Patent search ap:"Acucela Inc." Page 6

51.

外观设计
Optical coherence tomography system 有权

公开(公告)号：USD950618S1

公开(公告)日：2022-05-03

申请号：US29718289

申请日：2019-12-23

Applicant: ACUCELA INC.

Designer： Karim Haroud , Matthias Pfister , Jean-Christophe Roulet , Stefan Troller , Jacob Schubert

52.

发明申请
INHIBITORS OF VAP-1 有权

公开(公告)号：US20220024915A1

公开(公告)日：2022-01-27

申请号：US17279422

申请日：2019-09-27

Applicant: ACUCELA INC.

Inventor： Mark W. ORME , Edison S. ZUNIGA , Vladimir A. KUKSA , Russell Stuart CRAFT , Eduardo Moreno SAVEEDRA , Johannes Wilhelm Georg MEISSNER , Jacobus Antonius Joseph den HARTOG , Albert Cornelis DROS

IPC: C07D471/04 , C07D487/04

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

53.

发明申请
APPARATUS AND METHODS FOR THE TREATMENT OF REFRACTIVE ERROR USING ACTIVE STIMULATION 有权

公开(公告)号：US20210389607A1

公开(公告)日：2021-12-16

申请号：US17303889

申请日：2021-06-09

Applicant: ACUCELA INC.

Inventor： Philip M. BUSCEMI , Ryo KUBOTA

IPC: G02C7/04 , G02B27/01 , G02C7/14

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

54.

发明申请
STICK ON DEVICES USING PERIPHERAL DEFOCUS TO TREAT PROGRESSIVE REFRACTIVE ERROR 有权

公开(公告)号：US20210382326A1

公开(公告)日：2021-12-09

申请号：US17304630

申请日：2021-06-23

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA , Philip M. BUSCEMI , Amitava GUPTA , Stefan BAUER , Benjamin CROOK , Julien SAUVET

IPC: G02C7/08 , G02C7/06 , G02C7/02 , G02C7/14 , G02C7/10

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

55.

发明申请
LENS WITH ASYMMETRIC PROJECTION TO TREAT ASTIGMATISM 有权

公开(公告)号：US20210379399A1

公开(公告)日：2021-12-09

申请号：US17304666

申请日：2021-06-24

Applicant: ACUCELA INC.

Inventor： Philip M. BUSCEMI , Ryo KUBOTA

IPC: A61N5/06

Abstract: A stimulus is configured to treat astigmatism with changes in retinal thickness, independently of, or in combination with, treatment for myopia. In some embodiments, a stimulus pattern is arranged with respect to an astigmatic axis of the eye to decrease ocular growth in relation to the astigmatic axis. In some embodiments, the apparatus is configured to direct light to regions of retina outside the macula in relation to the astigmatic axis of the eye. In some embodiments, the intensity is modulated to provide the effect. A lens, such as a contact lens or spectacle lens may be configured with a plurality of light sources, such as projection units having a light source and focusing optics that work together to project anteriorly or posteriorly defocused images onto the retina at locations eccentric to the fovea.

56.

发明授权
Methods for the treatment of diabetic retinopathy and other ophthalmic diseases 有权

公开(公告)号：US10730825B2

公开(公告)日：2020-08-04

申请号：US15967080

申请日：2018-04-30

Applicant: Acucela Inc.

Inventor： Claes Olof Bavik , Susan Hayes Henry , Ryo Kubota , Vladimir A. Kuksa

IPC: A61K31/138 , A61K45/06 , A61K31/137 , A61K31/35 , A61K31/765 , C07C215/08 , C07C211/27 , C07C217/20 , C07C323/32 , C07D309/06

Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

57.

发明授权
Alkoxy compounds for disease treatment 有权

公开(公告)号：US09458088B2

公开(公告)日：2016-10-04

申请号：US14631763

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, Jr. , Anna Gall , Feng Hong

IPC: C09B11/02 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33

CPC classification number: A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

58.

发明申请
STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开
Title translation: 用于治疗眼底疾病和疾病的苯乙烯衍生化合物

公开(公告)号：US20150238497A1

公开(公告)日：2015-08-27

申请号：US14631711

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott , Vladimir Aleksandrovich Kuksa , Anna Gall , Mark W. Orme , Jennifer Gage , Thomas L. Little, JR. , Qin Jiang , Lana Michele Rossiter , Kevin F. McGee, JR. , Ryo Kubota

IPC: A61K31/5375 , A61K31/40 , A61K31/145 , A61K31/495 , A61K31/167 , A61K31/137 , A61K31/4453

CPC classification number: A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Abstract translation: 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。本文提供了苯乙烯衍生物化合物，包括但不限于二苯乙烯衍生物化合物，以及包含这些化合物的组合物，其可用于治疗和预防眼科疾病和病症，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。