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公开(公告)号：US07803902B2
公开(公告)日：2010-09-28
申请号：US12252062
申请日：2008-10-15
Applicant: Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
Inventor： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
IPC: C07K14/00
CPC classification number: C07K14/811 , A61K8/64 , A61Q7/02
Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.
Abstract translation: 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。
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52.发明申请PERSONAL CARE COMPOSITIONS COMPRISING MODIFIED VARIANT BOWMAN BIRK PROTEASE INHIBITORS 有权包含改性变体BAMMAN BIRK蛋白酶抑制剂的个人护理组合物公开(公告)号：US20100092409A1
公开(公告)日：2010-04-15
申请号：US12252032
申请日：2008-10-15
Applicant: Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
Inventor： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
CPC classification number: A61K8/64 , A61K38/55 , A61Q1/02 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q3/00 , A61Q3/02 , A61Q5/006 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/002 , A61Q19/04 , A61Q19/10
Abstract: The present invention relates to compositions that comprise modified variant Bowman Birk Protease Inhibitor proteins (BBPIs). The modified variant BBPIs comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses the compositions comprising the modified variant BBPIs, and the methods for making and using the compositions in personal care.
Abstract translation: 本发明涉及包含修饰的变体Bowman Birk蛋白酶抑制蛋白（BBPI）的组合物。 修饰的变体BBPI包含结合靶蛋白的肽，并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括包含修饰变体BBPI的组合物，以及在个人护理中制备和使用组合物的方法。
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53.发明申请VARIANTS OF BACILLUS LICHENIFORMIS ALPHA-AMYLASE WITH INCREASED THERMOSTABILITY AND/OR DECREASED CALCIUM DEPENDENCE 审中-公开BACILLUS LICHENIFORMIS ALPHA-AMYLASE具有增加的热稳定性和/或降低钙依赖性的变体公开(公告)号：US20090238923A1
公开(公告)日：2009-09-24
申请号：US12263804
申请日：2008-11-03
Applicant: Andrew SHAW , Sandra W. Ramer , Scott D. Power , Jayarama K. Shetty , Bradley A. Paulson , Vivek Sharma , Donald Ward
Inventor： Andrew SHAW , Sandra W. Ramer , Scott D. Power , Jayarama K. Shetty , Bradley A. Paulson , Vivek Sharma , Donald Ward
IPC: A21D8/04 , C12N9/28 , C12N15/11 , C12N15/00 , C12N1/21 , C12N1/19 , C12P7/10 , C11D7/42 , D06M16/00 , C12S11/00
CPC classification number: C11D3/38609 , C11D3/38618 , C12N9/2417 , Y02E50/16 , Y02E50/17
Abstract: Variants of B. licheniformis alpha-amylase exhibit improved enzymatic performance, including increased themostability and reduced calcium dependence. Compositions comprising the variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal. The nucleic acids encoding the variants are also disclosed.
Abstract translation: 地衣芽孢杆菌α-淀粉酶的变体表现出改善的酶性能，包括增加其稳定性和减少的钙依赖性。 包含变体的组合物可用于淀粉加工，淀粉液化，粉化，淀粉糖化，清洁，洗衣，纺织品退浆，烘烤和生物膜除去的方法。 还公开了编码变体的核酸。
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公开(公告)号：US07541026B2
公开(公告)日：2009-06-02
申请号：US12263631
申请日：2008-11-03
Applicant: Scott D. Power , Sandra W. Ramer , Andrew Shaw
Inventor： Scott D. Power , Sandra W. Ramer , Andrew Shaw
CPC classification number: C11D3/38681 , C11D3/386 , C12N9/2417 , D06M16/003
Abstract: Disclosed are compositions comprising variants of a parent G. stearothermophilus alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions comprise an additional enzyme such as a phytase. Also disclosed are methods of using the compositions, and kits related thereto.
Abstract translation: 公开了包含具有α-淀粉酶活性的亲代嗜热脂肪芽孢杆菌α-淀粉酶的变体的组合物，并且相对于从其衍生的亲本AmyS样α-淀粉酶表现出改变的性质。 组合物包含另外的酶如植酸酶。 还公开了使用组合物的方法和与其相关的试剂盒。
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公开(公告)号：US07485618B2
公开(公告)日：2009-02-03
申请号：US10984410
申请日：2004-11-08
Applicant: Anthony G. Day , Christopher J. Murray , Scott D. Power , Beverley Rider Turnquest
Inventor： Anthony G. Day , Christopher J. Murray , Scott D. Power , Beverley Rider Turnquest
IPC: A61K38/08
CPC classification number: C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
Abstract: The present invention provides peptides and supported peptides that bind to FGF-5.
