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    Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
    55.
    发明授权
    Imidazo[4,5-d]pyrimidines, their uses and methods of preparation 有权
    咪唑并[4,5-d]嘧啶，其用途和制备方法

    公开(公告)号：US07790730B2

    公开(公告)日：2010-09-07

    申请号：US11190751

    申请日：2005-07-26

    申请人： Choung U. Kim ,  Johan Neyts ,  David A. Oare ,  Gerhard Puerstinger

    发明人： Choung U. Kim ,  Johan Neyts ,  David A. Oare ,  Gerhard Puerstinger

    IPC分类号： C07D473/02 ,  A61P31/14 ,  A61K31/52 ,  C07D471/04 ,  A61K31/4745 ,  C07D261/08

    CPC分类号： C07D471/04 ,  C07D473/00 ,  C07D473/30

    摘要： The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one compound having the general formula (A): wherein U is N or C; X is selected from C1-C10 alkylene, C2-10 alkenylene or C2-10 alkynylene, where each may include one or more intrachain heteroatoms selected from O, S, or NR11, provided any such heteroatom is not adjacent to the N in the ring; R3 is selected from aryl, aryloxy, arylthio, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl-N(R10)—, or heterocycle, where each said substituent is optionally substituted with at least one R17, provided that for cycloalkenyl the double bond is not adjacent to a nitrogen; and the other substituents are described in the specification. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula, their pharmaceutically acceptable formulations and their use as a medicine or to treat or prevent viral infections.

    摘要翻译： 本发明涉及用于治疗或预防病毒感染的药物组合物，其包含至少一种具有通式（A）的化合物作为活性成分：其中U为N或C; X选自C1-C10亚烷基，C2-10亚烯基或C2-10亚炔基，其中每个可以包括一个或多个选自O，S或NR 11的链内杂原子，条件是任何这样的杂原子不与环中的N相邻 ; R 3选自芳基，芳氧基，芳硫基，环烷基，环烯基，环炔基，芳基-N（R 10） - 或杂环，其中每个所述取代基任选被至少一个R 17取代，条件是对于环烯基，双键不相邻 到氮气 并且其它取代基在说明书中描述。 本发明还涉及制备具有上述通式的本发明化合物及其药学上可接受的制剂及其作为药物的用途或用于治疗或预防病毒感染的化合物的方法。