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    Systems and methods for facilitating electronic transactions and deterring fraud
    51.
    发明授权
    Systems and methods for facilitating electronic transactions and deterring fraud 有权
    促进电子交易和阻止欺诈的系统和方法

    公开(公告)号：US08078515B2

    公开(公告)日：2011-12-13

    申请号：US12115538

    申请日：2008-05-05

    申请人： Michael Sasha John

    发明人： Michael Sasha John

    IPC分类号： G06Q40/00

    CPC分类号： G06Q20/4016 ,  G06F21/32 ,  G06F21/35 ,  G06F21/606 ,  G06F21/6263 ,  G06Q20/123 ,  G06Q20/382 ,  G06Q20/40 ,  G06Q20/4012 ,  G06Q20/40145 ,  G06Q20/405 ,  G06Q20/409 ,  G06Q20/425 ,  G06Q30/06 ,  G06Q30/0601 ,  G06Q30/0613 ,  G06Q40/00

    摘要： Systems and methods are described for providing fraud deterrents during e-commerce, e-transactions, and digital rights management and access. One or more fraud deterrents may be automatically selected by a client, seller, bank, or other 3rd party and may be implemented or presented to the client as a potential fraud deterrent option that may be chosen. Fraud deterrent options may be provided which are associated with particular aspects of the transaction including a client's profile, the value of an item, or the preferences of the seller. The fraud deterrent features can be provided as part of a digital shopping cart and may be highly customized by the client including allowing the client to customize conceptual passwords which are presented during subsequent transactions.

    摘要翻译： 描述了在电子商务，电子交易和数字版权管理和访问期间提供欺诈威慑的系统和方法。 一个或多个欺诈威慑可以由客户，卖方，银行或其他第三方自动选择，并且可以被实施或呈现给客户，作为可以选择的潜在的欺诈威慑选项。 可以提供与交易的特定方面相关联的欺诈威慑选项，包括客户的简档，项目的价值或卖方的偏好。 欺诈威慑特征可以作为数字购物车的一部分提供，并且可以由客户端高度定制，包括允许客户端定制在后续交易中呈现的概念密码。

    Methods and systems for semi-automatic adjustment of medical monitoring and treatment
    52.
    发明授权
    Methods and systems for semi-automatic adjustment of medical monitoring and treatment 有权
    半自动调整医疗监护和治疗的方法和系统

    公开(公告)号：US07899545B2

    公开(公告)日：2011-03-01

    申请号：US11932805

    申请日：2007-10-31

    申请人： Michael Sasha John

    发明人： Michael Sasha John

    IPC分类号： A61B5/05

    CPC分类号： G06F19/3468 ,  A61B5/00 ,  A61B5/4082 ,  A61B5/4094 ,  A61B5/4809 ,  A61B5/4812 ,  A61B5/4818 ,  A61M5/142 ,  A61M5/14276 ,  A61M5/172 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/18 ,  A61M2230/005 ,  A61M2230/201 ,  A61M2230/63 ,  A61N1/3605 ,  A61N1/36082 ,  A61N1/37235 ,  A61N1/37247 ,  A61N1/37258 ,  G06F19/00 ,  G06F19/325 ,  G06F19/3481 ,  G16H40/63 ,  G16H50/20

    摘要： Systems and methods are described for adjusting the operation of implantable stimulation devices used to provide medical monitoring and treatment. Several hierarchical algorithms are described which operate according to conditionally obtaining a patient response to an alert signal. In one such strategy semi-automatic therapy adjustment occurs by automatically issuing patient alert messages when selected operations are to occur, and using a patient's response to the alert message that is provided within a selected time limit in order to contingently adjust therapy. Methods are also described for resolving conflicts which may occur when time information and sensed data information each indicate different patient states are occurring. Although treatment of neural and cardiac disorders is emphasized, the techniques can be applied to the monitoring and treatment of any medical disorder with an implanted device.

    摘要翻译： 描述了用于调整用于提供医疗监测和治疗的可植入刺激装置的操作的系统和方法。 描述了根据有条件地获得对警报信号的患者响应进行操作的几种分级算法。 在一种这样的策略中，半自动治疗调整是通过在选择的操作发生时自动发出病人警报消息，并且使用患者对在所选时限内提供的警报消息的响应来偶然地调整治疗。 还描述了用于解决当时间信息和感测数据信息各自表示不同的患者状态发生时可能发生的冲突的方法。 虽然强调了神经和心脏疾病的治疗，但是该技术可以应用于用植入装置监测和治疗任何医学障碍。

