公开(公告)号：US20140209041A1

公开(公告)日：2014-07-31

申请号：US14163561

申请日：2014-01-24

申请人： Ryan Hardesty ,  Dan Karch ,  David King ,  Aaron Smith

发明人： Ryan Hardesty ,  Dan Karch ,  David King ,  Aaron Smith

IPC分类号： F24H9/20 ,  F24H9/12

CPC分类号： F24H1/186 ,  F24D17/0026 ,  F24D17/0089 ,  F24D19/1051 ,  F24H1/18 ,  F24H1/182 ,  F24H1/208 ,  F24H1/22 ,  F24H9/124 ,  F24H9/148 ,  F24H9/2007 ,  G05D23/1931

摘要： A hot water heater appliance includes a boiler, a companion water heater and a controller. The controller is configured to control the water heater appliance in response to a scheduled plurality of performance modes based on a preset schedule. A first performance mode is scheduled to be performed at an expected low usage time and a second performance mode is scheduled to be performed at an expected high usage time relative to the expected low usage time.

摘要翻译： 热水器设备包括锅炉，伴热水器和控制器。 控制器被配置为基于预设的时间表来响应于预定的多个演奏模式来控制热水器具。 预定在期望的低使用时间执行第一演奏模式，并且相对于预期的低使用时间在预期的高使用时间调度第二演奏模式。

公开(公告)号：US08512474B2

公开(公告)日：2013-08-20

申请号：US13357741

申请日：2012-01-25

申请人： Rocky Kruger ,  Aaron Smith ,  Thomas M. Moore

发明人： Rocky Kruger ,  Aaron Smith ,  Thomas M. Moore

IPC分类号： C23C16/00 ,  B05C11/00

CPC分类号： C23C16/4481 ,  C23C16/45561 ,  C23C16/48 ,  C23C16/52 ,  C23C16/54

摘要： A precursor delivery system for an irradiation beam instrument includes an injection tube for injecting gasses into the instrument vacuum chamber and a main gas line having an inlet and an outlet. The outlet is connected to the injection tube, and the inlet is connected to a sequential pair of valves connected to a carrier gas source. A crucible for holding precursor material is selectively connected to the main gas line at a location between the pair of valves and the injection tube. The source of carrier gas may be selectively connected to the inlet by sequential operation of the pair of carrier gas valves, so that pulses of carrier gas assist the flow of precursor material to the injection tube. Rapid purging of the system between precursors is enabled by a valve selectively connecting the main line to an envelope in communication with the instrument vacuum.

摘要翻译： 用于照射束仪器的前体传送系统包括用于将气体注入仪器真空室的注入管和具有入口和出口的主气体管线。 出口连接到注射管，入口连接到连接到载气源的顺序一对阀。 用于保持前体材料的坩埚在一对阀和注射管之间的位置处选择性地连接到主气体管线。 载气源可以通过一对载气阀的顺序操作选择性地连接到入口，使得载气的脉冲有助于前体材料流到注射管。 通过阀选择性地将主管线连接到与仪器真空连通的外壳，能够快速清洗前体之间的系统。

公开(公告)号：US20130109682A1

公开(公告)日：2013-05-02

申请号：US13807993

申请日：2011-07-04

申请人： Matthew Burger ,  Yu Ding ,  Wooseok Han ,  Mika Lindvall ,  Gisele A. Nishiguchi ,  Alice Rico ,  Aaron Smith ,  Huw Tanner ,  Lifeng Wan

发明人： Matthew Burger ,  Yu Ding ,  Wooseok Han ,  Mika Lindvall ,  Gisele A. Nishiguchi ,  Alice Rico ,  Aaron Smith ,  Huw Tanner ,  Lifeng Wan

IPC分类号： C07D417/14 ,  A61K31/444 ,  A61K45/06 ,  A61K31/506 ,  A61K31/501 ,  A61K31/541 ,  C07D405/14 ,  A61K31/497

CPC分类号： C07D417/14 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/541 ,  A61K45/06 ,  C07D405/14 ,  C07D407/04 ,  C07D407/14 ,  C07D491/04 ,  A61K2300/00

摘要： The present invention provides certain compounds of Formula (I): and pharmaceutically acceptable salts thereof, as further described herein. Also provided are formulations comprising compounds of formula I, and a method to use such compounds for treating a disease or condition mediated by Provirus Integration of Maloney Kinase (PIM Kinase), GSK3, PKC, KDR, PDGFRa, FGFR3, FLT3, or cABL.

