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    Process for producing high-purity oligoglucosylfructosides
    52.
    发明授权
    Process for producing high-purity oligoglucosylfructosides 失效
    生产高纯度低聚葡糖基果糖苷的方法

    公开(公告)号：US4843156A

    公开(公告)日：1989-06-27

    申请号：US692066

    申请日：1985-01-16

    申请人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

    发明人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

    IPC分类号： A23L27/30 ,  C07H1/06 ,  C07H3/06 ,  C13K13/00

    CPC分类号： C07H3/06 ,  C13K13/005

    摘要： Oligoglucosylfructosides wherein an oligoglucosylfructoside having a polymerization degree of 2 or 3 glucose units are recovered in a high purity from a feed solution additionally containing substantial amounts of higher- and lower-oligosaccharides by sequentially admitting predetermined volumes of the feed solution and water to the column of a strongly-acidic cation exchange resin in alkaline-earth metal form; sequentially separating the effluents from the column into the first fraction rich in the higher oligosaccharide, the second fraction rich in the higher oligosaccharide but highly contaiminated with the oligoglucosylfructoside, the first fraction rich in the oligoglucosylfructoside, the fourth fraction rich in the oligoglucosylfructoside but highly contaminated with the lower oligosaccharide, and the fifth fraction rich in the lower oligosaccharide; and recovering the third fraction. The second- and fourth fractions can be admitted to the column so as to decrease the amount of elution water and also to recover the high-oligoglucosylfructoside fraction in a much higher concentration and recovery yield.

    摘要翻译： 其中通过依次将预定体积的进料溶液和水顺序地加入到含有大量低聚糖的进料溶液的塔中，通过另外含有大量的高级和低级寡糖的进料溶液以高纯度从高纯度回收聚合度为2或3个葡萄糖单元的寡葡糖基果糖苷 碱土金属形式的强酸性阳离子交换树脂; 将从柱中排出的污水依次分离成富含较高寡糖的第一级分，第二级分富含高寡聚物，但与寡葡糖基果糖苷高度接触，第一级富含寡聚葡糖基果糖苷，第四级富含低聚葡糖基果糖苷但高度污染 低级寡糖，第五级富含低聚糖; 并回收第三部分。 可以将第二和第四级分进入柱，以减少洗脱水的量，并且还可以以更高的浓度和回收率获得高寡葡糖基果糖苷级分。

    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    53.
    发明申请
    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
    生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US20130295618A1

    公开(公告)日：2013-11-07

    申请号：US13980223

    申请日：2012-03-07

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/18

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    PARTICULATE COMPOSITION CONTAINING ANHYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PROCESS FOR PRODUCING THE SAME, AND USES THEREOF
    54.
    发明申请
    PARTICULATE COMPOSITION CONTAINING ANHYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PROCESS FOR PRODUCING THE SAME, AND USES THEREOF 有权
    包含无水晶体2-O-α-D-葡糖醛酸-L-抗坏血酸的颗粒组合物，其生产方法及其用途

    公开(公告)号：US20110091726A1

    公开(公告)日：2011-04-21

    申请号：US12875786

    申请日：2010-09-03

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： B32B5/00 ,  C07H19/01 ,  C12P19/60

    CPC分类号： C12P19/60 ,  A23L33/10 ,  A23L33/15 ,  A61K8/0241 ,  A61K8/676 ,  A61K8/732 ,  A61K31/7048 ,  A61K2800/57 ,  A61K2800/654 ,  A61Q19/02 ,  C07H17/04 ,  Y10T428/2982

    摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, when calculated based on a profile of powder X-ray diffraction analysis of the particulate composition, and a dynamic vapor sorption level of 0.01% by weight or lower, when kept at 25° C. under a relative humidity of 35% by weight for 12 hours after removal water in the particulate composition under nitrogen gas stream; and by providing a process for producing the same and uses thereof.

