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    DISTRIBUTED SYSTEM AND METHODS FOR MODELING POPULATION-CENTRIC ACTIVITIES
    51.
    发明申请
    DISTRIBUTED SYSTEM AND METHODS FOR MODELING POPULATION-CENTRIC ACTIVITIES 审中-公开
    分布式系统和建模人口中心活动的方法

    公开(公告)号：US20130254152A1

    公开(公告)日：2013-09-26

    申请号：US13429139

    申请日：2012-03-23

    申请人： Rui Zhang ,  Maurice Kyojin Chu ,  Kurt E. Partridge ,  James M. A. Begole

    发明人： Rui Zhang ,  Maurice Kyojin Chu ,  Kurt E. Partridge ,  James M. A. Begole

    IPC分类号： G06N5/02 ,  G06F15/16

    CPC分类号： G06Q30/0631 ,  G06N20/00 ,  G06Q30/0201

    摘要： A client device can receive information about a population to which a user belongs. During operation, the client device determines information about a user, determines a group identifier for the user, and communicates the determined information about the local user and the group identifier to a group-modeling server. The client device then receives a group-activity model that corresponds to the group identifier, and generates a user-activity model for the local user based on the group-activity model and the determined information about the local user. The client device uses the user-activity model to compute an activity probability for a corresponding target activity. The group-modeling server receives user information from a plurality of client devices of a group, and generates a group-activity model for the group based on the user information. The server then sends the group-activity model to users of the identified group.

    摘要翻译： 客户端设备可以接收有关用户所属的群体的信息。 在操作期间，客户端设备确定关于用户的信息，确定用户的组标识符，并将确定的关于本地用户和组标识符的信息传送到组建模服务器。 然后，客户端设备接收与组标识符相对应的组活动模型，并且基于组活动模型和所确定的关于本地用户的信息为本地用户生成用户活动模型。 客户端设备使用用户活动模型来计算相应目标活动的活动概率。 组建模服务器从组的多个客户端设备接收用户信息，并且基于用户信息生成组的组活动模型。 然后，服务器将组活动模型发送给所识别组的用户。

    Recombinant human EPO-FC fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo
    52.
    发明授权
    Recombinant human EPO-FC fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo 有权
    重组人EPO-FC融合蛋白具有延长的半衰期和体内增强的红细胞生成活性

    公开(公告)号：US08431132B2

    公开(公告)日：2013-04-30

    申请号：US12555743

    申请日：2009-09-08

    申请人： Haitao Wang ,  Du Yong ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

    发明人： Haitao Wang ,  Du Yong ,  Rui Zhang ,  Jing Xu ,  Longbin Liu

    IPC分类号： A61K39/00 ,  C07K1/00 ,  C07K16/00

    CPC分类号： C07K14/505 ,  A61K9/0019 ,  A61K38/00 ,  A61K47/6811 ,  C07K2317/53 ,  C07K2319/30

    摘要： A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.

    摘要翻译： 描述了包含与免疫球蛋白肽部分连接的人促红细胞生成素肽部分的重组融合蛋白。 与天然存在的或重组的天然人促红细胞生成素相比，融合蛋白在体内具有延长的半衰期。 在本发明的一个实施方案中，蛋白质的体内半衰期比天然人促红细胞生成素高至少三倍。 与天然人促红细胞生成素相比，融合蛋白也表现出增强的红细胞生物活性。 在一个实施方案中，融合蛋白包含人促红细胞生成素（EPO）分子的完整肽序列和人免疫球蛋白IgG1的Fc片段的肽序列。 融合蛋白中的Fc片段包括人免疫球蛋白IgG1的铰链区，CH2和CH3结构域。 EPO分子可以直接连接到Fc片段，以避免外来的肽接头并且当在体内施用时减轻免疫原性应答的风险。 在一个实施方案中，铰链区是在氨基酸6具有非半胱氨酸残基的人Fc片段变体。本发明还涉及编码融合蛋白和转染细胞系的核酸和氨基酸序列以及用于产生融合蛋白的方法。 本发明还包括包含融合蛋白的药物组合物和使用融合蛋白和/或药物组合物的方法，例如刺激需要治疗的受试者的红细胞生成。

    MULTIPLE-ELECTRODE AND METAL-COATED PROBES
    56.
    发明申请
    MULTIPLE-ELECTRODE AND METAL-COATED PROBES 有权
    多电极和金属涂层探针