摘要翻译： 本发明提供了本文进一步描述的某些式（I）化合物及其药学上可接受的盐。 还提供了包含式I化合物的制剂和使用这些化合物治疗由Maloney激酶（PIM激酶），GSK3，PKC，KDR，PDGFRa，FGFR3，FLT3或cABL的Provirus整合介导的疾病或病症的方法。

公开(公告)号：US08129394B2

公开(公告)日：2012-03-06

申请号：US12383035

申请日：2009-03-19

申请人： Zilin Hunag ,  Jeff Jin ,  Timothy Machajewski ,  William R. Antonios-McCrea ,  Maureen McKenna ,  Daniel Poon ,  Paul A. Renhowe ,  Martin Sendzik ,  Cynthia Shafer ,  Aaron Smith ,  Yongjin Xu ,  Qiong Zhang ,  Zheng Chen

发明人： Zilin Hunag ,  Jeff Jin ,  Timothy Machajewski ,  William R. Antonios-McCrea ,  Maureen McKenna ,  Daniel Poon ,  Paul A. Renhowe ,  Martin Sendzik ,  Cynthia Shafer ,  Aaron Smith ,  Yongjin Xu ,  Qiong Zhang ,  Zheng Chen

IPC分类号： A61K31/4965 ,  A61K31/505 ,  A01N43/54 ,  C07D403/00 ,  C07D401/00 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00

CPC分类号： C07D498/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Novel imidazole compounds of the general formula are disclosed, wherein R1 and R2 comprise heteroaryl groups. These compounds and compositions containing them are useful in methods to treat Raf kinase-mediated disorders such as cancer.

摘要翻译： 公开了通式的新型咪唑化合物，其中R 1和R 2包含杂芳基。 这些含有它们的化合物和组合物可用于治疗Raf激酶介导的疾病如癌症的方法。

公开(公告)号：US20100048547A1

公开(公告)日：2010-02-25

申请号：US12449286

申请日：2008-02-06

申请人： Gordana Atallah ,  Sarah Bartulis ,  Matthew Burger ,  Hanne Merritt ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Aaron Smith ,  Charles Voliva ,  Allan Wagman ,  Yanchen Zhang

发明人： Gordana Atallah ,  Sarah Bartulis ,  Matthew Burger ,  Hanne Merritt ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Aaron Smith ,  Charles Voliva ,  Allan Wagman ,  Yanchen Zhang

IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61K31/538 ,  A61P29/00 ,  A61P35/00 ,  A61P11/00 ,  A61P37/08 ,  A61P37/00 ,  A61P9/00

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14

摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.

摘要翻译： 磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗特征在于生长因子异常活性，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶（包括增殖性疾病）的疾病中的用途， 炎性和阻塞性气道疾病，过敏性疾病，自身免疫性疾病和心血管疾病。

公开(公告)号：US20090223451A1

公开(公告)日：2009-09-10

申请号：US12399579

申请日：2009-03-06

申请人： Rocky Kruger ,  Aaron Smith ,  Thomas M. Moore

发明人： Rocky Kruger ,  Aaron Smith ,  Thomas M. Moore

IPC分类号： C23C16/54

CPC分类号： C23C16/4481 ,  C23C16/45561 ,  C23C16/48 ,  C23C16/52 ,  C23C16/54

摘要： A precursor delivery system for an irradiation beam instrument having a vacuum chamber includes an injection tube for injecting gasses into the vacuum chamber of the instrument and a main gas line having an inlet and an outlet. The outlet is connected to the injection tube, and the inlet is connected to a sequential pair of valves connected to a carrier gas source. A crucible for holding precursor material is selectively connected to the main gas line at a location between the pair of valves and the injection tube. The source of carrier gas may be selectively connected to the inlet by sequential operation of the pair of carrier gas valves, so that pulses of carrier gas assist the flow of precursor material to the injection tube. Rapid purging of the system between precursors is enabled by a valve selectively connecting the main line to an envelope in communication with the instrument vacuum. Methods of CVD and etching using the system are also disclosed.