    摘要翻译： 本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。 本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上时，基于颗粒组合物的粉末X射线衍射分析曲线和动态蒸气 当在氮气流下除去颗粒组合物中的水后，在25℃相对湿度35重量％下保持12小时，吸附水平为0.01重量％以下; 并提供其制造方法及其用途。

    Process for producing a high-purity maltose
    58.
    再颁专利
    Process for producing a high-purity maltose 失效
    生产高纯度麦芽糖的方法

    公开(公告)号：USRE33047E

    公开(公告)日：1989-09-05

    申请号：US202249

    申请日：1988-06-06

    申请人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

    发明人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

    IPC分类号： C13K1/08 ,  C07H1/06 ,  C07H3/04 ,  C13K7/00

    CPC分类号： C07H3/04 ,  C13K7/00

    摘要： High-purity maltose is produced by applying a feed starch sugar solution with a maltose content of at least 70% to a column packed with a strongly-acidic cation exchange resin of alkali metal- or alkaline earth metalform; fractionating the feed solution by charging water thereto in a high-dextrin fraction, a high-dextrin.maltose fraction, a high-maltose fraction, a high-maltose.glucose fraction, and a high-glucose fraction, in the given order; and recovering the high-maltose fraction. This process constantly provides a fraction with a maltose content of 93% or higher, and enables industrial-scale production of a high-purity maltose much easier and at lower-cost than conventional processes.

    Crystalline maltopentaose and process for producing the same
    59.
    发明授权
    Crystalline maltopentaose and process for producing the same 失效
    结晶麦芽五糖及其制备方法

    公开(公告)号：US4652640A

    公开(公告)日：1987-03-24

    申请号：US764176

    申请日：1985-08-09

    申请人： Shuzo Sakai ,  Takashi Shibuya ,  Toshio Miyake

    发明人： Shuzo Sakai ,  Takashi Shibuya ,  Toshio Miyake

    IPC分类号： C07H1/06 ,  C07H3/06 ,  C07H1/00

    CPC分类号： C07H3/06

    摘要： Maltopentaose is crystallized from a supersaturated solution of a high-purity maltopentaose, obtained by fractionation of a feed solution, containing maltopentaose along with additional higher and lower maltooligosaccharides, using a strongly-acidic cation exchange resin in a salt form (e.g. alkali- or alkaline-metal form). Crystalline maltopentaose is non-hygroscopic and non-deliquescent. A pulverulent solid containing crystalline maltopentaose is found substantially non-hygroscopic. Crystalline maltopentaose is favorably usable as the substrate to assay serum amylase. Crystalline maltopentaose and pulverulent solid containing the same are favorably usable to produce foodstuffs, pharmaceuticals, cosmetics, and chemicals.

    摘要翻译： 麦芽五糖通过使用盐形式的强酸性阳离子交换树脂（例如碱金属或碱性的）将高分子麦芽五糖的过饱和溶液结晶，所述高纯度麦芽五糖通过将含有麦芽五糖与其它更高和更低的麦芽低聚糖进料分馏而得到 金属形式）。 结晶麦芽五糖是非吸湿性和非潮解性的。 发现含有结晶麦芽五糖的粉状固体基本上不吸湿。 结晶麦芽五糖有利地用作测定血清淀粉酶的底物。 结晶麦芽五糖和含有它们的粉状固体有利地用于生产食品，药物，化妆品和化学品。

    Process for producing a high-purity isomaltose
    60.
    发明授权
    Process for producing a high-purity isomaltose 失效
    生产高纯度异麦芽糖的方法

    公开(公告)号：US4521252A

    公开(公告)日：1985-06-04

    申请号：US420702

    申请日：1982-09-21

    申请人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

    发明人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

    IPC分类号： C07H3/04 ,  C13D3/12 ,  C13D3/14

    CPC分类号： C07H3/04

    摘要： The present invention relates to a process for producing a high-purity isomaltose by applying an aqueous solution, containing isomaltose, to a column packed with a strongly-acidic cation exchange resin of alkali metal- or alkaline earth metal-form; and fractionating by charging water to obtain a high-isomaltose fraction with an isomaltose content of at least 40%, thereby enabling industrial-scale production of a high-purity isomaltose much easier at lower cost.

    摘要翻译： 本发明涉及通过将含有异麦芽糖的水溶液施加到填充有碱金属或碱土金属形式的强酸性阳离子交换树脂的柱中来生产高纯度异麦芽糖的方法; 并通过加水分馏，得到异麦芽糖含量至少为40％的高异麦芽糖馏分，从而以较低成本容易地进行工业规模生产高纯度异麦芽糖。