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    Microparticle protection of therapeutic agents
    51.
    发明申请
    Microparticle protection of therapeutic agents 审中-公开
    治疗剂微粒保护

    公开(公告)号：US20050124571A1

    公开(公告)日：2005-06-09

    申请号：US10965967

    申请日：2004-10-15

    申请人： Wendy Naimark ,  Maria Palasis

    发明人： Wendy Naimark ,  Maria Palasis

    IPC分类号： A61J3/07 ,  A61K9/00 ,  A61K9/10 ,  A61K35/12 ,  A61K35/74 ,  A61K35/76 ,  A61K47/32 ,  A61K48/00 ,  A61L2/00 ,  A61M5/14 ,  A61M25/00 ,  A01N43/04

    CPC分类号： A61K47/32 ,  A61K9/0019 ,  A61K9/10 ,  A61L2/0088

    摘要： The present invention is directed to the use of microparticles to protect the pharmaceutical effectiveness of a pharmaceutically active agent. According to one embodiment, a pharmaceutically acceptable suspension is provided that comprises microparticles and a pharmaceutically active agent. This pharmaceutically acceptable suspension is then exposed to a component or condition that is incompatible with the pharmaceutically active agent, such that the microparticles provide a pharmaceutical effectiveness that is greater than it would have been in the absence of the microparticles. Preferably, the microparticles result in a pharmaceutical effectiveness of the pharmaceutically active agent that is at least 10% greater than the pharmaceutical effectiveness of the pharmaceutically active agent would have been in the absence of the microparticles. Polymer microparticles, such as polystyrene microparticles, are one preferred class of microparticles. The microparticles preferably range from 0.01 to 100 microns in largest dimension, more preferably 0.1 to 10 microns in largest dimension. The microparticles are preferably provided in an amount of 0.1 to 1 wt % within the suspension. Agents comprising polynucleotides, including cells, plasmids and viral vectors, are a preferred class of pharmaceutically active agent. Other embodiments on the invention are directed to pharmaceutically acceptable suspensions, medical devices for parenteral injection, and methods of treatment.

    摘要翻译： 本发明涉及微粒用于保护药物活性剂的药学有效性的用途。 根据一个实施方案，提供了包含微粒和药物活性剂的药学上可接受的悬浮液。 然后将这种药学上可接受的悬浮液暴露于与药物活性剂不相容的组分或病症，使得微粒提供的药物效力大于在不存在微粒时所具有的药效。 优选地，微粒导致药物活性剂的药学有效性比药物活性剂在不存在微粒时所具有的药物有效性至少高10％。 聚合物微粒，例如聚苯乙烯微粒，是一类优选的微粒。 微粒的最大尺寸优选为0.01〜100微米，更优选为0.1〜10微米。 在悬浮液中，微粒优选以0.1〜1重量％的量提供。 包含多核苷酸，包括细胞，质粒和病毒载体的试剂是优选的一类药物活性剂。 本发明的其它实施方案涉及药学上可接受的悬浮液，用于肠胃外注射的医疗装置和治疗方法。

    Medical devices for delivery of therapeutic agents
    53.
    发明授权
    Medical devices for delivery of therapeutic agents 有权
    用于递送治疗剂的医疗装置

    公开(公告)号：US08361143B2

    公开(公告)日：2013-01-29

    申请号：US12349563

    申请日：2009-01-07

    申请人： Maria Palasis ,  Wendy Naimark ,  Robert E. Richard

    发明人： Maria Palasis ,  Wendy Naimark ,  Robert E. Richard

    IPC分类号： A61F2/06

    CPC分类号： A61L27/34 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L27/54

    摘要： The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally include (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices.

    摘要翻译： 本发明通常涉及医疗装置，更具体地涉及至少部分可插入或植入患者体内的医疗装置。 医疗装置通常包括（a）治疗剂，更典型的是高分子量治疗剂，和（b）至少一个聚合物层，其通常用于控制治疗剂从医疗装置释放。 本文还公开了制造这种医疗装置的方法。

    Medical device for delivery of a biologically active material to a lumen
    56.
    发明授权
    Medical device for delivery of a biologically active material to a lumen 有权
    用于将生物活性物质递送至内腔的医疗装置

    公开(公告)号：US07569032B2

    公开(公告)日：2009-08-04

    申请号：US10645652

    申请日：2003-08-20

    申请人： Wendy Naimark ,  Maria Palasis ,  Robbert A Herrmann

    发明人： Wendy Naimark ,  Maria Palasis ,  Robbert A Herrmann

    IPC分类号： A61M31/00

    CPC分类号： A61M37/0015 ,  A61M25/10 ,  A61M37/00 ,  A61M2025/0093 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2025/1072 ,  A61M2025/1081 ,  A61M2025/1086 ,  B33Y80/00

