公开(公告)号：US20090009834A1

公开(公告)日：2009-01-08

申请号：US11868394

申请日：2007-10-05

申请人： Zahid Yaqoob ,  Emily McDowell ,  Changhuei Yang

发明人： Zahid Yaqoob ,  Emily McDowell ,  Changhuei Yang

IPC分类号： G03H1/08

CPC分类号： G03H1/0005 ,  G03H2001/0083 ,  G03H2001/0268 ,  G03H2001/0413 ,  G03H2001/0415 ,  G03H2210/63 ,  G03H2222/56

摘要： An optical phase processing system for a scattering medium. A first beam has a direction and a wavefront and the first beam is configured to enter a holographic recording medium. A scattering medium is illuminated by a signal beam generating at least one scattered beam. An interference pattern is recorded from the at least one scattered beam and the first beam. A second beam is generated in a direction opposite to the direction of the first beam, the second beam having a wavefront and a phase substantially opposite to a phase of the wavefront of the first beam, and the second beam is configured to enter the holographic recording medium. The second beam and the interference pattern interact to generate at least one reconstructed beam having a phase substantially opposite to a phase of the at least one scattered beam, and the at least one reconstructed beam is configured to be viewable through the scattering medium.

摘要翻译： 一种用于散射介质的光学相位处理系统。 第一光束具有方向和波前，并且第一光束被配置为进入全息记录介质。 散射介质由产生至少一个散射光束的信号光束照射。 从至少一个散射光束和第一光束记录干涉图案。 在与第一光束的方向相反的方向上产生第二光束，第二光束具有波前和与第一光束的波阵面的相位基本相反的相位，第二光束被配置为进入全息记录 中。 所述第二光束和所述干涉图案相互作用以产生具有与所述至少一个散射光束的相位基本相反的相位的至少一个重建光束，并且所述至少一个重建光束被配置为通过所述散射介质可观看。

公开(公告)号：US07385460B1

公开(公告)日：2008-06-10

申请号：US11264980

申请日：2005-11-01

申请人： Fei Wang ,  David Erickson ,  Changhuei Yang

发明人： Fei Wang ,  David Erickson ,  Changhuei Yang

IPC分类号： H01P5/00

CPC分类号： H01P5/00

摘要： A system for detecting interactions between charged targets and analytes. The system includes a fluid channel, and a waveguide associated with the fluid channel. A detection region is associated with the waveguide, and a biasing element is operatively coupled to the detection region. The biasing element is adapted to electrically bias a portion of the waveguide at the detection region, and the charged targets are electrostatically bound to the detection region when the portion of the waveguide is electrically biased. An optical detector is adapted to detect optical changes from the detection region.

摘要翻译： 用于检测带电目标和分析物之间相互作用的系统。 该系统包括流体通道和与流体通道相关联的波导。 检测区域与波导相关联，并且偏置元件可操作地耦合到检测区域。 偏置元件适于在检测区域电偏置波导的一部分，并且当波导的部分被电偏置时，带电目标被静电地结合到检测区域。 光学检测器适于检测来自检测区域的光学变化。

公开(公告)号：US20070258096A1

公开(公告)日：2007-11-08

申请号：US11743581

申请日：2007-05-02

申请人： Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis

发明人： Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer ,  Demetri Psaltis

IPC分类号： G01B9/02

CPC分类号： G02B21/0056 ,  G01N21/553 ,  G02B21/18 ,  G02B21/361

摘要： A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination source, and a photodetector to receive Young's interference from the illumination passing through the pair of two apertures. In addition, a surface plasmon assisted optofluidic microscope and method utilize an illumination source, a fluid channel having a layer with at least one aperture as a surface, and a photodetector that receives a signal based on the illumination passing through the aperture. The layer is corrugated (e.g., via fabrication) and parameters of the corrugation optimize the signal received on the photodetector.

摘要翻译： 差分干涉对比度（DIC）确定装置和方法利用照明源，具有一对两个孔的层，其接收来自照明源的照明，以及光电检测器，用于接收来自穿过该对两个孔的照明的杨氏干扰。 此外，表面等离子体激元辅助光流体显微镜和方法利用照明源，具有至少一个孔作为表面的层的流体通道，以及基于穿过孔的照明而接收信号的光电检测器。 该层是波纹状的（例如通过制造），并且波纹的参数优化了在光电检测器上接收的信号。

公开(公告)号：US20050271548A1

公开(公告)日：2005-12-08

申请号：US11125718

申请日：2005-05-09

申请人： Changhuei Yang ,  Demetri Psaltis

发明人： Changhuei Yang ,  Demetri Psaltis

IPC分类号： G01N21/00 ,  G01N21/64

CPC分类号： G01N21/6458 ,  B82Y10/00 ,  B82Y20/00

摘要： An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light imaging elements in the bottom of the fluid channel may be used to image the object.

