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144 条记录 (耗时 0.042 秒)

    Tetrahydronaphthalene compounds
    51.
    发明授权
    Tetrahydronaphthalene compounds 失效
    四氢萘化合物

    公开(公告)号：US5837807A

    公开(公告)日：1998-11-17

    申请号：US607734

    申请日：1996-02-27

    申请人： Christine Abrecht ,  Alfred Grieder ,  Klaus Muller ,  Daniel Obrecht

    发明人： Christine Abrecht ,  Alfred Grieder ,  Klaus Muller ,  Daniel Obrecht

    IPC分类号： A61K38/00 ,  C07K1/107 ,  C07K7/06 ,  C07K7/08 ,  C07K4/00 ,  C07D285/00 ,  C07K5/12

    CPC分类号： C07K7/08

    摘要： This invention is directed to tetrahydronaphthalene compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, bromine, cyano, formyl, hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, aryloxy, lower aralkoxy or aryl; R.sup.2 is an amino acid residue or a chain of 2 to 20 amino acid residues wherein reactive moieties in the side chains of the amino acid residue(s) is/are protected or unprotected, and wherein the amino group of the N-terminal amino acid is a free or protected amino group; A.sup.1, A.sup.2, A.sup.3 and A.sup.4 each are .alpha.-amino acid residues wherein A.sup.1 and A.sup.2 are in the L configuration and A.sup.3 and A.sup.4 are in the D configuration when the .alpha.-C atom of said .alpha.-amino acid residue is asymmetric; X is oxygen or sulphur; Y is a residue of the formula ##STR2## n is 0 or 1; R.sup.3 is hydrogen or lower alkyl; R.sup.4 is hydrogen or lower alkyl; and Z and the two C atoms together are an aromatic ring selected from the group of benzene, furan, thiophene, pyridine or pyrimidine, wherein said aromatic ring is substituted or unsubstituted; and salts thereof and their intermediates. The compounds are useful as mimetics of exposed helical domains of proteins in order to clarify their role with respect to interactions with other proteins or with DNA or RNA through .alpha.-helical conformation. They are therefore valuable aids in the determination of biologically active peptide sequences and are accordingly so-called "research tools". They are also potentially useful as medicaments.

    摘要翻译： 本发明涉及下式的四氢化萘化合物，其中R 1是氢，溴，氰基，甲酰基，羟基，低级烷基，低级烯基，低级炔基，低级烷氧基，芳氧基，低级芳烷氧基或芳基。 R2是氨基酸残基或2至20个氨基酸残基的链，其中氨基酸残基的侧链中的活性部分被保护或未被保护，并且其中N-末端氨基酸的氨基 是一个游离或保护的氨基; A1，A2，A3和A4各自为α-氨基酸残基，其中A1和A2为L构型，当所述α-氨基酸残基的α-C原子不对称时，A3和A4为D构型; X是氧或硫; （a）下式的残基：（a）（b）n为0或1; R3是氢或低级烷基; R4是氢或低级烷基; Z和两个C原子一起是选自苯，呋喃，噻吩，吡啶或嘧啶的芳环，其中所述芳环是取代或未取代的; 及其盐及其中间体。 这些化合物可用作蛋白质暴露的螺旋结构域的模拟物，以便澄清其在与其他蛋白质的相互作用或通过α-螺旋构象与DNA或RNA的作用。 因此，它们是测定生物活性肽序列的有价值的辅助因素，因此是所谓的“研究工具”。 它们也可能用作药物。

    Tetrahydronaphthalene derivatives
    54.
    发明授权
    Tetrahydronaphthalene derivatives 失效
    四氢萘衍生物

    公开(公告)号：US5644024A

    公开(公告)日：1997-07-01

    申请号：US292128

    申请日：1994-08-17

    申请人： Christine Abrecht ,  Klaus Muller ,  Daniel Obrecht ,  Arnold Trzeciak

    发明人： Christine Abrecht ,  Klaus Muller ,  Daniel Obrecht ,  Arnold Trzeciak

    IPC分类号： G01N33/68 ,  A61K38/00 ,  C07K5/062 ,  C07K7/06 ,  C07K7/08 ,  C07K7/54 ,  C07D285/00 ,  C07K4/00

    CPC分类号： C07K7/08 ,  Y02P20/55

    摘要： The present invention is concerned with tetrahydronaphthalene derivatives which are mimics of domains of peptides or proteins which can interact with other proteins or with DNA or RNA through .alpha.-helical conformation, said tetrahydronaphthalene derivatives having the formulae: ##STR1## are valuable aids in the determination of biologically active peptide sequences and are accordingly so-called "research tools". They are, however, also potentially suitable as medicaments.

