公开(公告)号：US20080076169A1

公开(公告)日：2008-03-27

申请号：US11528286

申请日：2006-09-26

申请人： Robin R. Miles ,  William J. Benett ,  Matthew A. Coleman ,  Francesca S. Pearson ,  Shanavaz L. Nasarabadi

发明人： Robin R. Miles ,  William J. Benett ,  Matthew A. Coleman ,  Francesca S. Pearson ,  Shanavaz L. Nasarabadi

IPC分类号： G01N33/558 ,  C12M1/34

CPC分类号： G01N33/558

摘要： A lateral flow strip assay apparatus comprising a housing; a lateral flow strip in the housing, the lateral flow strip having a receiving portion; a sample collection unit; and a reagent reservoir. Saliva and/or buccal cells are collected from an individual using the sample collection unit. The sample collection unit is immersed in the reagent reservoir. The tip of the lateral flow strip is immersed in the reservoir and the reagent/sample mixture wicks up into the lateral flow strip to perform the assay.

摘要翻译： 一种侧流条测定装置，包括壳体; 所述外壳中的横向流动条，所述横向流动带具有接收部分; 样本收集单元; 和试剂储存器。 使用样品收集单元从个体收集唾液和/或颊细胞。 样品收集单元浸入试剂容器中。 横向流动条的尖端浸入储存器中，并将试剂/样品混合物吸入侧流条中以进行测定。

公开(公告)号：US07342311B2

公开(公告)日：2008-03-11

申请号：US11326967

申请日：2006-01-05

申请人： Peter A. Krulevitch ,  Mariam N. Maghribi ,  William J. Benett ,  Julie K. Hamilton ,  Klint A. Rose ,  James Courtney Davidson ,  Mark S. Strauch

发明人： Peter A. Krulevitch ,  Mariam N. Maghribi ,  William J. Benett ,  Julie K. Hamilton ,  Klint A. Rose ,  James Courtney Davidson ,  Mark S. Strauch

IPC分类号： H01L23/04 ,  H01L23/34

CPC分类号： H01L25/165 ,  B81C1/0023 ,  H01L21/6835 ,  H01L31/048 ,  H01L31/0543 ,  H01L2221/68345 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/19041 ,  H01L2924/19105 ,  Y02E10/52 ,  H01L2924/00

摘要： A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.

摘要翻译： 剥离和粘贴电子系统包括硅树脂体和至少一个可操作地连接到硅氧烷体的电子单元。 该电子系统是通过在衬底上提供硅树脂层，在硅树脂层上提供金属层，并提供至少一个与金属层连接的电子单元来制造的。

公开(公告)号：US07036220B2

公开(公告)日：2006-05-02

申请号：US10742112

申请日：2003-12-18

申请人： J. Courtney Davidson ,  Peter A. Krulevitch ,  Mariam N. Maghribi ,  Julie K. Hamilton ,  William J. Benett ,  Armando R. Tovar

发明人： J. Courtney Davidson ,  Peter A. Krulevitch ,  Mariam N. Maghribi ,  Julie K. Hamilton ,  William J. Benett ,  Armando R. Tovar

IPC分类号： H05K3/10

CPC分类号： H01L21/76838 ,  H05K3/4053 ,  H05K2203/0195 ,  H05K2203/0338 ,  Y10T29/49155

摘要： A method of metalization of an integrated microsystem. The method comprises providing a substrate and applying a conductive material to the substrate by taking up small aliquots of conductive material and releasing the conductive material onto the substrate to produce a circuit component.

摘要翻译： 一种集成微系统的金属化方法。 该方法包括提供衬底并且通过吸收导电材料的小等分试样并将导电材料释放到衬底上以产生电路部件来向衬底施加导电材料。

公开(公告)号：US07025323B2

公开(公告)日：2006-04-11

申请号：US09957894

申请日：2001-09-21

申请人： Peter A. Krulevitch ,  William J. Benett ,  Klint A. Rose ,  Julie Hamilton ,  Mariam Maghribi

发明人： Peter A. Krulevitch ,  William J. Benett ,  Klint A. Rose ,  Julie Hamilton ,  Mariam Maghribi

IPC分类号： F16K31/124

CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0011 ,  F16K99/0015 ,  F16K99/0044 ,  F16K99/0048 ,  F16K99/0059 ,  F16K99/0061 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084

摘要： Low power integrated pumping and valving arrays which provide a revolutionary approach for performing pumping and valving approach for performing pumping and valving operations in microfabricated fluidic systems for applications such as medical diagnostic microchips. Traditional methods rely on external, large pressure sources that defeat the advantages of miniaturization. Previously demonstrated microfabrication devices are power and voltage intensive, only function at sufficient pressure to be broadly applicable. This approach integrates a lower power, high-pressure source with a polymer, ceramic, or metal plug enclosed within a microchannel, analogous to a microsyringe. When the pressure source is activated, the polymer plug slides within the microchannel, pumping the fluid on the opposite side of the plug without allowing fluid to leak around the plug. The plugs also can serve as microvalves.