摘要翻译： 具有真空室的照射束装置的前体输送系统包括用于将气体注入仪器的真空室的注入管和具有入口和出口的主气体管线。 出口连接到注射管，入口连接到连接到载气源的顺序一对阀。 用于保持前体材料的坩埚在一对阀和注射管之间的位置处选择性地连接到主气体管线。 载气源可以通过一对载气阀的顺序操作选择性地连接到入口，使得载气的脉冲有助于前体材料流到注射管。 通过阀选择性地将主管线连接到与仪器真空连通的外壳，能够快速清洗前体之间的系统。 还公开了使用该系统的CVD和蚀刻的方法。

公开(公告)号：US20080091203A1

公开(公告)日：2008-04-17

申请号：US11948189

申请日：2007-11-30

申请人： Mark Warburton ,  Robert Fencl ,  John Capo ,  Virak Tan ,  Aaron Smith

发明人： Mark Warburton ,  Robert Fencl ,  John Capo ,  Virak Tan ,  Aaron Smith

IPC分类号： A61B17/58 ,  A61B17/56

CPC分类号： A61B17/1725 ,  A61B17/1659 ,  A61B17/1668 ,  A61B17/1684 ,  A61B17/72 ,  A61B17/848 ,  A61B17/861 ,  A61B17/8875 ,  A61B2017/0046 ,  A61B2017/922 ,  A61B2090/062

摘要： An intramedullary fixation assembly usable with different long bone types and a guide assembly for guiding deployment of the intramedullary fixation assembly. The intramedullary fixation assembly includes a fixation member that has ends and a curved body extending between the ends. The curved body of the fixation member has a radius of curvature configured to extend through the medullary canal regardless of the long bone anatomy. Fasteners fix the fixation member to the bone fragments and are guided by a guide assembly. The guide assembly includes a guide body defining openings configured to guide the fasteners through openings defined in the fixation member and into the bone fragments. A fixation end of the guide body includes a pair of opposing, converging surfaces that are configured to engage in a positive fit with an exposed end of the fixation member accessible through the side aperture in the first fragment.

摘要翻译： 可用于不同长骨类型的髓内固定组件和用于引导髓内固定组件的部署的引导组件。 髓内固定组件包括具有端部的固定构件和在端部之间延伸的弯曲体。 固定构件的弯曲体具有构造成延伸穿过髓管的曲率半径，而不管长骨解剖结构如何。 紧固件将固定构件固定在骨碎片上并由导向组件引导。 引导组件包括引导体，该引导体限定了被构造成引导紧固件通过限定在固定构件中的开口并进入骨碎片的开口。 引导体的固定端包括一对相对的会聚表面，其被配置成与通过第一片段中的侧孔可接近的固定构件的暴露端以正配合接合。

公开(公告)号：US20070283680A1

公开(公告)日：2007-12-13

申请号：US11568836

申请日：2005-05-12

申请人： Robin Willats ,  Anthony Morales ,  Joseph Callahan ,  Kenneth Cook ,  Gregory Ross ,  Glen Holtz ,  John Zimmer ,  Stephen Allen ,  Ivan Arbuckle ,  Kwin Abram ,  Aaron Smith

发明人： Robin Willats ,  Anthony Morales ,  Joseph Callahan ,  Kenneth Cook ,  Gregory Ross ,  Glen Holtz ,  John Zimmer ,  Stephen Allen ,  Ivan Arbuckle ,  Kwin Abram ,  Aaron Smith

IPC分类号： F01N7/10

CPC分类号： F01N1/023 ,  F01N1/084 ,  F01N1/10 ,  F01N1/165 ,  F01N1/24 ,  F01N2260/14 ,  F01N2430/02 ,  F01N2470/02

摘要： An exhaust processor (12) comprises an isolated interior volume (16) that is defined in a housing (18) of the exhaust processor (12) so as to be isolated from exhaust gas in the housing (18). A motion converter (20) is positioned in the isolated interior volume (16) and is configured to convert in the isolated interior volume (16) linear movement of a linear valve actuator (22) into rotation of an exhaust valve (17). A cushioning pad (120, 122, 320, 420) can be used in a variety of exhaust processors (12, 212) to facilitate positioning of the exhaust valve (17). An associated method is disclosed.