    公开(公告)号：US20120282644A1

    公开(公告)日：2012-11-08

    申请号：US13263234

    申请日：2010-04-23

    申请人： Haim H. Bau ,  Michael G. Schrlau ,  Rui Zhang

    发明人： Haim H. Bau ,  Michael G. Schrlau ,  Rui Zhang

    IPC分类号： C12M1/34 ,  B44C1/22 ,  G01N27/26 ,  B05D5/12

    CPC分类号： G01N33/48728

    摘要： Provided are probes featuring multiple electrodes, which probes have diameters in the nanometer range and may be inserted into cells or other subjects so as to monitor an electrical characteristic of the subject. The probes may also include a conductive coating on at least one probe element to improve the probes' performance. The probes may also be used to inject a fluid or other agent into the subject and simultaneously monitor changes in the subject's electrical characteristics in response to the injection. Related methods of fabricating and of using the inventive probes are also provided.

    摘要翻译： 提供了具有多个电极的探针，其探针具有纳米范围的直径并且可以插入细胞或其他受试者中，以便监测受试者的电特性。 探针还可以包括至少一个探针元件上的导电涂层以改善探针的性能。 探针还可以用于将流体或其它试剂注射到受试者中并且同时监测受试者响应于注射的电特征的变化。 还提供了制造和使用本发明的探针的相关方法。

    Reduced bandwidth off-loading of entropy coding/decoding
    57.
    发明授权
    Reduced bandwidth off-loading of entropy coding/decoding 有权
    降低熵编码/解码带宽的卸载

    公开(公告)号：US08270495B2

    公开(公告)日：2012-09-18

    申请号：US12370699

    申请日：2009-02-13

    申请人： Jim Chen Chou ,  Rui Zhang

    发明人： Jim Chen Chou ,  Rui Zhang

    IPC分类号： H04N7/26

    CPC分类号： H04N19/40 ,  H04N19/42 ,  H04N19/46 ,  H04N19/61

    摘要： Techniques are provided herein to produce encoded video bitstreams and to similarly decode encoded video bitstreams according to a coding standard not supported by an on-chip encoder/decoder. For purposes of encoding, a video sequence is received at a first device. A first bitstream is generated at the first device by encoding the video sequence according to a first coding standard and information associated with the video sequence is generated at the first device according to a second coding standard. The first bitstream and the information are then transmitted to a second device. At the second device the first bitstream is decoded to produce a second bitstream. The second bitstream and the information are combined by removing syntax elements associated with the first coding standard from the second bitstream and adding the information to produce a third bitstream according to the second coding standard. Similar techniques are provided for decoding an encoded bitstream to recover a video sequence.

    摘要翻译： 本文提供了技术来产生编码视频比特流，并且根据不由片上编码器/解码器支持的编码标准类似地解码经编码的视频比特流。 为了编码的目的，在第一设备处接收视频序列。 通过根据第一编码标准编码视频序列，在第一设备处产生第一比特流，并且根据第二编码标准在第一设备处生成与视频序列相关联的信息。 然后将第一比特流和信息发送到第二设备。 在第二设备处，第一比特流被解码以产生第二比特流。 通过从第二比特流中除去与第一编码标准相关联的语法元素，并根据第二编码标准添加信息以产生第三比特流，来组合第二比特流和信息。 提供了用于解码编码比特流以恢复视频序列的类似技术。

    Condenser microphone
    59.
    发明授权
    Condenser microphone 有权
    冷凝器麦克风

    公开(公告)号：US08249281B2

    公开(公告)日：2012-08-21

    申请号：US12651455

    申请日：2010-01-01

    申请人： Rui Zhang

    发明人： Rui Zhang

    IPC分类号： H04R25/00

    CPC分类号： H04R19/005

    摘要： A condenser microphone is disclosed. The condenser microphone includes a substrate having a cavity, a backplate connected to the substrate, a diaphragm facing to the backplate, and an anchor supporting the diaphragm. A first gap is formed between the diaphragm and the backplate. A groove is arranged on the anchor and the diaphragm partially covers the groove. The diaphragm and the groove forms a second gap communicating with the first gap.

    摘要翻译： 公开了一种电容麦克风。 电容麦克风包括具有空腔的基板，连接到基板的背板，面向背板的隔膜和支撑隔膜的锚固件。 在隔膜和背板之间形成第一间隙。 在锚上布置有凹槽，并且隔膜部分地覆盖凹槽。 隔膜和凹槽形成与第一间隙连通的第二间隙。