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公开(公告)号：US20120213831A1
公开(公告)日：2012-08-23
申请号：US13462004
申请日：2012-05-02
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
IPC分类号： A61K9/14 , A61K31/4375 , A61K49/18 , A61K31/704 , A61P35/00 , B82Y5/00 , B82B1/00
CPC分类号： A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
摘要翻译： 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US08142815B2
公开(公告)日：2012-03-27
申请号：US10919257
申请日：2004-08-17
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.
摘要翻译： 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。
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53.发明授权公开(公告)号：US07670592B2
公开(公告)日：2010-03-02
申请号：US12348867
申请日：2009-01-05
申请人： Egisto Boschetti
发明人： Egisto Boschetti
IPC分类号： A61K49/00
CPC分类号： A61K9/1635 , A61K47/6927
摘要： The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.
摘要翻译： 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及聚乙烯醇微球的制造方法。
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公开(公告)号：US07591993B2
公开(公告)日：2009-09-22
申请号：US10692785
申请日：2003-10-27
申请人： Egisto Boschetti
发明人： Egisto Boschetti
CPC分类号： A61K9/1635 , A61K47/6927
摘要： The present invention relates to microspheres useful for embolization which comprises polyvinylalcohol. The present invention also relates to an injectable suspension suitable for embolization which comprises the polyvinylalcohol microspheres and a suitable liquid carrier. The present invention further relates to a method for prophylactic or therapeutic embolization which comprises administering to a mammal an injectable suspension containing the polyvinylalcohol microspheres and a suitable liquid carrier. Finally, the present invention relates to a process for producing the polyvinylalcohol microspheres.
摘要翻译： 本发明涉及包含聚乙烯醇的栓塞用微球。 本发明还涉及适用于栓塞的可注射悬浮液，其包含聚乙烯醇微球和合适的液体载体。 本发明还涉及一种用于预防或治疗性栓塞的方法，其包括向哺乳动物施用含有聚乙烯醇微球和适合的液体载体的可注射悬浮液。 最后，本发明涉及聚乙烯醇微球的制造方法。
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公开(公告)号：US20090186094A1
公开(公告)日：2009-07-23
申请号：US12197187
申请日：2008-08-22
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K31/78 , A61K31/785 , A61L27/3804 , A61L27/3839 , A61L27/50 , A61L31/005 , A61L31/14 , A61L2400/06
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.
摘要翻译： 本发明涉及包含可用于组织膨胀的生物相容性，可溶胀，亲水，无毒和基本上为球形的微球的可注射组合物。 本发明还涉及使用可注射组合物的组织膨胀方法，特别是用于治疗胃食管反流病，尿失禁或尿反流疾病的方法。
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公开(公告)号：US20090179146A1
公开(公告)日：2009-07-16
申请号：US11915151
申请日：2006-01-19
申请人： Lee O. Lomas , Jian Ding , Egisto Boschetti
发明人： Lee O. Lomas , Jian Ding , Egisto Boschetti
CPC分类号： G01N30/461 , B01D15/325 , B01D15/362 , B01D15/363 , B01L3/5025 , B01L3/50255 , B01L3/563 , B01L2200/026 , B01L2200/028 , B01L2300/0681 , B01L2300/0829 , B01L2300/087 , B01L2400/0487 , C07K1/34 , G01N27/44704 , G01N27/44795 , G01N30/466 , G01N30/468 , Y10T137/2224 , Y10T137/794 , Y10T137/86187 , Y10T436/255
摘要： The present invention contemplates various devices that are configured to separate a sample, which contains more than one unique species, into any desired number of sub-samples by passing the sample across a like number of separation media configured for a first separation protocol. Each of the sub-samples may be further separated by an additional separation protocol, thereby creating a plurality of mini-samples, each of which may be further separated and/or analyzed. The invention also contemplates using a simple method of using conduits to form a fluid path that passes through a plurality of separation media, each of which media is configured to isolate a particular sub-sample. After various sub-samples of the sample are isolated by the various separation media, the conduits may be removed, thereby enabling each of the isolated sub-samples to be further separated and/or analyzed independent of any other sub-sample.
