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    Phosthetic ligament
    54.
    发明授权
    Phosthetic ligament 失效
    假韧带

    公开(公告)号：US4790850A

    公开(公告)日：1988-12-13

    申请号：US64634

    申请日：1987-06-22

    申请人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  James A. Davidson ,  Neil B. Beals ,  Yancy L. Gill

    发明人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  James A. Davidson ,  Neil B. Beals ,  Yancy L. Gill

    IPC分类号： A61F2/08

    CPC分类号： A61F2/08 ,  D04C1/12 ,  D10B2509/00

    摘要： A prosthetic ligament assembly includes a nonaugmented prosthetic ligament for permanently replacing a natural ligament spanning first and second body members, such as the femur and tibia, and a bone screw adapted for tensioning the prosthetic ligament during implantation. The prosthetic ligament includes a load bearing member intertwined into a plain braid from a plurality of biocompatible, high strength, ultra high molecular weight polyethylene yarns. Each yarn includes at least fifty fibers and has a tensile strength greater than or equal to about 100,000 psi. The load bearing member has a gage section and a loop at each end thereof for anchoring the load bearing member to the body members. The load bearing member is preloaded to remove slack therefrom. The load bearing member may be used alone or may be formed into a hollow braid having a core disposed within the hollow portion of the braid to permit radiographic visualization of the prosthetic ligament. A sheath may be friction fit or molded onto the exterior of the gage section. The assembly also includes one or two bone screws for complimentary engagement with the loops of the load bearing member. The bone screws have a tapered section extending beneath the head of the screw to the shank for tensioning the prosthetic ligament during implantation.

    摘要翻译： 假肢韧带组件包括用于永久地替换跨越第一和第二身体构件（例如股骨和胫骨）的天然韧带的修饰韧带，以及适于在植入期间张紧假体韧带的骨螺钉。 假体韧带包括从多个生物相容的高强度超高分子量聚乙烯纱线缠绕成平纹编织物的承载构件。 每个纱线包括至少五十根纤维，并且具有大于或等于约100,000psi的拉伸强度。 承载构件在其每个端部具有一定量部分和一个环，用于将承载构件锚固到主体构件上。 承载构件被预加载以从其中移除松弛。 承载构件可以单独使用或者可以形成为具有设置在编织物的中空部分内的芯的中空编织物，以允许假体韧带的放射线显影。 护套可以摩擦配合或模制到计量部分的外部。 组件还包括一个或两个骨螺钉，用于与承载构件的环互补接合。 骨螺钉具有在螺钉头部下方延伸到柄部的锥形部分，用于在植入期间张紧假体韧带。

    Prosthetic ligament
    55.
    发明授权
    Prosthetic ligament 失效
    假肢韧带

    公开(公告)号：US4731084A

    公开(公告)日：1988-03-15

    申请号：US840298

    申请日：1986-03-14

    申请人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  Richard W. Treharne, III

    发明人： Richard L. Dunn ,  Danny H. Lewis ,  Thomas W. Sander ,  Richard W. Treharne, III

    IPC分类号： A61F2/08

    CPC分类号： A61F2/08 ,  D04C1/12 ,  D10B2509/00

    摘要： A nonaugmented prosthetic ligament for permanently replacing a natural ligament spanning first and second body members, such as the femur and tibia includes a load bearing member formed from a plurality of biocompatible polyolefin fibers positioned at angles of from 0.degree. to 55.degree. relative to the longitudinal axis of the load bearing member. Each fiber is less than 100 microns in diameter and has a tensile strength greater than or equal to about 50,000 psi. The load bearing member may be used alone or may be formed into a hollow braid having a core disposed within the hollow portion of the braid to provide shape for the load bearing member. A sheath may be friction fit or molded onto the exterior of the load bearing member to prevent abrasion of the fibers.