公开(公告)号：US06897557B2

公开(公告)日：2005-05-24

申请号：US09885434

申请日：2001-06-19

申请人： William J. Benett ,  Harold D. Ackler

发明人： William J. Benett ,  Harold D. Ackler

IPC分类号： H01R13/11 ,  H05K7/10 ,  H01L23/52 ,  H01L23/04 ,  H01L23/48 ,  H01L29/40

CPC分类号： H01R13/11 ,  H05K7/1084

摘要： An electrical connector is formed from a sheet of electrically conductive material that lies in between the two layers of nonconducting material that comprise the casing of an electrical chip. The connector is electrically connected to an electrical element embedded within the chip. An opening in the sheet is concentrically aligned with a pair of larger holes respectively bored through the nonconducting layers. The opening is also smaller than the diameter of an electrically conductive contact pin. However, the sheet is composed flexible material so that the opening adapts to the diameter of the pin when the pin is inserted therethrough. The periphery of the opening applies force to the sides of the pin when the pin is inserted, and thus holds the pin within the opening and in contact with the sheet, by friction. The pin can be withdrawn from the connector by applying sufficient axial force.

摘要翻译： 电连接器由位于包括电芯片的壳体的两层不导电材料之间的导电材料片形成。 连接器电连接到嵌入芯片内的电气元件。 片材中的开口与分别穿过非导电层的一对较大的孔同心对准。 该开口也小于导电接触销的直径。 然而，该片是由柔性材料构成的，使得当销插入其中时，开口适应销的直径。 当销插入时，开口的周边对销的侧面施加力，从而通过摩擦将销保持在开口内并与片接触。 通过施加足够的轴向力，销可以从连接器中取出。

公开(公告)号：US06319474B1

公开(公告)日：2001-11-20

申请号：US09327401

申请日：1999-06-07

申请人： Peter A. Krulevitch ,  Abraham P. Lee ,  M. Allen Northrup ,  William J. Benett

发明人： Peter A. Krulevitch ,  Abraham P. Lee ,  M. Allen Northrup ,  William J. Benett

IPC分类号： B01L1100

CPC分类号： G01N1/31 ,  G01N1/06 ,  Y10T83/222 ,  Y10T83/9493

摘要： A microfabricated biopsy/histology instrument which has several advantages over the conventional procedures, including minimal specimen handling, smooth cutting edges with atomic sharpness capable of slicing very thin specimens (approximately 2 &mgr;m or greater), micro-liter volumes of chemicals for treating the specimens, low cost, disposable, fabrication process which renders sterile parts, and ease of use. The cutter is a “cheese-grater” style design comprising a block or substrate of silicon and which uses anisotropic etching of the silicon to form extremely sharp and precise cutting edges. As a specimen is cut, it passes through the silicon cutter and lies flat on a piece of glass which is bonded to the cutter. Microchannels are etched into the glass or silicon substrates for delivering small volumes of chemicals for treating the specimen. After treatment, the specimens can be examined through the glass substrate.

摘要翻译： 一种微加工活检/组织学仪器，其具有优于常规程序的几个优点，包括最小的样品处理，具有能够切割非常薄的样品（约2μm或更大）的原子清晰度的平滑切割边缘，用于处理样品的微量体积的化学品 ，低成本，一次性的制造工艺，使无菌部件和易于使用。 切割器是包括硅块或硅衬底的“干酪磨”式设计，其使用硅的各向异性蚀刻来形成非常清晰和精确的切割边缘。 当样品被切割时，它通过硅切割器并且平坦地放置在粘合到切割器上的一块玻璃上。 将微通道蚀刻到玻璃或硅衬底中，用于递送少量用于处理样品的化学品。 处理后，可以通过玻璃基板检查样品。

公开(公告)号：US5911737A

公开(公告)日：1999-06-15

申请号：US807412

申请日：1997-02-28

申请人： Abraham P. Lee ,  M. Allen Northrup ,  Dino R. Ciarlo ,  Peter A. Krulevitch ,  William J. Benett

发明人： Abraham P. Lee ,  M. Allen Northrup ,  Dino R. Ciarlo ,  Peter A. Krulevitch ,  William J. Benett

IPC分类号： A61B17/00 ,  A61B17/12 ,  A61M25/16 ,  A61B17/28

CPC分类号： A61B17/1214 ,  A61B17/12022 ,  A61B2017/00867 ,  A61B2017/00871 ,  A61B2017/12068 ,  A61B2017/12077

摘要： Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a release actuator for the delivery of embolic coils through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use.

