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    Tricyclic condensed heterocyclic compound, process of producing same, and use thereof
    41.
    发明授权
    Tricyclic condensed heterocyclic compound, process of producing same, and use thereof 有权
    三环稠合杂环化合物，其制备方法及其用途

    公开(公告)号：US09376415B2

    公开(公告)日：2016-06-28

    申请号：US13259227

    申请日：2010-03-24

    申请人： Seizo Sato ,  Fumie Iwata ,  Shoichi Yamada ,  Jiro Takeo ,  Akihisa Abe ,  Hiroyuki Kawahara

    发明人： Seizo Sato ,  Fumie Iwata ,  Shoichi Yamada ,  Jiro Takeo ,  Akihisa Abe ,  Hiroyuki Kawahara

    IPC分类号： C07D307/77 ,  C12P17/04 ,  C12R1/465

    CPC分类号： C07D307/93 ,  C07D307/77 ,  C12P17/04 ,  C12R1/465

    摘要： A compound derived from the culture product of an actinomycete and having an antitumor activity is provided. Provided is a compound represented by any one of formulas (I), (II) and (III)or an optical isomer thereof or a pharmaceutically acceptable salt thereof which can be isolated from the culture fluid of an actinomycete which belongs to the genus Streptomyces, wherein R1, R2, R5 and R6 each independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyl group, or a double bond by which R1 and R2 or R5 and R6 are bonded; R3, R4, R7 and R8 each independently represent a methyl group or a hydroxymethyl group; and R9 represents a hydrogen atom or a hydroxyl group.

    摘要翻译： 提供了源自放线菌培养物并具有抗肿瘤活性的化合物。 提供可以从属于链霉菌属的放线菌的培养液中分离的由式（I），（II）和（III）中的任何一种表示的化合物或其旋光异构体或其药学上可接受的盐， 其中R1，R2，R5和R6各自独立地表示氢原子，甲基，羟甲基，羟基或R1和R2或R5和R6键合的双键; R 3，R 4，R 7和R 8各自独立地表示甲基或羟甲基; 并且R 9表示氢原子或羟基。

    ENZYMES FOR PRODUCING NON-STRAIGHT-CHAIN FATTY ACIDS
    42.
    发明申请
    ENZYMES FOR PRODUCING NON-STRAIGHT-CHAIN FATTY ACIDS 审中-公开
    生产非直链脂肪酸的酶

    公开(公告)号：US20150376659A1

    公开(公告)日：2015-12-31

    申请号：US14755213

    申请日：2015-06-30

    申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

    发明人： Rachelle A.S. Lemke ,  Timothy James Donohue ,  Joshua J. Coon ,  Amelia C. Peterson ,  Michael S. Westphall

    IPC分类号： C12P7/64 ,  C12P17/04

    CPC分类号： C12P7/6409 ,  C12N9/1007 ,  C12P17/04

    摘要： Enzymes for producing non-straight-chain fatty acids, microorganisms comprising the enzymes, and in vivo and in vitro uses of the enzymes. Provided are enzymes capable of producing various non-straight-chain fatty acids, including branched-chain fatty acids, cyclic fatty acids, and furan-containing fatty acids. The enzymes include RSP2144, RSP1091, and RSP1090 from Rhodobacter sphaeroides and homologs thereof. The enzymes can be purified to produce non-straight-chain fatty acids in vitro or expressed in microorganisms to produce non-straight-chain fatty acids in vivo. The microorganisms can be fine-tuned to produce a specific type of non-straight-chain fatty acid by expressing, overexpressing, or deleting the enzymes in various combinations.

    摘要翻译： 用于生产非直链脂肪酸的酶，包含酶的微生物以及酶的体内和体外应用。 提供能够产生各种非直链脂肪酸的酶，包括支链脂肪酸，环状脂肪酸和含呋喃的脂肪酸。 酶包括来自球形红细菌的RSP2144，RSP1091和RSP1090及其同系物。 可以纯化酶以在体外产生非直链脂肪酸或在微生物中表达以在体内产生非直链脂肪酸。 通过以各种组合表达，过表达或缺失酶，微生物可被微调以产生特定类型的非直链脂肪酸。

    GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND HYDROXYCORNEXISTIN
    43.
    发明申请
    GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND HYDROXYCORNEXISTIN 有权
    金丝桃素和羟基喹诺酮的生物合成基因组

    公开(公告)号：US20150275248A1

    公开(公告)日：2015-10-01

    申请号：US14441215

    申请日：2013-11-13

    申请人： BASF SE

    发明人： Oskar Zelder ,  Birgit Hoff ,  Hartwig Schroeder ,  Andrea Molt ,  Holger Hartmann ,  Klaus Ditrich ,  Michael Breuer ,  Rüdiger Reingrubber ,  Jakob Weber

    IPC分类号： C12P17/04 ,  C12N15/80

    CPC分类号： C12P17/04 ,  A01N37/42 ,  A01N37/46 ,  A01N63/04 ,  C07D307/93 ,  C07K14/37 ,  C12N15/52 ,  C12N15/67 ,  C12N15/80

    摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.

