公开(公告)号：US10238627B2

公开(公告)日：2019-03-26

申请号：US15889409

申请日：2018-02-06

Applicant: Indiana University Research and Technology Corporation ,  Gachon University of Industry-Academic Cooperation Foundation

Inventor： Timothy W. Corson ,  Halesha D. Basavarajappa ,  Seung-Yong Seo ,  Bit Lee ,  Xiang Fei

IPC: A61K31/352 ,  A61K9/00 ,  A61P35/00

Abstract: Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.

公开(公告)号：US10234423B2

公开(公告)日：2019-03-19

申请号：US15606478

申请日：2017-05-26

Applicant: Indiana University Research and Technology Corporation

Inventor： David E. Clemmer ,  Michael A. Ewing

IPC: H01J49/00 ,  G01N27/62 ,  H01J49/26 ,  H01J49/44 ,  H01J49/46 ,  H01J49/02

Abstract: A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least one ion steering channel controllable to selectively pass ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to selectively pass ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube. The single-pass drift tube separates in time ions traveling therethrough according to a first function of ion mobility, and the multiple-pass drift tube separates in time ions traveling one or more times therethrough according to the first or a second function of ion mobility.

公开(公告)号：US10208358B2

公开(公告)日：2019-02-19

申请号：US15304019

申请日：2015-04-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Adam Zlotnick ,  Stella Vieweger

IPC: C12N7/04 ,  A61K39/12 ,  A61K39/17 ,  C12N7/00 ,  C12Q1/68 ,  C12Q1/70 ,  C12Q1/6818

Abstract: Virus capsids protect the viral genome and play roles in its delivery and intracellular transport, making them an attractive target for antiviral therapeutics. The difficulty in targeting capsid assembly is to identify molecules that interfere with the weak protein-protein interactions that drive the reaction. We have developed an in vitro assay for capsid assembly that works on a range of viruses at biologically relevant protein concentrations to facilitate screening large libraries of chemicals for lead compounds.

公开(公告)号：US10184851B2

公开(公告)日：2019-01-22

申请号：US15198452

申请日：2016-06-30

Applicant: Indiana University Research and Technology Corporation ,  Purdue Research Foundation

Inventor： A. George Akingba ,  Jason V. Clark

IPC: G01L7/08 ,  G01L9/12 ,  A61B5/0215 ,  G01L9/00 ,  A61B5/03 ,  A61B5/08 ,  A61B5/113 ,  A61B5/00 ,  A61M16/00 ,  H04R19/00

Abstract: Apparatus and methods for a MEMS-fabricated variable capacitor. In one embodiment the capacitor is a comb drive comprising a plurality of plates interdigitated with a corresponding blades. As the plates move relative to the blades, the capacitance of the sensor changes. The capacitor is sufficiently sensitive to measure respiratory pressure in an animal.

公开(公告)号：US20190000891A1

公开(公告)日：2019-01-03

申请号：US15891252

申请日：2018-02-07

Applicant: Indiana University Research and Technology Corporation

Inventor： Mervin C. Yoder ,  Paul Critser ,  Sherry Voytik-Harbin

IPC: A61K35/51 ,  A61L27/24 ,  A61L27/38 ,  A61K9/70

CPC classification number: A61K35/51 ,  A61K9/70 ,  A61L27/24 ,  A61L27/3808

Abstract: Materials and methods are disclosed for controlling vasculogenesis using building blocks of a collagen matrix and endothelial colony forming cells (ECFC). The building blocks may be isolated by fractionating an acid soluble Type I collagen. The building blocks comprising monomers and/or oligomers may be recombined in desired ratios to alter the matrix microenvironment and to influence ECFC behavior.

