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    Flexural plate wave sensor and array
    52.
    发明授权
    Flexural plate wave sensor and array 有权
    弯曲板波传感器和阵列

    公开(公告)号：US07000453B2

    公开(公告)日：2006-02-21

    申请号：US10844278

    申请日：2004-05-12

    Applicant: Brian T. Cunningham ,  John R. Williams

    Inventor： Brian T. Cunningham ,  John R. Williams

    IPC: G01N29/02

    CPC classification number: G01N29/022 ,  G01N29/22 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106 ,  Y10T29/42 ,  Y10T29/49007

    Abstract: A flexural plate wave sensor array includes a substrate, and a plurality of flexural plate wave sensors, each sensor including a cavity formed in the substrate, a thin film membrane layer spanning the cavity, a piezoelectric layer disposed on the thin film membrane layer, a transducer disposed on the piezoelectric layer and an absorptive coating disposed on said thin film membrane layer within the cavity. The cavity of each of the sensors includes interior walls which are substantially parallel to each other and to the interior walls of adjacent sensors.

    Abstract translation: 挠曲板波传感器阵列包括基板和多个弯曲板波传感器，每个传感器包括形成在基板中的空腔，跨越空腔的薄膜膜层，设置在薄膜膜层上的压电层， 设置在压电层上的传感器和设置在空腔内的所述薄膜膜层上的吸收涂层。 每个传感器的空腔包括彼此基本平行的相邻传感器的内壁和内壁。

    Surface enhanced raman spectroscopy on optical resonator (e.g., photonic crystal) surfaces
    53.
    发明授权
    Surface enhanced raman spectroscopy on optical resonator (e.g., photonic crystal) surfaces 有权
    在光学谐振器（例如，光子晶体）表面上的表面增强拉曼光谱

    公开(公告)号：US08384892B2

    公开(公告)日：2013-02-26

    申请号：US12586516

    申请日：2009-09-22

    Applicant: Brian T. Cunningham

    Inventor： Brian T. Cunningham

    IPC: G01J3/44

    CPC classification number: G01J3/44 ,  G01N21/658 ,  G02B1/005

    Abstract: Highly sensitive Surface Enhanced Raman Spectroscopy (SERS) sensors are described in the form of a optical resonator and a metal nanostructure deposited on surface of the optical resonator. In one embodiment the optical resonator is in the form of a photonic crystal, but other optical resonators are contemplated. Examples are described in which the resonant near-fields of a large-area replica molded photonic crystal efficiently couples light from a laser to dielectric-metal “post-cap” nanostructures deposited on the photonic crystal surface by a glancing angle evaporation technique, achieving a high SERS enhancement factor. Other constructions are also contemplated a metal nanostructure formed on a dielectric support deposited on the photonic crystal, including a metallic film deposited over close-packed surface of nanospheres, arrays of metallic nanotriangles, metallic nanorods, metallic nanohelices, arrays of metallic nanospheres, and roughened metal surfaces.

    Abstract translation: 高灵敏度表面增强拉曼光谱（SERS）传感器以沉积在光学谐振器表面上的光学谐振器和金属纳米结构的形式进行描述。 在一个实施例中，光学谐振器是光子晶体的形式，但是可以考虑其它光学谐振器。 描述了这样的实例，其中大面积复制光子晶体的共振近场通过扫掠角蒸发技术有效地将光从激光耦合到沉积在光子晶体表面上的电介质金属后帽纳米结构，实现高SERS 增强因子。 还考虑了其​​它结构，其形成在沉积在光子晶体上的电介质载体上，包括沉积在纳米球的紧密堆积表面上的金属膜，金属纳米管阵列，金属纳米棒，金属纳米螺旋，金属纳米球阵列和粗糙化 金属表面。

    Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis
    54.
    发明授权
    Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis 有权
    具有集成流体容纳结构的光子晶体传感器，结合其的样品处理装置及其用于生物分子相互作用分析的用途

    公开(公告)号：US07968836B2

    公开(公告)日：2011-06-28

    申请号：US12800082

    申请日：2010-05-06

    Applicant: Brian T. Cunningham ,  Charles Choi

    Inventor： Brian T. Cunningham ,  Charles Choi

    IPC: H01L31/00

    CPC classification number: G01N21/4133 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/5085 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0487 ,  B82Y20/00 ,  G01N21/253 ,  G01N21/7743 ,  G02B2006/1213

    Abstract: Photonic crystal (PC) sensors, and sensor arrays and sensing systems incorporating PC sensors are described which have integrated fluid containment and/or fluid handling structures. The PC sensors are further integrated into a sample handling device such as a microwell plate. Sensors and sensing systems of the present disclosure are capable of high throughput sensing of analytes in fluid samples, bulk refractive index detection, and label-free detection of a range of molecules, including biomolecules and therapeutic candidates. The present disclosure also provides a commercially attractive fabrication platform for making photonic crystal sensors and systems wherein an integrated fluid containment structure and a photonic crystal structure are fabricated in a single molding or imprinting processing step amendable to high throughput processing.

