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    Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same
    51.
    发明授权
    Centrifugal force-based microfluidic device for protein detection and microfluidic system including the same 有权
    用于蛋白质检测和微流体系统的基于离心力的微流体装置包括相同的

    公开(公告)号：US07776267B2

    公开(公告)日：2010-08-17

    申请号：US11850129

    申请日：2007-09-05

    申请人： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

    发明人： Beom-seok Lee ,  Yoon-kyoung Cho ,  Jeong-gun Lee ,  Jong-myeon Park

    IPC分类号： G01N9/30

    CPC分类号： G01N33/54326 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0633 ,  B01L2400/0677 ,  B01L2400/0688 ,  G01N33/54366 ,  Y10T436/25375

    摘要： A centrifugal force-based microfluidic device for the detection of a target biomolecule and a microfluidic system including the same are provided. The device includes a body of revolution; a microfluidic structure disposed in the body of revolution including chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structures transmitting fluid using centrifugal force due to rotation of the body of revolution; and beads disposed in the microfluidic structures, the beads having capture probes on the surfaces thereof which are selectively bonded with target protein; and a detection probe disposed in the microfluidic structures and selectively bonded to the target protein, and which includes a material required to express an optical signal, wherein the microfluidic structure mixes the beads, biological samples, and the detection probe to react and washes and separates the beads after the reaction.

    摘要翻译： 提供了用于检测靶生物分子的离心力微流体装置和包括其的微流体系统。 该装置包括一个革命体; 设置在旋转体中的微流体结构，包括腔室，连接腔室的通道，以及设置在通道中的阀，以控制流体流动，微流体结构由于旋转体旋转而使用离心力传送流体; 和珠子，其设置在微流体结构中，珠粒在其表面上具有与靶蛋白质选择性结合的捕获探针; 以及设置在微流体结构中并选择性地结合到靶蛋白上并且包括表达光信号所需的材料的检测探针，其中微流体结构混合珠，生物样品和检测探针以反应和洗涤和分离 反应后的珠子。

    Optical system for analyzing multi-channel samples and multi-channel sample analyzer employing the same
    55.
    发明授权
    Optical system for analyzing multi-channel samples and multi-channel sample analyzer employing the same 有权
    用于分析多通道样品的光学系统和采用该多通道样品的多通道样品分析仪

    公开(公告)号：US07209237B2

    公开(公告)日：2007-04-24

    申请号：US11227385

    申请日：2005-09-15

    申请人： Gyeong-sik Ok ,  Yoon-kyoung Cho ,  Jin-tae Kim ,  Kwang-wook Oh

    发明人： Gyeong-sik Ok ,  Yoon-kyoung Cho ,  Jin-tae Kim ,  Kwang-wook Oh

    IPC分类号： G01N21/25

    CPC分类号： G01N21/645

    摘要： Provided are an optical system for analyzing multi-channel samples which uses a mirror rotating at high speeds and an aspherical mirror, and a multi-channel sample analyzer employing the optical system. The optical system for analyzing multi-channel samples, includes a light source unit which emits light traveling along an optical axis; a semi-spheroid aspherical mirror disposed in rotational symmetry about the optical axis; and an inclined mirror which reflects the light exiting the light source unit to the semi-spheroid aspherical mirror, while rotating about the optical axis, wherein an opening is formed in the center of the semi-spheroid aspherical mirror such that the light exiting the light source unit enters the inclined mirror through the semi-spheroid aspherical mirror.

    摘要翻译： 提供了一种用于分析使用高速旋转的反射镜的多通道样品和非球面镜的光学系统，以及采用该光学系统的多通道样本分析仪。 用于分析多通道样品的光学系统包括发射沿着光轴行进的光的光源单元; 围绕光轴旋转对称设置的半球体非球面镜; 以及倾斜镜，其在围绕光轴旋转的同时将离开光源单元的光反射到半球形非球面镜，其中在半球镜非球面镜的中心形成开口，使得离开光的光 源单元通过半球体非球面镜进入倾斜镜。

    Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device
    59.
    发明授权
    Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device 有权
    用于核酸提取的离心力微流体装置和包括微流体装置的微流体系统

    公开(公告)号：US08420026B2

    公开(公告)日：2013-04-16

    申请号：US13594293

    申请日：2012-08-24

    申请人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

    发明人： Yoon-kyoung Cho ,  Jeong-gun Lee ,  Beom-seok Lee ,  Jong-myeon Park

    IPC分类号： B04B13/00

    CPC分类号： B01L3/502738 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0019 ,  F16K99/0032 ,  F16K99/004 ,  F16K2099/0076 ,  F16K2099/0084

    摘要： A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels to control fluid flow, the microfluidic structure transmitting the fluid using centrifugal force due to rotation of the body of revolution; and magnetic beads contained in one of the chambers which collect a target material from a biomaterial sample flowing into the chamber, wherein the microfluidic structure washes the magnetic beads which collect the target material, and separates nucleic acid by electromagnetic wave irradiation from an external energy source to the magnetic beads. The microfluidic system includes the microfluidic device; a rotation operating unit which rotates the body of revolution; and an external energy source which irradiates electromagnetic waves.

    摘要翻译： 提供了用于核酸提取的离心力微流体装置和微流体系统。 微流体装置包括一个革命体; 设置在旋转体内的微流体结构，所述微流体结构包括多个室，连接所述室的通道和设置在通道中的阀以控制流体流动，所述微流体结构由于所述体的旋转而使用离心力传递流体 的革命 以及包含在其中一个室中的磁珠，其从流入腔室的生物材料样品收集目标材料，其中微流体结构洗涤收集目标材料的磁珠，并通过来自外部能量源的电磁波照射分离核酸 到磁珠。 微流体系统包括微流体装置; 使旋转体旋转的旋转操作单元; 以及照射电磁波的外部能量源。