公开(公告)号：US11932973B2

公开(公告)日：2024-03-19

申请号：US17511641

申请日：2021-10-27

Applicant: Academia Sinica

Inventor： Chia-Fu Chou ,  Balchandar Navaneethan

IPC: D03D27/00 ,  D01D5/00

CPC classification number: D03D27/00 ,  D01D5/003 ,  D10B2331/041

Abstract: A method for manufacturing a polymer-based fibrous scaffold is disclosed. The method includes the following step: providing an electrospinning device comprising a collector; and injecting a polymer solution into the electrospinning device to produce a single jet fiber, wherein the single jet fiber is piled on the collector to form a fibrous scaffold.

公开(公告)号：US11919886B2

公开(公告)日：2024-03-05

申请号：US17811880

申请日：2022-07-12

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Chi-Huey Wong ,  Pan-Chyr Yang ,  Rong-Jie Chein ,  Szu-Hua Pan ,  Ting-Jen R. Cheng

IPC: A61K31/4025 ,  A61K31/4178 ,  C07D307/92 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

CPC classification number: C07D405/12 ,  A61K31/4025 ,  A61K31/4178 ,  C07D307/92 ,  C07D403/12 ,  C07D413/12

Abstract: The present disclosure provides compounds of Formulas (I), (II), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating proliferative diseases, for example, cancer (e.g., lung cancer), and infectious diseases (e.g., bacterial infections).

公开(公告)号：US11918975B2

公开(公告)日：2024-03-05

申请号：US16444682

申请日：2019-06-18

Applicant: Academia Sinica

Inventor： Jia-Hui Wang ,  Hao-Ju Chou ,  Po-Wen Chung

IPC: B01J20/00 ,  B01D53/02 ,  B01J20/20 ,  B01J20/28 ,  B01J20/30 ,  B01J27/02 ,  B01J31/04 ,  B01J37/20 ,  C01B32/318 ,  C01B32/354

CPC classification number: B01J20/20 ,  B01D53/02 ,  B01J20/28059 ,  B01J20/3071 ,  B01J20/3078 ,  B01J20/3085 ,  B01J27/02 ,  B01J31/04 ,  B01J37/20 ,  C01B32/318 ,  C01B32/354 ,  B01D2253/102 ,  C01P2002/72 ,  C01P2002/76 ,  C01P2002/78 ,  C01P2002/82 ,  C01P2002/85

Abstract: Disclosed is a modified carbonaceous material, which includes hexagonal carbon networks in a layered stacking structure and acidic functional groups bonded to the hexagonal carbon networks and mainly existing at edges of the layered carbonaceous structure. Accordingly, the close proximity of acid moiety at the edges can resemble the center of hydrolysis enzymes, resulting in enhancement of hydrolytic efficiency. Additionally, the acid-functionalized carbonaceous material can also be applied in the capture and storage of carbon dioxide due to its unexpectedly higher capacity for CO2 molecular.

公开(公告)号：US11879006B2

公开(公告)日：2024-01-23

申请号：US17851277

申请日：2022-06-28

Applicant: Academia Sinica

Inventor： Shang-Te Danny Hsu ,  Hui-Wen Chang ,  Chia-Yu Chang

IPC: C07K16/00 ,  C07K16/10 ,  G01N33/569

CPC classification number: C07K16/10 ,  G01N33/56983 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  G01N2333/17

Abstract: Disclosed herein is a recombinant antibody exhibiting binding affinity and/or neutralizing activity to porcine epidemic diarrhea virus (PEDV). According to some embodiments of the present disclosure, the PEDV is genotype 1 (G1) or genotype 2b (G2b) PEDV. Also disclosed herein are methods of diagnosing and treating PEDV infection by use of the present recombinant antibody.

公开(公告)号：US20240016917A1

公开(公告)日：2024-01-18

申请号：US18005573

申请日：2022-04-12

Applicant: ACADEMIA SINICA

Inventor： Che MA ,  Chi-Huey WONG ,  Han-Yi HUANG

IPC: A61K39/215 ,  A61P31/04

CPC classification number: A61K39/215 ,  A61P31/04 ,  A61K2039/55505

Abstract: The present disclosure provides a glycoengineered SARS-CoV-2 spike protein which is capable of eliciting an enhanced immune response relative to a native spike protein of SARS-CoV-2 and its variants. The glycoengineered spike protein exposes the glycosylation sites and at the same time preserves the tertiary structure of the spike protein. The present disclosure therefore provides improved immunogens, vaccines, and methods for better prevention and treatment of the emerging coronavirus infections.

