Combinatorial Analysis and Repair
    52.
    发明申请
    Combinatorial Analysis and Repair 审中-公开
    组合分析与修复

    公开(公告)号:US20110212090A1

    公开(公告)日:2011-09-01

    申请号:US13055321

    申请日:2009-07-22

    摘要: A method for the repair of a unit, by specific diagnosis of the undesired state, and its appropriate repair, using said specific diagnosis as a means to repair in an appropriate way said unit. The diagnosis and repair processes may involve chemical, physical, or mechanical means. The units being diagnosed and repaired include live matter (e.g. human beings, animals, plants) as well as non-live matter (e.g. buildings, electronic equipment, polymer materials).

    摘要翻译: 通过特定诊断不期望的状态及其适当的修复,使用所述特定诊断作为以适当方式修复所述单元的手段来修复单元的方法。 诊断和修复过程可能涉及化学,物理或机械手段。 被诊断和修复的单位包括活物(例如人类,动物,植物)以及非活体物质(例如建筑物,电子设备,聚合物材料)。

    Oxaloacetate hydrolase deficient fungal host cells
    53.
    发明授权
    Oxaloacetate hydrolase deficient fungal host cells 有权
    草酰乙酸水解酶缺陷型真菌宿主细胞

    公开(公告)号:US07919275B2

    公开(公告)日:2011-04-05

    申请号:US12719648

    申请日:2010-03-08

    IPC分类号: C12N1/15 C12P21/00

    CPC分类号: C12Q1/6895 C12N9/14

    摘要: An isolated mutant host cell produced by disrupting or deleting, in a parent cell, a nucleic acid sequence encoding an oxaloacetate hydrolase, or a promoter thereof, which results in the mutant cell producing less of the oxaloacetate hydrolase than the parent cell is disclosed. The disclosure also relates to recombinant methods for producing the products such as polypeptides.

    摘要翻译: 公开了一种分离的突变宿主细胞,其通过在母体细胞中破坏或缺失编码草酰乙酸水解酶的核酸序列或其启动子,导致突变体细胞产生比母细胞少的草酰乙酸酯水解酶。 本公开还涉及用于生产诸如多肽的产物的重组方法。

    Microarrays displaying encoded molecules
    56.
    发明申请
    Microarrays displaying encoded molecules 审中-公开
    显示编码分子的微阵列

    公开(公告)号:US20060234231A1

    公开(公告)日:2006-10-19

    申请号:US10518056

    申请日:2003-06-20

    IPC分类号: C40B30/04 C40B40/08

    摘要: Disclosed is a microarray comprising a plurality of single stranded nucleic acid probes immobilized in discrete areas of a solid support, said probes being hybridised to a library of complexes, wherein each complex comprises an encoded molecule and a template which codes for said molecule, said template comprising a number of codons which codes for chemical entities which upon reaction form a reaction product which at least partly form part of the encoded molecule.

    摘要翻译: 公开了一种微阵列,其包含固定在固体支持物的离散区域中的多个单链核酸探针,所述探针与复合物文库杂交,其中每个复合物包含编码分子和编码所述分子的模板,所述模板 包括编码化学实体的多个密码子,其在反应时形成至少部分形成编码分子的一部分的反应产物。

    Oxaloacetate hydrolase deficient fungal host cells
    57.
    发明申请
    Oxaloacetate hydrolase deficient fungal host cells 有权
    草酰乙酸水解酶缺陷型真菌宿主细胞

    公开(公告)号:US20050202502A1

    公开(公告)日:2005-09-15

    申请号:US11122506

    申请日:2005-05-04

    CPC分类号: C12Q1/6895 C12N9/14

    摘要: The present invention relates to isolated nucleic acid sequences encoding polypeptides having oxaloacetate hydrolase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.

    摘要翻译: 本发明涉及编码具有草酰乙酸水解酶活性的多肽的分离的核酸序列。 本发明还涉及包含核酸序列的核酸构建体,载体和宿主细胞以及用于产生多肽的重组方法。