID, A MICROSPHERE FOR COATING AND ITS PREPARATION METHODS AND APPLICATIONS 审中-公开

    公开(公告)号：US20200086012A1

    公开(公告)日：2020-03-19

    申请号：US16691688

    申请日：2019-11-22

    申请人： WUHAN YOUNGSEN BIOTECH CO., LTD.

    发明人： TUO YAN ,  CHENXI OUYANG ,  YAWEN LIU ,  SISHI LIU ,  YUAN LIU

    IPC分类号： A61L33/00 ,  A61L33/12 ,  A61L33/04

    摘要： The present invention discloses a compound heparin anticoagulant coating liquid, a microsphere for coating and its preparation methods and applications. In the present invention, the combination of curcumin and heparin can enhance the anticoagulation functions of heparin coating, and further enhance the stability using the properties of PLA-PEG-PLA drug-loaded sustained-release microspheres, achieving the functions of anti-tissue proliferation and anti-inflammatory reactions that cannot be achieved by coatings alone such as heparin or protein, which is very important for implanted devices such as artificial blood vessels, vascular stents and vascular patches to reduce thrombosis in the human body, lower postoperative complications and improve product lifespan.

    ANTITHROMBOTIC METALLIC MATERIAL
    45.
    发明申请
    ANTITHROMBOTIC METALLIC MATERIAL 审中-公开

    公开(公告)号：US20180344906A1

    公开(公告)日：2018-12-06

    申请号：US15562324

    申请日：2016-03-31

    申请人： Toray Industries, Inc.

    发明人： Koji Kadowaki ,  Masaki Fujita ,  Yuka Sakaguchi ,  Kazuhiro Tanahashi

    IPC分类号： A61L33/00 ,  A61L33/06 ,  A61L33/04

    摘要： An antithrombogenic metallic material includes a metallic material whose surface is coated with a coating material, the coating material containing: a phosphonic acid derivative or a catechol derivative; a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride; and an anionic compound containing a sulfur atom and having anticoagulant activity; the polymer being covalently bound to the phosphonic acid derivative or the catechol derivative, the phosphonic acid derivative or the catechol derivative being bound to the metallic material through a phosphonic acid group or a catechol group thereof, wherein the abundance ratio of nitrogen atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on the surface is 4.0 to 13.0 atomic percent.

    MEDICAL DEVICE
    48.
    发明申请
    MEDICAL DEVICE 审中-公开
    医疗装置

    公开(公告)号：US20140171347A1

    公开(公告)日：2014-06-19

    申请号：US14186276

    申请日：2014-02-21

    申请人： TERUMO KABUSHIKI KAISHA

    发明人： Hiromasa Kohama ,  Kenichi Shimura ,  Satoshi Sawada

    IPC分类号： A61L33/04

    CPC分类号： A61L33/04 ,  A61L29/041 ,  A61L29/085 ,  A61L29/145 ,  A61L2400/10 ,  A61M2025/0046 ,  F04C2270/041 ,  C08L23/06 ,  C08L71/02

    摘要： A medical device of which the surface exhibits lubricity and/or antithrombotic activity when wet. The medical device includes a base material layer, and a hydrophilic layer that is supported on at least a portion of the base material layer, in which the hydrophilic layer is obtained by forming a crosslinked structure by reacting a compound having plural thiol groups in a molecule with a compound having reactive functional groups binding to the thiol group and hydrophilic groups in a molecule, and the reactive functional groups are thiol groups, alkenyl groups, acryl groups, or methacryl groups.

    摘要翻译： 一种医疗装置，其表面在湿润时表现出润滑性和/或抗血栓活性。 医疗装置包括基材层和亲水层，所述亲水层被支撑在基材层的至少一部分上，通过在分子中使具有多个硫醇基的化合物反应形成交联结构而获得亲水层 具有与硫醇基结合的反应性官能团的化合物和分子中的亲水基团，反应性官能团是硫醇基，烯基，丙烯酰基或甲基丙烯酰基。