    Implantable system enabling responsive therapy for pain
    53.
    发明授权
    Implantable system enabling responsive therapy for pain 有权
    可植入系统，能够对疼痛进行反应性治疗

    公开(公告)号：US07894905B2

    公开(公告)日：2011-02-22

    申请号：US11374380

    申请日：2006-03-13

    申请人： Benjamin D. Pless ,  Michael Sasha John

    发明人： Benjamin D. Pless ,  Michael Sasha John

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36071 ,  A61F7/007 ,  A61F2007/0075 ,  A61M5/1723 ,  A61M2005/1726 ,  A61N1/36135 ,  A61N2/006 ,  A61N5/0622

    摘要： An implantable neurostimulator system for treating pain includes scheduled and responsive therapy capabilities including responsive stimulation applied to the brain and peripheral sections of the nervous system. Methods for treating chronic nociceptive, neuropathic, and psychogenic pain employ an inventive system to advantageously reduce multiple symptoms and components of pain and to address underlying causes of pain.

    摘要翻译： 用于治疗疼痛的可植入神经刺激器系统包括计划和响应的治疗能力，包括应用于神经系统的大脑和周边部分的响应刺激。 用于治疗慢性伤害感受神经病和心理性疼痛的方法采用本发明的系统来有利地减少疼痛的多种症状和成分并解​​决潜在的疼痛原因。

    Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
    54.
    发明申请
    Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations 有权
    可编程的药物输送系统和用于输送多种流体和浓度的方法

    公开(公告)号：US20100318025A1

    公开(公告)日：2010-12-16

    申请号：US12853941

    申请日：2010-08-10

    申请人： Michael Sasha John

    发明人： Michael Sasha John

    IPC分类号： A61M25/14 ,  A61M31/00

    CPC分类号： A61M5/16809 ,  A61B5/14532 ,  A61B5/412 ,  A61M5/1408 ,  A61M5/14276 ,  A61M5/16827 ,  A61M5/172 ,  A61M5/1723 ,  A61M25/00 ,  A61M25/0026 ,  A61M25/003 ,  A61M25/0097 ,  A61M2005/14208 ,  A61M2025/0002 ,  A61M2025/0036 ,  A61M2025/0037 ,  A61M2025/004 ,  A61M2205/3523 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17

    摘要： A drug delivery system provides for mixing various drugs in an optimally controlled manner, for using flow controllers to guide multiple drugs into a single or into multiple catheters, for enabling a single lumen catheter to treat a specific region with several drugs, for allowing for dilution of a concentrated drug in order to both increase the time between refilling and also for providing any concentration of a drug that might be desired, for using a buffer fluid to deliver exact amounts of several drugs from the same catheter or to separate several drugs within a single catheter, for using external fluid present in the human body either as a diluent or buffer fluid, and for providing for a drug testing/filler apparatus to be used prior to implant to ensure proper function and easy means of filling multiple reservoirs with different fluids, and also after implant for refilling operations. The drug delivery system (DDS) can perform both bolus and continuous delivery of substances, and enable the measured delivery of any one of several drugs to one or more distal locations at independently programmable rates. New types of catheter systems and uses therefore are also described. Catheter hub assemblies allowing for easy replacement of drug delivery systems offer advantages when replacing drug delivery systems. New methods for using the DDS in the promotion of healthy pregnancy and treatment of a developing fetus are also possible.

    摘要翻译： 药物递送系统提供以最佳控制的方式混合各种药物，用于使用流量控制器将多种药物引导到单个或多个导管中，以使单腔导管能够用几种药物治疗特定区域，以允许稀释 的浓缩药物，以便增加再填充之间的时间，并且还提供可能需要的任何浓度的药物，以使用缓冲液从相同的导管输送精确量的几种药物或在一 单个导管，用于使用存在于人体内的外部流体作为稀释剂或缓冲液，并且用于提供在植入之前使用的药物测试/填充装置，以确保适当的功能，并且容易地用不同流体填充多个储存器 ，并且在植入后用于再填充操作。 药物递送系统（DDS）可以进行物质的推注和连续递送，并且使得可以以独立可编程的速率将测量的几种药物中的任一种递送到一个或多个远端位置。 因此也描述了新型导管系统和用途。 在更换药物输送系统时，允许容易更换药物输送系统的导管毂组件提供了优势。 使用DDS促进健康怀孕和治疗发育中的胎儿的新方法也是可行的。

    System and methods for detecting ischemia with a limited extracardiac lead set
    55.
    发明申请
    System and methods for detecting ischemia with a limited extracardiac lead set 审中-公开
    用有限的心外导联检测缺血的系统和方法

