公开(公告)号：US20240132955A1

公开(公告)日：2024-04-25

申请号：US18475532

申请日：2023-09-27

Applicant: Ultima Genomics, Inc.

Inventor： Linda LEE ,  Theo Nikiforov ,  Alexander Joseph Limardo ,  Maya H. Reamey ,  Steven Menchen ,  Gilad Almogy

IPC: C12Q1/6874 ,  C12Q1/6806 ,  G01N21/64

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  G01N21/6486

Abstract: Provided herein are reagents, compositions, and methods for sequencing nucleic acids. Among the reagents disclosed are nucleotides labeled with cleavable linkers. Certain linkers are configured to undergo immolation reactions following cleavage, which can generate scars with enhanced properties for nucleic acid sequencing and synthesis. The present disclosure also provides reagents, compositions, and methods for capping scars generated through linker cleavage, which can alter scar properties, and in some cases can increase the rate and accuracy of nucleotide incorporations during polymerization.

公开(公告)号：US20240027425A1

公开(公告)日：2024-01-25

申请号：US18224378

申请日：2023-07-20

Applicant: Ultima Genomics, Inc.

Inventor： Kristopher BARBEE ,  Nathan BECKETT ,  Denis PRISTINSKI ,  Derek SCHULTE ,  Avishai BARTOV ,  Jamie SULLIVAN ,  Dumitru BRINZA ,  Abizar LAKDAWALLA ,  Steven MENCHEN ,  Gilad ALMOGY ,  Mark PRATT

IPC: G01N33/49 ,  G01N1/02 ,  G01Q10/04

CPC classification number: G01N33/492 ,  G01N1/02 ,  G01Q10/04 ,  G01N2001/2291

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.

公开(公告)号：US11807851B1

公开(公告)日：2023-11-07

申请号：US17176617

申请日：2021-02-16

Applicant: Ultima Genomics, Inc.

Inventor： Linda G. Lee ,  Steven Menchen

IPC: A61K31/7072 ,  A61K31/706 ,  C12N15/113 ,  C07H21/04 ,  A61K47/65 ,  A61K49/00 ,  C07H19/14 ,  C12Q1/6874 ,  C07K5/02 ,  C07H19/00

CPC classification number: C12N15/113 ,  A61K47/65 ,  A61K49/0021 ,  C07H19/14 ,  C07H21/04 ,  C07K5/0205 ,  C12Q1/6874 ,  C07H19/00 ,  C12Q1/6874 ,  C12Q2521/101 ,  C12Q2525/101

Abstract: The present disclosure provides modified substrates such as modified polynucleotides, proteins, antibodies, lipids, and cells and uses thereof. Method of generating the modified substrates, which may comprise cleavage of a cleavable group linking the substrate to a labeling moiety, are also provided herein.

公开(公告)号：US20230343416A1

公开(公告)日：2023-10-26

申请号：US18025603

申请日：2021-09-10

Applicant: Ultima Genomics, Inc.

Inventor： Yoav ETZIONI ,  Omer BARAD ,  Avishai BARTOV ,  Ilya SOIFER ,  Ehud AMITAI ,  Asaf HALLE

IPC: G16B40/10 ,  C12Q1/6869 ,  G16B40/20 ,  G16B30/10 ,  G06N3/0464

CPC classification number: G16B40/10 ,  C12Q1/6869 ,  G16B40/20 ,  G16B30/10 ,  G06N3/0464

Abstract: The present disclosure provides methods, systems, and media for accurate and efficient estimation of a genome of a genus. The methods and systems described herein may be used to accurately determine a base sequence of a polynucleotide. Additionally, the methods and systems may be used to identify base variants of a polynucleotide.

公开(公告)号：US20230332226A1

公开(公告)日：2023-10-19

申请号：US18176418

申请日：2023-02-28

Applicant: Ultima Genomics, Inc.