摘要翻译： 公开了一种光流体显微镜装置。 该装置包括具有表面的流体通道，诸如细菌或病毒的物体可以流过流体通道。 流体通道底部的光成像元件可用于成像物体。

公开(公告)号：US06934035B2

公开(公告)日：2005-08-23

申请号：US10024455

申请日：2001-12-18

申请人： Changhuei Yang ,  Adam Wax ,  Ramachandra R. Dasari ,  Michael S. Feld

发明人： Changhuei Yang ,  Adam Wax ,  Ramachandra R. Dasari ,  Michael S. Feld

IPC分类号： A61B3/10 ,  G01B9/02 ,  G01B11/00 ,  G01B11/02 ,  G01J9/04 ,  G01N21/17 ,  G01N21/45

CPC分类号： G01B9/02007 ,  G01B9/02002 ,  G01B9/02078 ,  G01B9/0209 ,  G01B2290/45 ,  G01J9/04 ,  G01N21/45

摘要： The methods of the present invention are directed at an accurate phase-based technique for measuring arbitrarily long optical distances with sub-nanometer precision. A preferred embodiment of the present invention method employs a interferometer, for example, a Michelson interferometer, with a pair of harmonically related light sources, one continuous wave (CW) and a second source having low coherence. By slightly adjusting the center wavelength of the low coherence source between scans of the target sample, the phase relationship between the heterodyne signals of the CW and low coherence light is used to measure the separation between reflecting interfaces with sub-nanometer precision. As the preferred embodiment of this method is completely free of 2π ambiguity, an issue that plagues most phase-based techniques, it can be used to measure arbitrarily long optical distances without loss of precision.

摘要翻译： 本发明的方法涉及用于以亚纳米精度测量任意长的光学距离的精确的基于相位的技术。 本发明方法的优选实施例采用干涉仪，例如迈克尔逊干涉仪，具有一对谐波相关的光源，一个连续波（CW）和具有低相干性的第二源。 通过在目标样本的扫描之间稍微调整低相干光源的中心波长，使用CW的外差信号与低相干光之间的相位关系来测量具有亚纳米精度的反射界面之间的距离。 由于该方法的优选实施例完全不存在2pi模糊度，这是一种困扰大多数基于相位的技术的问题，可以用于测量任意长的光学距离而不损失精度。

公开(公告)号：US09086536B2

公开(公告)日：2015-07-21

申请号：US13415657

申请日：2012-03-08

申请人： Shuo Pang ,  Changhuei Yang

发明人： Shuo Pang ,  Changhuei Yang

IPC分类号： H01L27/146 ,  G02B5/18 ,  G02B21/06 ,  G02B21/36

CPC分类号： G02B5/1842 ,  G02B21/06 ,  G02B21/367

摘要： Talbot imaging systems comprising a Talbot element, a phase gradient generating device, a light detector, and a processor. The Talbot element repeats a Talbot image at a distance from the Talbot element. The phase gradient generating device scans the Talbot image at a plane at the distance from the Talbot element by incrementally changing a phase gradient of a light field incident the Talbot element. As the Talbot image is scanned, the light detector captures time varying data associated with light altered by an object located at the distance from the Talbot element. The processor reconstructs an image of the object based on the time-varying light data.

摘要翻译： Talbot成像系统包括Talbot元件，相梯度产生装置，光检测器和处理器。 Talbot元素重复了距离Talbot元素一段距离的Talbot图像。 相位梯度发生装置通过逐渐改变入射到塔尔博特元件的光场的相位梯度来扫描与Talbot元件距离的平面处的Talbot图像。 当Talbot图像被扫描时，光检测器捕获与位于距离Talbot元件距离的物体改变的光相关联的时变数据。 处理器基于时变光数据重建对象的图像。

公开(公告)号：US08325988B2

公开(公告)日：2012-12-04

申请号：US12397152

申请日：2009-03-03

申请人： Jian Ren ,  Changhuei Yang

发明人： Jian Ren ,  Changhuei Yang

IPC分类号： G06K9/00

CPC分类号： A61B3/0008 ,  A61B1/00009 ,  A61B1/313 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/064 ,  A61B5/065 ,  A61B5/6848 ,  G06T11/006 ,  G06T2211/436

摘要： A system, method, and apparatus provide the ability to reconstruct an image from an object. A hand-held image acquisition device is configured to acquire local image information from a physical object. A tracking system obtains displacement information for the hand-held acquisition device while the device is acquiring the local image information. An image reconstruction system computes the inverse of the displacement information and combines the inverse with the local image information to transform the local image information into a reconstructed local image information. A display device displays the reconstructed local image information.

