公开(公告)号：US20170140545A1

公开(公告)日：2017-05-18

申请号：US15341789

申请日：2016-11-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Bahram Jalali ,  Mohammad Asghari

IPC: G06T7/168 ,  G06T7/13

CPC classification number: G06T7/168 ,  G06T7/13 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/20036 ,  G06T2207/20056

Abstract: Object and shape detection in digital images utilizing edge detection is described. In a first edge detection approach, phase transformation is utilized in the frequency domain, such as in response to Fourier transform, followed by use of a frequency-domain phase kernel and inverse-Fourier transform. Edge detection is also provided using a phase transform in the spatial domain utilizing a convolution approach. In a second edge detection approach, phase stretching is utilized, such as in combination with phase histogramming along with thresholding and morphological operations. Numerous example images are provided illustrating benefits of the disclosed technology with different applications and under different conditions.

公开(公告)号：US20170138857A1

公开(公告)日：2017-05-18

申请号：US15221065

申请日：2016-07-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Eric D. Diebold ,  Bahram Jalali ,  Brandon Buckley

IPC: G01N21/64 ,  G02F1/11 ,  G01N21/05 ,  G02B21/00 ,  G02B27/10

CPC classification number: G01N21/6408 ,  G01N21/05 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2201/06113 ,  G02B21/0076 ,  G02B21/0084 ,  G02B21/16 ,  G02B27/1006 ,  G02F1/11

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

公开(公告)号：US20160006453A1

公开(公告)日：2016-01-07

申请号：US14749626

申请日：2015-06-24

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Bahram Jalali ,  Mohammad H. Asghari

IPC: H03M5/22 ,  H03M7/30

CPC classification number: H03M5/22 ,  H03M7/3059

Abstract: A method and apparatus for compression of digital and analog data utilizing an anamorphic spectrum transformation to warp an analog or digital signal to provide time-bandwidth compression after sampling is performed on the warped signal. The anamorphic spectrum transformation performs reallocating samples to assign more samples to fine features with high frequency waveform portions and fewer samples to coarse features with low frequency portions of the analog temporal signal, resulting in shorter record length and fewer number of samples.

Abstract translation: 使用变形频谱变换压缩数字和模拟数据以扭曲模拟或数字信号以在采样之后对翘曲信号执行采样之后的时间带宽压缩的方法和装置。 变形频谱变换执行重新分配样本，以将具有高频波形部分的精细特征和较少采样的样本分配给具有模拟时间信号的低频部分的粗略特征，导致更短的记录长度和更少的样本数量。

公开(公告)号：US20160003741A1

公开(公告)日：2016-01-07

申请号：US14792282

申请日：2015-07-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Eric D. Diebold ,  Bahram Jalali ,  Brandon Buckley

IPC: G01N21/64 ,  G02B21/16

CPC classification number: G01N21/6408 ,  G01N21/05 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2201/06113 ,  G02B21/0076 ,  G02B21/0084 ,  G02B21/16 ,  G02B27/1006 ,  G02F1/11

Abstract: Apparatus and methods for fluorescence imaging using radiofrequency multiplexed excitation. One apparatus splits an excitation laser beam into two arms of a Mach-Zehnder interferometer. The light in the first beam is frequency shifted by an acousto-optic deflector, which is driven by a phase-engineered radiofrequency comb designed to minimize peak-to-average power ratio. This RF comb generates multiple deflected optical beams possessing a range of output angles and frequency shifts. The second beam is shifted in frequency using an acousto-optic frequency shifter. After combining at a second beam splitter, the two beams are focused to a line on the sample using a conventional laser scanning microscope lens system. The acousto-optic deflectors frequency-encode the simultaneous excitation of an entire row of pixels, which enables detection and de-multiplexing of fluorescence images using a single photomultiplier tube and digital phase-coherent signal recovery techniques.

Abstract translation: 使用射频复用激发进行荧光成像的装置和方法。 一个装置将激发激光束分成Mach-Zehnder干涉仪的两个臂。 第一光束中的光被声光偏转器偏移，声光偏转器由相位设计的射频梳驱动，旨在最小化峰值与平均功率比。 该RF梳产生具有一定范围的输出角和频移的多个偏转光束。 第二个波束使用声光移频器在频率上移动。 在第二分光器组合之后，使用传统的激光扫描显微镜透镜系统将两个光束聚焦到样品上的线上。 声光偏转器对整行像素的同时激励进行频率编码，这使得能够使用单个光电倍增管和数字相位相干信号恢复技术来检测和解复用荧光图像。

公开(公告)号：US20150205090A1

公开(公告)日：2015-07-23

申请号：US14610851

申请日：2015-01-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Bahram Jalali ,  Keisuke Goda ,  Kevin Kin-Man Tsia

IPC: G02B21/36

CPC classification number: G02B21/361 ,  A61B1/00009 ,  A61B1/00193 ,  A61B1/0638 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/7257 ,  G01B9/02004 ,  G01B9/02014 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02091 ,  G01B11/2441 ,  G01B2290/20 ,  G01B2290/65 ,  G06K9/2036 ,  G06K2209/05 ,  H04N9/045