    摘要： An apparatus for delivery of biologically active materials comprises a catheter and balloon having micro-needles or pores. In the apparatus, the balloon can have a polymer coating containing the biologically active material, and the apparatus can include a sheath surrounding the balloon. In one embodiment the biologically active material is delivered through lumens in the micro-needles. Another embodiment of the invention is an apparatus for delivery of biologically active materials comprising a catheter with a balloon disposed thereon and a shockwave generator for producing a shockwave for delivering the biologically active material to a body lumen. Methods for delivery of biologically active materials are also disclosed.

    摘要翻译： 用于递送生物活性材料的装置包括具有微针或孔的导管和球囊。 在该装置中，球囊可以具有包含生物活性材料的聚合物涂层，并且该装置可以包括围绕气囊的护套。 在一个实施方案中，生物活性物质通过微针中的内腔递送。 本发明的另一个实施方案是用于递送生物活性材料的装置，其包括其上设置有球囊的导管和用于产生用于将生物活性物质输送到体腔的冲击波的冲击波发生器。 还公开了递送生物活性物质的方法。

    Processes for producing polymer coatings through surface polymerization
    57.
    发明申请
    Processes for producing polymer coatings through surface polymerization 失效
    通过表面聚合生产聚合物涂层的方法

    公开(公告)号：US20080145516A1

    公开(公告)日：2008-06-19

    申请号：US12070275

    申请日：2008-02-14

    申请人： Robert A. Herrmann ,  Frederick H. Strickler ,  Wendy Naimark ,  Peter L. Dayton

    发明人： Robert A. Herrmann ,  Frederick H. Strickler ,  Wendy Naimark ,  Peter L. Dayton

    IPC分类号： B05D3/10 ,  A61F2/82

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/606

    摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species. a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.

    摘要翻译： 具有治疗剂释放聚合物涂层的医疗装置。 该医疗装置由一种方法提供，该方法包括：（a）将至少一种反应性物质附着到医疗器械表面上，该反应性物质在单体存在下导致链增长聚合; （b）使反应性物质与至少一种单体物质接触，从而在医疗装置的表面上形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。 治疗剂可以在形成聚合物涂层期间或在形成聚合物涂层之后引入。 至少一种反应性物质可以包含例如自由基物质，碳负离子物质。 碳阳离子种类，齐格勒 - 纳塔聚合络合物，茂金属络合物和/或原子转移自由基聚合引发剂。 或者，医疗装置由包括以下步骤的方法提供：（a）在医疗器械表面固定最少一种聚合催化剂，该聚合催化剂在单体存在下导致聚合; （b）使医疗器械表面与至少一种单体物质接触，从而在医疗装置的表面形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。

    Therapeutic pastes for medical device coating
    58.
    发明申请
    Therapeutic pastes for medical device coating 审中-公开
    医疗器械涂层治疗膏

    公开(公告)号：US20060286071A1

    公开(公告)日：2006-12-21

    申请号：US11158452

    申请日：2005-06-21

    申请人： Samuel Epstein ,  Wendy Naimark

    发明人： Samuel Epstein ,  Wendy Naimark

    IPC分类号： A61K48/00

    CPC分类号： A61K9/06 ,  A61K9/0024 ,  A61K31/711 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/258 ,  A61L2300/606 ,  C08L53/02

    摘要： This invention provides a high-solids therapeutic composition for coating a medical device comprising: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the composition is in a singular stable phase. Also provided is a mold-cast medical device, said medical device comprising a cured mixture of: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the mixture forms a high-solids device. Further provided is an injectable polymer comprising: (a) a first material which is a hydrophilic therapeutic agent; and (b) a second material which includes a hydrophobic polymer and an emulsifying surfactant, wherein the polymer is in a singular stable phase.

    摘要翻译： 本发明提供了用于涂覆医疗装置的高固体治疗组合物，其包括：（a）作为亲水治疗剂的第一材料; 和（b）包含疏水性聚合物和乳化表面活性剂的第二种材料，其中所述组合物处于单一的稳定相。 还提供了一种模铸医疗装置，所述医疗装置包括：（a）作为亲水治疗剂的第一材料的固化混合物; 和（b）包含疏水性聚合物和乳化表面活性剂的第二种材料，其中混合物形成高固体装置。 还提供了一种可注射聚合物，其包含：（a）作为亲水性治疗剂的第一材料; 和（b）包含疏水性聚合物和乳化表面活性剂的第二种材料，其中所述聚合物处于单一的稳定相。