摘要翻译： 本发明考虑了通过将样品穿过配置用于第一分离方案的相似数量的分离介质，将被配置成将含有多于一种独特物种的样品分离成任何所需数量的子样品的各种装置。 每个子样品可以通过另外的分离方案进一步分离，从而产生多个微型样品，每个小样品可进一步分离和/或分析。 本发明还考虑使用简单的方法来使用导管来形成通过多个分离介质的流体路径，其中每个介质被配置为隔离特定的子样品。 在通过各种分离介质分离样品的各种亚样品之后，可以去除导管，从而使每个分离的子样品能够独立于任何其它亚样品进一步分离和/或分析。
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公开(公告)号：US20080220077A1
公开(公告)日：2008-09-11
申请号：US12122590
申请日：2008-05-16
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
CPC分类号： A61K9/1635 , A61K31/715 , A61K45/06 , A61L2430/36 , Y10T428/2982
摘要： The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
摘要翻译： 本发明涉及包含生物相容的，可溶胀的，基本上亲水的，无毒的和基本上为球形的聚合物材料载体的可注射组合物，其能够有效地输送用于栓塞药物治疗的生物活性治疗因子。 本发明还涉及使用可注射组合物的栓塞基因治疗方法，特别是用于治疗血管生成和非血管生成依赖性疾病的方法。
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公开(公告)号：US20080118569A1
公开(公告)日：2008-05-22
申请号：US12009181
申请日：2008-01-16
申请人： Jean-Marie Vogel , Egisto Boschetti
发明人： Jean-Marie Vogel , Egisto Boschetti
CPC分类号： A61L27/3834 , A61K9/0024 , A61K9/08 , A61K9/1635 , A61K9/1658 , A61K9/167 , A61K35/12 , A61K35/28 , A61K35/34 , A61K35/36 , A61L2400/06 , C12N5/0075 , C12N2533/30
摘要： The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue construction and generation. The invention also relates to methods of tissue construction and generation, for the treatment of various tissue damage and defects, using the injectable compositions.
摘要翻译： 本发明涉及包含与用于组织构建和产生的干细胞相关的生物相容性，亲水性，无毒性和基本上为球形的微球的可注射组合物。 本发明还涉及使用可注射组合物来治疗各种组织损伤和缺陷的组织结构和产生方法。
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59.发明申请公开(公告)号：US20070065953A1
公开(公告)日：2007-03-22
申请号：US11495842
申请日：2006-07-28
申请人： Egisto Boschetti , David Hammond
发明人： Egisto Boschetti , David Hammond
CPC分类号： G01N33/6803 , C40B30/04 , G01N33/543 , G01N33/54306 , G01N33/6845
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.
摘要翻译： 本发明涉及分子生物学，组合化学和生物化学领域。 特别地，本发明描述了用于动态地减少从复杂混合物中取出的分析物之间的方差的方法和试剂盒
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公开(公告)号：US07183544B2
公开(公告)日：2007-02-27
申请号：US11014225
申请日：2004-12-17
申请人： Egisto Boschetti , Luc Bourgeois
发明人： Egisto Boschetti , Luc Bourgeois
CPC分类号： B01J39/26 , B01D15/361 , B01J20/3204 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3221 , B01J20/3257 , B01J20/3272 , B01J20/3274 , B01J20/3289 , B01J41/20 , B01J47/016 , B01J2220/54 , G01N33/54393 , G01N33/6851
摘要： In relation to a chromatographic chip, for protein separation, a polymer surface is provided that has a first polymer layer, attached to a support surface, which can be anionic or cationic. To the first layer is attached a second polymer layer, characterized by an opposite charge.
摘要翻译： 关于色谱芯片，对于蛋白质分离，提供聚合物表面，其具有连接到支撑表面的第一聚合物层，其可以是阴离子或阳离子的。 第一层附着有第二聚合物层，其特征在于相反的电荷。
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