公开(公告)号：US20190000312A1

公开(公告)日：2019-01-03

申请号：US16062621

申请日：2016-12-20

Applicant: Indiana University Research and Technology Corporation

Inventor： Ping Situ ,  Carolyn Begley ,  Trefford L. Simpson

IPC: A61B3/09 ,  A61B3/00

Abstract: A method of determining a predisposition to contact lens discomfort in a patient is provided, comprising determining a detection threshold of the patient by delivering a cool mechanical stimulus to the cornea of the patient, optionally applying a series of cool mechanical stimuli to the cornea of the patient, and classifying the patient as being predisposed to contact lens discomfort if the detection threshold is at or below a cut-off value predetermined to be associated with predisposition to contact lens discomfort and/or the patient does not adapt to the series of cool mechanical stimuli.

公开(公告)号：US20180372641A1

公开(公告)日：2018-12-27

申请号：US15739152

申请日：2016-07-06

Applicant: Indiana University Research and Technology Corporation

Inventor： Hany OSMAN

IPC: G01N21/64 ,  A61B90/20 ,  G02B21/16 ,  G02B7/00

CPC classification number: G01N21/6458 ,  A61B18/20 ,  A61B18/203 ,  A61B90/20 ,  A61B2017/00486 ,  A61B2018/00577 ,  A61B2018/00982 ,  G02B7/004 ,  G02B21/16 ,  G02B21/26

Abstract: The present disclosure provides a method and system including a non-confocal microscope with an attached imaging fiber optic for direct and real time visualization of mammalian microscopic structures for diagnostic and therapeutic uses.

公开(公告)号：US10154973B2

公开(公告)日：2018-12-18

申请号：US15868245

申请日：2018-01-11

Applicant: Indiana University Research and Technology Corporation ,  Apexian Pharmaceuticals, Inc.

Inventor： Mark R. Kelley ,  James H. Wikel

IPC: C07D295/185 ,  C07D295/192 ,  C07C235/78 ,  C07D211/76 ,  C07C259/06 ,  A61K31/165 ,  A61K31/185 ,  A61K31/45 ,  A61K31/495 ,  A61K31/5375

Abstract: The invention described herein pertains to compounds and compositions for treating Ape1 mediated diseases. In particular, the invention described herein pertains to quinone compounds and pharmaceutical compositions containing them for treating Ape1 mediated diseases.

公开(公告)号：US20180305420A1

公开(公告)日：2018-10-25

申请号：US15771036

申请日：2016-10-28

Applicant: Indiana University Research and Technology Corporation

Inventor： Tarek Maurice Ashkar ,  Radmila Micanovic

IPC: C07K14/47 ,  A61P13/12

CPC classification number: C07K14/47 ,  A61K35/00 ,  A61K35/22 ,  A61K38/00 ,  A61K38/1709 ,  A61P13/12 ,  C07K14/435

Abstract: Embodiments of the present disclosure provide polypeptides, related materials and compositions, and methods for their use. In certain embodiments, the present disclosure provides a monomeric Tamm-Horsfall Protein polypeptide, or a biologically active truncation thereof. Other embodiments provide polynucleotides encoding a polypeptide described herein, nucleic acid expression vectors including the polynucleotides, and recombinant host cells including the expression vector. Yet other embodiments provide pharmaceutical compositions including a polypeptide described herein. Also provided are methods for treating a renal disease, disorder, or condition in a subject and/or modulating an immune response in a subject.

公开(公告)号：US20180263860A1

公开(公告)日：2018-09-20

申请号：US15756811

申请日：2016-08-23

Applicant: Indiana University Research and Technology Corporation

Inventor： Ghaeth H. Yassen ,  Jeffrey A. Platt ,  Richard L. Gregory

IPC: A61K6/00

CPC classification number: A61K6/0067 ,  A61K6/002 ,  A61K6/0035

Abstract: Antibiotic gel formulations for use in dental applications are disclosed. More particularly, the present disclosure is directed to antibiotic gel formulations including low concentrations of antibiotics that are capable of killing root canal pathogens without harming the stem cells inside the root canal. Additionally, the present disclosure is directed to delivery systems and methods for applying the antibiotic gel formulations into a subject's intracanal region.