公开(公告)号：US11482052B2

公开(公告)日：2022-10-25

申请号：US16234385

申请日：2018-12-27

Applicant: IntegenX Inc.

Inventor： Robert A. Schueren ,  David King ,  Chungsoo Charles Park ,  Stevan B. Jovanovich

IPC: G06V40/70 ,  G10L17/00 ,  G16H40/63 ,  G16H10/40 ,  G16B50/00 ,  G16B50/30 ,  G06V40/10 ,  G06V40/60 ,  G16B99/00 ,  G06K9/00

Abstract: A biometric biochemical analysis system includes a user interface module to provide instructions for collecting and handling biochemical sampling and processing related to biometric data gathering as well as capturing biometric data using digital data capturing devices. The user interface module and display are integrated with analysis and communications portions of the biometric biochemical analysis system to provide a portable system for multi-portion data collecting, storage, verification, and analysis.

公开(公告)号：US11231945B2

公开(公告)日：2022-01-25

申请号：US16941169

申请日：2020-07-28

Applicant: INTEGENX INC.

Inventor： David King ,  Chungsoo Charles Park

IPC: G06F3/0481 ,  G06F9/451 ,  G06F3/0487 ,  G06Q30/00

Abstract: A live help system provides an intuitive display of help information on a user's graphical user interface. A request is received from a client device for help, and a live help provider interface is initiated at a live help location. Data is acquired regarding a user's location, including data on external devices in the user's location. Indicators are provided to allow the live help provider to point to or otherwise indicate items on the user interface or outside of the user interface. Live help input is captured at the live help provider interface. Instructions are then transmitted to the display of the client device to display live help input, as though the agent were present and interacting with or indicating items on the screen or off the screen.

公开(公告)号：US10855748B2

公开(公告)日：2020-12-01

申请号：US15910743

申请日：2018-03-02

Applicant: IntegenX Inc.

Inventor： Robert A. Schueren ,  David King ,  Chungsoo Charles Park ,  Arnaldo Barican ,  Charles David Troup

IPC: H04L29/08 ,  G01N27/447 ,  G16B40/00 ,  G16B50/40 ,  G06F3/01 ,  G06F3/0481

Abstract: A command center includes at least one network communications interface configured for two-way communications with a plurality of sites remote from the command center and at least one display screen and user interface. Each of the plurality of sites includes at least one forensic field test device configured to identify individuals using DNA samples from the individuals. The display screen and user interface are configured to depict aspects of forensic field test devices of the plurality of sites, wherein the aspects include a site identifier for each of the forensic field test devices and one or more additional aspects.

公开(公告)号：US20190233888A1

公开(公告)日：2019-08-01

申请号：US16264389

申请日：2019-01-31

Applicant: IntegenX, Inc.

Inventor： Philip Justus Wunderle ,  Chungsoo Charles Park ,  David King ,  Dennis Lehto

IPC: C12Q1/6874 ,  C12Q1/686 ,  F16K99/00 ,  B01L3/00

CPC classification number: C12Q1/6874 ,  B01F13/0059 ,  B01F13/02 ,  B01L3/502738 ,  B01L3/502753 ,  B01L7/52 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0478 ,  B01L2400/0655 ,  C12Q1/686 ,  F16K99/0015 ,  F16K99/0034 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface, wherein (II) the cartridge interface comprises: (A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and (B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.

公开(公告)号：USD853873S1

公开(公告)日：2019-07-16

申请号：US29650002

申请日：2018-06-04

Applicant: IntegenX Inc.

Designer： Robert A. Schueren ,  Alexander Kindwall ,  David King ,  Chungsoo Charles Park ,  James Klevenberg

公开(公告)号：US09731266B2

公开(公告)日：2017-08-15

申请号：US14804675

申请日：2015-07-21

Applicant: IntegenX Inc.

Inventor： Seth Stern ,  Stevan B. Jovanovich

IPC: B01L3/00 ,  B01J19/00 ,  F16K99/00 ,  C12Q1/68 ,  B01L7/00

CPC classification number: B01J19/0046 ,  B01J2219/00389 ,  B01J2219/00599 ,  B01J2219/00716 ,  B01J2219/00722 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/043 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6874 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0084

Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.

