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    Composite organic-inorganic nanoparticles and methods for use thereof
    51.
    发明申请
    Composite organic-inorganic nanoparticles and methods for use thereof 审中-公开
    复合有机 - 无机纳米颗粒及其使用方法

    公开(公告)号：US20050142567A1

    公开(公告)日：2005-06-30

    申请号：US10830422

    申请日：2004-04-21

    申请人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    发明人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    IPC分类号： G01N21/65 ,  G01N33/543 ,  C12Q1/68 ,  G01N33/553

    CPC分类号： G01N33/54346 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/658 ,  G01N2021/6482 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656

    摘要： Composite organic-inorganic nanoparticles (COIN) and clusters of such nanoparticles are provided that produce surface-enhanced Raman signals when excited by a laser. The nanoparticles include metallic colloids and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanoparticle, and a wide variety of Raman-active organic compounds can be incorporated into the particle. Methods for producing the nanoparticles and clusters of nanoparticles are also provided. In addition, polymeric microspheres containing the nanoparticles and clusters of nanoparticles and methods of making them are also provided. Methods for using the nanoparticles, clusters, and microspheres in assays for multiplex detection of biological molecules do not require signal amplification techniques.

    摘要翻译： 提供复合有机 - 无机纳米颗粒（COIN）和这种纳米颗粒的簇，当激光激发时产生表面增强的拉曼信号。 纳米颗粒包括金属胶体和拉曼活性有机化合物。 实现合适的SERS信号所需的金属在纳米颗粒中是固有的，并且可以将多种拉曼活性有机化合物掺入颗粒中。 还提供了制备纳米颗粒和纳米颗粒簇的方法。 此外，还提供了包含纳米颗粒和纳米颗粒簇的聚合物微球及其制备方法。 在用于多重检测生物分子的测定中使用纳米颗粒，簇和微球的方法不需要信号放大技术。

    Composite organic-inorganic nanoparticles and methods for use thereof
    52.
    发明申请
    Composite organic-inorganic nanoparticles and methods for use thereof 审中-公开
    复合有机 - 无机纳米颗粒及其使用方法

    公开(公告)号：US20050147963A1

    公开(公告)日：2005-07-07

    申请号：US10748336

    申请日：2003-12-29

    申请人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    发明人： Xing Su ,  Jingwu Zhang ,  Lei Sun ,  Andrew Berlin

    IPC分类号： G01N21/65 ,  G01N33/543 ,  C12Q1/70 ,  C12M1/34 ,  C12Q1/68

    CPC分类号： G01N33/54346 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/658 ,  G01N2021/6482 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2021/656

    摘要： Composite organic-inorganic nanoparticles (COIN) are provided that produce surface-enhanced Raman signals when excited by a laser. The nanoparticles include metallic colloids and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanoparticle, and a wide variety of Raman-active organic compounds can be incorporated into the particle. Indeed, a large number of unique Raman signatures can be created by employing nanoparticles containing Raman-active organic compounds of different structures, mixtures, and ratios. Thus, nanoparticles and methods described herein are useful for the simultaneous detection of many analytes in a mixture, resulting in rapid qualitative analysis of a mixture. In addition, since many Raman-active organic compounds can be incorporated into a single nanoparticle, the SERS signal from a single COIN particle is strong relative to SERS signals obtained from Raman-active materials that do not contain the nanoparticles described herein.

    摘要翻译： 提供了复合有机 - 无机纳米粒子（COIN），当激光激发时产生表面增强的拉曼信号。 纳米颗粒包括金属胶体和拉曼活性有机化合物。 实现合适的SERS信号所需的金属在纳米颗粒中是固有的，并且可以将多种拉曼活性有机化合物掺入颗粒中。 实际上，通过使用含有不同结构，混合物和比例的拉曼活性有机化合物的纳米颗粒，可以产生大量独特的拉曼特征。 因此，本文所述的纳米颗粒和方法可用于同时检测混合物中的许多分析物，导致混合物的快速定性分析。 另外，由于许多拉曼活性有机化合物可以并入单个纳米颗粒中，所以来自单个COIN颗粒的SERS信号相对于不含本文所述纳米颗粒的拉曼活性材料获得的SERS信号是强的。

    Method and apparatus for nucleic acid sequencing and identification
    53.
    发明申请
    Method and apparatus for nucleic acid sequencing and identification 审中-公开
    用于核酸测序和鉴定的方法和装置

