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72 条记录 (耗时 0.05 秒)

    Polypeptides their production and use
    52.
    发明授权
    Polypeptides their production and use 失效
    多肽的生产和使用

    公开(公告)号：US06228984B1

    公开(公告)日：2001-05-08

    申请号：US08776971

    申请日：1997-02-07

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K1447

    CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/575 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选 的药物候选化合物。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

    Polypeptide having c-AMP-producing activity
    53.
    发明授权
    Polypeptide having c-AMP-producing activity 失效
    具有C-AMP生产活性的多肽

    公开(公告)号：US5208320A

    公开(公告)日：1993-05-04

    申请号：US732059

    申请日：1991-07-18

    申请人： Chieko Kitada ,  Takuya Watanabe

    发明人： Chieko Kitada ,  Takuya Watanabe

    IPC分类号： A61K38/00 ,  C07K14/575

    CPC分类号： C07K14/57563 ,  A61K38/00

    摘要： A polypeptide or a pharmaceutically acceptable salt thereof having c-AMP-producing activity is disclosed, the polypeptide being represented by the following general formula:X-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Y (X-SEQ ID NO:2-Y)wherein X represents any amino acid residue or an acyl group, and Y represents NH.sub.2, OH, Ala-NH.sub.2, Ala-OH, Ala-Ala-NH.sub.2, Ala-Ala-OH, Ala-Ala-Val-NH.sub.2 or Ala-Ala-Val-OH.

    Polypeptide-diesters, their production and use
    54.
    发明授权
    Polypeptide-diesters, their production and use 失效
    多肽 - 二酯，其生产和使用

    公开(公告)号：US4559324A

    公开(公告)日：1985-12-17

    申请号：US513340

    申请日：1983-07-13

    申请人： Masahiko Fujino ,  Chieko Kitada

    发明人： Masahiko Fujino ,  Chieko Kitada

    IPC分类号： A61K38/00 ,  A61K38/22 ,  A61P25/04 ,  A61P43/00 ,  C07K7/06 ,  C07K7/22 ,  A61K37/02

    CPC分类号： C07K7/22 ,  A61K38/00 ,  Y02P20/55

    摘要： Novel polypeptide-diesters, inclusive of salts thereof, which have the formula: ##STR1## wherein A.sub.1 is arginine or lysine or a di- or tripeptide residue having arginine or lysine at its N-terminal; A.sub.2 is an aromatic amino acid residue; A.sub.3 is a neutral amino acid or aromatic amino acid residue; each of the amino acid residues mentioned may be optionally L-configured or D-configured; and n is 0, 1 or 2. These compounds are useful as analgesics.

    摘要翻译： 新颖的多肽 - 二酯，包括其盐，其具有下式：其中A1是精氨酸或赖氨酸或其N-末端具有精氨酸或赖氨酸的二肽或三肽残基; A2是芳香族氨基酸残基; A3是中性氨基酸或芳香族氨基酸残基; 所提及的每个氨基酸残基可以任选地L构型或D构型; 并且n为0,1或2.这些化合物可用作止痛剂。

    GONADAL FUNCTION IMPROVING AGENTS
    57.
    发明申请
    GONADAL FUNCTION IMPROVING AGENTS 审中-公开
    全功能改善剂

    公开(公告)号：US20110052563A1

    公开(公告)日：2011-03-03

    申请号：US12710864

    申请日：2010-02-23

    申请人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    IPC分类号： A61K39/395 ,  A61K38/16 ,  A61K31/7088 ,  A61K31/711 ,  A61P15/08 ,  A61P15/00 ,  A61P5/00

    CPC分类号： G01N33/689 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/1709

    摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.

    摘要翻译： 促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂， 并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。

    Anti-metastin antibody and its use
    58.
    发明授权
    Anti-metastin antibody and its use 有权
    抗转移抗体及其用途

    公开(公告)号：US07691979B2

    公开(公告)日：2010-04-06

    申请号：US11498439

    申请日：2006-08-02

    申请人： Hirokazu Matsumoto ,  Yasuko Horikoshi ,  Chieko Kitada ,  Tetsuya Ohtaki

    发明人： Hirokazu Matsumoto ,  Yasuko Horikoshi ,  Chieko Kitada ,  Tetsuya Ohtaki

    IPC分类号： C07K16/00

    CPC分类号： G01N33/689 ,  C07K16/18 ,  G01N33/6857 ,  G01N2800/368

    摘要： The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same. Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.

    摘要翻译： 本发明的目的在于提供抗体，通过该抗体可以以高灵敏度特异性地定量分析蛋白或其衍生物，使用抗体检测/定量分析蛋白或其衍生物的方法，以及诊断剂（例如，怀孕诊断） 一样。 具体而言，能够与具有SEQ ID NO：1所示的氨基酸序列的多肽的N末端或C末端的部分肽特异性反应的抗体或其衍生物，以及检测/定量分析的方法 衍生物以及使用该抗体的诊断剂。