Abstract: An apparatus and method for ultrafast real-time optical imaging that can be used for imaging dynamic events such as microfluidics or laser surgery is provided. The apparatus and methods encode spatial information from a sample into a back reflection of a two-dimensional spectral brush that is generated with a two-dimensional disperser and a light source that is mapped in to the time domain with a temporal disperser. The temporal waveform is preferably captured by an optical detector, converted to an electrical signal that is digitized and processed to provide two dimensional and three dimensional images. The produced signals can be optically or electronically amplified. Detection may be improved with correlation matching against a database in the time domain or the spatial domain. Embodiments for endoscopy, microscopy and simultaneous imaging and laser ablation with a single fiber are illustrated.

Abstract translation: 提供了一种用于超快速实时光学成像的装置和方法，可用于成像诸如微流体或激光手术的动态事件成像。 该装置和方法将来自样本的空间信息编码成二维光谱刷的背反射，其由二维分散器和用时间分散器映射到时域的光源产生。 时间波形优选地由光学检测器捕获，转换成被数字化和处理以提供二维和三维图像的电信号。 产生的信号可以是光学或电子放大的。 可以通过与时域或空间域中的数据库的相关匹配来改进检测。 示出了用于内窥镜检查，显微镜和同时成像以及使用单纤维的激光烧蚀的实施例。

公开(公告)号：US08870060B2

公开(公告)日：2014-10-28

申请号：US13770678

申请日：2013-02-19

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Keisuke Goda ,  Kevin Kin-Man Tsia

IPC: G06F17/00 ,  G06K7/10 ,  G06K7/14

CPC classification number: G06K7/1439 ,  G06K7/10712 ,  G06K7/10831 ,  G06K7/14

Abstract: A barcode reading apparatus and method in which the spectrum of a probe light is first Fourier-transformed into space, directed upon a barcode, and then Fourier-transformed converting the spectrally encoded barcode pattern to a time domain waveform. In one implementation, the Fourier transformation from the spectrum domain into a spatial domain is performed by a dispersive element, while the Fourier transformation from the spectrally encoded barcode pattern to a time domain waveform is performed by group-velocity dispersion (GVD). The temporally encoded barcode pattern is detected by a photodetector, digitized by a digitizer, and analyzed by a digital signal processor. The invention is applicable to a number of fields which involve the reading of one- and two-dimensional barcodes, displacement sensing, surface measurements, measurement of width and gap, flow cytometry, reading of optical media, presense or absence detection, and other related fields.

Abstract translation: 一种条形码读取装置和方法，其中探针光的光谱首先被傅里叶变换为空间，指向条形码，然后经频谱转换成频谱编码的条形码图案到时域波形。 在一个实现中，通过色散元素执行从频域到空间域的傅立叶变换，而通过组速度色散（GVD）执行从频谱编码的条形码图案到时域波形的傅里叶变换。 时间编码的条形码图案由光电检测器检测，由数字化仪数字化，并由数字信号处理器分析。 本发明可应用于涉及读取一维和二维条形码，位移检测，表面测量，宽度和间隙测量，流式细胞术，光学介质读数，预存或不存在检测等多个领域 领域。

公开(公告)号：US20140067300A1

公开(公告)日：2014-03-06

申请号：US13855564

申请日：2013-04-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Shalabh Gupta ,  Bahram Jalali ,  Ali Motafakker-Fard

IPC: G01R13/02

CPC classification number: G01R13/0218 ,  G02F1/225 ,  G02F7/00 ,  H03M1/1042 ,  H03M1/12

Abstract: A time-stretched enhanced recording scope (TiSER) is described using time stretch analog-to-digital conversion in a real-time burst mode. A chirped optical signal is modulated in response to receiving segments of an input signal. The optical signal with its modulated input signal, is stretched through an optical medium and digitized to represent the waveform segment. TiSER provides ultra-fast real-time sampling within short segment bursts of the original input signal while providing an ability to detect non-repetitive events. Methods and apparatus are also described for providing real-time information about inter-symbol information (ISI), rapidly determining bit-error rates (BER), performing time-domain reflectometry (TDR), generating eye diagrams for serial data, facilitating digital correction of data, clock recovery, optical carrier phase recovery, and otherwise increasing the speed and/or accuracy of a diverse range of high-speed signal measurement and processing activities.

Abstract translation: 使用实时突发模式中的时间拉伸模数转换来描述时间延长的增强记录范围（TiSER）。 响应于输入信号的接收段调制啁啾光信号。 具有调制输入信号的光信号通过光学介质被拉伸并数字化以表示波形段。 TiSER在原始输入信号的短片段突发中提供超快速实时采样，同时提供检测非重复事件的能力。 还描述了用于提供关于符号间信息（ISI），快速确定误码率（BER），执行时域反射计（TDR），生成串行数据眼图，促进数字校正的实时信息的方法和装置 的数据，时钟恢复，光载波相位恢复，否则增加了各种范围的高速信号测量和处理活动的速度和/或精度。