    摘要翻译： 本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。 它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。 还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

    Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
    45.
    发明授权
    Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors 有权
    1,4-丁二醇及其前体的生物合成的组合物和方法

    公开(公告)号：US08969054B2

    公开(公告)日：2015-03-03

    申请号：US13717350

    申请日：2012-12-17

    申请人： Genomatica, Inc.

    发明人： Mark J. Burk ,  Stephen J. Van Dien ,  Anthony P. Burgard ,  Wei Niu

    IPC分类号： C12P7/18 ,  C12N1/21 ,  C12P7/42 ,  C12N9/04 ,  C12N9/02 ,  C12N9/88 ,  C12N9/00 ,  C12P7/52 ,  C12P17/04

    CPC分类号： C12N15/52 ,  B01D3/002 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/88 ,  C12N9/93 ,  C12N15/70 ,  C12N15/81 ,  C12P7/18 ,  C12P7/42 ,  C12P7/52 ,  C12P17/04 ,  C12Y101/01061 ,  C12Y102/01076 ,  C12Y401/01071 ,  C12Y602/01004 ,  Y02P20/52

    摘要： The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (BDO). Additionally provided are methods for the production of 4-HB and BDO.

    摘要翻译： 本发明提供了一种非天然存在的微生物生物催化剂，其包括具有4-羟基丁酸（4-HB）生物合成途径的微生物生物，其具有至少一种编码4-羟基丁酸脱氢酶的外源核酸，琥珀酰辅酶A合成酶，CoA依赖性琥珀酸半醛 脱氢酶或α-酮戊二酸脱羧酶，其中外源核酸以足够的量表达以产生单体4-羟基丁酸（4-HB）。 还提供了非天然存在的微生物生物催化剂，其包括具有4-羟基丁酸（4-HB）和1,4-丁二醇（BDO）生物合成途径的微生物生物，该途径包括至少一种编码4-羟基丁酸脱氢酶的外源核酸 ，琥珀酰辅酶A合成酶，CoA依赖性琥珀酸半醛脱氢酶，4-羟基丁酸酯：CoA转移酶，4-丁酸酯激酶，磷酸转移酶，α-酮戊二酸脱羧酶，醛脱氢酶，醇脱氢酶或醛/醇脱氢酶，其中外源核酸为 以足够的量表示产生1,4-丁二醇（BDO）。 另外提供了用于生产4-HB和BDO的方法。

    MICROBIAL PRODUCTION OF L-ASCORBIC ACID
    49.
    发明申请
    MICROBIAL PRODUCTION OF L-ASCORBIC ACID 审中-公开
    L-抗坏血酸的微生物生产

    公开(公告)号：US20130217080A1

    公开(公告)日：2013-08-22

    申请号：US13683487

    申请日：2012-11-21

    申请人： DSM IP ASSETS B.V.

    发明人： Alan BERRY ,  Connie LEE ,  Anne Francois MAYER ,  Masako SHINJOH

    IPC分类号： C12P17/04

    CPC分类号： C12P17/04 ,  C12N9/0006 ,  C12N9/0008 ,  C12P7/60

    摘要： The present invention discloses an isolated polynucleotide molecule derived from a polynucleotide encoding a polypeptide having L-sorbosone dehydrogenase activity comprising a partial nucleotide sequence of at least 20 consecutive nucleotides of SEQ ID NO:1. The present invention further relates to a process for the production of L-ascorbic acid in high yield, in particular a process using resting cells of a microorganism able to convert given carbon sources into vitamin C. The thus obtained vitamin C may be further processed by purification and/or separation steps.

    摘要翻译： 本发明公开了衍生自编码具有L-山梨糖酮脱氢酶活性的多肽的多核苷酸的分离的多核苷酸分子，其包含SEQ ID NO：1的至少20个连续核苷酸的部分核苷酸序列。 本发明还涉及以高产率生产L-抗坏血酸的方法，特别是使用能够将给定碳源转化成维生素C的微生物的静息细胞的方法。由此获得的维生素C可以进一步由 纯化和/或分离步骤。