公开(公告)号：US11858965B2

公开(公告)日：2024-01-02

申请号：US17327514

申请日：2021-05-21

Applicant: ACADEMIA SINICA

Inventor： Wen-Hsiung Li ,  Anandharaj Marimuthu ,  Jui-Jen Chang ,  Yu-Ju Lin ,  Rizwana Parveen Rani Mohamed Gobil ,  Chieh-Chen Huang

IPC: C07K14/195 ,  C12P7/06 ,  C12P19/02 ,  C12N9/42 ,  C12N9/02 ,  C12P19/14

CPC classification number: C07K14/195 ,  C12N9/0069 ,  C12N9/2437 ,  C12P7/06 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01004 ,  C07K2319/00

Abstract: The present disclosure relates to a recombinant protein comprising a plurality of type II cohesin repeats. The present disclosure provides a recombinant cellulosome complex comprising: the recombinant protein comprising a plurality of type II cohesin repeats; a recombinant cellulosome complex integrating protein A comprising a plurality of type I cohesin repeats, a plurality of cellulose-binding modules and a type II dockerin; and a plurality of recombinant enzymes each comprising a type I dockerin. A cell, a method for digesting a cellulose and a method for producing ethanol are also provided.

公开(公告)号：US11826307B2

公开(公告)日：2023-11-28

申请号：US17019437

申请日：2020-09-14

Applicant: Academia Sinica

Inventor： Fu-Liang Yang ,  Chang-Kuei Chung

IPC: A61H9/00

CPC classification number: A61H9/0092 ,  A61H2201/1409 ,  A61H2201/5046 ,  A61H2201/5092 ,  A61H2209/00 ,  A61H2230/045

Abstract: An external counter pulsation system (ECP) and method for using the system to improve circulation as well as cardiovascular related diseases. The ECP system of the present invention comprises a helical air bladder for modulating blood flow of major veins and arteries of the thigh. High efficiency is realized with the helical shape of the air bladder to lower the cost, weight and size of the ECP of the present invention.

公开(公告)号：US11789251B2

公开(公告)日：2023-10-17

申请号：US17592211

申请日：2022-02-03

Applicant: ACADEMIA SINICA

Inventor： Jung-Chi Liao ,  Yi-De Chen ,  Chih-Wei Chang ,  Weng Man Chong

IPC: G02B21/36 ,  G02B21/26 ,  G02B21/06 ,  G06V10/25 ,  G06V10/141 ,  G06V20/69 ,  H04N23/56 ,  H04N23/74

CPC classification number: G02B21/365 ,  G02B21/06 ,  G02B21/26 ,  G06V10/141 ,  G06V10/25 ,  G06V20/693 ,  H04N23/56 ,  H04N23/74

Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.

公开(公告)号：US11781124B2

公开(公告)日：2023-10-10

申请号：US17094623

申请日：2020-11-10

Applicant: ACADEMIA SINICA

Inventor： Jui-Jen Chang ,  Caroline Thia ,  Hao-Yeh Lin ,  Yu-Ju Lin ,  Chieh-Chen Huang ,  Wen-Hsiung Li

IPC: C12N9/14 ,  C12P23/00 ,  C12N15/81

CPC classification number: C12N9/14 ,  C12N15/815 ,  C12P23/00

Abstract: Disclosed herein are recombinant polynucleotide sequences, vectors, host cells and methods for producing astaxanthin. The recombinant polynucleotide sequence is designed to provide a higher level of astaxanthin precursors via a shorter metabolic pathway, and thereby attains higher level of end products (e.g., astaxanthin) with desired stereoisomeric form and/or esterified form.

公开(公告)号：US11771651B2

公开(公告)日：2023-10-03

申请号：US17586807

申请日：2022-01-28

Applicant: Academia Sinica

Inventor： Hsien-Ming Lee ,  Hua-De Gao ,  Jia-Lin Hong ,  Chih-Yu Kuo ,  Cheng-Bang Jian

IPC: A61K9/127 ,  A61K47/69 ,  A61K47/65

CPC classification number: A61K9/1271 ,  A61K47/65 ,  A61K47/6911

Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.