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公开(公告)号：US11026894B2
公开(公告)日：2021-06-08
申请号：US16739197
申请日：2020-01-10
发明人： Darrell J. Irvine , Ron Weiss , Tasuku Kitada , Mariane Melo , Yuan Zhang
摘要： Disclosed herein are lipid nanoparticles comprising 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000](DSPE-PEG2000), compositions including such lipid nanoparticles, and methods of treatment using such lipid nanoparticles and compositions.
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公开(公告)号：US20200224174A1
公开(公告)日：2020-07-16
申请号：US16739182
申请日：2020-01-10
发明人： Darrell J. Irvine , Ron Weiss , Yingzhong Li
摘要： The disclosure provides methods for an in vitro evolution technique to identify and characterize mutations in the non-structural genes of an alphavirus replicon that increase the strength and persistence of expression of the replicon genome. Also provided herein are in vivo methods for administering to an animal model a mutated alphavirus replicon that codes for a gene of experimental or therapeutic interest in the subgenome of the alphavirus replicon. The mutations identified herein improve the therapeutic potential of self-replicating RNA, which may have implications for cancer immunotherapy and beyond, e.g., for vaccination or gene therapy.
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公开(公告)号：US20200222332A1
公开(公告)日：2020-07-16
申请号：US16739197
申请日：2020-01-10
发明人： Darrell J. Irvine , Ron Weiss , Tasuku Kitada , Mariane Melo , Yuan Zhang
摘要： Disclosed herein are lipid nanoparticles having a specific composition, compositions including such lipid nanoparticles, and methods of treatment using such lipid nanoparticles and compositions.
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公开(公告)号：US10300145B2
公开(公告)日：2019-05-28
申请号：US15650177
申请日：2017-07-14
发明人： Darrell J. Irvine , Eric Dane
IPC分类号： A61K9/51 , A61K47/64 , C07K19/00 , C08G69/10 , A61K47/68 , C07K14/00 , A61K47/54 , A61K47/69
摘要： The present disclosure provides a synthetic nanoparticle comprising a peptide nucleic acid (PNA) oligomer conjugated to a lipid, wherein the PNA oligomer noncovalently complexes with an immunomodulatory compound, thereby forming a nanoparticle. The nanoparticles are useful to elicit immune responses and can be used to treat a broad range of cancers and infectious diseases.
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公开(公告)号：US10226510B2
公开(公告)日：2019-03-12
申请号：US15470169
申请日：2017-03-27
发明人： Li Tang , Darrell J. Irvine
摘要： The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.
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公开(公告)号：US09709479B2
公开(公告)日：2017-07-18
申请号：US14523376
申请日：2014-10-24
发明人： Marc Castellarnau , Gregory Lee Szeto , Darrell J. Irvine , John Christopher Love , Joel Voldman
CPC分类号： G01N15/1463 , G01N15/10 , G01N15/1484 , G01N35/00732 , G01N2015/0065 , G01N2015/008 , G01N2015/1006 , G01N2015/149 , G01N2035/00811 , G01N2035/00831
摘要： A method of tracking cell identity across analytical platforms uses stochastic barcoding (SB). SB uses a randomly generated code based on one or more of the number, color and position of beads encapsulated together with a set of cells of interest. SB use is demonstrated in an application where cells are transferred from a microwell array into a microtiter plate while keeping their identity, and obtained an average identification accuracy of 96% for transfer of 100 blocks. Model scaling of the method up to 1000 blocks demonstrated that SB is able to achieve approximately 90% accuracy.
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公开(公告)号：US20160038415A1
公开(公告)日：2016-02-11
申请号：US14741694
申请日：2015-06-17
发明人： Darrell J. Irvine , Jaehyun Moon
CPC分类号： A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要： The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
摘要翻译： 本发明提供由稳定的多层泡囊组成的递送系统，以及组合物，合成方法及其使用方法。 稳定的多层囊泡在其表面和/或内部包含带有末端半胱氨酸的抗原或半胱氨酸修饰的抗原。
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公开(公告)号：US20140127774A1
公开(公告)日：2014-05-08
申请号：US13667775
申请日：2012-11-02
IPC分类号： C12N11/08
CPC分类号： C12N11/08 , C12N5/0068 , C12N2533/30 , C12N2533/80
摘要： Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs).
摘要翻译： 均匀的功能性聚合物贴剂可以附着在活细胞表面积的一部分。 这些表面修饰的细胞在附着功能性贴片后保持活性。 贴片不会完全遮挡周围环境中的细胞表面。 由贴片携带的功能性有效载荷可以包括例如药物或其它小分子，肽，蛋白质，热响应聚合物和纳米颗粒，或可并入亚细胞尺寸的聚合物贴片中的任何其它材料。 贴剂可以包括一种或多种聚电解质多层（PEM）。
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公开(公告)号：US12018315B2
公开(公告)日：2024-06-25
申请号：US16887649
申请日：2020-05-29
IPC分类号： C12Q1/6806 , C12M1/34 , C12Q1/6823 , G01N21/64
CPC分类号： C12Q1/6806 , C12M41/36 , C12Q1/6823 , G01N21/6428 , C12Q2565/1025 , C12Q2565/629
摘要： The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin.
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公开(公告)号：US11964026B2
公开(公告)日：2024-04-23
申请号：US17892496
申请日：2022-08-22
发明人： Antonio Eric Barberio , Santiago Correa Echavarria , Mariane Bandeira Melo , Talar Tokatlian , Erik Christopher Dreaden , Paula T. Hammond , Darrell J. Irvine
CPC分类号： A61K47/6911 , A61K9/0019 , A61K9/1271 , A61K38/208 , A61K47/544 , A61P35/00
摘要： Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
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