    公开(公告)号：US20090048528A1

    公开(公告)日：2009-02-19

    申请号：US11889752

    申请日：2007-08-16

    申请人： Bruce Hopenfeld ,  Michael Sasha John ,  Tim Fischell

    发明人： Bruce Hopenfeld ,  Michael Sasha John ,  Tim Fischell

    IPC分类号： A61B5/0472

    CPC分类号： A61B5/042 ,  A61B5/0031 ,  A61B5/0472 ,  A61B5/7275

    摘要： Disclosed is a system for detecting pathophysiological cardiac conditions from a reduced number of extracardiac leads. A right side lead measures the electrical signal between the middle superior chest region over the heart and inferior right torso position. A left side lead measures the electrical signal between the left precordial chest region and an inferior left lateral or posterior torso position. The lead montage is preferably chosen so that, regardless of patient position (e.g. supine, upright), negative ST segments and/or T waves are used to detect right coronary or left circumflex ischemia. Also, in these positions, reduced slope of the final deflection in the QRS can be used to detect these types of ischemia. To detect transmural ischemia, the system examines changes in QRS slopes, ST segment, T wave and the difference between the J point and the PQ potentials. In addition, for transmural ischemia associated with the left anterior descending artery, a proxy for the propagation time across the front of the heart is examined by comparing QRS features of the right side lead with QRS features of the left side lead. Histogram profiles, trends, and statistical summaries, especially running averages, of all of the above mentioned features, corrected for heart rate, are maintained.

    摘要翻译： 公开了一种用于从减少数量的心外引线检测病理生理学心脏病的系统。 右侧导线测量心脏上中部上胸部区域和右下躯干位置之间的电信号。 左侧导线测量左心耳前胸部区域和左下侧后躯干位置之间的电信号。 优选选择引导蒙太奇，使得不管患者的位置（例如仰卧，直立），使用负ST段和/或T波来检测右冠状动脉或左回旋缺血。 此外，在这些位置，可以使用QRS中的最终偏转的减小的斜率来检测这些类型的缺血。 为了检测透壁缺血，系统检查QRS斜率，ST段，T波的变化以及J点与PQ电位之间的差异。 此外，对于与左前降支动脉相关的透壁性缺血，通过将右侧引线的QRS特征与左侧引线的QRS特征进行比较来检查穿过心脏前部的传播时间的代理。 维持所有上述功能的直方图，趋势和统计摘要，特别是运行平均值。

    Brain function scan system
    56.
    发明授权
    Brain function scan system 有权
    脑功能扫描系统

    公开(公告)号：US07471978B2

    公开(公告)日：2008-12-30

    申请号：US10045799

    申请日：2002-01-10

    申请人： Erwin Roy John ,  Michael Sasha John

    发明人： Erwin Roy John ,  Michael Sasha John

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0476 ,  A61B5/0002 ,  A61B5/0006 ,  A61B5/0484 ,  A61B5/407 ,  A61B5/4076 ,  A61B5/7257

    摘要： A portable EEG (electroencephalograph) instrument, especially for use in emergencies and brain assessments in physicians' offices, detects and amplifies brain waves and converts them into digital data for analysis by comparison with data from normal groups. In one embodiment, the EEG electrodes are in a headband which broadcasts the data, by radio or cellular phone, to a local receiver for re-transmission and/or analysis. In another embodiment, the subject is stimulated in two modes, i.e., aural and sensory, at two different frequencies to provide the subject's EPs (Evoked Potentials), assessing transmission through the brainstem and thalamus.

    摘要翻译： 一种便携式EEG（脑电图仪），特别适用于医生办公室的紧急情况和脑部评估，可以检测和放大脑波，并将其转换为数字数据进行分析，与正常组数据进行比较。 在一个实施例中，EEG电极处于通过无线电或蜂窝电话将数据广播到本地接收机以进行重新传输和/或分析的头带中。 在另一个实施方案中，以两种不同的频率以两种模式（即听觉和感觉）刺激受试者，以提供受试者的EP（诱发电位），评估通过脑干和丘脑的传播。

    Systems and methods for improved spinal cord stimulation
    57.
    发明授权
    Systems and methods for improved spinal cord stimulation 有权

    公开(公告)号：US12059567B1

    公开(公告)日：2024-08-13

    申请号：US18456202

    申请日：2023-08-25

    申请人： Michael Sasha John

    发明人： Michael Sasha John

    IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/04 ,  A61N1/05

    CPC分类号： A61N1/36178 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/37235 ,  A61N1/0456 ,  A61N1/0529 ,  A61N1/36071 ,  A61N1/36114

    摘要： Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation modalities. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Improvements for the treatment of pain are disclosed.