公开(公告)号：US09663819B2

公开(公告)日：2017-05-30

申请号：US14552389

申请日：2014-11-24

Applicant: IntegenX Inc.

Inventor： Stevan B. Jovanovich ,  William D. Nielsen ,  Mattias Vangbo ,  Ezra Van Gelder ,  Omar El-Sissi

IPC: G01N1/10 ,  G01N33/00 ,  C12Q1/68 ,  G01N35/00 ,  G01N1/31 ,  G01N27/74 ,  G01N21/64 ,  G01N27/447 ,  G01N1/40 ,  G01J3/44

CPC classification number: C12Q1/6806 ,  G01J3/4406 ,  G01N1/31 ,  G01N1/405 ,  G01N21/64 ,  G01N27/44721 ,  G01N27/44791 ,  G01N27/745 ,  G01N35/00029 ,  G01N2035/00148 ,  G01N2035/00247 ,  G01N2201/06113 ,  G01N2201/062 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

公开(公告)号：US20160305972A1

公开(公告)日：2016-10-20

申请号：US15037039

申请日：2014-11-17

Applicant: INTEGENX INC.

Inventor： James Ogg ,  David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich

IPC: G01N35/00 ,  B01L7/00 ,  C12Q1/68 ,  B01L3/00

CPC classification number: G01N35/00663 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L7/52 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2300/1827 ,  B01L2400/0421 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0638 ,  B01L2400/0644 ,  B01L2400/0655 ,  C12Q1/6818 ,  C12Q1/686 ,  C12Q1/6888 ,  G01N2035/00673

Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.

Abstract translation: 本文提供了用于处理样品的仪器和墨盒。 墨盒包括其中流体运动可由隔膜阀调节的流体回路。 在某些盒中，提供隔膜的可变形材料接触仪器中的界面，直接致动隔膜，而不需要中间的致动层。 某些盒具有多个流体回路和流体分配通道或气动分配通道，其被配置为将流体或气动压力选择性地输送到任何流体回路。 某些墨盒具有含有载体试剂的隔室。 隔室可以通过热封将附着在盒体上的膜封闭。

公开(公告)号：US20150136602A1

公开(公告)日：2015-05-21

申请号：US14552389

申请日：2014-11-24

Applicant: INTEGENX INC.

Inventor： Stevan B. Jovanovich ,  William D. Nielsen ,  David S. Cohen ,  Michael Recknor ,  Mattias Vangbo ,  Ezra Van Gelder ,  Lars Majlof ,  Omar El-Sissi

IPC: C12Q1/68 ,  G01N21/64 ,  G01N27/447

CPC classification number: C12Q1/6806 ,  G01J3/4406 ,  G01N1/31 ,  G01N1/405 ,  G01N21/64 ,  G01N27/44721 ,  G01N27/44791 ,  G01N27/745 ,  G01N35/00029 ,  G01N2035/00148 ,  G01N2035/00247 ,  G01N2201/06113 ,  G01N2201/062 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

Abstract translation: 本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。 例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。 该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。 在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。 在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。 墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。 该系统适合不超过10英尺3的外壳。 并且可以是封闭的，便携式的和/或电池供电的系统。 该系统可用于在不到4小时内从原始样品进行分析。

公开(公告)号：US09012236B2

公开(公告)日：2015-04-21

申请号：US13967957

申请日：2013-08-15

Applicant: IntegenX Inc.

Inventor： Stevan B. Jovanovich ,  William D. Nielsen ,  David S. Cohen ,  Michael Recknor ,  Mattias Vangbo ,  Ezra Van Gelder ,  Omar El-Sissi

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  C12Q1/68 ,  G01N35/00 ,  G01N1/31 ,  G01N27/74 ,  G01N1/40

CPC classification number: C12Q1/6806 ,  G01J3/4406 ,  G01N1/31 ,  G01N1/405 ,  G01N21/64 ,  G01N27/44721 ,  G01N27/44791 ,  G01N27/745 ,  G01N35/00029 ,  G01N2035/00148 ,  G01N2035/00247 ,  G01N2201/06113 ,  G01N2201/062 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

Abstract translation: 本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。 例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。 该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。 在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。 在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。 墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。 该系统适合不超过10英尺3的外壳。 并且可以是封闭的，便携式的和/或电池供电的系统。 该系统可用于在不到4小时内从原始样品进行分析。