Inventor： Florian OBERSTRASS ,  Theo NIKIFOROV ,  Mark STAPLETON ,  Daniel MAZUR ,  Gilad ALMOGY ,  Ishminder MANN ,  Chandan SHEE ,  Benjamin SCHROEDER

IPC: C12Q1/6874 ,  C12Q1/6855

CPC classification number: C12Q1/6874 ,  C12Q1/6855

Abstract: The present disclosure provides compositions, methods, and systems for enrichment and analysis of template nucleic acid molecules, e.g., of a biological sample. Further provided herein are methods of using a plurality of unique bead species each comprising a unique set of identical primer molecules.

公开(公告)号：US20230279487A1

公开(公告)日：2023-09-07

申请号：US18124481

申请日：2023-03-21

Applicant: Ultima Genomics, Inc.

Inventor： Gilad ALMOGY ,  Nathan BECKETT ,  Mark PRATT ,  Anatoly A. SURDUTOVICH ,  Nathan CASWELL ,  Patrick D. KINNEY

IPC: C12Q1/6869 ,  B01L3/00 ,  G01N35/10

CPC classification number: C12Q1/6869 ,  B01L3/5085 ,  G01N35/1002 ,  B01L2200/16 ,  B01L2300/023

Abstract: Provided herein methods, systems, and apparatus for high throughput sequencing, such as at an industrial scale. A sequencing system and/or apparatus may comprise one or more stations that can be operated in parallel and/or independent of one or more other stations.

公开(公告)号：USD998172S1

公开(公告)日：2023-09-05

申请号：US29774033

申请日：2021-03-12

Applicant: Ultima Genomics, Inc.

Designer： Jacob Wolf ,  Nathan Beckett

Abstract: FIG. 1 is a top perspective view of a sample rack showing a sample tube out of its place in the sample rack;
FIG. 2 is a top perspective view of the sample rack showing the sample tube in its place in the sample rack;
FIG. 3 is a bottom perspective view thereof;
FIG. 4 is a top view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a bottom view thereof;
FIG. 7 is a left side view thereof;
FIG. 8 is a front view thereof; and,
FIG. 9 is a back view thereof.
Broken lines shown in the drawings are included for illustrating portions of the sample rack that form no part of the claimed design.

公开(公告)号：US11747323B2

公开(公告)日：2023-09-05

申请号：US17962163

申请日：2022-10-07

Applicant: Ultima Genomics, Inc.

Inventor： Kristopher Barbee ,  Nathan Beckett ,  Denis Pristinski ,  Derek Schulte ,  Avishai Bartov ,  Jamie Sullivan ,  Dumitru Brinza ,  Abizar Lakdawalla ,  Steven Menchen ,  Gilad Almogy ,  Mark Pratt

IPC: G01N33/49 ,  G01N1/02 ,  G01Q10/04 ,  G01N1/22

CPC classification number: G01N33/492 ,  G01N1/02 ,  G01Q10/04 ,  G01N2001/2291

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.

公开(公告)号：US20230272221A1

公开(公告)日：2023-08-31

申请号：US18111220

申请日：2023-02-17

Applicant: Ultima Genomics, Inc.

Inventor： Linda G. LEE ,  Steven MENCHEN

IPC: C09B49/04 ,  C09B11/24 ,  C07H19/20

CPC classification number: C09B49/04 ,  C09B11/24 ,  C07H19/20

Abstract: The present disclosure provides labeling reagents for labeling substrates such as nucleotides, proteins, antibodies, lipids, and cells. The labeling reagents provided herein may comprise fluorescent labels and semi-rigid linkers. Methods for nucleic acid sequencing using materials comprising such labeling reagents are also provided herein. Also provided are labeling reagents for labeling multiple substrates simultaneously using energy transfer.

公开(公告)号：US20230183778A1

公开(公告)日：2023-06-15

申请号：US17985542

申请日：2022-11-11

Applicant: ULTIMA GENOMICS, INC.

Inventor： Eliane TREPAGNIER ,  Mark PRATT ,  Theo NIKIFOROV ,  Gilad ALMOGY

IPC: C12Q1/6818 ,  C12Q1/6869

CPC classification number: C12Q1/6818 ,  C12Q1/6869

Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules in a manner that enables higher sequencing accuracy. Methods and systems provided herein may enable sequences that may have low-accuracy reads, such as homopolymer sequences or other repeating sequences, to be determined at a higher accuracy and efficiency.