    公开(公告)号：US20050019784A1

    公开(公告)日：2005-01-27

    申请号：US10701650

    申请日：2003-11-04

    申请人： Xing Su ,  Andrew Berlin

    发明人： Xing Su ,  Andrew Berlin

    IPC分类号： B01L3/00 ,  C12M1/34 ,  C12Q1/68 ,  G01N27/447

    CPC分类号： C12Q1/6869 ,  B01L3/5027 ,  B82Y30/00 ,  G01N33/48721 ,  C12Q2565/631 ,  C12Q2563/155 ,  C12Q2527/113

    摘要： The methods and apparatus disclosed herein are of use for sequencing and/or identifying nucleic acids. Nucleic acids containing labeled nucleotides may be synthesized and passed through nanopores. Detectors operably coupled to the nanopores may detect the labeled nucleotides. By determining the time intervals at which labeled nucleotides are detected, distance maps for each type of labeled nucleotide may be compiled. The distance maps in turn may be used to sequence and/or identify the nucleic acid. In different embodiments of the invention, luminescent nucleotides or nanoparticles may be detected using photodetectors or electrical detectors. Apparatus and sub-devices of use for nucleic acid sequencing and/or identification are also disclosed herein.

    摘要翻译： 本文公开的方法和装置可用于测序和/或鉴定核酸。 含有标记核苷酸的核酸可以合成并通过纳米孔。 可操作地偶联到纳米孔的检测器可以检测标记的核苷酸。 通过确定检测到标记的核苷酸的时间间隔，可以编译每种类型的标记核苷酸的距离图。 距离图依次可以用于序列和/或识别核酸。 在本发明的不同实施方案中，可以使用光电检测器或电检测器检测发光核苷酸或纳米颗粒。 本文还公开了用于核酸测序和/或鉴定的装置和子装置。

    Methods and apparatus for 3D printing
    58.
    发明申请
    Methods and apparatus for 3D printing 审中-公开
    3D打印方法和设备

    公开(公告)号：US20050280185A1

    公开(公告)日：2005-12-22

    申请号：US11097987

    申请日：2005-04-01

    申请人： David Russell ,  Andres Hernandez ,  Joshua Kinsley ,  Andrew Berlin

    发明人： David Russell ,  Andres Hernandez ,  Joshua Kinsley ,  Andrew Berlin

    IPC分类号： B28B7/46 ,  B29C41/02 ,  B29C67/00

    CPC分类号： B28B7/465 ,  B28B1/001 ,  B29C64/165 ,  B33Y10/00 ,  B33Y30/00

    摘要： The invention relates to methods and apparatus for fabricating a three-dimensional object from a representation of the object stored in memory. The apparatus includes a stationary build table for receiving successive layers of a build material and at least one movable printhead disposed above the build table. The printhead deposits a binding material in a predetermined pattern on each successive layer of the build material to form the three-dimensional object.

    摘要翻译： 本发明涉及从存储在存储器中的对象的表示来制造三维物体的方法和装置。 该装置包括用于接收构建材料的连续层的静止构建工作台和布置在构建工作台上方的至少一个可移动打印头。 打印头在构建材料的每个连续层上以预定图案沉积粘合材料以形成三维物体。

    Hydrodynamic focusing devices
    60.
    发明授权
    Hydrodynamic focusing devices 有权
    流体动力学聚焦装置

    公开(公告)号：US08883091B2

    公开(公告)日：2014-11-11

    申请号：US11450083

    申请日：2006-06-09

    申请人： Narayanan Sundararajan ,  Andrew Berlin

    发明人： Narayanan Sundararajan ,  Andrew Berlin

    IPC分类号： B01L3/00 ,  B01F13/00 ,  G01N15/14

    CPC分类号： B01F13/0062 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2300/0874 ,  B01L2300/0887 ,  G01N15/1404 ,  G01N2015/1413 ,  Y10T436/25 ,  Y10T436/2575

    摘要： A micro-fluidic device containing a micro-fluidic inlet channel to convey a process flow, a plurality of micro-fluidic focusing channels to each convey one of a plurality of focusing flows, a focusing manifold coupled with the inlet channel at an inlet port thereof and with the plurality of focusing channels at a plurality of focusing channel ports thereof to focus the process flow by contacting and hydrodynamically impacting at least three sides of the process flow with the focusing flows, and a micro-fluidic outlet channel coupled with the focusing manifold at an outlet channel port to convey the combined focused process flow and focusing flow from the focusing manifold.

    摘要翻译： 一种微流体装置，其包含用于输送工艺流的微流体入口通道，多个微流体聚焦通道，每个输送多个聚焦流中的一个;聚焦歧管，其与入口通道在其入口端口处连接 并且多个聚焦通道在其多个聚焦通道端口处，以通过与聚焦流接触和流体动力地冲击处理流的至少三个侧面来聚焦工艺流程，以及与聚焦歧管耦合的微流体出口通道 在出口通道端口处传送来自聚焦歧管的组合的聚焦过程流和聚焦流。