    摘要翻译： 本发明涉及四氢萘衍生物，其是模拟可通过α-螺旋构象与其他蛋白质或与其它蛋白质或DNA或RNA相互作用的肽或蛋白质的结构域，所述四氢萘衍生物具有下列结构式： 有用的帮助确定生物活性肽序列，因此是所谓的“研究工具”。 然而，它们也可能适合作为药物。

    Highly wear-resistant overlay with improved slip and a method of its production
    57.
    发明授权
    Highly wear-resistant overlay with improved slip and a method of its production 失效
    高度耐磨的覆盖层，具有改进的滑动性及其生产方法

    公开(公告)号：US5300368A

    公开(公告)日：1994-04-05

    申请号：US768088

    申请日：1991-09-25

    申请人： Michael Kubert ,  Klaus Muller

    发明人： Michael Kubert ,  Klaus Muller

    IPC分类号： C25D5/26 ,  C25D7/10 ,  F16C33/12 ,  B32B15/01 ,  C22F1/00 ,  F16C33/14

    CPC分类号： F16C33/124 ,  F16C33/121 ,  Y10S384/912 ,  Y10S428/941 ,  Y10T428/12458 ,  Y10T428/12681 ,  Y10T428/12687 ,  Y10T428/12708

    摘要： Highly wear-resistant sliding bearings with good sliding properties are difficult to manufacture by electrochemical deposition of the sliding alloy, because the corresponding electrolyte solutions are unstable. Conventional sliding alloys are also too hard for a run-in period and wear too rapidly when used in accordance with specifications. The new sliding layer is simple to manufacture and has an extremely favorable run-in period. The soft constituent of the sliding layer is present in a concentration which decreases along a concentration gradient perpendicular to the effective surface of the sliding layer as the distance from the effective surface increases. The sliding layer is particularly suitable for use as a lead-tin-copper alloy in a multilayered bearing.

    摘要翻译： PCT No.PCT / DE91 / 00079 Sec。 371日期1991年9月25日 102（e）1991年9月25日PCT 1991年1月26日PCT PCT。 公开号WO91 / 11545 日期：1991年8月8日。具有良好滑动性能的高耐磨滑动轴承难以通过滑动合金的电化学沉积而制造，因为相应的电解质溶液是不稳定的。 常规的滑动合金对于磨合时间也是太硬的，并且在根据规格使用时磨损太快。 新的滑动层制造简单，具有非常有利的磨合期。 随着距离有效表面的距离增加，滑动层的软组分以沿垂直于滑动层的有效表面的浓度梯度减小的浓度存在。 滑动层特别适用于多层轴承中的铅 - 锡 - 铜合金。

    C-shaped sheet-metal nut
    59.
    发明授权
    C-shaped sheet-metal nut 失效
    C形金属板螺母

    公开(公告)号：US4793753A

    公开(公告)日：1988-12-27

    申请号：US937390

    申请日：1986-12-03

    申请人： Klaus Muller ,  Lothar Escher ,  Gerhard Mack ,  Ernst Kramer

    发明人： Klaus Muller ,  Lothar Escher ,  Gerhard Mack ,  Ernst Kramer

    IPC分类号： B23P19/06 ,  B25B23/04 ,  B25B23/08 ,  B25B27/20 ,  B25B31/00 ,  F16B37/04 ,  F16B37/12 ,  F16B39/28

    CPC分类号： B25B27/20 ,  B25B23/08 ,  B25B31/00 ,  F16B37/041 ,  Y10S277/907 ,  Y10T24/44 ,  Y10T29/53487 ,  Y10T29/535

    摘要： A clip-like, C-shaped sheet-metal nut and an assembly device therefor, the nut having a thread leg with an embossed thread portion and a clip leg having a through hole, with the forward end of the thread leg having an upwardly and forwardly inclined insertion plate. A pair of guide webs are integrally formed on the two lateral edges of the thread leg that extend upwardly at right angles to the leg with the upper edges of the webs protruding above the insertion plate and running parallel to the clip leg and with their side surfaces being in line with the lateral edges of the clip leg to provide a substantially outer rectangular perimeter to the nut.

    摘要翻译： 夹子状的C形金属片螺母及其组装装置，该螺母具有带有压花螺纹部分的螺纹腿和具有通孔的夹腿，其中，所述螺纹腿的前端具有向上且 向前倾斜插入板。 一对引导腹板一体地形成在螺纹腿的两个侧边缘上，与腿部成直角向上延伸，腹板的上边缘突出于插入板的上方并平行于夹子腿并且与其侧面 与夹腿的侧边缘一致，以向螺母提供基本上外部的矩形周边。

    Self-locking sheet-metal nut
    60.
    发明授权
    Self-locking sheet-metal nut 失效
    自锁钣金螺母

    公开(公告)号：US4714392A

    公开(公告)日：1987-12-22

    申请号：US917484

    申请日：1986-10-10

    申请人： Klaus Muller ,  Bernd Mutz ,  Helmo Daler

    发明人： Klaus Muller ,  Bernd Mutz ,  Helmo Daler

    IPC分类号： F16B37/04 ,  F16B37/02

    CPC分类号： F16B37/041

    摘要： A self-locking sheet-metal nut having a generally flat leg with an embossed thread portion for receipt of a screw and a pair of locking tabs resiliently and integrally connected to one end of said leg that extend over and are spaced from the leg. The tabs are approximately perpendicular to the axis of the screw and have clamping edges which are directed toward each other and form an opening downstream of the embossed thread portion that is smaller than the core diameter of the screw to be threaded into the nut. Upon turning of a screw through the nut, the clamping edges are forced apart and resiliently grip the core of the screw to lock it in place.

    摘要翻译： 一种具有大致扁平腿部的自锁金属螺母，其具有用于接收螺钉的压花螺纹部分和一对弹性地并且整体地连接到所述腿部的一端延伸并与腿部间隔开的一对锁定突出部。 突片大致垂直于螺钉的轴线并且具有彼此指向的夹持边缘，并且在压花螺纹部分的下游形成小于要拧入螺母的螺钉的芯直径的开口。 当螺钉通过螺母转动时，夹紧边缘被强制分开并弹性地夹紧螺钉的芯部以将其锁定就位。