摘要翻译： 使用形状记忆聚合物（SMP），在特定温度（Tg）下经历相变的基于聚氨酯的材料制造微制剂治疗致动器。 在高于温度的温度下，Tg材料是柔软的并且可以容易地重塑成另一种构型。 当温度降低到温度Tg以下时，只要材料保持低于温度Tg，新形状就会被固定和锁定。 将材料重新加热至高于Tg的温度时，材料将恢复到原来的形状。 通过使用这种SMP材料，SMP微管可以用作例如通过导管将栓塞线圈输送到动脉瘤中的释放致动器。 微管可以以各种尺寸制造，相变温度Tg对于预期的温度目标和预期用途是确定的。

公开(公告)号：US5722989A

公开(公告)日：1998-03-03

申请号：US812142

申请日：1997-03-06

申请人： Joseph P. Fitch ,  Karla Hagans ,  Robert Clough ,  Dennis L. Matthews ,  Abraham P. Lee ,  Peter A. Krulevitch ,  William J. Benett ,  Luiz Da Silva ,  Peter M. Celliers

发明人： Joseph P. Fitch ,  Karla Hagans ,  Robert Clough ,  Dennis L. Matthews ,  Abraham P. Lee ,  Peter A. Krulevitch ,  William J. Benett ,  Luiz Da Silva ,  Peter M. Celliers

IPC分类号： B25J15/08 ,  A61B17/00 ,  A61B17/12 ,  A61B17/28 ,  A61B19/00 ,  B81B3/00

CPC分类号： A61B17/1214 ,  A61B17/12022 ,  A61B17/29 ,  A61B2017/00292 ,  A61B2017/00345 ,  A61B2017/00398 ,  A61B2017/1205 ,  A61B2017/12068 ,  A61B2017/12077 ,  A61B2017/12081 ,  A61B2017/2926

摘要： A micro-mechanical system for medical procedures is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a near end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a near end for external coupling of laser light energy. A microgripper is attached to the distal end of the catheter and providing for the gripping or releasing of an object within the body. A laser-light-to-mechanical-power converter is connected to receive laser light from the distal end of the fiberoptic cable and connected to mechanically actuate the microgripper.

摘要翻译： 用于医疗程序的微机械系统以导管的基本形式构造，其具有用于插入身体内部和在身体内操作的远端，并且近端提供用户以控制身体内的远端的操纵。 光纤电缆设置在导管内并且具有靠近导管远端的远端和用于激光光能的外部耦合的近端。 微型抓爪附接到导管的远端，并提供用于在体内夹持或释放物体。 连接激光 - 光机械功率转换器以接收来自光纤电缆的远端的激光并连接到机械致动微型抓爪。

公开(公告)号：US5105429A

公开(公告)日：1992-04-14

申请号：US549509

申请日：1990-07-06

申请人： David C. Mundinger ,  William J. Benett ,  Raymond J. Beach

发明人： David C. Mundinger ,  William J. Benett ,  Raymond J. Beach

IPC分类号： H01S5/024 ,  H01S5/40

CPC分类号： H01S5/024 ,  H01S5/4025 ,  H01S5/02272 ,  H01S5/02423

摘要： A laser diode array is disclosed that includes a plurality of planar packages and active cooling. The laser diode array may be operated in a long duty cycle, or in continuous operation. A laser diode bar and a microchannel heat sink are thermally coupled in a compact, thin planar package having the laser diode bar located proximate to one edge. In an array, a number of such thin planar packages are secured together in a stacked configuration, in close proximity so that the laser diodes are spaced closely. The cooling means includes a microchannel heat sink that is attached proximate to the laser bar so that it absorbs heat generated by laser operation. To provide the coolant to the microchannels, each thin planar package comprises a thin inlet manifold and a thin outlet manifold connected to an inlet corridor and an outlet corridor. The inlet corridor comprises a hole extending through each of the packages in the array, and the outlet corridor comprises a hole extending through each of the packages in the array. The inlet and outlet corridors are connected to a conventional coolant circulation system. The laser diode array with active cooling has application as an optical pump for high power solid state lasers. Further, it can be incorporated in equipment such as communications devices and active sensors, and in military and space applications, and it can be useful in applications having space constraints and energy limitations.

摘要翻译： 公开了一种激光二极管阵列，其包括多个平面封装和主动冷却。 激光二极管阵列可以在长占空比或连续操作中操作。 激光二极管条和微通道散热器以紧凑的薄平面封装热耦合，其中激光二极管条位于一个边缘附近。 在阵列中，许多这样的薄平面封装以堆叠的结构紧密地固定在一起，使得激光二极管紧密地间隔开。 冷却装置包括靠近激光棒附接的微通道散热器，从而吸收由激光操作产生的热量。 为了将冷却剂提供给微通道，每个薄平面封装包括薄入口歧管和连接到入口走廊和出口走廊的薄出口歧管。 入口走廊包括延伸穿过阵列中每个包装的孔，并且出口走廊包括延伸穿过阵列中的每个包装的孔。 入口和出口走廊连接到常规的冷却剂循环系统。 具有主动冷却的激光二极管阵列具有作为大功率固态激光器的光泵的应用。 此外，它可以被并入诸如通信设备和有源传感器的设备中，以及在军事和空间应用中，并且在具有空间限制和能量限制的应用中是有用的。