    摘要翻译： 用于永久性地替换跨越第一和第二身体构件（例如股骨和胫骨）的天然韧带的未修复的假体韧带包括由多个生物相容性聚烯烃纤维形成的承载构件，所述承载构件相对于纵向方向以0°至55°的角度定位 承载构件的轴线。 每个纤维的直径小于100微米，并且具有大于或等于约50,000psi的拉伸强度。 承载构件可以单独使用或者可以形成为具有设置在编织物的中空部分内的芯的中空编织物，以为承载构件提供形状。 护套可以摩擦配合或模制在承载构件的外部上以防止纤维的磨损。

    NOVEL SUSTAINED RELEASE POLYMER
    58.
    发明申请
    NOVEL SUSTAINED RELEASE POLYMER 有权
    新型可持续发布聚合物

    公开(公告)号：US20080194663A1

    公开(公告)日：2008-08-14

    申请号：US11469392

    申请日：2006-08-31

    申请人： Richard L. Dunn

    发明人： Richard L. Dunn

    IPC分类号： A61K47/30 ,  C08G63/00 ,  A61K31/4178 ,  A61P35/00

    CPC分类号： C08G63/08 ,  A61J1/2089 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/1647 ,  A61K9/5153 ,  A61K38/08 ,  A61K38/09 ,  A61K47/22 ,  A61K47/34 ,  A61K47/6937 ,  C08G63/00 ,  C08L67/02 ,  C08L67/04

    摘要： A polymer and a method for its preparation are provided. The polymer comprises poly(lactide), poly(lactide/glycolide) or poly(lactic acid/glycolic acid) segments bonded by ester linkages to both ends of an alkanediol core unit. The polymer is for use in a controlled release formulation for a medicament, preferably leuprolide acetate. The controlled release formulation is administered to a patient as a subcutaneous depot of a flowable composition comprising the polymer, a biocompatible solvent, and the medicament. Controlled release formulations comprising the polymer release leuprolide for treatment of prostate cancer patients over periods of 3-6 months.

    摘要翻译： 提供聚合物及其制备方法。 聚合物包括聚（丙交酯），聚（丙交酯/乙交酯）或聚（乳酸/乙醇酸）链段通过酯键连接到链烷二醇核心单元的两端。 聚合物用于药物，优选醋酸亮丙瑞林的控制释放制剂中。 将控释制剂作为包含聚合物，生物相容性溶剂和药物的可流动组合物的皮下贮库施用于患者。 包含聚合物释放亮丙瑞林以控制3-6个月时间的前列腺癌患者的控制释放制剂。

    Biodegradable in situ forming film dressing
    60.
    发明授权
    Biodegradable in situ forming film dressing 失效
    可生物降解原位成膜

    公开(公告)号：US5792469A

    公开(公告)日：1998-08-11

    申请号：US482851

    申请日：1995-06-07

    申请人： Arthur J. Tipton ,  Shawn M. Fujita ,  Richard L. Dunn

    发明人： Arthur J. Tipton ,  Shawn M. Fujita ,  Richard L. Dunn

    IPC分类号： A61L27/00 ,  A61K9/70 ,  A61L15/44 ,  A61L24/00 ,  A61L26/00 ,  A61F2/02

    CPC分类号： A61L15/44 ,  A61K9/7015 ,  A61L24/0042 ,  A61L26/00 ,  A61L26/0066 ,  A61L26/0076 ,  A61L26/0085 ,  A61L26/009 ,  A61L2300/252 ,  A61L2300/604

    摘要： The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing-on a human or animal tissue. The film dressing is formed from a liquid composition of at least one biodegradable/bioerodible thermoplastic polymer in a pharmaceutically acceptable solvent. The spray apparatus includes a vessel containing the liquid composition with a dispensing means. The film is formed by dispensing, preferably by spraying, the liquid composition onto a tissue site and contacting the liquid composition with an aqueous based fluid to coagulate or solidify the film onto the human or animal tissue. The biodegradable film can be used to protect and to promote healing of injured tissue and/or to deliver biologically active agents.

    摘要翻译： 本发明涉及具有或不具有另外的治疗剂的可生物降解的膜敷料，用于喷雾递送的装置和用于在人或动物组织上形成膜的方法。 薄膜敷料由药学上可接受的溶剂中的至少一种可生物降解/生物侵蚀的热塑性聚合物的液体组合物形成。 喷雾装置包括容纳具有分配装置的液体组合物的容器。 通过优选通过将液体组合物分配到组织部位上并将液体组合物与基于水的液体接触使凝胶或固化到人体或动物组织上而形成薄膜。 可生物降解膜可用于保护和促进损伤组织的愈合和/或递送生物活性剂。