    Abstract translation: 描述了具有集成流体容纳和/或流体处理结构的光子晶体（PC）传感器以及包含PC传感器的传感器阵列和感测系统。 PC传感器进一步集成到诸如微孔板之类的样品处理装置中。 本公开的传感器和感测系统能够高流量感测流体样品中的分析物，体积折射率检测和一系列分子（包括生物分子和治疗候选物）的无标记检测。 本公开还提供了用于制造光子晶体传感器和系统的商业上有吸引力的制造平台，其中集成流体容纳结构和光子晶体结构在可修改为高通量处理的单个模制或压印处理步骤中制造。

    Passive and active photonic crystal structures and devices
    58.
    发明授权
    Passive and active photonic crystal structures and devices 有权
    被动和有源光子晶体结构和器件

    公开(公告)号：US07854505B2

    公开(公告)日：2010-12-21

    申请号：US11686452

    申请日：2007-03-15

    Applicant: Brian T. Cunningham ,  Dennis W. Dobbs

    Inventor： Brian T. Cunningham ,  Dennis W. Dobbs

    IPC: G02C7/10 ,  G02F1/00

    CPC classification number: G02B5/28 ,  A61F9/022 ,  G02B1/005 ,  G02C7/107 ,  G02F2201/30 ,  G02F2202/022 ,  G02F2202/32

    Abstract: The present invention provides photonic crystal devices, device components and methods for preventing transmission of electromagnetic radiation from one or more laser sources or laser modes so as to provide an optical shield for protecting a users eyes or an optical sensor. The present invention also provides dynamic photonic crystals and devices incorporating dynamic photonic crystals for optically modulating the intensity of one or more beams of electromagnetic radiation and other optical switching applications.

    Abstract translation: 本发明提供了用于防止来自一个或多个激光源或激光模式的电磁辐射传输的光子晶体器件，器件部件和方法，以便提供用于保护用户眼睛或光学传感器的光学屏蔽。 本发明还提供了动态光子晶体和结合动态光子晶体的装置，用于光学调制一个或多个电磁辐射束和其它光交换应用的强度。

    GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR
    59.
    发明申请
    GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 有权
    基于GRATING的传感器组合无标签绑定检测和荧光放大和读取传感器系统

    公开(公告)号：US20100227769A1

    公开(公告)日：2010-09-09

    申请号：US11490556

    申请日：2006-07-20

    Applicant: Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

    Inventor： Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

    IPC: C40B30/04 ,  G01N30/00 ,  C12M1/34 ,  C40B60/12 ,  G01N21/00 ,  G01N33/00 ,  C12Q1/70 ,  G01N33/48 ,  G01N33/543 ,  C12Q1/02 ,  G01N33/567 ,  G01N33/554 ,  G01N21/55 ,  G01J3/28

    CPC classification number: G01N21/648 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/7743 ,  Y10S435/808 ,  Y10S436/805 ,  Y10T436/143333

    Abstract: A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

    Abstract translation: 公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。 公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。 其他实施方案针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。 还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。 还公开了一种用于这种传感器的读出系统。 一个实施例包括优化用于收集无标记检测数据的第一光源，为采集ER荧光放大数据而优化的第二光源和至少一个检测器。 在一个实施例中，检测器是成像系统，并且包括用于收集ER和无标签数据的CCD照相机。 在其他实施例中，至少一个检测器采用用于收集无标签数据的光谱仪的形式和用于收集ER数据的光电倍增管。 在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

    Fluorescence detection enhancement using photonic crystal extraction
    60.
    发明授权
    Fluorescence detection enhancement using photonic crystal extraction 有权
    使用光子晶体提取的荧光检测增强

    公开(公告)号：US07768640B2

    公开(公告)日：2010-08-03

    申请号：US11986156

    申请日：2007-11-19

    Applicant: Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

    Inventor： Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

    IPC: G01J3/30

    CPC classification number: G01N21/648 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/6428 ,  G01N33/54373 ,  G01N33/582 ,  G01N2021/7786 ,  G02B2006/1213

    Abstract: Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.

    Abstract translation: 描述了结合到样品并存在于二维光子晶体表面上的荧光团的荧光发射的增强。 归因于泄漏的光子晶体本征模式（共振模式），通过高强度近场和强相干散射效应的组合来实现荧光的增强。 光子晶体同时呈现与荧光团的吸收和发射波长重叠的共振模式。 证明了来自荧光团在光子晶体表面上的荧光强度的显着增强。

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