摘要翻译： 排气处理器（12）包括限定在排气处理器（12）的壳体（18）中的隔离的内部容积（16），以便与壳体（18）中的废气隔离。 运动转换器（20）定位在隔离的内部容积（16）中，并且被配置成将线性阀致动器（22）的隔离内部空间（16）线性运动转换成排气阀（17）的旋转。 缓冲垫（120,122,320,420）可用于各种排气处理器（12,212）中，以便于排气阀（17）的定位。 公开了一种相关联的方法。

公开(公告)号：US20070153794A1

公开(公告)日：2007-07-05

申请号：US11685614

申请日：2007-03-13

申请人： Aaron Smith ,  Jeffrey Eschbach ,  Senaka Balasuriya ,  Jie Weng ,  Walter Johnson

发明人： Aaron Smith ,  Jeffrey Eschbach ,  Senaka Balasuriya ,  Jie Weng ,  Walter Johnson

IPC分类号： H04L12/56

CPC分类号： H04L63/0414 ,  H04L63/061 ,  H04W8/26 ,  H04W80/04 ,  H04W80/10

摘要： Session Inter-Device (SD) mobility networks (50, 100, 150) ate described in which a seamless transfer of a communication session from a first device (56, 106, 116) to a second device (66, 116, 166) can be achieved without interrupting the active session. According to the SID mobility network (50), the transfer can be accomplished by transferring away from the Transferring Node or first device (56) the IP address associated with the active session (58) so that the network (50) will route the session to the desired Target Node or second device (66). The Transferring Node (56) transfers its IP address (58) to the Agent (60) and stops requesting data packets addressed to its IP address (58). The Agent (60) then begins to request and eventually receive the packets addressed to the Transferring Node's IP address (58). The Agent (60) then transfers the packets to the Target Node (66). In an alternate SD mobility network (100), the Transferring Node (106) transfers a session specific IP address (114) to the Agent (110). The Agent (110) then transfers packets sent to the session specific IP address (114) to the Target Node (120). In another SID mobility network (150), the Transferring Node (162) obtains a temporary IP address (170) and transfers its IP address (164) to a Session Agent (166). The Session Agent (166) begins to request and eventually receive the packets addressed to the Transferring Node's IP address (164), and for each received packet determines if it belongs to the session the Transferring Node (162) requested to transfer to the Target Node (176). If it does, the Session Agent (166) will transfer the packet to the Target Node (176) at the Target Node's IP address (178). If it does not, the Session Agent (166) will transfer the packet to the Transferring Node (162) at its temporary IP address (170). In each SID mobility network, the session with respect to the Correspondent Node continues without interruption throughout the transfer, thereby providing a seamless transfer of the session from a first device to a second device.

公开(公告)号：US20070095695A1

公开(公告)日：2007-05-03

申请号：US11262402

申请日：2005-10-28

申请人： Aaron Smith

发明人： Aaron Smith

IPC分类号： B65D85/00

CPC分类号： B42F17/08

摘要： A card file is described herein including a base and a lid hingedly joined together. The base includes a base panel, front, back and side walls. Likewise, the lid includes a lid panel, front, back and side walls. The front, back, and side walls, of both the base and lid extend away from respective ones of the base and lid panels. The front and back walls diverge away from one another moving away from the base or lid panel. Likewise, the side walls diverge away from one another moving away from the base or lid panel. A first storage space is defined between the base panel and respective front back and side walls of the base. Similarly, a second storage space is defined between the lid panel, and respective front, back and side walls of the lid. Thus, both the first and second storage spaces are generally smaller in cross-sectional area near respective base or lid panels than near the exposed edges of the front, back and side walls of the base and lid. The card file is stackable with like card files in a nested configuration.

摘要翻译： 本文描述的卡片文件包括铰链地连接在一起的底座和盖子。 底座包括一个底板，前，后和侧壁。 同样地，盖子包括盖板，前，后和侧壁。 基座和盖子的前壁，后壁和侧壁均远离基座和盖板中的相应的一个。 前壁和后壁彼此远离基座或盖板。 同样地，侧壁彼此远离基座或盖板分开。 第一存储空间被限定在底板和基座的相应的前后侧壁和侧壁之间。 类似地，在盖板和盖的相应的前，后和侧壁之间限定第二存储空间。 因此，第一和第二存储空间通常相对于基座或盖板附近的横截面面积小于基座和盖子的前，后和侧壁的暴露边缘附近。 卡片文件可以像嵌套配置中的卡片文件一样堆叠。