摘要翻译： 系统，方法和装置提供从对象重建图像的能力。 手持图像获取装置被配置为从物理对象获取本地图像信息。 跟踪系统在获取本地图像信息的同时获得手持式采集装置的位移信息。 图像重建系统计算位移信息的倒数，并将该反相与局部图像信息相结合，将局部图像信息变换为重建的局部图像信息。 显示装置显示重建的局部图像信息。

公开(公告)号：US20120267515A1

公开(公告)日：2012-10-25

申请号：US13451543

申请日：2012-04-20

申请人： Jigang Wu ,  Shuo Pang ,  Zheng Li ,  Guoan Zheng ,  Changhuei Yang

发明人： Jigang Wu ,  Shuo Pang ,  Zheng Li ,  Guoan Zheng ,  Changhuei Yang

IPC分类号： G01J1/04 ,  G02B5/18 ,  G01J1/44

CPC分类号： G02B21/086 ,  G02B21/0044 ,  G02B21/244 ,  G02B21/361 ,  G02B27/4227

摘要： A Talbot-illuminated imaging system for focal plane tuning, the device comprising a Talbot element, a tunable illumination source, a scanning mechanism, a light detector, and a processor. The element generate san array of focused light spots at a focal plane. The tunable illumination source shifts the focal plane to a plane of interest by adjusting a wavelength of light incident the Talbot element. The scanning mechanism scans an object across an array of focused light spots in a scanning direction. The light detector determines time-varying light data associated with the array of focused light spots as the object scans across the array of light spots. The processor constructs an image of the object based on the time-varying data.

摘要翻译： 一种用于焦平面调谐的Talbot照明成像系统，该装置包括Talbot元件，可调谐照明源，扫描机构，光检测器和处理器。 该元素在聚焦平面上产生聚焦光斑的圣阵列。 可调谐照明源通过调节入射到Talbot元件的光的波长将焦平面移动到感兴趣的平面。 扫描机构沿着扫描方向的聚焦光点阵列扫描物体。 光检测器确定随着对象扫描光点阵列而与聚焦光点阵列相关联的时变光数据。 处理器基于时变数据构建对象的图像。

公开(公告)号：US20120228475A1

公开(公告)日：2012-09-13

申请号：US13415657

申请日：2012-03-08

申请人： Shuo Pang ,  Changhuei Yang

发明人： Shuo Pang ,  Changhuei Yang

IPC分类号： H01L27/146 ,  G02B5/18

CPC分类号： G02B5/1842 ,  G02B21/06 ,  G02B21/367

摘要： Talbot imaging systems comprising a Talbot element, a phase gradient generating device, a light detector, and a processor. The Talbot element repeats a Talbot image at a distance from the Talbot element. The phase gradient generating device scans the Talbot image at a plane at the distance from the Talbot element by incrementally changing a phase gradient of a light field incident the Talbot element. As the Talbot image is scanned, the light detector captures time varying data associated with light altered by an object located at the distance from the Talbot element. The processor reconstructs an image of the object based on the time-varying light data.

摘要翻译： Talbot成像系统包括Talbot元件，相梯度产生装置，光检测器和处理器。 Talbot元素重复了距离Talbot元素一段距离的Talbot图像。 相位梯度发生装置通过逐渐改变入射到塔尔博特元件的光场的相位梯度来扫描与Talbot元件距离的平面处的Talbot图像。 当Talbot图像被扫描时，光检测器捕获与位于距离Talbot元件距离的物体改变的光相关联的时变数据。 处理器基于时变光数据重建对象的图像。

公开(公告)号：US20120098950A1

公开(公告)日：2012-04-26

申请号：US13281287

申请日：2011-10-25

申请人： Guoan Zheng ,  Samuel Yang ,  Seung Ah Lee ,  Changhuei Yang

发明人： Guoan Zheng ,  Samuel Yang ,  Seung Ah Lee ,  Changhuei Yang

IPC分类号： H04N7/18

CPC分类号： H04N7/183 ,  G02B21/0008 ,  G02B21/06 ,  G02B21/367 ,  G03H2001/0447

摘要： A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest.

摘要翻译： 一种扫描投影镜头无显微镜装置，包括一个样品表面，一个带有光元件的扫描照明源，在样品表面外部的光检测器和一个处理器。 扫描照明源将光元件扫描到多个扫描位置以向样品表面上的物体提供照明。 光检测器对与多个扫描位置对应的子像素偏移投影对象图像序列进行采样。 处理器基于子像素移位的投影图像的序列和感兴趣的平面上的投影的运动矢量来构建对象的高分辨率图像。