Abstract translation: 本发明提供了结合FGF-5的肽和负载的肽。
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Patent Agency Ranking
56.发明申请公开(公告)号：US20080234465A1
公开(公告)日：2008-09-25
申请号：US11848196
申请日：2007-08-30
Applicant: Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
Inventor： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
CPC classification number: C12N15/80 , C07K14/811
Abstract: Described herein are protease inhibitors, variants thereof and methods for their production.
Abstract translation: 本文描述的是蛋白酶抑制剂，其变体及其制备方法。
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公开(公告)号：US20080233100A1
公开(公告)日：2008-09-25
申请号：US11972517
申请日：2008-01-10
Applicant: Yiyou Chen , Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power , Volker Schellenberger
Inventor： Yiyou Chen , Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power , Volker Schellenberger
CPC classification number: A61K38/46 , C07K2319/01 , C12N9/86 , C12Y305/02006
Abstract: The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.
Abstract translation: 本发明提供了靶向酶，其比相同的预靶向酶更好地结合靶，在相似条件下与目标酶结合，制备靶向酶的方法，使用靶向酶治疗疾病的方法，以及包含靶向酶的药物组合物。
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公开(公告)号：US5030240A
公开(公告)日：1991-07-09
申请号：US932717
申请日：1986-11-19
Applicant: Richard J. Wiersema , Anna G. Stanislowski , Gregory L. Gray , Ayrookaram J. Poulose , Scott D. Power
Inventor： Richard J. Wiersema , Anna G. Stanislowski , Gregory L. Gray , Ayrookaram J. Poulose , Scott D. Power
IPC: C12P7/00 , C11D3/20 , C11D3/386 , C11D3/39 , C11D3/395 , C11D3/60 , C11D7/42 , C11D7/54 , C12N9/20 , C12N15/00 , C12P7/40 , C12P7/62 , C12R1/40 , D06L4/40
CPC classification number: D06L3/11 , C11D3/2093 , C11D3/38627 , C11D3/39 , C11D3/391 , C11D3/3945 , C12N9/20
Abstract: An enzymatic perhydrolysis system, useful for bleaching, has a novel enzyme, a substrate, and a source of hydrogen peroxide, and provides in situ formation of peracid in aqueous solution. The substrate is selected for enzyme catalyzed reaction, and preferably is an acylglycerol with two or three fatty acid chains. The enzyme is hydrolytically and perhydrolytically active even in the presence of anionic surfactants, has lipase activity, and is isolatable from Pseudomonas putida ATCC 53552.
Abstract translation: 可用于漂白的酶促过水解系统具有新型酶，底物和过氧化氢源，并且在水溶液中原位形成过酸。 选择底物用于酶催化反应，并且优选是具有两个或三个脂肪酸链的酰基甘油。 该酶即使在阴离子表面活性剂存在下也具有水解和全水解活性，具有脂肪酶活性，并且可从恶臭假单胞菌ATCC 53552中分离。
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59.发明授权公开(公告)号：US08507244B2
公开(公告)日：2013-08-13
申请号：US13410486
申请日：2012-03-02
Applicant: Andrew Shaw , Sandra Ramer , Scott D. Power , Claudine Chang , Melodie Estabrook , Brian E. Jones , Clement Choy , Marc Kolkmam , Chris Leeflang , Casper Vroeman , Walter Weyler , Karsten Kraugh , Mansi Goyal , Thomas Graycar , Victoria Huang
Inventor： Andrew Shaw , Sandra Ramer , Scott D. Power , Claudine Chang , Melodie Estabrook , Brian E. Jones , Clement Choy , Marc Kolkmam , Chris Leeflang , Casper Vroeman , Walter Weyler , Karsten Kraugh , Mansi Goyal , Thomas Graycar , Victoria Huang
IPC: C12N9/28 , C12N9/26 , C12N9/24 , C12N1/20 , C12N1/00 , C12N15/00 , C12P21/06 , C12P19/34 , C07H21/04 , C07K1/00
CPC classification number: C12N9/2417 , A21D8/042 , A23K20/189 , A23K50/75 , A23L29/06
Abstract: Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased thermostability, reduced calcium dependence, increased washing/cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.
Abstract translation: 芽孢杆菌的变种 TS-23菌株α-淀粉酶表现出改善的酶性能，包括增加的热稳定性，降低的钙依赖性，提高的洗涤/清洁性能和烘烤能力。 包含这些变体的组合物可用于淀粉加工，淀粉液化，粉化，淀粉糖化，清洗，洗衣，纺织品退浆，烘烤和生物膜除去的方法。
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公开(公告)号：US08394941B2
公开(公告)日：2013-03-12
申请号：US13082979
申请日：2011-04-08
Applicant: Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
Inventor： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
IPC: C12N15/00
CPC classification number: C07K14/811 , A61K8/64 , A61Q7/02
Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.
Abstract translation: 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。
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